Overview
Background
During my postgraduate studies and postdoctoral fellowship, I gained experience in a wide range of chemical biology techniques as well as in initiating and managing collaborations. Building on a background in chemistry and biochemistry, I developed my skills in peptide chemistry and NMR spectroscopy during my PhD in Australia, synthesizing a variety of disulfide-rich cyclic peptides and elucidating their structures and dynamics by NMR spectroscopy. I have gained further experience in protein chemistry, solid phase peptide synthesis and protein ligations during my postdoctoral fellowship in Vienna, collaborating with Syntab Therapeutics on a project involving synthesis and development of synthetic antibodies for cancer therapy. I have recently taken up a UQ Development Fellowship to establish my independent research area in synthesis and structural biology of posttranslationally modified proteins.
Availability
- Dr Anne Conibear is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Understanding the role of posttranslational modifications in protein structure and function
I aim to understand how proteins are regulated by chemical on/off switches - post-translational modifications (PTMs). I use protein chemical synthesis and semi-synthesis to provide access to post-translationally modified proteins for structural biology. The outcome will be new atomic resolution knowledge of how cells use chemical switches to respond to their environments and understanding of how fundamental life processes are controlled.
Works
Search Professor Anne Conibear’s works on UQ eSpace
2024
Journal Article
Site‐selectively Phosphorylated Hsp90 C‐terminal Domain Variants Provide Access to Deciphering the Chaperone Code
Gajsek, Oliver, Becker, Christian F. W. and Conibear, Anne Claire (2024). Site‐selectively Phosphorylated Hsp90 C‐terminal Domain Variants Provide Access to Deciphering the Chaperone Code. Chemistry – A European Journal. doi: 10.1002/chem.202403676
2024
Journal Article
Outstanding Reviewers for <i>RSC Chemical Biology</i> in 2023
Conibear, Anne C., Gersch, Malte, Holland, Jason, Jamieson, Andrew G., van Noort, Gerbrand van der Heden, Wagner, Gerd, Yuan, Lin, Zhu, Guangyu and Zou, Taotao (2024). Outstanding Reviewers for RSC Chemical Biology in 2023. Rsc Chemical Biology, 5 (10), 962-962. doi: 10.1039/d4cb90038c
2024
Journal Article
Phosphorylation of the HMGN1 nucleosome binding domain decreases helicity and interactions with the acidic patch
Iebed, Dina, Gökler, Tobias, van Ingen, Hugo and Conibear, Anne Claire (2024). Phosphorylation of the HMGN1 nucleosome binding domain decreases helicity and interactions with the acidic patch. ChemBioChem, 25 (22) e202400589, e202400589. doi: 10.1002/cbic.202400589
2024
Journal Article
Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies
Dilly, Joshua J., Morgan, Alexandra L., Bedding, Max J., Low, Jason K. K., Mackay, Joel P., Conibear, Anne C., Bhusal, Ram Prasad, Stone, Martin J., Franck, Charlotte and Payne, Richard J. (2024). Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies. ACS Chemical Biology, 19 (7), 1426-1432. doi: 10.1021/acschembio.4c00230
2024
Journal Article
Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail
Vogl, Dominik P., Mateos, Borja, Migotti, Mario, Felkl, Manuel, Conibear, Anne C., Konrat, Robert and Becker, Christian F.W. (2024). Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail. Bioorganic and Medicinal Chemistry, 100 117617, 117617. doi: 10.1016/j.bmc.2024.117617
2023
Journal Article
Reflections on navigating a pandemic: perspectives from the chemical biology community
Conibear, Anne C. and Hartrampf, Nina (2023). Reflections on navigating a pandemic: perspectives from the chemical biology community. ChemBioChem, 24 (14) e202300258, 1-7. doi: 10.1002/cbic.202300258
2023
Journal Article
Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR
Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023
2021
Journal Article
A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4
Clark, Richard J., Phan, Thanh Huyen, Song, Angela, Ouellette, André J., Conibear, Anne C. and Rosengren, K. Johan (2021). A conserved β‐bulge glycine residue facilitates folding and increases stability of the mouse α‐defensin cryptdin‐4. Peptide Science, 114 (1) e24250. doi: 10.1002/pep2.24250
2021
Journal Article
Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins
Vogl, Dominik P., Conibear, Anne C. and Becker, Christian F. W. (2021). Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins. RSC Chemical Biology, 2 (5), 1441-1461. doi: 10.1039/d1cb00045d
2021
Journal Article
Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications
Niederacher, Gerhard, Urwin, Debra, Dijkwel, Yasmin, Tremethick, David J., Rosengren, K. Johan, Becker, Christian F. W. and Conibear, Anne C. (2021). Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology, 2 (2), 537-550. doi: 10.1039/d0cb00175a
2021
Journal Article
Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding
Ho, Thao N. T., Lee, Han Siean, Swaminathan, Shilpa, Goodwin, Lewis, Rai, Nishant, Ushay, Brianna, Lewis, Richard J., Rosengren, K. Johan and Conibear, Anne C. (2021). Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Medicinal Chemistry, 12 (9), 1574-1584. doi: 10.1039/d1md00182e
2020
Journal Article
Deciphering protein post-translational modifications using chemical biology tools
Conibear, Anne C. (2020). Deciphering protein post-translational modifications using chemical biology tools. Nature Reviews Chemistry, 4 (12), 674-695. doi: 10.1038/s41570-020-00223-8
2020
Journal Article
Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives
Adeyemi, Christiana M., Conibear, Anne C., Mutorwa, Marius K., Nokalipa, Iviwe C., Isaacs, Michelle, Mnkandhla, Dumisani, Hoppe, Heinrich C., Lobb, Kevin A., Klein, Rosalyn and Kaye, Perry T. (2020). Synthesis and anti-parasitic activity of achiral N-benzylated phosphoramidic acid derivatives. Bioorganic Chemistry, 101 103947, 103947. doi: 10.1016/j.bioorg.2020.103947
2019
Journal Article
Random coil shifts of posttranslationally modified amino acids
Conibear, Anne C., Rosengren, K. Johan, Becker, Christian F. W. and Kaehlig, Hanspeter (2019). Random coil shifts of posttranslationally modified amino acids. Journal of Biomolecular NMR, 73 (10-11), 587-599. doi: 10.1007/s10858-019-00270-4
2019
Journal Article
Tumor-targeting immune system engagers (ISErs) activate human neutrophils after binding to cancer cells
Pötgens, André J. G., Conibear, Anne C., Altdorf, Claudia, Hilzendeger, Clarissa and Becker, Christian F. W. (2019). Tumor-targeting immune system engagers (ISErs) activate human neutrophils after binding to cancer cells. Biochemistry, 58 (22) acs.biochem.9b00169, 2642-2652. doi: 10.1021/acs.biochem.9b00169
2019
Journal Article
Multifunctional scaffolds for assembling cancer-targeting immune stimulators using chemoselective ligations
Conibear, Anne C., Thewes, Karine, Groysbeck, Nadja and Becker, Christian F.W. (2019). Multifunctional scaffolds for assembling cancer-targeting immune stimulators using chemoselective ligations. Frontiers in Chemistry, 7 (MAR) 113, 113. doi: 10.3389/fchem.2019.00113
2019
Conference Publication
Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany
Bello, Claudia, Hartrampf, Nina, Walport, Louise J. and Conibear, Anne C. (2019). Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany. 8th Chemical Protein Synthesis, Berlin, Germany, 16-19 June 2019. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.chembiol.2019.09.011
2018
Journal Article
Native chemical ligation in protein synthesis and semi-synthesis
Conibear, Anne C., Watson, Emma E., Payne, Richard J. and Becker, Christian F. W. (2018). Native chemical ligation in protein synthesis and semi-synthesis. Chemical Society Reviews, 47 (24), 9046-9068. doi: 10.1039/c8cs00573g
2018
Conference Publication
Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel
Conibear, Anne C. and Muttenthaler, Markus (2018). Advancing the frontiers of chemical protein synthesis - the 7CPS meeting, Haifa, Israel. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.chembiol.2018.03.001
2018
Journal Article
Synthetic cancer-targeting innate immune stimulators give insights into avidity effects
Conibear, Anne C., Poetgens, Andre J. G., Thewes, Karine, Altdorf, Claudia, Hilzendeger, Clarissa and Becker, Christian F. W. (2018). Synthetic cancer-targeting innate immune stimulators give insights into avidity effects. ChemBioChem, 19 (5), 459-469. doi: 10.1002/cbic.201700522
Funding
Past funding
Supervision
Availability
- Dr Anne Conibear is:
- Available for supervision
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Supervision history
Completed supervision
-
2024
Master Philosophy
The Structural and Functional Role of Post-translational Modification in the µ-Conotoxins
Associate Advisor
Other advisors: Associate Professor Richard Clark, Associate Professor Johan Rosengren
Media
Enquiries
Contact Dr Anne Conibear directly for media enquiries about:
- nuclear magnetic resonance
- peptides
- protein modifications
- proteins
- structural biology
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