Associate Professor Johan Rosengren
Associate Professor

Johan Rosengren

Email: 
Phone: 
+61 7 336 51403

Background

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Masters (Coursework) of Biomedical Chemistry, University of Kalmar
  • Doctor of Philosophy, The University of Queensland

Search Professor Johan Rosengren’s works on UQ eSpace

167 works between 2001 and 2024
All (167) Journal Article (137) Book Chapter (3) Conference Publication (26) Other Outputs (1)

161 - 167 of 167 works

2003

Journal Article

Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone

Rosengren, K. J., Clark, R. J., Daly, N. L., Goransson, U., Jones, A. and Craik, D. J. (2003). Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. Journal of the American Chemical Society, 125 (41), 12464-12474. doi: 10.1021/JA0367703

Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone

2003

Other Outputs

Twists, knots and rings : structural features of antimicrobial peptides

Rosengren, Karl Johan (2003). Twists, knots and rings : structural features of antimicrobial peptides. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/253396

Twists, knots and rings : structural features of antimicrobial peptides

2002

Journal Article

The structural and functional diversity of naturally occurring antimicrobial peptides

Rosengren, K. J., Mcmanus, A. and Craik, D. J. (2002). The structural and functional diversity of naturally occurring antimicrobial peptides. Current Medicinal Chemistry - Anti-Infective Agents, 1 (4), 319-341. doi: 10.2174/1568012023354712

The structural and functional diversity of naturally occurring antimicrobial peptides

2002

Journal Article

Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin

Kragol, Goran, Hoffmann, Ralf, Chattergoon, Michael A., Lovas, Sandor, Cudic, Mare, Bulet, Philippe, Condie, Barry A., Rosengren, K. Johan, Montaner, Luis J. and Otvos, Laszlo (2002). Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin. European Journal of Biochemistry, 269 (17), 4226-4237. doi: 10.1046/j.1432-1033.2002.03119.x

Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin

2002

Journal Article

Solution Structures of the cis- and trans-Pro30 Isomers of a Novel 38-Residue Toxin from the Venom of Hadronyche Infensa sp. that Contains a Cystine-Knot Motif within Its Four Disulfide Bonds

Rosengren, K. Johan, Wilson, David, Daly, Norelle L., Alewood, Paul F. and Craik, David J. (2002). Solution Structures of the cis- and trans-Pro30 Isomers of a Novel 38-Residue Toxin from the Venom of Hadronyche Infensa sp. that Contains a Cystine-Knot Motif within Its Four Disulfide Bonds. Biochemistry, 41 (10), 3294-3301. doi: 10.1021/bi011932y

Solution Structures of the cis- and trans-Pro30 Isomers of a Novel 38-Residue Toxin from the Venom of Hadronyche Infensa sp. that Contains a Cystine-Knot Motif within Its Four Disulfide Bonds

2001

Journal Article

Solution structures by H-1 NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant

Korsinczky, M. L. J., Schirra, H. J., Rosengren, K. J., West, J., Condie, B. A., Otvos, L., Anderson, M. A. and Craik, D. J. (2001). Solution structures by H-1 NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant. Journal of Molecular Biology, 311 (3), 579-591. doi: 10.1006/jmbi.2001.4887

Solution structures by H-1 NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant

2001

Journal Article

Solution structure of BSTI: A new trypsin inhibitor from skin secretions of Bombina bombina

Rosengren, K. J., Daly, N. L., Scanlon, M. J. and Craik, D. J. (2001). Solution structure of BSTI: A new trypsin inhibitor from skin secretions of Bombina bombina. Biochemistry, 40 (15), 4601-4609. doi: 10.1021/bi002623v

Solution structure of BSTI: A new trypsin inhibitor from skin secretions of Bombina bombina

Current funding

  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2022
    Buried treasure: bioactive plant seed proteins evolving inside hosts (ARC Discovery Project administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Novel chemical methods to produce next generation insulin analogues (NHMRC Project Grant led by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2019 - 2022
    Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
    NHMRC Project Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Modulating Trk receptors for the treatment of dementia and Alzheimer's disease
    Alzheimers Research UK - Target Validation Pathfinder Grant
    Open grant
  • 2017 - 2019
    Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 (NHMRC Project Grant administered by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2016 - 2019
    Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    Bioactive Peptides as Pharmacological Tools and Novel Drug Leads
    ARC Future Fellowships
    Open grant
  • 2014
    How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene?
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2014 - 2016
    Interrogating peptide receptor targets (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2017
    Modulation of feeding through pharmacological targeting of the relaxin-3 receptor RXFP3
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Determinants of relaxin and INSL3 receptor binding
    University of Melbourne
    Open grant
  • 2012 - 2014
    How do sunflowers make protein drugs in their seeds? (ARC Discovery Project administered by UWA)
    University of Western Australia
    Open grant
  • 2012
    How do sunflowers make protein drugs in their seeds?
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Development of single-chain peptide ligands for the INSL5 receptor RXFP4
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2012
    Characterization of the interaction between relaxin-3 and its receptor RXFP3
    UQ Early Career Researcher
    Open grant
  • 2010 - 2014
    NHMRC Career Development Award: Molecular mechanism and modulation of relaxin family peptide receptors
    NHMRC Career Development Award
    Open grant

Availability

Associate Professor Johan Rosengren is:
Available for supervision

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Available projects

  • Modulating the relaxin-3 neuropeptide receptor to treat anxiety and depression

    The relaxin-3 neuropeptide hormone is involved in criticial signalling controlling motivation and arousal thus its receptor RXFP3 is a potential target for new drugs for depression, anxiety and control of food intake. Out lab has 20 years experience in structure based design of peptide modulators targeting this receptor. Student working in this project will have an opportunity to be involved in peptide design and structural studies using NMR specstroscopy, peptide synthesis and chemistry, as well as functional and stability assays.

Supervision history

Current supervision

Completed supervision

Enquiries

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