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2024 Journal Article Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosisWang, XinYue, Jowsey, William J., Cheung, Chen-Yi, Smart, Caitlan J., Klaus, Hannah R., Seeto, Noon EJ, Waller, Natalie JE, Chrisp, Michael T., Peterson, Amanda L., Ofori-Anyinam, Boatema, Strong, Emily, Nijagal, Brunda, West, Nicholas P., Yang, Jason H., Fineran, Peter C., Cook, Gregory M., Jackson, Simon A. and McNeil, Matthew B. (2024). Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis. Nature Communications, 15 (1) 9791, 9791. doi: 10.1038/s41467-024-54072-w |
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2024 Journal Article Identification of axinellamines A and B as anti-tubercular agentsStrong, Emily J., Tan, Lendl, Hayes, Sasha, Whyte, Hayden, Davis, Rohan A. and West, Nicholas P. (2024). Identification of axinellamines A and B as anti-tubercular agents. Marine Drugs, 22 (7) 298, 298. doi: 10.3390/md22070298 |
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2024 Journal Article Reassessing the putative molecular Target(s) of potent antitubercular 2-(Alkylsulfonyl)acetamidesFarr, Dylan C., Haselhorst, Thomas, Tan, Lendl, Furness, Juanelle, Strong, Emily, Grice, I. Darren, West, Nicholas P. and Houston, Todd A. (2024). Reassessing the putative molecular Target(s) of potent antitubercular 2-(Alkylsulfonyl)acetamides. European Journal of Medicinal Chemistry, 264 115983, 1-12. doi: 10.1016/j.ejmech.2023.115983 |
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2022 Journal Article FDA-approved amoxapine effectively promotes macrophage control of mycobacteria by inducing autophagyWang, Jia, Sha, Jian, Strong, Emily, Chopra, Ashok K. and Lee, Sunhee (2022). FDA-approved amoxapine effectively promotes macrophage control of mycobacteria by inducing autophagy. Microbiology Spectrum, 10 (5). doi: 10.1128/spectrum.02509-22 |
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2022 Journal Article Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacyGonzalez-Orozco, Maria, Strong, Emily J., Paroha, Ruchi and Lee, Sunhee (2022). Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy. BMC Immunology, 23 (1) 43. doi: 10.1186/s12865-022-00518-z |
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2022 Journal Article Mycobacterium tuberculosis PPE51 inhibits autophagy by suppressing toll-like receptor 2-dependent signalingStrong, Emily J., Wang, Jia, Ng, Tony W., Porcelli, Steven A. and Lee, Sunhee (2022). Mycobacterium tuberculosis PPE51 inhibits autophagy by suppressing toll-like receptor 2-dependent signaling. MBio, 13 (3). doi: 10.1128/mbio.02974-21 |
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2022 Journal Article Induced synthesis of mycolactone restores the pathogenesis of Mycobacterium ulcerans in vitro and in vivoStrong, Emily, Hart, Bryan, Wang, Jia, Orozco, Maria Gonzalez and Lee, Sunhee (2022). Induced synthesis of mycolactone restores the pathogenesis of Mycobacterium ulcerans in vitro and in vivo. Frontiers in Immunology, 13 750643. doi: 10.3389/fimmu.2022.750643 |
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2021 Journal Article Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 proteins inhibit autophagy by interaction with Rab1AStrong, Emily J., Ng, Tony W., Porcelli, Steven A. and Lee, Sunhee (2021). Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 proteins inhibit autophagy by interaction with Rab1A. Msphere, 6 (4), 1-17. doi: 10.1128/msphere.00549-21 |
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2021 Journal Article Targeting autophagy as a strategy for developing new vaccines and host-directed therapeutics against mycobacteriaStrong, Emily J. and Lee, Sunhee (2021). Targeting autophagy as a strategy for developing new vaccines and host-directed therapeutics against mycobacteria. Frontiers in Microbiology, 11 614313. doi: 10.3389/fmicb.2020.614313 |
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2020 Journal Article Identification of autophagy-inhibiting factors of mycobacterium tuberculosis by high-throughput loss-of-function screeningStrong, Emily J., Jurcic Smith, Kristen L., Saini, Neeraj K., Ng, Tony W., Porcelli, Steven A. and Lee, Sunhee (2020). Identification of autophagy-inhibiting factors of mycobacterium tuberculosis by high-throughput loss-of-function screening. Infection and Immunity, 88 (12) e00269-20. doi: 10.1128/IAI.00269-20 |
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2018 Journal Article Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning methodTan, Lendl, Strong, Emily J., Woods, Kyra and West, Nicholas P. (2018). Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method. PeerJ, 6 (6) e5146, e5146. doi: 10.7717/peerj.5146 |
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2018 Journal Article Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosisStrong, Emily J. and West, Nicholas P. (2018). Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosis. Scientific Reports, 8 (1) 5604, 5604. doi: 10.1038/s41598-018-23893-3 |
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2016 Journal Article Burkholderia pseudomallei capsule exacerbates respiratory melioidosis but does not afford protection against antimicrobial signaling or bacterial killing in human olfactory ensheathing cellsDando, Samantha J., Ipe, Deepak S., Batzloff, Michael, Sullivan, Matthew J., Crossman, David K., Crowley, Michael, Strong, Emily, Kyan, Stephanie, Leclercq, Sophie Y., Ekberg, Jenny A. K., St John, James, Beacham, Ifor R. and Ulett, Glen C. (2016). Burkholderia pseudomallei capsule exacerbates respiratory melioidosis but does not afford protection against antimicrobial signaling or bacterial killing in human olfactory ensheathing cells. Infection and Immunity, 84 (7), 1941-1956. doi: 10.1128/IAI.01546-15 |
