Overview
Background
I am a toxicologist with expertise in venom research and bioanalytical techniques. My current focus lies in investigating the therapeutic potential of small molecule enzyme inhibitors to counteract the toxic effects of snake venom, supported by industry collaborations such as Ophirex. I also explore the effects of venom on cellular models using advanced tools like Electric Cell-substrate Impedance Sensing (ECIS).
Throughout my career, I have led laboratory operations, mentored students, and managed complex research projects while ensuring compliance with Good Laboratory Practices (GLP). My hands-on experience spans the use of specialized analytical instruments, including StarMax Coagulation Analyzer, Thromboelastography (TEG 5000), and Hamilton robotics for automated processes. I am passionate about advancing research with meaningful applications, aiming to bridge academic knowledge with industry solutions. My work emphasizes collaboration, innovation, and impactful outcomes in toxicology and biotechnology.
Availability
- Dr Abhinandan Chowdhury is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor of Biotechnology, Swinburne University of Technology
- Masters (Coursework) of Analytical Biochemistry, University of Huddersfield
- Doctor of Philosophy, The University of Queensland
Research interests
-
Snake Venom Inhibitors and Therapeutic Applications
My research bridges toxinology and biomedical sciences, focusing on the therapeutic potential of small molecule inhibitors against venom-induced toxicity. Specifically, I explore inhibitors like Varespladib and Prinomastat, evaluating their efficacy using advanced tools such as Thromboelastography (TEG) and the StarMax Coagulation Analyzer to mitigate coagulation disturbances. Additionally, I use Electric Cell-substrate Impedance Sensing (ECIS) technology to investigate the cytotoxic effects of venom on cancer cells, including H1975 cell lines, integrating bioanalytical research with cell biology. My work emphasizes repurposing small molecules to develop innovative therapeutics, contributing to public health advancements. Collaborating with pharmaceutical partners, I aim to create impactful diagnostic and therapeutic strategies through interdisciplinary research and advanced bioanalytical techniques.
Research impacts
My research in toxinology focuses on mitigating the harmful effects of snake venom, with direct implications for public health and emergency care, particularly in regions where snakebites are prevalent. By exploring the therapeutic potential of small molecule enzyme inhibitors, such as prinomastat, marimastat, and varespladib, my work contributes to the development of novel, life-saving interventions. This research supports improved clinical management of envenomations and could reduce morbidity and mortality rates. In collaboration with industry partners like Ophirex, I’ve advanced research that bridges the gap between benchwork and practical healthcare solutions. The bioanalytical tools I use, such as ECIS technology, provide unique insights into cellular responses, contributing to better understanding and innovation in biotechnology.
Additionally, my work aligns with the global goal of sustainable healthcare solutions by enhancing anti-venom strategies, potentially reducing the reliance on animal-derived products. Through student mentorship I aim to foster the next generation of toxinologists and promote awareness about the significance of venom research in improving health outcomes.
Works
Search Professor Abhinandan Chowdhury’s works on UQ eSpace
2024
Journal Article
In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib
Chowdhury, Abhinandan, Fry, Bryan G., Samuel, Stephen P., Bhalla, Ashish, Vaiyapuri, Sakthi, Bhargava, Parul, Carter, Rebecca W. and Lewin, Matthew R. (2024). In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib. Toxicon, 252 108178, 108178. doi: 10.1016/j.toxicon.2024.108178
2024
Journal Article
From venom to vein: factor VII activation as a major pathophysiological target for procoagulant Australian elapid snake venoms
Chandrasekara, Uthpala, Chowdhury, Abhinandan, Seneci, Lorenzo, Zdenek, Christina N., Dunstan, Nathan and Fry, Bryan G. (2024). From venom to vein: factor VII activation as a major pathophysiological target for procoagulant Australian elapid snake venoms. Toxins, 16 (10) 430. doi: 10.3390/toxins16100430
2024
Journal Article
Enhancing snakebite management: The role of small molecule therapeutics in complementing antivenom strategies
Silva, Glória Maria da and Chowdhury, Abhinandan (2024). Enhancing snakebite management: The role of small molecule therapeutics in complementing antivenom strategies. Toxicon, 249 108081, 108081. doi: 10.1016/j.toxicon.2024.108081
2024
Journal Article
Tiny but mighty: Vipera ammodytes meridionalis (eastern long-nosed viper) ontogenetic venom variations in procoagulant potency and the impact on antivenom efficacies
Qiao, Zichen, Jones, Lee, Bourke, Lachlan A., Seneci, Lorenzo, Chowdhury, Abhinandan, Violette, Aude, Fourmy, Rudy, Soria, Raul, Aldridge, Matt and Fry, Bryan G. (2024). Tiny but mighty: Vipera ammodytes meridionalis (eastern long-nosed viper) ontogenetic venom variations in procoagulant potency and the impact on antivenom efficacies. Toxins, 16 (9) 396. doi: 10.3390/toxins16090396
2024
Journal Article
The clot thickens: differential coagulotoxic and cardiotoxic activities of Anguimorpha lizard venoms
Dobson, James, Chowdhury, Abhinandan, Tai-A-Pin, Jeremie, van der Ploeg, Harold, Gillett, Amber and Fry, Bryan G. (2024). The clot thickens: differential coagulotoxic and cardiotoxic activities of Anguimorpha lizard venoms. Toxins, 16 (6) 283, 283. doi: 10.3390/toxins16060283
2023
Other Outputs
Therapeutic options for divergent snake venoms
Chowdhury, Abhinandan (2023). Therapeutic options for divergent snake venoms. PhD Thesis, School of Biological Sciences, The University of Queensland. doi: 10.14264/5ecd96c
2022
Journal Article
Extreme procoagulant potency in human plasma of venoms from the African viperid genera Atheris, Cerastes, and Proatheris and the relative efficacy of antivenoms and synthetic enzyme-inhibitors
Chowdhury, Abhinandan, Lewin, Matthew R., Carter, Rebecca, Soria, Raul, Aldridge, Matt and Fry, Bryan G. (2022). Extreme procoagulant potency in human plasma of venoms from the African viperid genera Atheris, Cerastes, and Proatheris and the relative efficacy of antivenoms and synthetic enzyme-inhibitors. Toxins, 14 (12) 836, 1-12. doi: 10.3390/toxins14120836
2022
Journal Article
Keel venom: Rhabdophis subminiatus (red-necked keelback) venom pathophysiologically affects diverse blood clotting pathways
Chowdhury, Abhinandan, Lewin, Matthew R., Carter, Rebecca W., Casewell, Nicholas R. and Fry, Bryan G. (2022). Keel venom: Rhabdophis subminiatus (red-necked keelback) venom pathophysiologically affects diverse blood clotting pathways. Toxicon, 218, 19-24. doi: 10.1016/j.toxicon.2022.08.017
2022
Journal Article
Diverse and dynamic alpha-neurotoxicity within venoms from the palearctic viperid snake clade of Daboia, Macrovipera, Montivipera, and Vipera
Chowdhury, Abhinandan, Zdenek, Christina N. and Fry, Bryan G. (2022). Diverse and dynamic alpha-neurotoxicity within venoms from the palearctic viperid snake clade of Daboia, Macrovipera, Montivipera, and Vipera. Neurotoxicity Research, 40 (6), 1-9. doi: 10.1007/s12640-022-00572-w
2022
Journal Article
The relative efficacy of chemically diverse small-molecule enzyme-inhibitors against anticoagulant activities of Black Snake (Pseudechis spp.) venoms
Chowdhury, Abhinandan, Youngman, Nicholas J., Liu, Jiaojiao, Lewin, Matthew R., Carter, Rebecca W. and Fry, Bryan G. (2022). The relative efficacy of chemically diverse small-molecule enzyme-inhibitors against anticoagulant activities of Black Snake (Pseudechis spp.) venoms. Toxicology Letters, 366, 26-32. doi: 10.1016/j.toxlet.2022.06.009
2022
Journal Article
Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacy
Zdenek, Christina N., Chowdhury, Abhinandan, Haw, Grace Y.H., Violette, Aude, Fourmy, Rudy, Christ, Thomas, Vonk, Freek J. and Fry, Bryan G. (2022). Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacy. Toxicon, 205, 11-19. doi: 10.1016/j.toxicon.2021.11.004
2021
Journal Article
The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Naja Species) Venoms
Chowdhury, Abhinandan, Lewin, Matthew R., Zdenek, Christina N., Carter, Rebecca and Fry, Bryan G. (2021). The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Naja Species) Venoms. Frontiers in Immunology, 12 752442, 1-9. doi: 10.3389/fimmu.2021.752442
2021
Journal Article
Clinical implications of ontogenetic differences in the coagulotoxic activity of Bothrops jararacussu venoms
Bittencourt Rodrigues, Caroline Fabri, Zdenek, Christina N., Bourke, Lachlan A., Seneci, Lorenzo, Chowdhury, Abhinandan, Freitas-de-Sousa, Luciana Aparecida, de Alcantara Menezes, Frederico, Moura-da-Silva, Ana Maria, Tanaka-Azevedo, Anita Mitico and Fry, Bryan G. (2021). Clinical implications of ontogenetic differences in the coagulotoxic activity of Bothrops jararacussu venoms. Toxicology Letters, 348, 59-72. doi: 10.1016/j.toxlet.2021.05.005
2021
Journal Article
Venom-induced blood disturbances by palearctic viperid snakes, and their relative neutralization by antivenoms and enzyme-inhibitors
Chowdhury, Abhinandan, Zdenek, Christina N., Lewin, Matthew R., Carter, Rebecca, Jagar, Tomaž, Ostanek, Erika, Harjen, Hannah, Aldridge, Matt, Soria, Raul, Haw, Grace and Fry, Bryan G. (2021). Venom-induced blood disturbances by palearctic viperid snakes, and their relative neutralization by antivenoms and enzyme-inhibitors. Frontiers in Immunology, 12 688802, 688802. doi: 10.3389/fimmu.2021.688802
2021
Journal Article
Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors
Chowdhury, Abhinandan, Zdenek, Christina N., Dobson, James S., Bourke, Lachlan A., Soria, Raul and Fry, Bryan G. (2021). Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors. Toxicology Letters, 340, 77-88. doi: 10.1016/j.toxlet.2020.12.019
2021
Journal Article
A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms
Seneci, Lorenzo, Zdenek, Christina N., Chowdhury, Abhinandan, Rodrigues, Caroline F. B., Neri-Castro, Edgar, Benard-Valle, Melisa, Alagon, Alejandro and Fry, Bryan G. (2021). A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms. Frontiers in Immunology, 12 612846, 612846. doi: 10.3389/fimmu.2021.612846
2021
Journal Article
Utilising venom activity to infer dietary composition of the Kenyan horned viper (Bitis worthingtoni)
Youngman, Nicholas J., Chowdhury, Abhinandan, Zdenek, Christina N., Coster, Kristian, Sundman, Eric, Braun, Ralph and Fry, Bryan G. (2021). Utilising venom activity to infer dietary composition of the Kenyan horned viper (Bitis worthingtoni). Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 240 108921, 108921. doi: 10.1016/j.cbpc.2020.108921
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