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Dr Anne Conibear
Dr

Anne Conibear

Email: 
Phone: 
+61 7 336 51738

Overview

Background

During my postgraduate studies and postdoctoral fellowship, I gained experience in a wide range of chemical biology techniques as well as in initiating and managing collaborations. Building on a background in chemistry and biochemistry, I developed my skills in peptide chemistry and NMR spectroscopy during my PhD in Australia, synthesizing a variety of disulfide-rich cyclic peptides and elucidating their structures and dynamics by NMR spectroscopy. I have gained further experience in protein chemistry, solid phase peptide synthesis and protein ligations during my postdoctoral fellowship in Vienna, collaborating with Syntab Therapeutics on a project involving synthesis and development of synthetic antibodies for cancer therapy. I have recently taken up a UQ Development Fellowship to establish my independent research area in synthesis and structural biology of posttranslationally modified proteins.

Availability

Dr Anne Conibear is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Understanding the role of posttranslational modifications in protein structure and function

    I aim to understand how proteins are regulated by chemical on/off switches - post-translational modifications (PTMs). I use protein chemical synthesis and semi-synthesis to provide access to post-translationally modified proteins for structural biology. The outcome will be new atomic resolution knowledge of how cells use chemical switches to respond to their environments and understanding of how fundamental life processes are controlled.

Works

Search Professor Anne Conibear’s works on UQ eSpace

41 works between 2010 and 2024

21 - 40 of 41 works

2017

Journal Article

A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold

Gell, Anna Lena, Groysbeck, Nadja, Becker, Christian F. W. and Conibear, Anne C. (2017). A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold. Journal of Peptide Science, 23 (12), 871-879. doi: 10.1002/psc.3051

A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold

2017

Journal Article

Recent Advances in Peptide-Based Approaches for Cancer Treatment

Conibear, Anne C., Schmid, Alanca, Kamalov, Meder, Becker, Christian F. W. and Bello, Claudia (2017). Recent Advances in Peptide-Based Approaches for Cancer Treatment. Current Medicinal Chemistry, 27 (8), 1174-1205. doi: 10.2174/0929867325666171123204851

Recent Advances in Peptide-Based Approaches for Cancer Treatment

2017

Journal Article

Multifunctional alpha(v)beta(6) integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting

Conibear, Anne C., Hager, Sonja, Mayr, Josef, Klose, Matthias H. M., Keppler, Bernhard K., Kowol, Christian R., Heffeter, Petra and Becker, Christian F. W. (2017). Multifunctional alpha(v)beta(6) integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting. Bioconjugate Chemistry, 28 (9), 2429-2439. doi: 10.1021/acs.bioconjchem.7b00421

Multifunctional alpha(v)beta(6) integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting

2016

Journal Article

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

2016

Journal Article

Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product

Conibear, Anne C., Farbiarz, Karine, Mayer, Rupert L., Matveenko, Maria, Kaehlig, Hanspeter and Becker, Christian F. W. (2016). Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product. Organic and Biomolecular Chemistry, 14 (26), 6205-6211. doi: 10.1039/c6ob00932h

Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product

2016

Journal Article

Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties

Wang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016). Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 (17), 5706-5713. doi: 10.1021/jacs.6b02575

Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties

2016

Journal Article

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization

2015

Journal Article

Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins

Akcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6), 682-692. doi: 10.1002/bip.22699

Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins

2014

Journal Article

Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis

Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c

Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis

2014

Journal Article

The chemistry and biology of theta defensins

Conibear, Anne C. and Craik, David J. (2014). The chemistry and biology of theta defensins. Angewandte Chemie International Edition, 53 (40), 10612-10623. doi: 10.1002/anie.201402167

The chemistry and biology of theta defensins

2014

Journal Article

Chemie und Biologie von Theta-Defensinen

Conibear, Anne C. and Craik, David J. (2014). Chemie und Biologie von Theta-Defensinen. Angewandte Chemie, 126 (40), 10786-10798. doi: 10.1002/ange.201402167

Chemie und Biologie von Theta-Defensinen

2014

Journal Article

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif

Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568

The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif

2014

Other Outputs

Characterisation and applications of theta-defensins

Conibear, Anne (2014). Characterisation and applications of theta-defensins. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2014.251

Characterisation and applications of theta-defensins

2013

Journal Article

Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors

Bodill, Taryn, Conibear, Anne C., Mutorwa, Marius K. M., Goble, Jessica L., Blatch, Gregory L., Lobb, Kevin A., Klein, Rosalyn and Kaye, Perry T. (2013). Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors. Bioorganic and Medicinal Chemistry, 21 (14), 4332-4341. doi: 10.1016/j.bmc.2013.04.076

Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors

2013

Journal Article

The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity

Conibear, Anne C., Rosengren, K. Johan, Daly, Norelle L., Henriques, Sonia Troeira and Craik, David J. (2013). The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. Journal of Biological Chemistry, 288 (15), 10830-10840. doi: 10.1074/jbc.M113.451047

The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity

2012

Journal Article

Structural characterization of the cyclic cystine ladder motif of θ-defensins

Conibear, Anne C., Rosengren, K. Johan, Harvey, Peta J. and Craik, David J. (2012). Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry, 51 (48), 9718-9726. doi: 10.1021/bi301363a

Structural characterization of the cyclic cystine ladder motif of θ-defensins

2012

Journal Article

Quantification of small cyclic disulfide-rich peptides

Conibear, Anne, Daly, Norelle L. and Craik, David J. (2012). Quantification of small cyclic disulfide-rich peptides. Biopolymers, 98 (6), 518-524. doi: 10.1002/bip.22121

Quantification of small cyclic disulfide-rich peptides

2011

Journal Article

Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals

Conibear, Anne C. and Craik, David J. (2011). Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals. Israel Journal of Chemistry, 51 (8-9), 908-916. doi: 10.1002/ijch.201100067

Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals

2011

Journal Article

The chemistry of cyclotides

Craik, David J. and Conibear, Anne C. (2011). The chemistry of cyclotides. Journal of Organic Chemistry, 76 (12), 4805-4817. doi: 10.1021/jo200520v

The chemistry of cyclotides

2011

Journal Article

Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors

Bodin, Taryn, Conibear, Anne C., Blatch, Gregory L., Lobb, Kevin A. and Kaye, Perry T. (2011). Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors. Bioorganic and Medicinal Chemistry, 19 (3), 1321-1327. doi: 10.1016/j.bmc.2010.11.062

Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors

Funding

Past funding

  • 2022
    Australian Peptide Display Facility (ARC LIEF administered by University of Sydney)
    University of Sydney
    Open grant
  • 2020 - 2021
    Decorated venom: Exploring the role of cone snail venom modifications
    UQ Early Career Researcher
    Open grant
  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2021
    Insights into protein modifications by NMR
    UQ Development Fellowships
    Open grant

Supervision

Availability

Dr Anne Conibear is:
Available for supervision

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Media

Enquiries

Contact Dr Anne Conibear directly for media enquiries about:

  • nuclear magnetic resonance
  • peptides
  • protein modifications
  • proteins
  • structural biology

Need help?

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communications@uq.edu.au