Associate Professor Johan Rosengren
Associate Professor

Johan Rosengren

Email: 
Phone: 
+61 7 336 51403

Background

Dr Rosengren is an Associate Professor at the School of Biomedical Sciences, University of Queensland. He completed his PhD, which focused on structure-activity relationships of antimicrobial peptides, under the supervision of Professor David Craik at the Institute for Molecular Bioscience, UQ, in 2003. After two years of post-doctoral work at IMB he moved to Sweden in 2005 to take up a position as Assistant Professor at Linnaeus University, Kalmar. During 2008-2009 he held a joint appointment between Linnaeus University and Uppsala University. In 2009 he was awarded the Swedish “Docent” title before returning to University of Queensland as a Senior Research Officer, funded by an NHMRC Career Development Award and an ARC Future Fellowship. Dr Rosengren’s research focuses on structure activity relationships of bioactive peptides, in particular peptide hormones and the use of NMR spectroscopy in the design of novel peptide drug leads.

Availability

Associate Professor Johan Rosengren is:
Available for supervision

Fields of research

Biomedical and Clinical Sciences Chemical Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Masters (Coursework) of Biomedical Chemistry, University of Kalmar
  • Doctor of Philosophy, The University of Queensland

Search Professor Johan Rosengren’s works on UQ eSpace

167 works between 2001 and 2024
All (167) Journal Article (137) Book Chapter (3) Conference Publication (26) Other Outputs (1)

41 - 60 of 167 works

2018

Journal Article

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

2018

Journal Article

Binding conformation and determinants of a single chain peptide antagonist at the relaxin-3 receptor RXFP3

Haugaard-Kedström, Linda M., Lee, Han Siean, Jones, Maryon V., Song, Angela, Rathod, Vishaal, Hossain, Mohammed Akhter, Bathgate, Ross A.D. and Rosengren, K. Johan (2018). Binding conformation and determinants of a single chain peptide antagonist at the relaxin-3 receptor RXFP3. Journal of Biological Chemistry, 293 (41), 15765-15776. doi: 10.1074/jbc.ra118.002611

Binding conformation and determinants of a single chain peptide antagonist at the relaxin-3 receptor RXFP3

2018

Journal Article

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

Wong, Lilian L. L., Scott, Daniel James, Hossain, Mohammed Akhter, Kaas, Quentin, Rosengren, K. Johan and Bathgate, Ross A. D. (2018). Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor. Journal of Biological Chemistry, 293 (41), 15777-15789. doi: 10.1074/jbc.ra118.002645

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

2018

Journal Article

Prediction of disulfide dihedral angles using chemical shifts

Armstrong, David A., Kaas, Quentin and Rosengren, K. Johan (2018). Prediction of disulfide dihedral angles using chemical shifts. Chemical Science, 9 (31), 6548-6556. doi: 10.1039/c8sc01423j

Prediction of disulfide dihedral angles using chemical shifts

2018

Journal Article

Alanine and lysine scans of the LL-37 derived peptide fragment KR-12 reveal key residues for antimicrobial activity

Gunasekera, Sunithi, Muhammad, Taj, Strömstedt, Adam A., Rosengren, K. Johan and Göransson, Ulf (2018). Alanine and lysine scans of the LL-37 derived peptide fragment KR-12 reveal key residues for antimicrobial activity. Chembiochem : A European Journal of Chemical Biology, 19 (9), 931-939. doi: 10.1002/cbic.201700599

Alanine and lysine scans of the LL-37 derived peptide fragment KR-12 reveal key residues for antimicrobial activity

2018

Journal Article

Front Cover: Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity (ChemBioChem 9/2018)

Gunasekera, Sunithi, Muhammad, Taj, Strömstedt, Adam A., Rosengren, K. Johan and Göransson, Ulf (2018). Front Cover: Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity (ChemBioChem 9/2018). ChemBioChem, 19 (9), 891-891. doi: 10.1002/cbic.201800188

Front Cover: Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity (ChemBioChem 9/2018)

2018

Journal Article

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

Jacobsson, Erik, Andersson, Håkan S., Strand, Malin, Peigneur, Steve, Eriksson, Camilla, Lodén, Henrik, Shariatgorji, Mohammadreza, Andrén, Per E., Lebbe, Eline K. M., Rosengren, K. Johan, Tytgat, Jan and Göransson, Ulf (2018). Peptide ion channel toxins from the bootlace worm, the longest animal on Earth. Scientific Reports, 8 (1) 4596, 4596. doi: 10.1038/s41598-018-22305-w

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

2018

Journal Article

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins

Franke, B., Mylne, J. S. and Rosengren, K. J. (2018). Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins. Natural Product Reports, 35 (2), 137-146. doi: 10.1039/c7np00066a

Buried treasure: biosynthesis, structures and applications of cyclic peptides hidden in seed storage albumins

2017

Journal Article

Cyclotide evolution: Insights from the analyses of their precursor sequences, structures and distribution in violets (viola)

Park, Sungkyu, Yoo, Ki-Oug, Marcussen, Thomas, Backlund, Anders, Jacobsson, Erik, Rosengren, K. Johan, Doo, Inseok and Göransson, Ulf (2017). Cyclotide evolution: Insights from the analyses of their precursor sequences, structures and distribution in violets (viola). Frontiers in Plant Science, 8 2058, 1-19. doi: 10.3389/fpls.2017.02058

Cyclotide evolution: Insights from the analyses of their precursor sequences, structures and distribution in violets (viola)

2017

Journal Article

Two proteins for the price of one: structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1

Franke, Bastian, James, Amy M., Mobli, Mehdi, Colgrave, Michelle L., Mylne, Joshua S. and Rosengren, K. Johan (2017). Two proteins for the price of one: structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1. The Journal of Biological Chemistry, 292 (30), 12398-12411. doi: 10.1074/jbc.M117.776955

Two proteins for the price of one: structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1

2017

Journal Article

Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883)

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883). Scientific Reports, 7 (1) 46816, 46816. doi: 10.1038/srep46816

Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883)

2017

Journal Article

Relaxin family peptides: structure-activity relationship studies

Patil, Nitin A., Rosengren, K. Johan, Separovic, Frances, Wade, John D., Bathgate, Ross A. D. and Hossain, Mohammed Akhter (2017). Relaxin family peptides: structure-activity relationship studies. British Journal of Pharmacology, 174 (10), 950-961. doi: 10.1111/bph.13684

Relaxin family peptides: structure-activity relationship studies

2017

Journal Article

Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883

Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a

2016

Conference Publication

The toxicity of ribbon worms: Alpha-nemertides or tetrodotoxin, or both?

Andersson, H. S., Jacobsson, E., Eriksson, C., Hedstrom, M., Seth, H., Sundberg, P., Rosengren, K. J., Strand, M. and Goransson, U. (2016). The toxicity of ribbon worms: Alpha-nemertides or tetrodotoxin, or both?. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen Denmark, Jul 24-27, 2016. STUTTGART: GEORG THIEME VERLAG KG. doi: 10.1055/s-0036-1596617

The toxicity of ribbon worms: Alpha-nemertides or tetrodotoxin, or both?

2016

Conference Publication

Peptide toxins from the longest animal on earth

Jacobsson, E., Andersson, H. S., Strand, M., Lebbe, E., Eriksson, C., Peigneur, S., Rosengren, J., Tytgat, J. and Goransson, U. (2016). Peptide toxins from the longest animal on earth. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen Denmark, Jul 24-27, 2016. STUTTGART: GEORG THIEME VERLAG KG. doi: 10.1055/s-0036-1596160

Peptide toxins from the longest animal on earth

2016

Journal Article

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana)

Franke, Bastian, Jayasena, Achala S., Fisher, Mark F., Swedberg, Joakim E., Taylor, Nicolas L., Mylne, Joshua S. and Rosengren, K. Johan (2016). Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana). Biopolymers, 106 (6), 806-817. doi: 10.1002/bip.22901

Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana)

2016

Journal Article

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I. and Craik, David J. (2016). Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering, 113 (10), 2202-2212. doi: 10.1002/bit.25993

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

2016

Journal Article

Mature forms of the major seed storage albumins in sunflower: a mass spectrometric approach

Franke, Bastian, Colgrave, Michelle L., Mylne, Joshua S. and Rosengren, K. Johan (2016). Mature forms of the major seed storage albumins in sunflower: a mass spectrometric approach. Journal of Proteomics, 147, 177-186. doi: 10.1016/j.jprot.2016.05.004

Mature forms of the major seed storage albumins in sunflower: a mass spectrometric approach

2016

Journal Article

Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling

Hojo, Keiko, Hossain, Mohammed Akhter, Tailhades, Julien, Shabanpoor, Fazel, Wong, Lilian L. L., Ong-Palsson, Emma E. K., Kastman, Hanna E., Ma, Sherie, Gundlach, Andrew L., Rosengren, K. Johan, Wade, John D. and Bathgate, Ross A. D. (2016). Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling. Journal of Medicinal Chemistry, 59 (16), 7445-7456. doi: 10.1021/acs.jmedchem.6b00265

Development of a single-chain peptide agonist of the relaxin-3 receptor using hydrocarbon stapling

2016

Journal Article

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Hossain, Mohammed Akhter, Kocan, Martina, Yao, Song T., Royce, Simon G., Nair, Vinojini B., Siwek, Christopher, Patil, Nitin A., Harrison, Ian P., Rosengren, K. Johan, Selemidis, Stavros, Summers, Roger J., Wade, John D., Bathgate, Ross A. D. and Samuel, Chrishan S. (2016). A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chemical Science, 7 (6), 3805-3819. doi: 10.1039/c5sc04754d

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Current funding

  • 2022 - 2025
    Making peptides orally bioavailable
    ARC Discovery Projects
    Open grant
  • 2022 - 2025
    Making peptide drugs orally bioavailable
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2019 - 2022
    Investigating the role of posttranslational modifications on protein structure and function using selective and segmental isotope labelling
    CIL Research Grant Program
    Open grant
  • 2019 - 2022
    Buried treasure: bioactive plant seed proteins evolving inside hosts (ARC Discovery Project administered by The University of Western Australia)
    University of Western Australia
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Novel chemical methods to produce next generation insulin analogues (NHMRC Project Grant led by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2019 - 2022
    Pharmacological modulation of the relaxin-3/RXFP3 neuropeptide system for controlling feeding
    NHMRC Project Grant
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Modulating Trk receptors for the treatment of dementia and Alzheimer's disease
    Alzheimers Research UK - Target Validation Pathfinder Grant
    Open grant
  • 2017 - 2019
    Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 (NHMRC Project Grant administered by Florey Institute of Neuroscience and Mental Health)
    The Florey Institute of Neuroscience and Mental Health
    Open grant
  • 2016 - 2019
    Development of technologies to monitor multimolecular complexes (ARC Linkage Project led by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    Bioactive Peptides as Pharmacological Tools and Novel Drug Leads
    ARC Future Fellowships
    Open grant
  • 2014
    How do sunflowers produce both a seed storage protein and a potent trypsin inhibitor from the same gene?
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2014 - 2016
    Interrogating peptide receptor targets (NHMRC Project Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2014 - 2017
    Modulation of feeding through pharmacological targeting of the relaxin-3 receptor RXFP3
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Determinants of relaxin and INSL3 receptor binding
    University of Melbourne
    Open grant
  • 2012 - 2014
    How do sunflowers make protein drugs in their seeds? (ARC Discovery Project administered by UWA)
    University of Western Australia
    Open grant
  • 2012
    How do sunflowers make protein drugs in their seeds?
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Development of single-chain peptide ligands for the INSL5 receptor RXFP4
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011
    Building UQ's analytical capacity in biomedical sciences
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2012
    Characterization of the interaction between relaxin-3 and its receptor RXFP3
    UQ Early Career Researcher
    Open grant
  • 2010 - 2014
    NHMRC Career Development Award: Molecular mechanism and modulation of relaxin family peptide receptors
    NHMRC Career Development Award
    Open grant

Availability

Associate Professor Johan Rosengren is:
Available for supervision

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Available projects

  • Modulating the relaxin-3 neuropeptide receptor to treat anxiety and depression

    The relaxin-3 neuropeptide hormone is involved in criticial signalling controlling motivation and arousal thus its receptor RXFP3 is a potential target for new drugs for depression, anxiety and control of food intake. Out lab has 20 years experience in structure based design of peptide modulators targeting this receptor. Student working in this project will have an opportunity to be involved in peptide design and structural studies using NMR specstroscopy, peptide synthesis and chemistry, as well as functional and stability assays.

Supervision history

Current supervision

Completed supervision

Enquiries

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