
Overview
Background
During my postgraduate studies and postdoctoral fellowship, I gained experience in a wide range of chemical biology techniques as well as in initiating and managing collaborations. Building on a background in chemistry and biochemistry, I developed my skills in peptide chemistry and NMR spectroscopy during my PhD in Australia, synthesizing a variety of disulfide-rich cyclic peptides and elucidating their structures and dynamics by NMR spectroscopy. I have gained further experience in protein chemistry, solid phase peptide synthesis and protein ligations during my postdoctoral fellowship in Vienna, collaborating with Syntab Therapeutics on a project involving synthesis and development of synthetic antibodies for cancer therapy. I have recently taken up a UQ Development Fellowship to establish my independent research area in synthesis and structural biology of posttranslationally modified proteins.
Availability
- Dr Anne Conibear is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Understanding the role of posttranslational modifications in protein structure and function
I aim to understand how proteins are regulated by chemical on/off switches - post-translational modifications (PTMs). I use protein chemical synthesis and semi-synthesis to provide access to post-translationally modified proteins for structural biology. The outcome will be new atomic resolution knowledge of how cells use chemical switches to respond to their environments and understanding of how fundamental life processes are controlled.
Works
Search Professor Anne Conibear’s works on UQ eSpace
2011
Journal Article
Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors
Bodin, Taryn, Conibear, Anne C., Blatch, Gregory L., Lobb, Kevin A. and Kaye, Perry T. (2011). Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors. Bioorganic and Medicinal Chemistry, 19 (3), 1321-1327. doi: 10.1016/j.bmc.2010.11.062
2010
Journal Article
P-31 NMR kinetic study of the tandem cleavage of phosphonate esters by bromotrimethylsilane
Conibear, Anne C., Lobb, Kevin A. and Kaye, Perry T. (2010). P-31 NMR kinetic study of the tandem cleavage of phosphonate esters by bromotrimethylsilane. Tetrahedron, 66 (43), 8446-8449. doi: 10.1016/j.tet.2010.08.058
Funding
Past funding
Supervision
Availability
- Dr Anne Conibear is:
- Available for supervision
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Supervision history
Completed supervision
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2024
Master Philosophy
The Structural and Functional Role of Post-translational Modification in the µ-Conotoxins
Associate Advisor
Other advisors: Associate Professor Richard Clark, Associate Professor Johan Rosengren
Media
Enquiries
Contact Dr Anne Conibear directly for media enquiries about:
- nuclear magnetic resonance
- peptides
- protein modifications
- proteins
- structural biology
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