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2023 Journal Article Potential of β2AR for added benefit in treating heart failure through a better understanding of signalingWalweel, Kafa, Cheesman, Elizabeth and Molenaar, Peter (2023). Potential of β2AR for added benefit in treating heart failure through a better understanding of signaling. Current Opinion in Physiology, 36 100719, 100719. doi: 10.1016/j.cophys.2023.100719 |
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2023 Journal Article Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6Walweel, Kafa, Beard, Nicole, van Helden, Dirk F. and Laver, Derek R. (2023). Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6. Journal of General Physiology, 155 (8) e202213277. doi: 10.1085/jgp.202213277 |
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2021 Journal Article Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep modelWalweel, K., Boon, A. C., See Hoe, L. E., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Colombo, S. M., Bartnikowski, N. J., Bouquet, M., Wells, M. A., Black, D. M., Pimenta, L. P., Stevenson, A. K., Bisht, K., Skeggs, K., Marshall, L., Prabhu, A., James, L. N., Platts, D. G., Macdonald, P. S., McGiffin, D. C., Suen, J. Y. and Fraser, J. F. (2021). Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model. Biomedical Journal, 45 (5), 776-787. doi: 10.1016/j.bj.2021.10.007 |
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2020 Journal Article Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion systemWalweel, K., Skeggs, K., Boon, A. C., See Hoe, L. E., Bouquet, M., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Wood, E. S., Reid, J., Colombo, S. M., Bartnikowski, N. J., Wells, M. A., Black, D., Pimenta, L. P., Stevenson, A. K., Bisht, K., Marshall, L., Prabhu, D. A., James, L., Platts, D. G., MacDonald, P. S., McGiffin, D. C., Suen, J. Y. and Fraser, J. F. (2020). Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system. Journal of Biomedical Science, 27 (1) 96, 96. doi: 10.1186/s12929-020-00690-7 |
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2019 Journal Article Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814Walweel, Kafa, Gomez-Hurtado, Nieves, Rebbeck, Robyn T., Oo, Ye Wint, Beard, Nicole A., Molenaar, Peter, dos Remedios, Cris, van Helden, Dirk F., Cornea, Razvan L., Knollmann, Björn C. and Laver, Derek R. (2019). Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814. Journal of Molecular and Cellular Cardiology, 130, 96-106. doi: 10.1016/j.yjmcc.2019.03.018 |
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2017 Journal Article Calmodulin mutants linked to catecholaminergic polymorphic ventricular tachycardia fail to inhibit human RyR2 channelsWalweel, Kafa, Gomez-Hurtado, Nieves, Oo, Ye Wint, Beard, Nicole A., dos Remedios, Cris, Johnson, Christopher N., Chazin, Walter J., van Helden, Dirk F., Knollmann, Björn C. and Laver, Derek R. (2017). Calmodulin mutants linked to catecholaminergic polymorphic ventricular tachycardia fail to inhibit human RyR2 channels. Journal of the American College of Cardiology, 70 (1), 115-117. doi: 10.1016/j.jacc.2017.04.055 |
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2017 Journal Article Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human heartsWalweel, K., Molenaar, P., Imtiaz, M. S., Denniss, A., dos Remedios, C., van Helden, D. F., Dulhunty, A. F., Laver, D. R. and Beard, N. A. (2017). Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts. Journal of Molecular and Cellular Cardiology, 104, 53-62. doi: 10.1016/j.yjmcc.2017.01.016 |
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2016 Journal Article The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantroleneWalweel, Kafa, Oo, Ye Win and Laver, Derek R. (2016). The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene. Clinical and Experimental Pharmacology and Physiology, 44 (1), 135-142. doi: 10.1111/1440-1681.12669 |
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2015 Journal Article Essential role of calmodulin in RyR inhibition by dantroleneOo, Ye Win, Gomez-Hurtado, Nieves, Walweel, Kafa, van Helden, Dirk F., Imtiaz, Mohammad S., Knollmann, Bjorn C. and Laver, Derek R. (2015). Essential role of calmodulin in RyR inhibition by dantrolene. Molecular Pharmacology, 88 (1), 57-63. doi: 10.1124/mol.115.097691 |
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2014 Journal Article Mechanisms of SR calcium release in healthy and failing human heartsWalweel, K. and Laver, D. R. (2014). Mechanisms of SR calcium release in healthy and failing human hearts. Biophysical Reviews, 7 (1), 33-41. doi: 10.1007/s12551-014-0152-4 |
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2014 Journal Article Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulumWalweel, Kafa, Li, Jiao, Molenaar, Peter, Imtiaz, Mohammad S., Quail, Anthony, dos Remedios, Cris G., Beard, Nicole A., Dulhunty, Angela F., van Helden, Dirk F. and Laver, Derek R. (2014). Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum. Journal of General Physiology, 144 (3), 263-271. doi: 10.1085/jgp.201311157 |
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2014 Journal Article Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutantsHwang, Hyun Seok, Nitu, Florentin R., Yang, Yi, Walweel, Kafa, Pereira, Laetitia, Johnson, Christopher N., Faggioni, Michela, Chazin, Walter J., Laver, Derek, George, Alfred L., Cornea, Razvan L., Bers, Donald M. and Knollmann, Björn C. (2014). Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circulation Research, 114 (7), 1114-1124. doi: 10.1161/circresaha.114.303391 |
