Associate Professor Johan Rosengren
Associate Professor

Johan Rosengren

Email: 
Phone: 
+61 7 336 51403

Background

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Masters (Coursework) of Biomedical Chemistry, University of Kalmar
  • Doctor of Philosophy, The University of Queensland

Search Professor Johan Rosengren’s works on UQ eSpace

167 works between 2001 and 2024
All (167) Journal Article (137) Book Chapter (3) Conference Publication (26) Other Outputs (1)

121 - 140 of 167 works

2010

Conference Publication

Characterisation of the human INSL5 solution structure

Haugaard-Kedstrom, M., Hossain, M. A., Daly, N. L., Bathgate, R. A. D., Craik, D. J., Wade, J. D. and Rosengren, K. J. (2010). Characterisation of the human INSL5 solution structure. EPS 2010: The 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Bognor Regis, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303

Characterisation of the human INSL5 solution structure

2009

Journal Article

How bugs make lassos

Rosengren, K. J. and Craik, D. J. (2009). How bugs make lassos. Chemistry and Biology, 16 (12), 1211-1212. doi: 10.1016/j.chembiol.2009.12.004

How bugs make lassos

2009

Journal Article

Theoretical and computational strategies for rational molecularly imprinted polymer design

Nicholls, Ian A., Andersson, Hakan S., Charlton, Christy, Henschel, Henning, Karlsson, Bjorn C. G., Karlsson, Jesper G., O'Mahony, John, Rosengren, Annika M., Rosengren, K. Johan and Wikman, Susanne (2009). Theoretical and computational strategies for rational molecularly imprinted polymer design. Biosensors & Bioelectronics, 25 (3), 543-552. doi: 10.1016/j.bios.2009.03.038

Theoretical and computational strategies for rational molecularly imprinted polymer design

2009

Journal Article

Discovery, structure and biological activities of cyclotides

Daly, N.L ., Rosengren, K. J. and Craik, D. J. (2009). Discovery, structure and biological activities of cyclotides. Advanced Drug Delivery Reviews, 61 (11), 918-930. doi: 10.1016/j.addr.2009.05.003

Discovery, structure and biological activities of cyclotides

2009

Journal Article

The conserved glu in the cyclotide cycloviolacin O2 has a key structural role

Goransson, Ulf, Herrmann, Anders, Burman, Robert, Haugaard-Jonsson, Linda M. and Rosengren, K. Johan (2009). The conserved glu in the cyclotide cycloviolacin O2 has a key structural role. Chembiochem, 10 (14), 2354-2360. doi: 10.1002/cbic.200900342

The conserved glu in the cyclotide cycloviolacin O2 has a key structural role

2009

Journal Article

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

Haugaard-Jonsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Craik, David J., Wade, John D. and Rosengren, K. Johan (2009). Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. Biochemical Journal, 419 (3), 619-627. doi: 10.1042/BJ20082353

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

2009

Journal Article

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009). Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 (16), 10672-10683. doi: 10.1074/jbc.M900021200

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

2009

Conference Publication

Retrocyclin-2: A potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif

Daly, Norelle L., Yi, Chen K., Rosengren, K. Johan, Marx, Ute C., Phillips, Martin L., Waring, Alan J., Wang, Wei, Lehrer, Robert I. and Craik, David J. (2009). Retrocyclin-2: A potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif. 20th American Peptide Society Symposium, Montreal, Canada, 26-30 June 2007. New York, United States: Springer New York LLC. doi: 10.1007/978-0-387-73657-0_254

Retrocyclin-2: A potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif

2009

Book Chapter

NMR of peptide toxins

Rosengren, K. Johan, Daly, N. L. and Craik, D. J. (2009). NMR of peptide toxins. Annual reports on NMR Spectroscopy. (pp. 89-147) edited by Graham A. Webb. Oxford England U.K.: Academic Press Elsevier. doi: 10.1016/S0066-4103(09)06802-1

NMR of peptide toxins

2009

Conference Publication

Structural properties of relaxin chimeras: NMR characterization of the R3/I5 relaxin peptide

Haugaard-Jonsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Wade, John D., Craik, David J. and Rosengren, K. Johan (2009). Structural properties of relaxin chimeras: NMR characterization of the R3/I5 relaxin peptide. Relaxin and Related Peptides Fifth International Conference, Maui, Hawaii, USA, 18-23 May, 2008. New York, U.S.A.: The Academy. doi: 10.1111/j.1749-6632.2008.03805.x

Structural properties of relaxin chimeras: NMR characterization of the R3/I5 relaxin peptide

2009

Journal Article

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

Hossain, Mohammed Akhter, Rosengren, K. Johan, Zhang, Suode, Bathgate, Ross A. D., Tregear, Geoffrey W., van Lierop, Bianca J., Robinson, Andrea J. and Wade, John D. (2009). Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity. Organic & Biomolecular Chemistry, 7 (8), 1547-1553. doi: 10.1039/b821882j

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

2009

Journal Article

The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BΔ23-27)R/I5

Akhter Hossain, Mohammed, Bathgate, Ross A. D., Rosengren, K. Johan, Shabanpoor, Fazel, Zhang, Suode, Lin, Feng, Tregear, Geoffrey W. and Wade, John D. (2009). The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BΔ23-27)R/I5. Chemical Biology and Drug Design, 73 (1), 46-52. doi: 10.1111/j.1747-0285.2008.00756.x

The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BΔ23-27)R/I5

2009

Conference Publication

Structural insights into the function of relaxins

Rosengren, K. Johan, Bathgate, Ross A. D., Craik, David J., Daly, Norelle L., Haugaard-Jonsson, Linda M., Hossain, Mohammed Akhter and Wade, John D. (2009). Structural insights into the function of relaxins. Relaxin and Related Peptides Fifth International Conference, Maui, Hawaii, USA, 18-23 May, 2008. New York, U.S.A.: The Academy. doi: 10.1111/j.1749-6632.2009.03833.x

Structural insights into the function of relaxins

2009

Journal Article

NMR of Peptide Toxins

Rosengren, K. Johan, Daly, Norelle L. and Craik, David J. (2009). NMR of Peptide Toxins. Annual Reports on NMR Spectroscopy, 68 (C), 89-147. doi: 10.1016/S0066-4103(09)06802-1

NMR of Peptide Toxins

2008

Journal Article

Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist

Haugaard-Jönsson, Linda M., Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Wade, John D., Craik, David J. and Rosengren, K. Johan (2008). Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist. The Journal of Biological Chemistry, 283 (35), 23811-23818. doi: 10.1074/jbc.M800489200

Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist

2008

Journal Article

Synthesis, conformation, and activity of human insulin-like Peptide 5 (INSL5)

Hossain, Mohammed Akhter, Bathgate, Ross A. D., Kong, Chze K., Shabanpoor, Fazel, Suode Zhang, Haugaard-Jönsson, Linda M., Rosengren, K. Johan, Tregear, Geoffrey W. and Wade, John D. (2008). Synthesis, conformation, and activity of human insulin-like Peptide 5 (INSL5). ChemBioChem, 9 (11), 1816-1822. doi: 10.1002/cbic.200800113

Synthesis, conformation, and activity of human insulin-like Peptide 5 (INSL5)

2008

Journal Article

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors

Hossain, M. A., Rosengren, K. J., Haugaard-Jonsson, L. M., Zhang, S., Layfield, S., Ferraro, T., Daly, N. L., Tregear, G. W., Wade, J. D. and Bathgate, R. A. D. (2008). The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. Journal of Biological Chemistry, 283 (25), 17287-17297. doi: 10.1074/jbc.M801911200

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors

2008

Journal Article

Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity

Simonsen, S. M., Sando, L., Rosengren, K. J., Wang, C. K., Colgrave, M. L., Daly, N. L. and Craik, D. J. (2008). Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity. Journal of Biological Chemistry, 283 (15), 9805-9813. doi: 10.1074/jbc.M709303200

Alanine Scanning mutagenesis of the prototypic cyclotide reveals a cluster of residues essential for bioactivity

2008

Journal Article

In vitro assays of molecular motors: Impact of motor-surface interactions

Mansson, Alf, Balaz, Martina, Albet-Torres, Nuria and Rosengren, K Johan (2008). In vitro assays of molecular motors: Impact of motor-surface interactions. Frontiers In Bioscience, 13 (15), 5732-5754. doi: 10.2741/3112

In vitro assays of molecular motors: Impact of motor-surface interactions

2007

Journal Article

Retrocyclin-2: Structural analysis of a potent anti-HIV θ-defensin

Daly, Norelle L., Chen, Y, Rosengren, KJ, Marx, UC, Phillips, ML, Waring, AJ, Wang, W, Lehrer, RI and Craik, David J. (2007). Retrocyclin-2: Structural analysis of a potent anti-HIV θ-defensin. Biochemistry, 46 (35), 9920-9928. doi: 10.1021/bi700720e

Retrocyclin-2: Structural analysis of a potent anti-HIV θ-defensin

Current funding

  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2022
    Buried treasure: bioactive plant seed proteins evolving inside hosts (ARC Discovery Project administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Novel chemical methods to produce next generation insulin analogues (NHMRC Project Grant led by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2019 - 2022
    Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
    NHMRC Project Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Modulating Trk receptors for the treatment of dementia and Alzheimer's disease
    Alzheimers Research UK - Target Validation Pathfinder Grant
    Open grant
  • 2017 - 2019
    Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 (NHMRC Project Grant administered by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2016 - 2019
    Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    Bioactive Peptides as Pharmacological Tools and Novel Drug Leads
    ARC Future Fellowships
    Open grant
  • 2014
    How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene?
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2014 - 2016
    Interrogating peptide receptor targets (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2017
    Modulation of feeding through pharmacological targeting of the relaxin-3 receptor RXFP3
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Determinants of relaxin and INSL3 receptor binding
    University of Melbourne
    Open grant
  • 2012 - 2014
    How do sunflowers make protein drugs in their seeds? (ARC Discovery Project administered by UWA)
    University of Western Australia
    Open grant
  • 2012
    How do sunflowers make protein drugs in their seeds?
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Development of single-chain peptide ligands for the INSL5 receptor RXFP4
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2012
    Characterization of the interaction between relaxin-3 and its receptor RXFP3
    UQ Early Career Researcher
    Open grant
  • 2010 - 2014
    NHMRC Career Development Award: Molecular mechanism and modulation of relaxin family peptide receptors
    NHMRC Career Development Award
    Open grant

Availability

Associate Professor Johan Rosengren is:
Available for supervision

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Available projects

  • Modulating the relaxin-3 neuropeptide receptor to treat anxiety and depression

    The relaxin-3 neuropeptide hormone is involved in criticial signalling controlling motivation and arousal thus its receptor RXFP3 is a potential target for new drugs for depression, anxiety and control of food intake. Out lab has 20 years experience in structure based design of peptide modulators targeting this receptor. Student working in this project will have an opportunity to be involved in peptide design and structural studies using NMR specstroscopy, peptide synthesis and chemistry, as well as functional and stability assays.

Supervision history

Current supervision

Completed supervision

Enquiries

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