Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia) (2016-2019)

This project aims to develop technologies to monitor how proteins and their interacting molecules (such as hormones) form multi-component complexes, and how these complexes function in the cell, including movement from the cell surface, into different cellular compartments and back up to the surface. It is significant as these technologies are expected to enable monitoring in live cells in real-time with exquisitely high sensitivity. This project will have broad benefits and impact for studying all aspects of the life sciences at the cellular and molecular levels. How these protein complexes function in cells underpins much of our understanding of biology, and technological tools to investigate this have substantial commercial potential.