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Dr Anne Conibear
Dr

Anne Conibear

Email: 
Phone: 
+61 7 336 51738

Overview

Background

During my postgraduate studies and postdoctoral fellowship, I gained experience in a wide range of chemical biology techniques as well as in initiating and managing collaborations. Building on a background in chemistry and biochemistry, I developed my skills in peptide chemistry and NMR spectroscopy during my PhD in Australia, synthesizing a variety of disulfide-rich cyclic peptides and elucidating their structures and dynamics by NMR spectroscopy. I have gained further experience in protein chemistry, solid phase peptide synthesis and protein ligations during my postdoctoral fellowship in Vienna, collaborating with Syntab Therapeutics on a project involving synthesis and development of synthetic antibodies for cancer therapy. I have recently taken up a UQ Development Fellowship to establish my independent research area in synthesis and structural biology of posttranslationally modified proteins.

Availability

Dr Anne Conibear is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Understanding the role of posttranslational modifications in protein structure and function

    I aim to understand how proteins are regulated by chemical on/off switches - post-translational modifications (PTMs). I use protein chemical synthesis and semi-synthesis to provide access to post-translationally modified proteins for structural biology. The outcome will be new atomic resolution knowledge of how cells use chemical switches to respond to their environments and understanding of how fundamental life processes are controlled.

Works

Search Professor Anne Conibear’s works on UQ eSpace

42 works between 2010 and 2024

1 - 20 of 42 works

2024

Journal Article

Site‐selectively Phosphorylated Hsp90 C‐terminal Domain Variants Provide Access to Deciphering the Chaperone Code

Gajsek, Oliver, Becker, Christian F. W. and Conibear, Anne Claire (2024). Site‐selectively Phosphorylated Hsp90 C‐terminal Domain Variants Provide Access to Deciphering the Chaperone Code. Chemistry – A European Journal. doi: 10.1002/chem.202403676

Site‐selectively Phosphorylated Hsp90 C‐terminal Domain Variants Provide Access to Deciphering the Chaperone Code

2024

Journal Article

Outstanding Reviewers for <i>RSC Chemical Biology</i> in 2023

Conibear, Anne C., Gersch, Malte, Holland, Jason, Jamieson, Andrew G., van Noort, Gerbrand van der Heden, Wagner, Gerd, Yuan, Lin, Zhu, Guangyu and Zou, Taotao (2024). Outstanding Reviewers for RSC Chemical Biology in 2023. Rsc Chemical Biology, 5 (10), 962-962. doi: 10.1039/d4cb90038c

Outstanding Reviewers for <i>RSC Chemical Biology</i> in 2023

2024

Journal Article

Phosphorylation of the HMGN1 nucleosome binding domain decreases helicity and interactions with the acidic patch

Iebed, Dina, Gökler, Tobias, van Ingen, Hugo and Conibear, Anne Claire (2024). Phosphorylation of the HMGN1 nucleosome binding domain decreases helicity and interactions with the acidic patch. ChemBioChem, 25 (22) e202400589, e202400589. doi: 10.1002/cbic.202400589

Phosphorylation of the HMGN1 nucleosome binding domain decreases helicity and interactions with the acidic patch

2024

Journal Article

Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies

Dilly, Joshua J., Morgan, Alexandra L., Bedding, Max J., Low, Jason K. K., Mackay, Joel P., Conibear, Anne C., Bhusal, Ram Prasad, Stone, Martin J., Franck, Charlotte and Payne, Richard J. (2024). Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies. ACS Chemical Biology, 19 (7), 1426-1432. doi: 10.1021/acschembio.4c00230

Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies

2024

Journal Article

Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail

Vogl, Dominik P., Mateos, Borja, Migotti, Mario, Felkl, Manuel, Conibear, Anne C., Konrat, Robert and Becker, Christian F.W. (2024). Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail. Bioorganic and Medicinal Chemistry, 100 117617, 117617. doi: 10.1016/j.bmc.2024.117617

Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail

2023

Journal Article

Reflections on navigating a pandemic: perspectives from the chemical biology community

Conibear, Anne C. and Hartrampf, Nina (2023). Reflections on navigating a pandemic: perspectives from the chemical biology community. ChemBioChem, 24 (14) e202300258, 1-7. doi: 10.1002/cbic.202300258

Reflections on navigating a pandemic: perspectives from the chemical biology community

2023

Journal Article

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

2021

Journal Article

A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4

Clark, Richard J., Phan, Thanh Huyen, Song, Angela, Ouellette, André J., Conibear, Anne C. and Rosengren, K. Johan (2021). A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4. Peptide Science, 114 (1) e24250. doi: 10.1002/pep2.24250

A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4

2021

Journal Article

Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins

Vogl, Dominik P., Conibear, Anne C. and Becker, Christian F. W. (2021). Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins. RSC Chemical Biology, 2 (5), 1441-1461. doi: 10.1039/d1cb00045d

Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins

2021

Journal Article

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications

Niederacher, Gerhard, Urwin, Debra, Dijkwel, Yasmin, Tremethick, David J., Rosengren, K. Johan, Becker, Christian F. W. and Conibear, Anne C. (2021). Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology, 2 (2), 537-550. doi: 10.1039/d0cb00175a

Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications

2021

Journal Article

Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding

Ho, Thao N. T., Lee, Han Siean, Swaminathan, Shilpa, Goodwin, Lewis, Rai, Nishant, Ushay, Brianna, Lewis, Richard J., Rosengren, K. Johan and Conibear, Anne C. (2021). Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Medicinal Chemistry, 12 (9), 1574-1584. doi: 10.1039/d1md00182e

Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding

2020

Journal Article

Deciphering protein post-translational modifications using chemical biology tools

Conibear, Anne C. (2020). Deciphering protein post-translational modifications using chemical biology tools. Nature Reviews Chemistry, 4 (12), 674-695. doi: 10.1038/s41570-020-00223-8

Deciphering protein post-translational modifications using chemical biology tools

2020

Journal Article

Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives

Adeyemi, Christiana M., Conibear, Anne C., Mutorwa, Marius K., Nokalipa, Iviwe C., Isaacs, Michelle, Mnkandhla, Dumisani, Hoppe, Heinrich C., Lobb, Kevin A., Klein, Rosalyn and Kaye, Perry T. (2020). Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives. Bioorganic Chemistry, 101 103947, 103947. doi: 10.1016/j.bioorg.2020.103947

Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives

2019

Journal Article

Random coil shifts of posttranslationally modified amino acids

Conibear, Anne C., Rosengren, K. Johan, Becker, Christian F. W. and Kaehlig, Hanspeter (2019). Random coil shifts of posttranslationally modified amino acids. Journal of Biomolecular NMR, 73 (10-11), 587-599. doi: 10.1007/s10858-019-00270-4

Random coil shifts of posttranslationally modified amino acids

2019

Journal Article

Tumor-targeting immune system engagers (ISErs) activate human neutrophils after binding to cancer cells

Pötgens, André J. G., Conibear, Anne C., Altdorf, Claudia, Hilzendeger, Clarissa and Becker, Christian F. W. (2019). Tumor-targeting immune system engagers (ISErs) activate human neutrophils after binding to cancer cells. Biochemistry, 58 (22) acs.biochem.9b00169, 2642-2652. doi: 10.1021/acs.biochem.9b00169

Tumor-targeting immune system engagers (ISErs) activate human neutrophils after binding to cancer cells

2019

Journal Article

Multifunctional scaffolds for assembling cancer-targeting immune stimulators using chemoselective ligations

Conibear, Anne C., Thewes, Karine, Groysbeck, Nadja and Becker, Christian F.W. (2019). Multifunctional scaffolds for assembling cancer-targeting immune stimulators using chemoselective ligations. Frontiers in Chemistry, 7 (MAR) 113, 113. doi: 10.3389/fchem.2019.00113

Multifunctional scaffolds for assembling cancer-targeting immune stimulators using chemoselective ligations

2019

Conference Publication

Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany

Bello, Claudia, Hartrampf, Nina, Walport, Louise J. and Conibear, Anne C. (2019). Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany. 8th Chemical Protein Synthesis, Berlin, Germany, 16-19 June 2019. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.chembiol.2019.09.011

Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany

2018

Journal Article

Native chemical ligation in protein synthesis and semi-synthesis

Conibear, Anne C., Watson, Emma E., Payne, Richard J. and Becker, Christian F. W. (2018). Native chemical ligation in protein synthesis and semi-synthesis. Chemical Society Reviews, 47 (24), 9046-9068. doi: 10.1039/c8cs00573g

Native chemical ligation in protein synthesis and semi-synthesis

2018

Conference Publication

Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel

Conibear, Anne C. and Muttenthaler, Markus (2018). Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.chembiol.2018.03.001

Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel

2018

Journal Article

Synthetic cancer-targeting innate immune stimulators give insights into avidity effects

Conibear, Anne C., Poetgens, Andre J. G., Thewes, Karine, Altdorf, Claudia, Hilzendeger, Clarissa and Becker, Christian F. W. (2018). Synthetic cancer-targeting innate immune stimulators give insights into avidity effects. ChemBioChem, 19 (5), 459-469. doi: 10.1002/cbic.201700522

Synthetic cancer-targeting innate immune stimulators give insights into avidity effects

Funding

Past funding

  • 2022
    Australian Peptide Display Facility (ARC LIEF administered by University of Sydney)
    University of Sydney
    Open grant
  • 2020 - 2021
    Decorated venom: Exploring the role of cone snail venom modifications
    UQ Early Career Researcher
    Open grant
  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2021
    Insights into protein modifications by NMR
    UQ Development Fellowships
    Open grant

Supervision

Availability

Dr Anne Conibear is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Media

Enquiries

Contact Dr Anne Conibear directly for media enquiries about:

  • nuclear magnetic resonance
  • peptides
  • protein modifications
  • proteins
  • structural biology

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au