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2014 Journal Article The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmiasChen, Wenqian, Wang, Ruiwu, Chen, Biyi, Zhong, Xiaowei, Kong, Huihui, Bai, Yunlong, Zhou, Qiang, Xie, Cuihong, Zhang, Jingqun, Guo, Ang, Tian, Xixi, Jones, Peter P., O'Mara, Megan L., Liu, Yingjie, Mi, Tao, Zhang, Lin, Bolstad, Jeff, Semeniuk, Lisa, Cheng, Hongqiang, Zhang, Jianlin, Chen, Ju, Tieleman, D. Peter, Gillis, Anne M., Duff, Henry J., Fill, Michael, Song, Long-Sheng and Chen, S. R. Wayne (2014). The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias. Nature Medicine, 20 (2), 184-192. doi: 10.1038/nm.3440 |
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2014 Journal Article Imperfect coordination chemistry facilitates metal ion release in the Psa permeaseCouñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382 |
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2012 Journal Article The effect of environment on the structure of a membrane protein: P-glycoprotein under physiological conditionsO’Mara, Megan L. and Mark, Alan E. (2012). The effect of environment on the structure of a membrane protein: P-glycoprotein under physiological conditions. Journal of Chemical Theory and Computation, 8 (10), 3964-3976. doi: 10.1021/ct300254y |
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2024 Journal Article Correction to: The net electrostatic potential and hydration of ABCG2 affect substrate transport (Nature Communications, (2023), 14, 1, (5035), 10.1038/s41467-023-40610-5)Gose, Tomoka, Aitken, Heather M., Wang, Yao, Lynch, John, Rampersaud, Evadnie, Fukuda, Yu, Wills, Medb, Baril, Stefanie A., Ford, Robert C., Shelat, Anang, O’Mara, Megan L. and Schuetz, John D. (2024). Correction to: The net electrostatic potential and hydration of ABCG2 affect substrate transport (Nature Communications, (2023), 14, 1, (5035), 10.1038/s41467-023-40610-5). Nature Communications, 15 (1) 8956. doi: 10.1038/s41467-024-53357-4 |
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2024 Journal Article The role of ATP-binding Cassette subfamily B member 6 in the inner earBaril, Stefanie A., Wilson, Katie A., Shaik, Md Munan, Fukuda, Yu, Umans, Robyn A., Barbieri, Alessandro, Lynch, John, Gose, Tomoka, Myasnikov, Alexander, Oldham, Michael L., Wang, Yao, Zhu, Jingwen, Fang, Jie, Zuo, Jian, Kalathur, Ravi C., Ford, Robert C., Coffin, Allison, Taylor, Michael R., O’Mara, Megan L. and Schuetz, John D. (2024). The role of ATP-binding Cassette subfamily B member 6 in the inner ear. Nature Communications, 15 (1) 9885, 1-17. doi: 10.1038/s41467-024-53663-x |
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2024 Journal Article Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating AgentsEl Safadi, Mahmoud, Wilson, Katie A., Strudwicke, Indigo J., O’Mara, Megan L., Bhadbhade, Mohan, Rawling, Tristan and McDonagh, Andrew M. (2024). Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents. Molecules, 29 (17) 4213, 4213. doi: 10.3390/molecules29174213 |
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2024 Journal Article How molecular architecture defines quantum yieldsPashley-Johnson, Fred, Munaweera, Rangika, Hossain, Sheikh I., Gauci, Steven C., Delafresnaye, Laura, Frisch, Hendrik, O’Mara, Megan L., Du Prez, Filip E. and Barner-Kowollik, Christopher (2024). How molecular architecture defines quantum yields. Nature Communications, 15 (1) 6033, 1-9. doi: 10.1038/s41467-024-50366-1 |
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2024 Journal Article AI is a viable alternative to high throughput screening: a 318-target studyWallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel ... The Atomwise AIMS Program (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports, 14 (1) 7526, 1-16. doi: 10.1038/s41598-024-54655-z |
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2024 Conference Publication Lipidome modifications in A. baumannii alter membrane properties and antimicrobial peptide interactionsO'Mara, Megan L., MacDermott-Opeskin, Hugo and Wilson, Katie A. (2024). Lipidome modifications in A. baumannii alter membrane properties and antimicrobial peptide interactions. Biophysical Society 68th Annual Meeting, Philadelphia, PA United States, 10-14 February 2024. Cambridge, MA United States: Cell Press. |
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2024 Conference Publication Lipidome modifications in A. baumannii alter membrane properties and antimicrobial peptide interactionsO'Mara, Megan L., MacDermott-Opeskin, Hugo and Wilson, Katie A. (2024). Lipidome modifications in A. baumannii alter membrane properties and antimicrobial peptide interactions. Biophysical Society 68th Annual Meeting, Philadelphia, PA United States, 10-14 February 2024. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2023.11.2771 |
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2024 Journal Article Main-chain macromolecular hydrazone photoswitchesThai, Linh Duy, Fanelli, Julian, Munaweera, Rangika, O'Mara, Megan L., Barner-Kowollik, Christopher and Mutlu, Hatice (2024). Main-chain macromolecular hydrazone photoswitches. Angewandte Chemie - International Edition, 63 (4) e202315887, 1-12. doi: 10.1002/anie.202315887 |
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2024 Journal Article Introduction to the <i>RSC Advances</i> themed collection on <i>New insights into biomolecular systems from large-scale simulations</i>O’Mara, Megan L., Rauscher, Sarah and Wetmore, Stacey D. (2024). Introduction to the RSC Advances themed collection on New insights into biomolecular systems from large-scale simulations. RSC Advances, 14 (10), 6985-6986. doi: 10.1039/d4ra90012j |
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2023 Journal Article The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sitesChater, Ryan Cantwell, Quinn, Ada S., Wilson, Katie, Frangos, Zachary J., Sutton, Patrick, Jayakumar, Srinivasan, Cioffi, Christopher L., O'Mara, Megan L. and Vandenberg, Robert J. (2023). The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites. Journal of Neurochemistry, 168 (9), 1973-1992. doi: 10.1111/jnc.16028 |
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2023 Journal Article The net electrostatic potential and hydration of ABCG2 affect substrate transportGose, Tomoka, Aitken, Heather M., Wang, Yao, Lynch, John, Rampersaud, Evadnie, Fukuda, Yu, Wills, Medb, Baril, Stefanie A., Ford, Robert C., Shelat, Anang, O'Mara, Megan L. and Schuetz, John D. (2023). The net electrostatic potential and hydration of ABCG2 affect substrate transport. Nature Communications, 14 (1) 5035, 5035. doi: 10.1038/s41467-023-40610-5 |
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2023 Journal Article Structural basis of promiscuous substrate transport by Organic Cation Transporter 1Zeng, Yi C., Sobti, Meghna, Quinn, Ada, Smith, Nicola J., Brown, Simon H.J., Vandenberg, Jamie I., Ryan, Renae M., O'Mara, Megan L. and Stewart, Alastair G. (2023). Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. Nature Communications, 14 (1) 6374, 1-14. doi: 10.1038/s41467-023-42086-9 |
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2023 Journal Article Extracellular vesicle lipids in cancer immunoevasionChen, Siyu, Iannotta, Dalila, O'Mara, Megan L., Goncalves, Jenifer Pendiuk and Wolfram, Joy (2023). Extracellular vesicle lipids in cancer immunoevasion. Trends in Cancer, 9 (11), 883-886. doi: 10.1016/j.trecan.2023.08.006 |
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2023 Journal Article Visible-Light-Reactive Single-Chain NanoparticlesMundsinger, Kai, Tuten, Bryan T., Wang, Lily, Neubauer, Kira, Kropf, Christian, O'Mara, Megan L. and Barner-Kowollik, Christopher (2023). Visible-Light-Reactive Single-Chain Nanoparticles. Angewandte Chemie - International Edition, 62 (23) e202302995, e202302995. doi: 10.1002/anie.202302995 |
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2023 Journal Article Visible light reactive single‐chain nanoparticlesMundsinger, Kai, Tuten, Bryan T., Wang, Lily, Neubauer, Kira, Kropf, Christian, O'Mara, Megan L. and Barner-Kowollik, Christopher (2023). Visible light reactive single‐chain nanoparticles. Angewandte Chemie, 135 (23) e202302995. doi: 10.1002/ange.202302995 |
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2023 Journal Article The impact of antimicrobial peptides on the Acinetobacter baumannii inner membrane is modulated by lipid polyunsaturationMacDermott-Opeskin, Hugo I., Wilson, Katie A. and O’Mara, Megan L. (2023). The impact of antimicrobial peptides on the Acinetobacter baumannii inner membrane is modulated by lipid polyunsaturation. ACS Infectious Diseases, 9 (4), 815-826. doi: 10.1021/acsinfecdis.2c00530 |
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2023 Conference Publication Identification and characterisation of lipids that are positive allosteric modulators of glycine receptorsGallagher, Casey I., Lin, Yie Chang, Kumar, Arvind, Ha, Damian, Cioffi, Christopher L., Chakrapani, Sudha, O'Mara, Megan L. and Vandenberg, Robert J. (2023). Identification and characterisation of lipids that are positive allosteric modulators of glycine receptors. 66th Annual Meeting of the Biophysical-Society, San Francisco Ca, Feb 19-23, 2022. CAMBRIDGE: CELL PRESS. |
