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Dr Sathish Periyasamy
Dr

Sathish Periyasamy

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Overview

Background

Dr Sathish Periyasamy is a Research Fellow at a Queensland Brain Institute and Senior Scientist at Queensland Centre for Mental Health Research. He is currently building and focusing on Systems/Genomic Medicine and conducting research in the interface of systems genetics and psychiatry. He is involved in studying the mechanisms of (patho-)physiological processes in psychiatric disorders using a unique combination of educational experience coupled with over twenty-five years of computer programming and eleven years of computational biology experience in biomedicine. Over the past 20 years, his experience working in chemical, biological and medical domains has enabled him to focus on the interface of basic and clinical research and contribute to translational research. From 2011 to 2014, he was involved in cancer genetics research at King Abdullah International Medical Research Centre, KSA. As the bioinformatics lead, with interdisciplinary skills and expertise at the interface of computational intelligence, systems biology, and quantitative/psychiatric genetics, He has been contributing to psychiatric genetics research since 2014 in Professor Bryan Mowry’s lab.

His current research areas include:

  • Bioinformatics, Systems Biology and Statistical Genetics - Developing and applying GWAS, post-GWAS bioinformatics, cross-population genetic association and systems genetics approaches.
  • Psychiatric Genomics
    • Common and rare variant association studies in schizophrenia using data generated from DNA microarray and whole-exome/whole-genome sequencing technologies.
    • Post-GWAS bioinformatics approaches to characterise risk variants discovered in schizophrenia GWAS.
    • Cross-population genetic association approaches in schizophrenia.
  • Computational Intelligence – Developing conventional and visible deep learning models for biomedicine.
  • Developing genetic resources for Indigenous Oceanic populations

Availability

Dr Sathish Periyasamy is:
Available for supervision

Qualifications

  • Masters (Coursework) of Information Technology, Keele University
  • Doctor of Philosophy of Bioinformatics (Advanced), Cardiff University

Research interests

  • Biological Complexity

    Studying the emergent properties of biological systems.

Works

Search Professor Sathish Periyasamy’s works on UQ eSpace

35 works between 2008 and 2024

1 - 20 of 35 works

Featured

2019

Journal Article

Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations

Peterson, Roseann E., Kuchenbaecker, Karoline, Walters, Raymond K., Chen, Chia-Yen, Popejoy, Alice B., Periyasamy, Sathish, Lam, Max, Iyegbe, Conrad, Strawbridge, Rona J., Brick, Leslie, Carey, Caitlin E., Martin, Alicia R., Meyers, Jacquelyn L., Su, Jinni, Chen, Junfang, Edwards, Alexis C., Kalungi, Allan, Koen, Nastassja, Majara, Lerato, Schwarz, Emanuel, Smoller, Jordan W., Stahl, Eli A., Sullivan, Patrick F., Vassos, Evangelos, Mowry, Bryan, Prieto, Miguel L., Cuellar-Barboza, Alfredo, Bigdeli, Tim B., Edenberg, Howard J. ... Duncan, Laramie E. (2019). Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. Cell, 179 (3), 589-603. doi: 10.1016/j.cell.2019.08.051

Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations

Featured

2019

Journal Article

Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study

Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Vinkhuyzen, Anna, McRae, Allan, Holliday, Elizabeth G., Nyholt, Dale R., Nancarrow, Derek, Bakshi, Andrew, Hemani, Gibran, Nertney, Deborah, Smith, Heather, Filippich, Cheryl, Patel, Kalpana, Fowdar, Javed, McLean, Duncan, Tirupati, Srinivasan, Nagasundaram, Arunkumar, Gundugurti, Prasad Rao, Selvaraj, Krishnamurthy, Jegadeesan, Jayaprakash, Jorde, Lynn B., Wray, Naomi R., Brown, Matthew A., Suetani, Rachel, Giacomotto, Jean ... Mowry, Bryan J. (2019). Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study. JAMA Psychiatry, 76 (10), 1026-1034. doi: 10.1001/jamapsychiatry.2019.1335

Association of schizophrenia risk with disordered niacin metabolism in an Indian genome-wide association study

2024

Journal Article

Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes

Periyasamy, Sathish, Youssef, Pierre, John, Sujit, Thara, Rangaswamy and Mowry, Bryan J. (2024). Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes. Frontiers in Genetics, 14 1301150, 1301150. doi: 10.3389/fgene.2023.1301150

Genetic interactions of schizophrenia using gene-based statistical epistasis exclusively identify nervous system-related pathways and key hub genes

2023

Other Outputs

Schizophrenia genetic interaction

Periyasamy, Sathish, Youssef, Pierre, John, Sujit, Thara, Rangaswamy and Mowry, Bryan (2023). Schizophrenia genetic interaction. The University of Queensland. (Dataset) doi: 10.48610/24c3e5e

Schizophrenia genetic interaction

2023

Conference Publication

Investigating The Genetic Interactions Of Schizophrenia Using Gene-based Statistical Epistasis

Periyasamy, Sathish, Youssef, Pierre, John, Sujit, Thara, Rangaswamy and Mowry, Bryan (2023). Investigating The Genetic Interactions Of Schizophrenia Using Gene-based Statistical Epistasis. World Congress of Psychiatric Genetics WCPG 2023, Montreal, QC Canada, 10-14 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2023.08.280

Investigating The Genetic Interactions Of Schizophrenia Using Gene-based Statistical Epistasis

2023

Journal Article

Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations

Liu, Dongjing, Meyer, Dara, Fennessy, Brian, Feng, Claudia, Cheng, Esther, Johnson, Jessica S., Park, You Jeong, Rieder, Marysia-Kolbe, Ascolillo, Steven, de Pins, Agathe, Dobbyn, Amanda, Lebovitch, Dannielle, Moya, Emily, Nguyen, Tan-Hoang, Wilkins, Lillian, Hassan, Arsalan, Burdick, Katherine E., Buxbaum, Joseph D., Domenici, Enrico, Frangou, Sophia, Hartmann, Annette M., Laurent-Levinson, Claudine, Malhotra, Dheeraj, Pato, Carlos N., Pato, Michele T., Ressler, Kerry, Roussos, Panos, Rujescu, Dan, Arango, Celso ... Catts, Stan (2023). Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics, 55 (3), 369-376. doi: 10.1038/s41588-023-01305-1

Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations

2022

Conference Publication

Investigating brain development using tissue and single-cell gene expression data

Periyasamy, Sathish , Youssef, Pierre and Mowry, Bryan (2022). Investigating brain development using tissue and single-cell gene expression data. The 21st International Conference on Systems Biology, Berlin, Germany, 8-12 October 2022.

Investigating brain development using tissue and single-cell gene expression data

2022

Book Chapter

Genome-wide association studies in schizophrenia

Mowry, Bryan J. and Periyasamy, Sathish (2022). Genome-wide association studies in schizophrenia. eLS. (pp. 1-14) Hoboken, NJ USA: John Wiley & Sons. doi: 10.1002/9780470015902.a0025337

Genome-wide association studies in schizophrenia

2022

Journal Article

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Trubetskoy, Vassily, Pardiñas, Antonio F, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B, Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A, Hall, Lynsey S, Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C, Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L, Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G ... Schizophrenia Working Group of the Psychiatric Genomics Consortium (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 604 (7906), 502-508. doi: 10.1038/s41586-022-04434-5

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

2022

Journal Article

BrainDevo: spatio-temporal gene regulation repository of brain development

Periyasamy, Sathish and Mowry, Bryan (2022). BrainDevo: spatio-temporal gene regulation repository of brain development. Frontiers in Molecular Neuroscience, 15 799801, 799801. doi: 10.3389/fnmol.2022.799801

BrainDevo: spatio-temporal gene regulation repository of brain development

2022

Journal Article

Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia

Pardiñas, Antonio F., Smart, Sophie E., Willcocks, Isabella R., Holmans, Peter A., Dennison, Charlotte A., Lynham, Amy J., Legge, Sophie E., Baune, Bernhard T., Bigdeli, Tim B., Cairns, Murray J., Corvin, Aiden, Fanous, Ayman H., Frank, Josef, Kelly, Brian, McQuillin, Andrew, Melle, Ingrid, Mortensen, Preben B., Mowry, Bryan J., Pato, Carlos N., Periyasamy, Sathish, Rietschel, Marcella, Rujescu, Dan, Simonsen, Carmen, St Clair, David, Tooney, Paul, Wu, Jing Qin, Andreassen, Ole A., Kowalec, Kaarina, Sullivan, Patrick F. ... Vázquez-Bourgon, Javier (2022). Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia. JAMA Psychiatry, 79 (3) 20213799, 260-269. doi: 10.1001/jamapsychiatry.2021.3799

Interaction testing and polygenic risk scoring to estimate the association of common genetic variants with treatment resistance in schizophrenia

2021

Journal Article

Genetic architecture of schizophrenia: a review of major advancements

Legge, Sophie E., Santoro, Marcos L., Periyasamy, Sathish, Okewole, Adeniran, Arsalan, Arsalan and Kowalec, Kaarina (2021). Genetic architecture of schizophrenia: a review of major advancements. Psychological Medicine, 51 (13) PII S0033291720005334, 1-10. doi: 10.1017/s0033291720005334

Genetic architecture of schizophrenia: a review of major advancements

2021

Other Outputs

BrainDevo

Periyasamy, Sathish (2021). BrainDevo. The University of Queensland. (Dataset) doi: 10.48610/5f24ed4

BrainDevo

2021

Journal Article

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Blokland, Gabriëlla A.M., Grove, Jakob, Chen, Chia-Yen, Cotsapas, Chris, Tobet, Stuart, Handa, Robert, Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B. ... iPSYCH (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry, 91 (1), 102-117. doi: 10.1016/j.biopsych.2021.02.972

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

2019

Journal Article

Comparative genetic architectures of schizophrenia in East Asian and European populations

Lam, Max, Chen, Chia-Yen, Li, Zhiqiang, Martin, Alicia R., Bryois, Julien, Ma, Xixian, Gaspar, Helena, Ikeda, Masashi, Benyamin, Beben, Brown, Brielin C., Liu, Ruize, Zhou, Wei, Guan, Lili, Kamatani, Yoichiro, Kim, Sung-Wan, Kubo, Michiaki, Kusumawardhani, Agung A. A. A., Liu, Chih-Min, Ma, Hong, Periyasamy, Sathish, Takahashi, Atsushi, Xu, Zhida, Yu, Hao, Zhu, Feng, Chen, Wei J., Faraone, Stephen, Glatt, Stephen J., He, Lin, Hyman, Steven E. ... Huang, Hailiang (2019). Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics, 51 (12), 1670-1678. doi: 10.1038/s41588-019-0512-x

Comparative genetic architectures of schizophrenia in East Asian and European populations

2019

Conference Publication

A novel approach for the generation of disease-specific genetic interaction data using gene-based statistical epistasis

Periyasamy, Sathish and Mowry, Bryan (2019). A novel approach for the generation of disease-specific genetic interaction data using gene-based statistical epistasis. International Conference on Systems Biology, Okinawa, Japan, 1-5 November 2019. Okinawa:

A novel approach for the generation of disease-specific genetic interaction data using gene-based statistical epistasis

2019

Conference Publication

Prioritising causal variants in schizophrenia GWAS by investigating the regulatory impact of non-coding variants using differential binding and brain EQTL data

Mowry, Bryan and Periyasamy, Sathish (2019). Prioritising causal variants in schizophrenia GWAS by investigating the regulatory impact of non-coding variants using differential binding and brain EQTL data. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA USA, 26-31 October 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.08.288

Prioritising causal variants in schizophrenia GWAS by investigating the regulatory impact of non-coding variants using differential binding and brain EQTL data

2019

Conference Publication

Modelling the impact of schizophrenia gwas loci during human brain development using spatio-temporal gene expression data

Periyasamy, Sathish and Mowry, Bryan (2019). Modelling the impact of schizophrenia gwas loci during human brain development using spatio-temporal gene expression data. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.489

Modelling the impact of schizophrenia gwas loci during human brain development using spatio-temporal gene expression data

2019

Conference Publication

First genome-wide association study of schizophrenia in an Indian population reveals a novel susceptibility locus

Periyasamy, Sathish, John, Sujit, Padmavati, Raman, Rajendren, Preeti, Thirunavukkarasu, Priyadarshini, Gratten, Jacob, Holliday, Elizabeth, Bakshi, Andrew, Jorde, Lynn, Brown, Matthew, Wray, Naomi, Suetani, Rachel, Giacomotto, Jean, Thara, Rangaswamy and Mowry, Bryan (2019). First genome-wide association study of schizophrenia in an Indian population reveals a novel susceptibility locus. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2018.08.017

First genome-wide association study of schizophrenia in an Indian population reveals a novel susceptibility locus

2018

Journal Article

Association between schizophrenia polygenic risk and neural correlates of emotion perception

Dzafic, Ilvana, Burianová, Hana, Periyasamy, Sathish and Mowry, Bryan (2018). Association between schizophrenia polygenic risk and neural correlates of emotion perception. Psychiatry research: Neuroimaging, 276, 33-40. doi: 10.1016/j.pscychresns.2018.04.005

Association between schizophrenia polygenic risk and neural correlates of emotion perception

Funding

Past funding

  • 2022
    Genotype Imputation Resources for Productive Genetic Disease Studies of Indigenous Oceanic Sub-Populations
    NHMRC IDEAS Grants
    Open grant

Supervision

Availability

Dr Sathish Periyasamy is:
Available for supervision

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Media

Enquiries

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