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2021 Journal Article Coordination of substrate binding and protonation in the N. gonorrhoeae MtrD efflux pump controls the functionally rotating transport mechanismFairweather, Stephen J., Gupta, Vrinda, Chitsaz, Mohsen, Booth, Lauren, Brown, Melissa H. and O'Mara, Megan L. (2021). Coordination of substrate binding and protonation in the N. gonorrhoeae MtrD efflux pump controls the functionally rotating transport mechanism. ACS Infectious Diseases, 7 (6), 1833-1847. doi: 10.1021/acsinfecdis.1c00149 |
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2021 Journal Article The role of plasmalogens, Forssman lipids, and sphingolipid hydroxylation in modulating the biophysical properties of the epithelial plasma membraneWilson, Katie A., Fairweather, Stephen J., MacDermott-Opeskin, Hugo I., Wang, Lily, Morris, Richard A. and O'Mara, Megan L. (2021). The role of plasmalogens, Forssman lipids, and sphingolipid hydroxylation in modulating the biophysical properties of the epithelial plasma membrane. The Journal of Chemical Physics, 154 (9) 095101, 095101. doi: 10.1063/5.0040887 |
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2021 Journal Article Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2Wilson, Katie A., Wang, Lily, Lin, Yie Chang and O'Mara, Megan L. (2021). Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2. BBA Advances, 1 100010, 100010. doi: 10.1016/j.bbadva.2021.100010 |
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2021 Journal Article The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavityWilson, Katie A., Mostyn, Shannon N., Frangos, Zachary J., Shimmon, Susan, Rawling, Tristan, Vandenberg, Robert J. and O'Mara, Megan L. (2021). The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity. Journal of Biological Chemistry, 296 100282, 100282. doi: 10.1016/j.jbc.2021.100282 |
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2020 Journal Article Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporterRawling, Tristan, MacDermott-Opeskin, Hugo, Roseblade, Ariane, Pazderka, Curtis, Clarke, Callum, Bourget, Kirsi, Wu, Xin, Lewis, William, Noble, Benjamin, Gale, Philip A., O'Mara, Megan L., Cranfield, Charles and Murray, Michael (2020). Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter. Chemical Science, 11 (47), 12677-12685. doi: 10.1039/d0sc02777d |
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2020 Journal Article Understanding the link between lipid diversity and the biophysical properties of the neuronal plasma membraneWilson, Katie A., MacDermott-Opeskin, Hugo I., Riley, Eden, Lin, Yiechang and O’Mara, Megan L. (2020). Understanding the link between lipid diversity and the biophysical properties of the neuronal plasma membrane. Biochemistry, 59 (33), 3010-3018. doi: 10.1021/acs.biochem.0c00524 |
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2020 Journal Article Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membraneCarey Hulyer, Alex R., Briggs, Deborah A., O'Mara, Megan L., Kerr, Ian D., Harmer, Jeffrey R. and Callaghan, Richard (2020). Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane. Journal of Structural Biology, 211 (1) 107513, 1-14. doi: 10.1016/j.jsb.2020.107513 |
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2020 Journal Article High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognitionOu, Arnold, Schmidberger, Jason W., Wilson, Katie A., Evans, Cameron W., Hargreaves, Jessica A., Grigg, Melanie, O'Mara, Megan L., Iyer, K. Swaminathan, Bond, Charles S. and Smith, Nicole M. (2020). High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition. Nucleic Acids Research, 48 (10), 5766-5776. doi: 10.1093/nar/gkaa262 |
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2020 Journal Article A multifunctional surfactant catalyst inspired by hydrolasesNothling, Mitchell D., Xiao, Zeyun, Hill, Nicholas S., Blyth, Mitchell T., Bhaskaran, Ayana, Sani, Marc-Antoine, Espinosa-Gomez, Andrea, Ngov, Kevin, White, Jonathan, Buscher, Tim, Separovic, Frances, O'Mara, Megan L., Coote, Michelle L. and Connal, Luke A. (2020). A multifunctional surfactant catalyst inspired by hydrolases. Science Advances, 6 (14) eaaz0404, eaaz0404. doi: 10.1126/sciadv.aaz0404 |
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2020 Journal Article Comparing nonbonded metal ion models in the divalent cation binding protein PsaAMacDermott-Opeskin, Hugo, McDevitt, Christopher A. and O'Mara, Megan L. (2020). Comparing nonbonded metal ion models in the divalent cation binding protein PsaA. Journal of Chemical Theory and Computation, 16 (3), 1913-1923. doi: 10.1021/acs.jctc.9b01180 |
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2020 Journal Article The fats of life: using computational chemistry to characterise the eukaryotic cell membraneWilson, Katie A., Wang, Lily, MacDermott-Opeskin, Hugo and O'Mara, Megan L. (2020). The fats of life: using computational chemistry to characterise the eukaryotic cell membrane. Australian Journal of Chemistry, 73 (2-3), 85-95. doi: 10.1071/ch19353 |
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2019 Journal Article Multidrug resistance in Neisseria gonorrhoeae: identification of functionally important residues in the MtrD efflux proteinChitsaz, Mohsen, Booth, Lauren, Blyth, Mitchell T., O’Mara, Megan L. and Brown, Melissa H. (2019). Multidrug resistance in Neisseria gonorrhoeae: identification of functionally important residues in the MtrD efflux protein. mBio, 10 (6) e02277-19. doi: 10.1128/mbio.02277-19 |
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2019 Journal Article Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesicsMostyn, Shannon N., Wilson, Katie A., Schumann-Gillette, Alexandra, Frangos, Zachary J., Shimmon, Susan, Rawling, Tristan, Ryan, Renae M., O'Mara, Megan L. and Vandenberg, Robert J. (2019). Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics. eLife, 8 e47150. doi: 10.7554/elife.47150 |
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2019 Journal Article Is protein structure enough? A review of the role of lipids in SLC6 transporter functionSchumann-Gillett, Alexandra, Blyth, Mitchell T. and O'Mara, Megan L. (2019). Is protein structure enough? A review of the role of lipids in SLC6 transporter function. Neuroscience Letters, 700, 64-69. doi: 10.1016/j.neulet.2018.05.020 |
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2019 Journal Article Lipid-based inhibitors act directly on GlyT2Schumann-Gillett, Alexandra and O'Mara, Megan L. (2019). Lipid-based inhibitors act directly on GlyT2. ACS Chemical Neuroscience, 10 (3), 1668-1678. doi: 10.1021/acschemneuro.8b00586 |
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2019 Journal Article Mutation p.R356Q in the collybistin phosphoinositide binding site Is associated with mild intellectual disabilityChiou, Tzu-Ting, Long, Philip, Schumann-Gillett, Alexandra, Kanamarlapudi, Venkateswarlu, Haas, Stefan A., Harvey, Kirsten, O'Mara, Megan L., De Blasi, Angel L., Kalscheuer, Vera M. and Harvey, Robert J. (2019). Mutation p.R356Q in the collybistin phosphoinositide binding site Is associated with mild intellectual disability. Frontiers in Molecular Neuroscience, 12 60. doi: 10.3389/fnmol.2019.00060 |
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2019 Journal Article Probing the pharmacological binding sites of P-glycoprotein using umbrella sampling simulationsSubramanian, Nandhitha, Schumann-Gillett, Alexandra, Mark, Alan E. and O’Mara, Megan L. (2019). Probing the pharmacological binding sites of P-glycoprotein using umbrella sampling simulations. Journal of Chemical Information and Modeling, 59 (5) acs.jcim.8b00624, 2287-2298. doi: 10.1021/acs.jcim.8b00624 |
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2019 Journal Article The effects of oxidised phospholipids and cholesterol on the biophysical properties of POPC bilayersSchumann-Gillett, Alexandra and O'Mara, Megan L. (2019). The effects of oxidised phospholipids and cholesterol on the biophysical properties of POPC bilayers. Biochimica et Biophysica Acta - Biomembranes, 1861 (1), 210-219. doi: 10.1016/j.bbamem.2018.07.012 |
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2018 Journal Article Molecular determinants for substrate interactions with the glycine transporter GlyT2Carland, Jane E., Thomas, Michael, Mostyn, Shannon N., Subramanian, Nandhitha, O'Mara, Megan L., Ryan, Renae M. and Vandenberg, Robert J. (2018). Molecular determinants for substrate interactions with the glycine transporter GlyT2. ACS Chemical Neuroscience, 9 (3), 603-614. doi: 10.1021/acschemneuro.7b00407 |
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2018 Journal Article The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environmentCondic-Jurkic, Karmen, Subramanian, Nandhitha, Mark, Alan E. and O'Mara, Megan L. (2018). The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environment. PloS One, 13 (1) e0191882, 1-24. doi: 10.1371/journal.pone.0191882 |
