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2025 Journal Article Whole genome sequencing in early onset advanced heart failureLinnér, Erik, Czuba, Tomasz, Gidlöf, Olof, Lundgren, Jakob, Bollano, Entela, Hellberg, Maria, Celik, Selvi, Pimpalwar, Neha, Rentzsch, Philipp, Martorella, Molly, Gummesson, Anders, Melander, Olle, Albinsson, Sebastian, Dellgren, Göran, Borén, Jan, Jeppsson, Anders, Lumbers, R. Thomas, Shah, Sonia, Nilsson, Johan, Natarajan, Pradeep, Lappalainen, Tuuli, Levin, Malin, Ehrencrona, Hans and Smith, J. Gustav (2025). Whole genome sequencing in early onset advanced heart failure. Scientific Reports, 15 (1) 4306, 1. doi: 10.1038/s41598-025-88465-8 |
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2025 Journal Article Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetesCao, Yuanzhao, Redd, Meredith, Outhwaite, Jennifer, Mizikovsky, Dalia, Shim, Woo Jun, Fang, Chen, Wu, Zhixuan, Daygon, Dara, Stark, Terra, Palfreyman, Robin, Chiu, Han Sheng, Tan, Clarissa, Thomas, Ulrich, Dragicevic, Elena, Sng, Julian, Barrett, Helen, Dorey, Emily, Shah, Sonia, Short, Kirsty and Palpant, Nathan J. (2025). Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes. doi: 10.1101/2025.01.29.635173 |
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2024 Journal Article Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseasesJiang, Jiayue-Clara, Singh, Kritika, Nitin, Rachana, Davis, Lea K., Wray, Naomi R. and Shah, Sonia (2024). Sex-specific association between genetic risk of psychiatric disorders and cardiovascular diseases. Circulation: Genomic and Precision Medicine, 17 (6) e004685, 1-12. doi: 10.1161/circgen.124.004685 |
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2024 Journal Article Proprotein convertase subtilisin/kexin type 9 as a drug target for abdominal aortic aneurysmGolledge, Jonathan, Lu, Hong S. and Shah, Sonia (2024). Proprotein convertase subtilisin/kexin type 9 as a drug target for abdominal aortic aneurysm. Current Opinion in Lipidology, 35 (5), 241-247. doi: 10.1097/MOL.0000000000000945 |
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2024 Journal Article Genomics for Improving Heart Failure Risk Assessment in Cancer PatientsShah, Sonia (2024). Genomics for Improving Heart Failure Risk Assessment in Cancer Patients. JACC: CardioOncology, 6 (5), 728-730. doi: 10.1016/j.jaccao.2024.06.001 |
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2024 Journal Article Featured CoverChauquet, Solal, Willis, Emily F., Grice, Laura, Harley, Samuel B. R., Powell, Joseph E., Wray, Naomi R., Nguyen, Quan, Ruitenberg, Marc J., Shah, Sonia and Vukovic, Jana (2024). Featured Cover. Aging Cell, 23 (7). doi: 10.1111/acel.14279 |
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2024 Journal Article Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brainChauquet, Solal, Willis, Emily F., Grice, Laura, Harley, Samuel B. R., Powell, Joseph E., Wray, Naomi R., Nguyen, Quan, Ruitenberg, Marc J., Shah, Sonia and Vukovic, Jana (2024). Exercise rejuvenates microglia and reverses T cell accumulation in the aged female mouse brain. Aging Cell, 23 (7) e14172, e14172. doi: 10.1111/acel.14172 |
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2023 Journal Article Phenotypic but not genetically predicted heart rate variability associated with all-cause mortalityTegegne, Balewgizie S., Said, M. Abdullah, Ani, Alireza, van Roon, Arie M., Shah, Sonia, de Geus, Eco J. C., van der Harst, Pim, Riese, Harriëtte, Nolte, Ilja M. and Snieder, Harold (2023). Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality. Communications Biology, 6 (1) 1013, 1-10. doi: 10.1038/s42003-023-05376-y |
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2023 Journal Article Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysisJiang, Jiayue-Clara, Hu, Chenwen, McIntosh, Andrew M. and Shah, Sonia (2023). Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis. Translational Psychiatry, 13 (1) 110, 110. doi: 10.1038/s41398-023-02403-8 |
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2022 Journal Article Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery diseaseCadby, Gemma, Giles, Corey, Melton, Phillip E., Huynh, Kevin, Mellett, Natalie A., Duong, Thy, Nguyen, Anh, Cinel, Michelle, Smith, Alex, Olshansky, Gavriel, Wang, Tingting, Brozynska, Marta, Inouye, Mike, McCarthy, Nina S., Ariff, Amir, Hung, Joseph, Hui, Jennie, Beilby, John, Dubé, Marie-Pierre, Watts, Gerald F., Shah, Sonia, Wray, Naomi R., Lim, Wei Ling Florence, Chatterjee, Pratishtha, Martins, Ian, Laws, Simon M., Porter, Tenielle, Vacher, Michael, Bush, Ashley I. ... Moses, Eric K. (2022). Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease. Nature Communications, 13 (1) 3124, 1-17. doi: 10.1038/s41467-022-30875-7 |
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2021 Journal Article The genomics of heart failure: design and rationale of the HERMES consortiumLumbers, R. Thomas, Shah, Sonia, Lin, Honghuang, Czuba, Tomasz, Henry, Albert, Swerdlow, Daniel I., Mälarstig, Anders, Andersson, Charlotte, Verweij, Niek, Holmes, Michael V., Ärnlöv, Johan, Svensson, Per, Hemingway, Harry, Sallah, Neneh, Almgren, Peter, Aragam, Krishna G., Asselin, Geraldine, Backman, Joshua D., Biggs, Mary L., Bloom, Heather L., Boersma, Eric, Brandimarto, Jeffrey, Brown, Michael R., Brunner‐La Rocca, Hans‐Peter, Carey, David J., Chaffin, Mark D., Chasman, Daniel I., Chazara, Olympe, Chen, Xing ... Regeneron Genetics Center (2021). The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Failure, 8 (6) ehf2.13517, 5531-5541. doi: 10.1002/ehf2.13517 |
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2021 Journal Article Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization studyChauquet, Solal, Zhu, Zhihong, O'Donovan, Michael C., Walters, James T. R., Wray, Naomi R. and Shah, Sonia (2021). Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study. JAMA Psychiatry, 78 (6), 623-631. doi: 10.1001/jamapsychiatry.2021.0005 |
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2020 Journal Article A genetic model of ivabradine recapitulates results from randomized clinical trialsLegault, Marc-André, Sandoval, Johanna, Provost, Sylvie, Barhdadi, Amina, Lemieux Perreault, Louis-Philippe, Shah, Sonia, Lumbers, R. Thomas, de Denus, Simon, Tyl, Benoit, Tardif, Jean-Claude and Dubé, Marie-Pierre (2020). A genetic model of ivabradine recapitulates results from randomized clinical trials. PLOS ONE, 15 (7) e0236193, e0236193. doi: 10.1371/journal.pone.0236193 |
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2020 Journal Article DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetesRoshandel, Delnaz, Chen, Zhuo, Canty, Angelo J., Bull, Shelley B., Natarajan, Rama, Paterson, Andrew D., Scherer, S., Miao, F., Zhang, L., Brown-Friday, J., Crandall, J., Engel, H., Engel, S., Martinez, H., Phillips, M., Reid, M., Shamoon, H., Sheindlin, J., Gubitosi-Klug, R., Wood, J., Mayer, L., Miller, D., Nayate, A., Novak, M., Pendegast, S., Singerman, L., Weiss, D., Zegarra, H., Brown, E. ... McVary, K. (2020). DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes. Clinical Epigenetics, 12 (1) 52, 1-16. doi: 10.1186/s13148-020-00840-6 |
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2020 Journal Article Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failureShah, Sonia, Henry, Albert, Roselli, Carolina, Lin, Honghuang, Sveinbjörnsson, Garðar, Fatemifar, Ghazaleh, Hedman, Åsa K., Wilk, Jemma B., Morley, Michael P., Chaffin, Mark D., Helgadottir, Anna, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Andersson, Charlotte, Aragam, Krishna G., Ärnlöv, Johan, Backman, Joshua D., Biggs, Mary L., Bloom, Heather L., Brandimarto, Jeffrey, Brown, Michael R., Buckbinder, Leonard, Carey, David J., Chasman, Daniel I., Chen, Xing, Chen, Xu, Chung, Jonathan, Chutkow, William ... Lumbers, R. Thomas (2020). Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nature Communications, 11 (1) 163, 163. doi: 10.1038/s41467-019-13690-5 |
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2018 Journal Article Identification of 55,000 replicated DNA methylation QTLMcRae, Allan F., Marioni, Riccardo E., Shah, Sonia, Yang, Jian, Powell, Joseph E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Bowdler, Lisa, Painter, Jodie N., Murphy, Lee, Martin, Nicholas G., Starr, John M., Wray, Naomi R., Deary, Ian J., Visscher, Peter M. and Montgomery, Grant W. (2018). Identification of 55,000 replicated DNA methylation QTL. Scientific Reports, 8 (1) 17605, 17605. doi: 10.1038/s41598-018-35871-w |
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2017 Journal Article Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosisBenyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu ... Fan, Dongsheng (2017). Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 (1) 611, 611. doi: 10.1038/s41467-017-00471-1 |
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2017 Journal Article Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohortGarton, Fleur C., Benyamin, Beben, Zhao, Qiongyi, Liu, Zhijun, Gratten, Jacob, Henders, Anjali K., Zhang, Zong-Hong, Edson, Janette, Furlong, Sarah, Morgan, Sarah, Heggie, Susan, Thorpe, Kathryn, Pfluger, Casey, Mather, Karen A., Sachdev, Perminder S., McRae, Allan F., Robinson, Matthew R., Shah, Sonia, Visscher, Peter M., Mangelsdorf, Marie, Henderson, Robert D., Wray, Naomi R. and McCombe, Pamela A. (2017). Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort. Molecular Genetics and Genomic Medicine, 5 (4), 418-428. doi: 10.1002/mgg3.302 |
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2017 Journal Article A genomic atlas of human adrenal and gonad developmentDel Valle, Ignacio, Buonocore, Federica, Duncan, Andrew J., Lin, Lin, Barenco, Martino, Parnaik, Rahul, Shah, Sonia, Hubank, Mike, Gerrelli, Dianne and Achermann, John C. (2017). A genomic atlas of human adrenal and gonad development. Wellcome Open Research, 2 25, 1-42. doi: 10.12688/wellcomeopenres.11253.2 |
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2017 Journal Article Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association studiesHedman, Åsa K., Mendelson, Michael M., Marioni, Riccardo E., Gustafsson, Stefan, Joehanes, Roby, Irvin, Marguerite R., Zhi, Degui, Sandling, Johanna K., Yao, Chen, Liu, Chunyu, Liang, Liming, Huan, Tianxiao, McRae, Allan F., Demissie, Serkalem, Shah, Sonia, Starr, John M., Cupples, L. Adrienne, Deloukas, Panos, Spector, Timothy D., Sundstrom, Johan, Krauss, Ronald M., Arnett, Donna K., Deary, Ian J., Lind, Lars, Levy, Daniel and Ingelsson, Erik (2017). Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association studies. Circulation: Cardiovascular Genetics, 10 (1) 001487. doi: 10.1161/CIRCGENETICS.116.001487 |
