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2024 Journal Article Repurposing a plant peptide cyclase for targeted lysine acylationRehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 2024 (9), 1-1. doi: 10.1038/s41557-024-01520-1 |
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2024 Journal Article Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptidesOshiro, Karen G. N., Freitas, Carlos D. P., Rezende, Samilla B., Orozco, Raquel M. Q., Chan, Lai Y., Lawrence, Nicole, Lião, Luciano M., Macedo, Maria L. R., Craik, David J., Cardoso, Marlon H. and Franco, Octávio L. (2024). Deciphering the structure and mechanism‐of‐action of computer‐designed mastoparan peptides. The FEBS Journal, 291 (5), 865-883. doi: 10.1111/febs.17010 |
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2023 Conference Publication Structure, function, and evolution of nettle caterpillar venom toxinsGoudarzi, Mohaddeseh H., Robinson, Samuel, Cardoso, Fernanda C., Lawrence, Nicole, Eagles, David, Chin, Y., King, Glenn F. and Walker, Andrew A. (2023). Structure, function, and evolution of nettle caterpillar venom toxins. V2D 2023: 8th Venoms to Drugs Conference, Moreton Island, QLD Australia, 9-13 October 2023. |
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2023 Journal Article The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisinWang, Conan K., Huang, Yen-Hua, Shabbir, Fatima, Pham, Huong T., Lawrence, Nicole, Benfield, Aurélie H., van der Donk, Wilfred, Henriques, Sónia T., Turner, Mark S. and Craik, David J. (2023). The circular bacteriocin enterocin NKR-5-3B has an improved stability profile over nisin. Peptides, 167 171049, 171049. doi: 10.1016/j.peptides.2023.171049 |
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2022 Conference Publication Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptakePhilippe, Gregoire, Huang, Yen-Hua, Mittermeier, Anna, Brown, Christopher, Wang, Conan, Kaas, Quentin, Lawrence, Nicole, Condon, Nicholas, Lane, David, Loewer, Alexander, Craik, David and Henriques, Sonia (2022). Activating the p53 pathway with peptide conjugates: synthesis, structure, activity and cellular uptake. 36th European Peptide Symposium 12th International Peptide Symposium, Barcelona, Spain, 28 August - 2 September 2022. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.3445 |
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2022 Conference Publication Structure, function, and evolution of nettle caterpillar venom toxinsGoudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Lawrence, Nicole, Chin, Yanni, King, Glenn F. and Walker, Andrew A. (2022). Structure, function, and evolution of nettle caterpillar venom toxins. Pathogens and Natural Toxins e-Conference, Brisbane, QLD Australia, 1 July - 31 August 2022. |
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2021 Journal Article Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternusMuller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716 |
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2021 Journal Article Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitorTombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Gilding, Edward K., Grazioso, Giovanni, Craik, David J. and Wang, Conan K. (2021). Bioactive cyclization optimizes the affinity of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) peptide inhibitor. Journal of Medicinal Chemistry, 64 (5) acs.jmedchem.0c01766, 2523-2533. doi: 10.1021/acs.jmedchem.0c01766 |
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2021 Journal Article Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cellsPhilippe, Grégoire J.-B., Mittermeier, Anna, Lawrence, Nicole, Huang, Yen-Hua, Condon, Nicholas D., Loewer, Alexander, Craik, David J. and Henriques, Sónia T. (2021). Angler peptides: macrocyclic conjugates inhibit p53:MDM2/X interactions and activate apoptosis in cancer cells. ACS Chemical Biology, 16 (2) acschembio.0c00988, 414-428. doi: 10.1021/acschembio.0c00988 |
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2021 Journal Article Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9)Tombling, Benjamin J., Lammi, Carmen, Lawrence, Nicole, Li, Jianqiang, Arnoldi, Anna, Craik, David J. and Wang, Conan K. (2021). Engineered EGF-A peptides with improved affinity for proprotein convertase subtilisin/kexin type 9 (PCSK9). ACS Chemical Biology, 16 (2) acschembio.0c00991, 429-439. doi: 10.1021/acschembio.0c00991 |
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2021 Journal Article Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cellsBenfield, Aurélie H., Defaus, Sira, Lawrence, Nicole, Chaousis, Stephanie, Condon, Nicholas, Cheneval, Olivier, Huang, Yen-Hua, Chan, Lai Yue, Andreu, David, Craik, David J. and Henriques, Sónia Troeira (2021). Cyclic gomesin, a stable redesigned spider peptide able to enter cancer cells. Biochimica et Biophysica Acta - Biomembranes, 1863 (1) 183480, 183480. doi: 10.1016/j.bbamem.2020.183480 |
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2021 Book Chapter Intracellular targeting of cyclotides for therapeutic applicationsLawrence, Nicole and Craik, David J. (2021). Intracellular targeting of cyclotides for therapeutic applications. Methods in pharmacology and toxicology. (pp. 229-248) New York, NY USA: Humana Press. doi: 10.1007/978-1-0716-1250-7_11 |
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2021 Journal Article Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunitsNevin, S. T., Lawrence, N., Nicke, A., Lewis, R. J. and Adams, D. J. (2021). Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits. Channels, 15 (1), 79-93. doi: 10.1080/19336950.2020.1860399 |
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2020 Journal Article Cyclotide structures revealed by NMR, with a little help from X-ray crystallographyHandley, Thomas N. G., Harvey, Peta J., Wang, Conan K., Lawrence, Nicole and Craik, David (2020). Cyclotide structures revealed by NMR, with a little help from X-ray crystallography. Chembiochem, 21 (24) cbic.202000315, 3463-3475. doi: 10.1002/cbic.202000315 |
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2020 Journal Article Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020)Handley, Thomas N. G., Wang, Conan K., Harvey, Peta J., Lawrence, Nicole and Craik, David J. (2020). Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020). ChemBioChem, 21 (24), 3449-3449. doi: 10.1002/cbic.202000778 |
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2020 Journal Article Safer in vitro drug screening models for melioidosis therapy developmentAmiss, Anna S., Webb, Jessica R., Mayo, Mark, Currie, Bart J., Craik, David J., Henriques, Sónia Troeira and Lawrence, Nicole (2020). Safer in vitro drug screening models for melioidosis therapy development. The American journal of tropical medicine and hygiene, 103 (5), 1846-1851. doi: 10.4269/ajtmh.20-0248 |
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2019 Journal Article Cyclic analogues of horseshoe crab peptide Tachyplesin I with anticancer and cell penetrating propertiesVernen, Felicitas, Craik, David J., Lawrence, Nicole and Troeira Henriques, Sónia (2019). Cyclic analogues of horseshoe crab peptide Tachyplesin I with anticancer and cell penetrating properties. ACS Chemical Biology, 14 (12), 2895-2908. doi: 10.1021/acschembio.9b00782 |
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2019 Journal Article Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer propertiesVernen, Felicitas, Harvey, Peta J., Dias, Susana A., Veiga, Ana Salomé, Huang, Yen-Hua, Craik, David J., Lawrence, Nicole and Troeira Henriques, Sónia (2019). Characterization of tachyplesin peptides and their cyclized analogues to improve antimicrobial and anticancer properties. International Journal of Molecular Sciences, 20 (17) 4184, 4184. doi: 10.3390/ijms20174184 |
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2019 Journal Article Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor propertiesPhilippe, Grégoire J. -B., Gaspar, Diana, Sheng, Caibin, Huang, Yen-Hua, Benfield, Aurélie H., Condon, Nicholas D., Weidmann, Joachim, Lawrence, Nicole, Löwer, Alexander, Castanho, Miguel A. R. B., Craik, David J. and Troeira Henriques, Sónia (2019). Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties. ACS Chemical Biology, 14 (9), 2071-2087. doi: 10.1021/acschembio.9b00593 |
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2019 Journal Article Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurélie H., Biswas, Kaustav, Craik, David J., Miranda, Les P., Henriques, Sónia Troeira and Schroeder, Christina I. (2019). Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chemical Biology, 14 (1), 118-130. doi: 10.1021/acschembio.8b00989 |
