Professor Megan O'Mara
Professor

Megan O'Mara

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Background

Megan O’Mara is a Professor and Group Leader at the Australian Institute for Bioengineering and Nanotechnology (AIBN), UQ. Her group uses multiscale modelling techniques to understand how changes in the biochemical environment of the cell membranes alters membrane properties and modulates the function of membrane proteins. She has research interests in multidrug resistance, computational drug design and delivery, biopolymers, and personalized medicine. Megan completed her PhD in biophysics at the Australian National University in 2005 before moving to the University of Calgary, Canada, to take up a Canadian Institutes of Health Research Postdoctoral Fellowship. In 2009, she returned to Australia to join University of Queensland’s School of Chemistry and Molecular Biosciences as a UQ Postdoctoral Fellow, before commencing an ARC DECRA in 2012 where she continued her computational work on membrane protein dynamics. In 2015, Megan joined the Research School of Chemistry, Australian National University in 2015 as Rita Cornforth Fellow and Senior Lecturer. In 2019 she was promoted to Associate Professor and was Associate Director (Education) of the Research School of Chemistry ANU in 2019-2021. In April 2022 she relocated to AIBN.

Availability

Professor Megan O'Mara is:
Available for supervision
Media expert

Fields of research

Biological Sciences Biological physics Biomedical and Clinical Sciences Biomolecular modelling and design Cell neurochemistry Characterisation of biological macromolecules Chemical Sciences Macromolecular and materials chemistry Medicinal and biomolecular chemistry Molecular medicine Physical Sciences Proteins and peptides Receptors and membrane biology Structural biology (incl. macromolecular modelling) Zoology

Qualifications

  • Bachelor, University of Canberra
  • Bachelor of Physical Sciences, Australian National University
  • Doctor of Philosophy of Physical Sciences, Australian National University
  • Associate Fellow, Australian National University, Australian National University

Research interests

  • computational drug design

    computational drug design, structure based drug design, structure activity relationships, computational fragment based drug design

  • membrane biophysics

    computational cell membrane biophysics, computational lipidomics, cell membrane properties in health, disease and senescence

  • multudrug resistance

    antimicrobial resistance, cancer chemotherapy resistance

  • polymer simulations

    biopolymers, self assembly, polymer properties

  • lipid delivery systems

    targeted lipid delivery systems, computational analysis, lipid formulations, LNP loading, computational simulations

  • computational structural biology

    membrane protein structure-function, computational biology, protein structure prediction

Research impacts

My research uses computational techniques and simulations to understand how the chemistry of biological and bioinspired systems influence their physical properties. My goal is to understand how biomolecules self-assemble and self-regulate in living cells. My work allows the rational design of new pharmaceuticals, drug and vaccine delivery systems and biocompatable materials, as well as understanding fundamental problems such as antibiotic resistance. My students gain skills in data science, computational chemistry, computational biology, high performance computing, rational drug design and research data management that are directly transferable to industry, government and policy development, as well as research. I collaborate broadly across UQ, Australia and internationally with researchers and industry.

Search Professor Megan O'Mara’s works on UQ eSpace

122 works between 2003 and 2024
All (122) Journal Article (99) Book Chapter (4) Conference Publication (19)

1 - 20 of 122 works

Featured

2014

Journal Article

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

Chen, Wenqian, Wang, Ruiwu, Chen, Biyi, Zhong, Xiaowei, Kong, Huihui, Bai, Yunlong, Zhou, Qiang, Xie, Cuihong, Zhang, Jingqun, Guo, Ang, Tian, Xixi, Jones, Peter P., O'Mara, Megan L., Liu, Yingjie, Mi, Tao, Zhang, Lin, Bolstad, Jeff, Semeniuk, Lisa, Cheng, Hongqiang, Zhang, Jianlin, Chen, Ju, Tieleman, D. Peter, Gillis, Anne M., Duff, Henry J., Fill, Michael, Song, Long-Sheng and Chen, S. R. Wayne (2014). The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Nature Medicine, 20 (2), 184-192. doi: 10.1038/nm.3440

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

Featured

2014

Journal Article

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Featured

2012

Journal Article

The effect of environment on the structure of a membrane protein: P-glycoprotein under physiological conditions

O’Mara, Megan L. and Mark, Alan E. (2012). The effect of environment on the structure of a membrane protein: P-glycoprotein under physiological conditions. Journal of Chemical Theory and Computation, 8 (10), 3964-3976. doi: 10.1021/ct300254y

The effect of environment on the structure of a membrane protein: P-glycoprotein under physiological conditions

2024

Journal Article

How molecular architecture defines quantum yields

Pashley-Johnson, Fred, Munaweera, Rangika, Hossain, Sheikh I., Gauci, Steven C., Delafresnaye, Laura, Frisch, Hendrik, O’Mara, Megan L., Du Prez, Filip E. and Barner-Kowollik, Christopher (2024). How molecular architecture defines quantum yields. Nature Communications, 15 (1) 6033, 6033. doi: 10.1038/s41467-024-50366-1

How molecular architecture defines quantum yields

2024

Journal Article

Lipidome modifications in A. baumannii alter membrane properties and antimicrobial peptide interactions

O'Mara, Megan L., MacDermott-Opeskin, Hugo and Wilson, Katie A. (2024). Lipidome modifications in A. baumannii alter membrane properties and antimicrobial peptide interactions. Biophysical Journal, 123 (3), 455a. doi: 10.1016/j.bpj.2023.11.2771

Lipidome modifications in A. baumannii alter membrane properties and antimicrobial peptide interactions

2024

Journal Article

Main-chain macromolecular hydrazone photoswitches

Thai, Linh Duy, Fanelli, Julian, Munaweera, Rangika, O'Mara, Megan L., Barner-Kowollik, Christopher and Mutlu, Hatice (2024). Main-chain macromolecular hydrazone photoswitches. Angewandte Chemie - International Edition, 63 (4) e202315887, 1-12. doi: 10.1002/anie.202315887

Main-chain macromolecular hydrazone photoswitches

2024

Journal Article

Introduction to the <i>RSC Advances</i> themed collection on <i>New insights into biomolecular systems from large-scale simulations</i>

O’Mara, Megan L., Rauscher, Sarah and Wetmore, Stacey D. (2024). Introduction to the RSC Advances themed collection on New insights into biomolecular systems from large-scale simulations. RSC Advances, 14 (10), 6985-6986. doi: 10.1039/d4ra90012j

Introduction to the <i>RSC Advances</i> themed collection on <i>New insights into biomolecular systems from large-scale simulations</i>

2023

Journal Article

The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites

Chater, Ryan Cantwell, Quinn, Ada S., Wilson, Katie, Frangos, Zachary J., Sutton, Patrick, Jayakumar, Srinivasan, Cioffi, Christopher L., O'Mara, Megan L. and Vandenberg, Robert J. (2023). The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites. Journal of Neurochemistry. doi: 10.1111/jnc.16028

The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites

2023

Journal Article

The net electrostatic potential and hydration of ABCG2 affect substrate transport

Gose, Tomoka, Aitken, Heather M., Wang, Yao, Lynch, John, Rampersaud, Evadnie, Fukuda, Yu, Wills, Medb, Baril, Stefanie A., Ford, Robert C., Shelat, Anang, O'Mara, Megan L. and Schuetz, John D. (2023). The net electrostatic potential and hydration of ABCG2 affect substrate transport. Nature Communications, 14 (1) 5035, 5035. doi: 10.1038/s41467-023-40610-5

The net electrostatic potential and hydration of ABCG2 affect substrate transport

2023

Journal Article

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H.J., Vandenberg, Jamie I., Ryan, Renae M., O'Mara, Megan L. and Stewart, Alastair G. (2023). Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. Nature Communications, 14 (1) 6374, 1-14. doi: 10.1038/s41467-023-42086-9

Structural basis of promiscuous substrate transport by Organic Cation Transporter 1

2023

Journal Article

Extracellular vesicle lipids in cancer immunoevasion

Chen, Siyu, Iannotta, Dalila, O'Mara, Megan L., Goncalves, Jenifer Pendiuk and Wolfram, Joy (2023). Extracellular vesicle lipids in cancer immunoevasion. Trends in Cancer, 9 (11), 883-886. doi: 10.1016/j.trecan.2023.08.006

Extracellular vesicle lipids in cancer immunoevasion

2023

Journal Article

Visible light reactive single‐chain nanoparticles

Mundsinger, Kai, Tuten, Bryan T., Wang, Lily, Neubauer, Kira, Kropf, Christian, O'Mara, Megan L. and Barner-Kowollik, Christopher (2023). Visible light reactive single‐chain nanoparticles. Angewandte Chemie, 135 (23) e202302995. doi: 10.1002/ange.202302995

Visible light reactive single‐chain nanoparticles

2023

Journal Article

Visible-Light-Reactive Single-Chain Nanoparticles

Mundsinger, Kai, Tuten, Bryan T., Wang, Lily, Neubauer, Kira, Kropf, Christian, O'Mara, Megan L. and Barner-Kowollik, Christopher (2023). Visible-Light-Reactive Single-Chain Nanoparticles. Angewandte Chemie - International Edition, 62 (23) e202302995, e202302995. doi: 10.1002/anie.202302995

Visible-Light-Reactive Single-Chain Nanoparticles

2023

Journal Article

The impact of antimicrobial peptides on the Acinetobacter baumannii inner membrane is modulated by lipid polyunsaturation

MacDermott-Opeskin, Hugo I., Wilson, Katie A. and O’Mara, Megan L. (2023). The impact of antimicrobial peptides on the Acinetobacter baumannii inner membrane is modulated by lipid polyunsaturation. ACS Infectious Diseases, 9 (4), 815-826. doi: 10.1021/acsinfecdis.2c00530

The impact of antimicrobial peptides on the Acinetobacter baumannii inner membrane is modulated by lipid polyunsaturation

2023

Conference Publication

Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors

Gallagher, Casey I., Lin, Yie Chang, Kumar, Arvind, Ha, Damian, Cioffi, Christopher L., Chakrapani, Sudha, O'Mara, Megan L. and Vandenberg, Robert J. (2023). Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors. 66th Annual Meeting of the Biophysical-Society, San Francisco Ca, Feb 19-23, 2022. CAMBRIDGE: CELL PRESS.

Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors

2023

Conference Publication

Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors

Gallagher, Casey I., Chang Lin, Yie, Kumar, Arvind, Ha, Damian, Cioffi, Christopher L., Chakrapani, Sudha, O'Mara, Megan L. and Vandenberg, Robert J. (2023). Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors. 67th Biophysical Society Annual Meeting 2023, San Diego, CA United States, 18-22 February 2023. St Louis, MO United States: Cell Press. doi: 10.1016/j.bpj.2022.11.2138

Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors

2023

Conference Publication

Polyunsaturated lipids promote membrane phase separation and antimicrobial sensitivity

MacDermott-Opeskin, Hugo, Wilson, Katie A., Eijkelkamp, Bart and O'Mara, Megan L. (2023). Polyunsaturated lipids promote membrane phase separation and antimicrobial sensitivity. Biophysical Society 67th Annual Meeting, San Diego, CA United States, 18-22 February 2023. St. Louis, MO United States: Cell Press. doi: 10.1016/j.bpj.2022.11.1805

Polyunsaturated lipids promote membrane phase separation and antimicrobial sensitivity

2023

Journal Article

Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2

Frangos, Zachary J., Wilson, Katie A., Aitken, Heather M., Cantwell Chater, Ryan, Vandenberg, Robert J. and O’Mara, Megan L. (2023). Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2. Life Science Alliance, 6 (4) e202201708, 1-17. doi: 10.26508/lsa.202201708

Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2

2022

Journal Article

Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids

MacDermott-Opeskin, Hugo, Clarke, Callum, Wu, Xin, Roseblade, Ariane, York, Edward, Pacchini, Ethan, Roy, Ritik, Cranfield, Charles, Gale, Philip A., O'Mara, Megan L., Murray, Michael and Rawling, Tristan (2022). Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids. Organic and Biomolecular Chemistry, 21 (1), 132-139. doi: 10.1039/d2ob02049a

Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids

2022

Journal Article

Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function

Qin, Jilong, Wilson, Katie A., Sarkar, Sohinee, Heras, Begoña, O'Mara, Megan L. and Totsika, Makrina (2022). Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function. Computational and Structural Biotechnology Journal, 20, 4532-4541. doi: 10.1016/j.csbj.2022.08.040

Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function

Current funding

  • 2023 - 2026
    Overcoming antiseptic and disinfectant resistance in staphylococci (NHMRC Ideas Grant administered by Flinders University)
    Flinders University
    Open grant

Past funding

  • 2022 - 2024
    Synthetic Biology for Synthesis of Novel Polymers Used in Energy Storage
    Commonwealth Defence Science and Technology Group
    Open grant
  • 2015
    Characterising new therapeutic targets in the fight against pneumococcal disease using computational simulations as an alternative to animal models
    The MAWA Trust
    Open grant
  • 2014
    A parallel computer facility for modelling and simulation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2015
    Membrane proteins: Understanding biological switches, motors and triggers.
    ARC Discovery Projects
    Open grant
  • 2013 - 2016
    Understanding multidrug resistance in cancer: identification of the substrate and inhibitor binding sites in P-glycoprotein
    NHMRC Project Grant
    Open grant
  • 2012
    ResTeach Funding 2012 0.05 FTE School of Math & Physics
    UQ ResTeach
    Open grant
  • 2012 - 2015
    Understanding multidrug resistance: identifying the molecular basis of substrate and inhibitor transport by P-glycoprotein
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2012
    ResTeach Funding 2012 0.05 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2011
    ResTeach 2010 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010
    The mechanism of viral entry into cells: understanding how Glycoprotein 2 from Ebola initiates membrane fusion
    UQ Early Career Researcher
    Open grant
  • 2010 - 2012
    The role of glutamine transporter SNAT3 in ion transport, cell signalling and ammonia detoxification (NHMRC project grant administered by the Australian National University)
    Australian National University
    Open grant

Availability

Professor Megan O'Mara is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Computational design of biocompatable delivery systems

    Biocompatible delivery systems allow enhanced delivery of pharmaceuticals, vaccines and other biological payload molecules, with varied effects including extending the pharmaceutical half-life of drugs, increasing adsorption and decreasing immunogenicity. While these agents have increased the efficacy of many biological therapies, very little work has been done on improving the targeting of these agents to the specific cell or receptor of interest. This project will examine strategies to increase the selectivity of biopolymer delivery systems to enhance the ability to target specific cell types or receptors, thereby reducing off target effects. This project will identify the chemical composition and biophysical characteristics of different cell membranes, and how this impacts their interaction with biopolymer delivery systems. The project requires good collaboration skills, an broad understanding of chemistry and biochemistry, and strong skills in multiscale modelling techniques, from QMMM to coarse grained molecular dynamics.

  • The impact of lipid modifications on cell membrane function

    Membrane lipid composition influences the localisation of membrane proteins and regulates their activity. The hundreds of chemically distinct lipids within cell membranes phase-separate to form microdomains that impact the localisation and interactions of membrane proteins. The composition of the cell membrane is tightly controlled in normal cellular function. There is now considerable evidence that altered cell homeostasis, ranging from inflammatory processes to cancer, cause alterations in metabolic pathways which impact membrane lipid distributions, cell biophysical properties and membrane protein function. This may have downstream impacts on the uptake and efficacy of a range of pharmaceuticals used to treat dysfunction. Using data derived from mass spectrometry and other experimental approaches, this project will use multiscale simulation techniques to examine how changes in lipid membrane composition in cancer and other disease states impacts drug uptake. This knowledge will provide a means to specifically target a given cell type through the drug delivery systems and targeted therapeutics.

  • Membrane mediated antimicrobial resistance

    Bacterial multidrug efflux pumps are the bacteria’s first line of defence against the action of antimicrobials. However, very little is currently known about the function and substrate range of these efflux pumps. This project will examine different multidrug efflux pumps to uncover the structural basis of substrate specificity and transport. It will examine the impact of bacterial membrane modifications on bacterial multidrug efflux pump function, and how peptide- and/or polymer-based antimicrobials inhibit multidrug efflux pumps and disrupt membrane integrity. Other avenues of investigation include characterising the effect of lipid modifications in antimicrobial resistance, and computational drug design of lead new candidates for antimicrobial design. This project uses a range of computational techniques, primarily multiscale molecular dynamics simulations.

  • Allosteric modulation of synaptic transmission by neurosteroids and oxysterols

    The development of effective therapeutics that target chronic pain in neurological diseases would significantly improve the quality of life for millions of people living with chronic pain. The glycinergic neuronal transport proteins are a promising target for the treatment of chronic pain. In neurons and other cells, the membrane lipid composition influences the localisation of membrane proteins and regulates their activity. The hundreds of chemically distinct lipids within cell membranes phase-separate to form microdomains that impact the localisation and interactions of membrane proteins. Oxidative stress is an early hallmark of inflammation and disease that causes chemical modifications to membrane lipids, proteins, and other biomolecules. This impacts their function and influences their biophysical properties. This project will examine the effect of oxysterols and neurosteroids on the inhibition of glycernergic synaptic membrane proteins for the development of targeted therapeutics for the treatment of chronic pain in specific disease states. This is a computational project. The direction of the project can be tailored to the interests of the student.

Supervision history

Current supervision

  • Doctor Philosophy

    Targeting alterations in cell membrane biophysics for disease intervention

    Principal Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    The effect of membrane composition on protein-ligand interactions in drug design and delivery

    Principal Advisor

    Other advisors: Professor Debra Bernhardt

  • Doctor Philosophy

    Investigation of the mechanisms of antimicrobial resistance and design of novel antimicrobials

    Principal Advisor

    Other advisors: Dr Evelyne Deplazes

  • Doctor Philosophy

    Allosteric modulation of synaptic proteins by endogenous and modified sterols

    Principal Advisor

    Other advisors: Professor David Ascher, Dr Evelyne Deplazes

  • Doctor Philosophy

    Computational design of targeted lipid technologies

    Principal Advisor

    Other advisors: Professor David Ascher

Completed supervision

Enquiries

Contact Professor Megan O'Mara directly for media enquiries about:

  • biophysics
  • computational chemistry
  • drug design
  • supercomputers - applications
  • women in STEM

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