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2001 Journal Article Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacyLiu, Wen jun, Zhao, Kong-Nan, Gao, Feng Guang, Leggatt, Graham R., Fernando, Germain J. and Frazer, Ian H. (2001). Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy. Vaccine, 20 (5-6), 862-869. doi: 10.1016/S0264-410X(01)00406-6 |
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2001 Journal Article Low level expression of human papillomavirus type 16 (HPV16) E6 in squamous epithelium does not elicit E6 specific B- or T-helper immunological responses, or influence the outcome of immunisation with E6 proteinAzoury-Ziadeh, R, Herd, K, Fernando, GJP, Lambert, P, Frazer, IH and Tindle, RW (2001). Low level expression of human papillomavirus type 16 (HPV16) E6 in squamous epithelium does not elicit E6 specific B- or T-helper immunological responses, or influence the outcome of immunisation with E6 protein. Virus Research, 73 (2), 189-199. doi: 10.1016/S0168-1702(00)00241-0 |
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2000 Journal Article Differences in the post-translational modifications of human papillomavirus type 6b major capsid protein expressed from a baculovirus system compared with a vaccinia virus systemFang, N., Frazer, I. H. and Fernando, G. J. (2000). Differences in the post-translational modifications of human papillomavirus type 6b major capsid protein expressed from a baculovirus system compared with a vaccinia virus system. Biotechnology And Applied Biochemistry, 32 (1), 27-33. doi: 10.1042/BA20000001 |
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2000 Journal Article Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunizationDoan, Tracy, Herd, Karen A., Lambert, Paul F., Fernando, Germain J. P., Street, Michael D. and Tindle, Robert W. (2000). Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunization. Cancer Research, 60 (11), 2810-2815. |
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1999 Journal Article Human papillomavirus type 16 E7 oncoprotein expressed in peripheral epithelium tolerizes E7-directed cytotoxic T-lymphocyte precursors restricted through human (and mouse) major histocompatibility complex class I allelesDoan, Tracy, Herd, Karen, Street, Michael, Bryson, Gregory, Fernando, Germain, Lambert, Paul and Tindle, Robert (1999). Human papillomavirus type 16 E7 oncoprotein expressed in peripheral epithelium tolerizes E7-directed cytotoxic T-lymphocyte precursors restricted through human (and mouse) major histocompatibility complex class I alleles. Journal of Virology, 73 (7), 6166-6170. doi: 10.1128/jvi.73.7.6166-6170.1999 |
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1999 Journal Article Post translational modifications of recombinant human Papillomavirus type 6b major capsid proteinFang, Ning-Xia, Frazer, Ian H., Zhou, Jian and Fernando, Germain J. P. (1999). Post translational modifications of recombinant human Papillomavirus type 6b major capsid protein. Virus Research, 60 (2), 113-121. doi: 10.1016/S0168-1702(98)00117-8 |
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1999 Journal Article Expression, purification and immunological characterization of the transforming protein E7, from cervical cancer-associated human papillomavirus type 16Fernando, G. J. P., Murray, B., Zhou, J. and Frazer, I. H. (1999). Expression, purification and immunological characterization of the transforming protein E7, from cervical cancer-associated human papillomavirus type 16. Clinical & Experimental Immunology, 115 (3), 397-403. doi: 10.1046/j.1365-2249.1999.00813.x |
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1999 Journal Article T-Helper epitopes identified within the E6 transforming protein of cervical cancer-associated human papillomavirus type 16Azoury-Ziadeh, Rania, Herd, Karen, Fernando, Germain J. P., Frazer, Ian H. and Tindle, Robert W. (1999). T-Helper epitopes identified within the E6 transforming protein of cervical cancer-associated human papillomavirus type 16. Viral Immunology, 12 (4), 297-312. doi: 10.1089/vim.1999.12.297 |
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1998 Journal Article Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytesFrazer, Ian H., Fernando, Germain J. P., Fowler, Nina, Leggatt, Graham R., Lambert, Paul F., Liem, Amy, Malcolm, Karen and Tindle, Robert W. (1998). Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes. European Journal of Immunology, 28 (9), 2791-2800. doi: 10.1002/(SICI)1521-4141(199809)28:093.0.CO;2-B |
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1998 Journal Article Th2-type CD4(+) cells neither enhance nor suppress antitumor CTL activity in a mouse tumor modelFernando, Germain J. P., Stewart, Trina J., Tindle, Robert W. and Frazer, Ian H. (1998). Th2-type CD4(+) cells neither enhance nor suppress antitumor CTL activity in a mouse tumor model. Journal of Immunology, 161 (5), 2421-2427. |
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1998 Journal Article Mice expressing the E7 oncogene of HPV16 in epithelium show central tolerance, and evidence of peripheral anergising tolerance, to E7-encoded cytotoxic T-lymphocyte epitopesDoan, Tracy, Chambers, Melita, Street, Michael, Fernando, Germain J. P., Herd, Karen, Lambert, Paul and Tindle, Robert (1998). Mice expressing the E7 oncogene of HPV16 in epithelium show central tolerance, and evidence of peripheral anergising tolerance, to E7-encoded cytotoxic T-lymphocyte epitopes. Virology, 244 (2), 352-364. doi: 10.1006/viro.1998.9128 |
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1998 Journal Article Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer termFernando, G. J. P., Stewart, T. J., Tindle, R. W. and Frazer, I. H. (1998). Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer term. Scandinavian Journal of Immunology, 47 (5), 459-465. doi: 10.1046/j.1365-3083.1998.00327.x |
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1998 Journal Article Papillomavirus virus-like particles can deliver defined CTL epitopes to the MHC class I pathwayPeng, Shiwen W., Frazer, Ian H., Fernando, Germain J. P. and Zhou, Jian (1998). Papillomavirus virus-like particles can deliver defined CTL epitopes to the MHC class I pathway. Virology, 240 (1), 147-157. doi: 10.1006/viro.1997.8912 |
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1998 Journal Article Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccinationThomson, SA, Sherritt, MA, Medveczky, J, Elliott, SL, Moss, DJ, Fernando, GJP, Brown, LE and Suhrbier, A (1998). Delivery of multiple CD8 cytotoxic T cell epitopes by DNA vaccination. Journal of Immunology, 160 (4), 1717-1723. doi: 10.4049/jimmunol.160.4.1717 |
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1997 Journal Article Presentation of the HPV16E7 protein by skin grafts is insufficient to allow graft rejection in an E7-primed animalDunn, Linda A., Evander, Magnus, Tindle, Robert W., Bulloch, Anne Louise, de Kluyver, Rachel L., Fernando, Germain J. P., Lambert, Paul F. and Frazer, Ian H. (1997). Presentation of the HPV16E7 protein by skin grafts is insufficient to allow graft rejection in an E7-primed animal. Virology, 235 (1), 94-103. doi: 10.1006/viro.1997.8650 |
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1997 Journal Article E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 proteinHerd, K., Fernando, G. J. P., Dunn, L. A., Frazer, I. H., Lambert, P. and Tindle, R. W. (1997). E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B- or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein. Virology, 231 (1), 155-165. doi: 10.1006/viro.1997.8491 |
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1995 Journal Article Purification, Characterization and Cdna Sequence of An Alkaline Chymotrypsin From the Midgut of Manduca-SextaPeterson, AM, Fernando, Gjp and Wells, MA (1995). Purification, Characterization and Cdna Sequence of An Alkaline Chymotrypsin From the Midgut of Manduca-Sexta. Insect Biochemistry and Molecular Biology, 25 (7), 765-774. doi: 10.1016/0965-1748(94)00092-V |
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1995 Journal Article Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin diseaseFrazer, I. H., Leippe, D. M., Dunn, L. A., Liem, A., Tindle, R. W., Fernando, G. J. P., Phelps, W. C. and Lambert, P. F. (1995). Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease. Cancer Research, 55 (12), 2635-2639. |
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1995 Journal Article T-helper epitopes of the E7 transforming protein of cervical-cancer associated human papillomavirus type-18 (hpv18)Fernando, G.J.P., Tindle, R.W and Frazer, I.H. (1995). T-helper epitopes of the E7 transforming protein of cervical-cancer associated human papillomavirus type-18 (hpv18). Virus Research, 36 (1), 1-13. doi: 10.1016/0168-1702(94)00101-H |
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1995 Journal Article A vaccine conjugate of 'ISCAR' immunocarrier and peptide epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1- and Th2-type responses in immunized mice in the absence of oil-based adjuvantsTindle, R. W., Croft, S., Herd, K., Malcolm, K., Geczy, A. F., Stewart, T. and Fernando, G. J. (1995). A vaccine conjugate of 'ISCAR' immunocarrier and peptide epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1- and Th2-type responses in immunized mice in the absence of oil-based adjuvants. Clinical and Experimental Immunology, 101 (2), 265-271. doi: 10.1111/j.1365-2249.1995.tb08349.x |
