
Overview
Background
During my postgraduate studies and postdoctoral fellowship, I gained experience in a wide range of chemical biology techniques as well as in initiating and managing collaborations. Building on a background in chemistry and biochemistry, I developed my skills in peptide chemistry and NMR spectroscopy during my PhD in Australia, synthesizing a variety of disulfide-rich cyclic peptides and elucidating their structures and dynamics by NMR spectroscopy. I have gained further experience in protein chemistry, solid phase peptide synthesis and protein ligations during my postdoctoral fellowship in Vienna, collaborating with Syntab Therapeutics on a project involving synthesis and development of synthetic antibodies for cancer therapy. I have recently taken up a UQ Development Fellowship to establish my independent research area in synthesis and structural biology of posttranslationally modified proteins.
Availability
- Dr Anne Conibear is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Understanding the role of posttranslational modifications in protein structure and function
I aim to understand how proteins are regulated by chemical on/off switches - post-translational modifications (PTMs). I use protein chemical synthesis and semi-synthesis to provide access to post-translationally modified proteins for structural biology. The outcome will be new atomic resolution knowledge of how cells use chemical switches to respond to their environments and understanding of how fundamental life processes are controlled.
Works
Search Professor Anne Conibear’s works on UQ eSpace
2017
Journal Article
Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation
Brehs, Manuel, Poetgens, Andre J. G., Steitz, Julia, Thewes, Karine, Schwarz, Janett, Conibear, Anne C., Bartneck, Matthias, Tacke, Frank and Becker, Christian F. W. (2017). Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation. Scientific Reports, 7 (1) 17592, 17592. doi: 10.1038/s41598-017-17627-0
2017
Journal Article
A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold
Gell, Anna Lena, Groysbeck, Nadja, Becker, Christian F. W. and Conibear, Anne C. (2017). A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold. Journal of Peptide Science, 23 (12), 871-879. doi: 10.1002/psc.3051
2017
Journal Article
Recent Advances in Peptide-Based Approaches for Cancer Treatment
Conibear, Anne C., Schmid, Alanca, Kamalov, Meder, Becker, Christian F. W. and Bello, Claudia (2017). Recent Advances in Peptide-Based Approaches for Cancer Treatment. Current Medicinal Chemistry, 27 (8), 1174-1205. doi: 10.2174/0929867325666171123204851
2017
Journal Article
Multifunctional alpha(v)beta(6) integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting
Conibear, Anne C., Hager, Sonja, Mayr, Josef, Klose, Matthias H. M., Keppler, Bernhard K., Kowol, Christian R., Heffeter, Petra and Becker, Christian F. W. (2017). Multifunctional alpha(v)beta(6) integrin-specific peptide-Pt(IV) conjugates for cancer cell targeting. Bioconjugate Chemistry, 28 (9), 2429-2439. doi: 10.1021/acs.bioconjchem.7b00421
2016
Journal Article
Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide
Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993
2016
Journal Article
Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product
Conibear, Anne C., Farbiarz, Karine, Mayer, Rupert L., Matveenko, Maria, Kaehlig, Hanspeter and Becker, Christian F. W. (2016). Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product. Organic and Biomolecular Chemistry, 14 (26), 6205-6211. doi: 10.1039/c6ob00932h
2016
Journal Article
Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties
Wang, Conan K., King, Gordon J., Conibear, Anne C., Ramos, Mariana C., Chaousis, Stephanie, Henriques, Sonia Troeira and Craik, David J. (2016). Mirror images of antimicrobial peptides provide reflections on their functions and amyloidogenic properties. Journal of American Chemical Society, 138 (17), 5706-5713. doi: 10.1021/jacs.6b02575
2016
Journal Article
Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization
Conibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767
2015
Journal Article
Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins
Akcan, Muharrem, Clark, Richard J., Daly, Norelle L., Conibear, Anne C., de Faoite, Andrew, Heghinian, Mari D., Sahil, Talwar, Adams, David J., Mari, Frank and Craik, David J. (2015). Transforming conotoxins into cyclotides: backbone cyclization of P-superfamily conotoxins. Peptide Science, 104 (6), 682-692. doi: 10.1002/bip.22699
2014
Journal Article
Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis
Conibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c
2014
Journal Article
The chemistry and biology of theta defensins
Conibear, Anne C. and Craik, David J. (2014). The chemistry and biology of theta defensins. Angewandte Chemie International Edition, 53 (40), 10612-10623. doi: 10.1002/anie.201402167
2014
Journal Article
Chemie und Biologie von Theta-Defensinen
Conibear, Anne C. and Craik, David J. (2014). Chemie und Biologie von Theta-Defensinen. Angewandte Chemie, 126 (40), 10786-10798. doi: 10.1002/ange.201402167
2014
Journal Article
The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif
Conibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568
2014
Other Outputs
Characterisation and applications of theta-defensins
Conibear, Anne (2014). Characterisation and applications of theta-defensins. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2014.251
2013
Journal Article
Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors
Bodill, Taryn, Conibear, Anne C., Mutorwa, Marius K. M., Goble, Jessica L., Blatch, Gregory L., Lobb, Kevin A., Klein, Rosalyn and Kaye, Perry T. (2013). Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors. Bioorganic and Medicinal Chemistry, 21 (14), 4332-4341. doi: 10.1016/j.bmc.2013.04.076
2013
Journal Article
The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity
Conibear, Anne C., Rosengren, K. Johan, Daly, Norelle L., Henriques, Sonia Troeira and Craik, David J. (2013). The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. Journal of Biological Chemistry, 288 (15), 10830-10840. doi: 10.1074/jbc.M113.451047
2012
Journal Article
Structural characterization of the cyclic cystine ladder motif of θ-defensins
Conibear, Anne C., Rosengren, K. Johan, Harvey, Peta J. and Craik, David J. (2012). Structural characterization of the cyclic cystine ladder motif of θ-defensins. Biochemistry, 51 (48), 9718-9726. doi: 10.1021/bi301363a
2012
Journal Article
Quantification of small cyclic disulfide-rich peptides
Conibear, Anne, Daly, Norelle L. and Craik, David J. (2012). Quantification of small cyclic disulfide-rich peptides. Biopolymers, 98 (6), 518-524. doi: 10.1002/bip.22121
2011
Journal Article
Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals
Conibear, Anne C. and Craik, David J. (2011). Chemical Synthesis of Naturally-Occurring Cyclic Mini-Proteins from Plants and Animals. Israel Journal of Chemistry, 51 (8-9), 908-916. doi: 10.1002/ijch.201100067
2011
Journal Article
The chemistry of cyclotides
Craik, David J. and Conibear, Anne C. (2011). The chemistry of cyclotides. Journal of Organic Chemistry, 76 (12), 4805-4817. doi: 10.1021/jo200520v
Funding
Past funding
Supervision
Availability
- Dr Anne Conibear is:
- Available for supervision
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Supervision history
Completed supervision
-
2024
Master Philosophy
The Structural and Functional Role of Post-translational Modification in the µ-Conotoxins
Associate Advisor
Other advisors: Associate Professor Richard Clark, Associate Professor Johan Rosengren
Media
Enquiries
Contact Dr Anne Conibear directly for media enquiries about:
- nuclear magnetic resonance
- peptides
- protein modifications
- proteins
- structural biology
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