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Professor Grant Montgomery
Professor

Grant Montgomery

Email: 
Phone: 
+61 7 334 62612

Overview

Background

Professor Grant Montgomery FAHMS FSRB Hon FRSNZ

Professor Montgomery was born in New Zealand, completed PhD studies in Animal Science at Massey University and post-doctoral research in France. In 1987, he co-founded the New Zealand Sheep Genomics Program in the Biochemistry Department at the University of Otago and pioneered the introduction of genome mapping methods in farm animals. He moved to Australia in 1999 and joined the Queensland Institute of Medical Research where he ran a successful genome mapping program for human complex disease. In 2016, he moved to the University of Queensland and holds joint appointments at the Institute for Molecular Bioscience (IMB) and the Queensland Brain Institute (QBI). He is a National Health and Medical Research Council Leadership Fellow and Director of the UQ Genome Innovation Hub. He was elected a Fellow the Society for Reproductive Biology in 2012, Fellow of the Australian Academy of Health and Medical Sciences in 2015, and Honorary Fellow of the Royal Society of New Zealand in 2016. His research focusses on discovery of critical genes and pathways increasing risk for common diseases especially reproductive diseases including endometriosis.

Availability

Professor Grant Montgomery is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, Massey University

Research impacts

Professor Montgomery has made substantial contributions to the worldwide effort to map genomic regions contributing to risk for complex traits and diseases, including endometriosis, age at menarche and menopause, cancers of the reproductive tract, melanoma and inflammatory bowel disease. He is conducting systems genetics and functional studies to identify the genes and pathways affected by these genetic risk factors. His work has identified possible target genes and functional consequences of genetic risk factors in genomic regions associated with endometriosis providing novel insights into the causes of this important disease. He lead a consortium of leading endometriosis clinicians and researchers in Australia awarded a MRFF Frontiers in Health and Medical Science to develop earlier diagnosis and personalised treatments for endometriosis. He is co-leader of International Endometriois Genetics Consortium, Patron of the Endometriosis Association (QLD) Inc (QENDO) and has worked closely with QENDO, other patient groups, clinicians and politicians to help develop the National Action Plan for Endometriosis. He is on the Executive Committee of the National Endometriosis Clinical and Scientific Trials (NECST) Network. He is also Director of the UQ Genome Innovation Hub developing novel methods and pipelines for genomics in health and agriculature that can be widely applied in programs across The University of Queensland.

Works

Search Professor Grant Montgomery’s works on UQ eSpace

841 works between 1978 and 2024

21 - 40 of 841 works

Featured

2015

Journal Article

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk

Painter J.N., O'Mara T.A., Batra J., Cheng T., Lose F.A., Dennis J., Michailidou K., Tyrer J.P., Ahmed S., Ferguson K., Healey C.S., Kaufmann S., Hillman K.M., Walpole C., Moya L., Pollock P., Jones A., Howarth K., Martin L., Gorman M., Hodgson S., De Polanco M.M.E., Sans M., Carracedo A., Castellvi-Bel S., Rojas-Martinez A., Santos E., Teixeira M.R., Carvajal-Carmona L. ... Spurdle A.B. (2015). Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Human Molecular Genetics, 24 (5), 1478-1492. doi: 10.1093/hmg/ddu552

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk

Featured

2014

Journal Article

Genetic and environmental exposures constrain epigenetic drift over the human life course

Shah, Sonia, McRae, Allan F., Marioni, Riccardo E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Redmond, Paul, Cox, Simon R., Pattie, Alison, Corley, Janie, Murphy, Lee, Martin, Nicholas G., Montgomery, Grant W., Starr, John M., Wray, Naomi R., Deary, Ian J. and Visscher, Peter M. (2014). Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Research, 24 (11), 1725-1733. doi: 10.1101/gr.176933.114

Genetic and environmental exposures constrain epigenetic drift over the human life course

Featured

2014

Journal Article

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry, John R. B., Day, Felix, Elks, Cathy E., Sulem, Patrick, Thompson, Deborah J., Ferreira, Teresa, He, Chunyan, Chasman, Daniel I., Esko, Toenu, Thorleifsson, Gudmar, Albrecht, Eva, Ang, Wei Q., Corre, Tanguy, Cousminer, Diana L., Feenstra, Bjarke, Franceschini, Nora, Ganna, Andrea, Johnson, Andrew D., Kjellqvist, Sanela, Lunetta, Kathryn L., McMahon, George, Nolte, Ilja M., Paternoster, Lavinia, Porcu, Eleonora, Smith, Albert V., Stolk, Lisette, Teumer, Alexander, Tsernikova, Natalia, Tikkanen, Emmi ... Middeldorp, Christel (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92-97. doi: 10.1038/nature13545

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Featured

2014

Journal Article

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets

Rahmioglu, Nilufer, Nyholt, Dale R., Morris, Andrew P., Missmer, Stacey A., Montgomery, Grant W. and Zondervan, Krina T. (2014). Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Human Reproduction Update, 20 (5) dmu015, 702-716. doi: 10.1093/humupd/dmu015

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets

Featured

2014

Journal Article

Contribution of genetic variation to transgenerational inheritance of DNA methylation

McRae, Allan F., Powell, Joseph E., Henders, Anjali K., Bowdler, Lisa, Hemani, Gibran, Shah, Sonia, Painter, Jodie N., Martin, Nicholas G., Visscher, Peter M. and Montgomery, Grant W. (2014). Contribution of genetic variation to transgenerational inheritance of DNA methylation. Genome Biology, 15 (5) ARTN R73, 1-10. doi: 10.1186/gb-2014-15-5-r73

Contribution of genetic variation to transgenerational inheritance of DNA methylation

Featured

2013

Journal Article

Systematic identification of trans eQTLs as putative drivers of known disease associations

Westra, Harm-Jan, Peters, Marjolein J., Esko, Tonu, Yaghootkar, Hanieh, Schurmann, Claudia, Kettunen, Johannes, Christiansen, Mark W., Fairfax, Benjamin P., Schramm, Katharina, Powell, Joseph E., Zhernakova, Alexandra, Zhernakova, Daria V., Veldink, Jan H., Van den Berg, Leonard H., Karjalainen, Juha, Withoff, Sebo, Uitterlinden, Andre G., Hofman, Albert, Rivadeneira, Fernando, Hoen, Peter A. C't, Reinmaa, Eva, Fischer, Krista, Nelis, Mari, Milani, Lili, Melzer, David, Ferrucci, Luigi, Singleton, Andrew B., Hernandez, Dena G., Nalls, Michael A. ... Franke, Lude (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45 (10), 1238-U195. doi: 10.1038/ng.2756

Systematic identification of trans eQTLs as putative drivers of known disease associations

Featured

2012

Journal Article

Genome-wide association meta-analysis identifies new endometriosis risk loci

Nyholt, Dale R., Low, Siew-Kee, Anderson, Carl A., Painter, Jodie N., Uno, Satoko, Morris, Andrew P., MacGregor, Stuart, Gordon, Scott D., Henders, Anjali K., Martin, Nicholas G., Attia, John, Holliday, Elizabeth G., McEvoy, Mark, Scott, Rodney J., Kennedy, Stephen H., Treloar, Susan A., Missmer, Stacey A., Adachi, Sosuke, Tanaka, Kenichi, Nakamura, Yusuke, Zondervan, Krina T., Zembutsu, Hitoshi and Montgomery, Grant W. (2012). Genome-wide association meta-analysis identifies new endometriosis risk loci. Nature Genetics, 44 (12), 1355-1359. doi: 10.1038/ng.2445

Genome-wide association meta-analysis identifies new endometriosis risk loci

Featured

2012

Journal Article

Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent

Powell, Joseph E., Henders, Anjali K., McRae, Allan F., Wright, Margaret J., Martin, Nicholas G., Dermitzakis, Emmanouil T., Montgomery, Grant W. and Visscher, Peter M. (2012). Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. Genome Research, 22 (3), 456-466. doi: 10.1101/gr.126540.111

Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent

Featured

2012

Journal Article

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk L., Perry J.R.B., Chasman D.I., He C., Mangino M., Sulem P., Barbalic M., Broer L., Byrne E.M., Ernst F., Esko T., Franceschini N., Gudbjartsson D.F., Hottenga J.-J., Kraft P., McArdle P.F., Porcu E., Shin S.-Y., Smith A.V., Van Wingerden S., Zhai G., Zhuang W.V., Albrecht E., Alizadeh B.Z., Aspelund T., Bandinelli S., Lauc L.B., Beckmann J.S., Boban M. ... Lunetta K.L. (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44 (3), 260-268. doi: 10.1038/ng.1051

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Featured

2011

Journal Article

Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis

Painter, JN, Anderson, CA, Nyholt, DR, Macgregor, S, Lin, JH, Lee, SH, Lambert, A, Zhao, ZZ, Roseman, F, Guo, Q, Gordon, SD, Wallace, L, Henders, AK, Visscher, PM, Kraft, P, Martin, NG, Morris, AP, Treloar, SA, Kennedy, SH, Missmer, SA, Montgomery, GW and Zondervan, KT (2011). Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nature Genetics, 43 (1), 51-54. doi: 10.1038/ng.731

Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis

2024

Journal Article

Endometrial cell-type specific regulation of the endocannabinoids system and the impact of menstrual cycle and endometriosis

Tanaka, Keisuke, Subramaniam, Sugarniya, Atluri, Sharat, Amoako, Akwasi A., Mortlock, Sally, Montgomery, Grant W. and McKinnon, Brett (2024). Endometrial cell-type specific regulation of the endocannabinoids system and the impact of menstrual cycle and endometriosis. Cannabis and Cannabinoid Research. doi: 10.1089/can.2024.0081

Endometrial cell-type specific regulation of the endocannabinoids system and the impact of menstrual cycle and endometriosis

2024

Journal Article

Genetic regulation of ovulation rate and multiple births

Montgomery, G. W. (2024). Genetic regulation of ovulation rate and multiple births. Reproduction, Fertility and Development, 36 (14) RD24083. doi: 10.1071/rd24083

Genetic regulation of ovulation rate and multiple births

2024

Journal Article

Exploring the germline genetics of in situ and invasive cutaneous melanoma: a genome-wide association study meta-analysis

Ingold, Nathan, Seviiri, Mathias, Ong, Jue Sheng, Neale, Rachel E., Pandeya, Nirmala, Whiteman, David C., Olsen, Catherine M., Martin, Nicholas G., Duffy, David L., Khosrotehrani, Kiarash, Hayward, Nicholas, Montgomery, Grant W., MacGregor, Stuart and Law, Matthew H. (2024). Exploring the germline genetics of in situ and invasive cutaneous melanoma: a genome-wide association study meta-analysis. JAMA Dermatology, 160 (9), 964. doi: 10.1001/jamadermatol.2024.2601

Exploring the germline genetics of in situ and invasive cutaneous melanoma: a genome-wide association study meta-analysis

2024

Journal Article

Predicting disease recurrence in patients with endometriosis: an observational study

Holdsworth-Carson, Sarah J., Chung, Jessica, Machalek, Dorothy A., Li, Rebecca, Jun, Byung Kyu, Griffiths, Meaghan J., Churchill, Molly, McCaughey, Tristan, Nisbet, Debbie, Dior, Uri, Donoghue, Jacqueline F., Montgomery, Grant W., Reddington, Charlotte, Girling, Jane E., Healey, Martin and Rogers, Peter A. W. (2024). Predicting disease recurrence in patients with endometriosis: an observational study. BMC Medicine, 22 (1) 320, 1-35. doi: 10.1186/s12916-024-03508-7

Predicting disease recurrence in patients with endometriosis: an observational study

2024

Journal Article

Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Kentistou, Katherine A., Kaisinger, Lena R., Stankovic, Stasa, Vaudel, Marc, Mendes de Oliveira, Edson, Messina, Andrea, Walters, Robin G., Liu, Xiaoxi, Busch, Alexander S., Helgason, Hannes, Thompson, Deborah J., Santoni, Federico, Petricek, Konstantin M., Zouaghi, Yassine, Huang-Doran, Isabel, Gudbjartsson, Daniel F., Bratland, Eirik, Lin, Kuang, Gardner, Eugene J., Zhao, Yajie, Jia, Raina Y., Terao, Chikashi, Riggan, Marjorie J., Bolla, Manjeet K., Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Bradfield, Jonathan P., Broer, Linda, Campbell, Archie ... The China Kadoorie Biobank Collaborative Group (2024). Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nature Genetics, 56 (8), 1-2. doi: 10.1038/s41588-024-01857-w

Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum

2024

Journal Article

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Kentistou, Katherine A., Kaisinger, Lena R., Stankovic, Stasa, Vaudel, Marc, Mendes de Oliveira, Edson, Messina, Andrea, Walters, Robin G., Liu, Xiaoxi, Busch, Alexander S., Helgason, Hannes, Thompson, Deborah J., Santoni, Federico, Petricek, Konstantin M., Zouaghi, Yassine, Huang-Doran, Isabel, Gudbjartsson, Daniel F., Bratland, Eirik, Lin, Kuang, Gardner, Eugene J., Zhao, Yajie, Jia, Raina Y., Terao, Chikashi, Riggan, Marjorie J., Bolla, Manjeet K., Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Bradfield, Jonathan P., Broer, Linda, Campbell, Archie ... The China Kadoorie Biobank Collaborative Group (2024). Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nature Genetics, 56 (7), 1-15. doi: 10.1038/s41588-024-01798-4

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

2024

Journal Article

Risk of iron deficiency in women with endometriosis: a population-based prospective cohort study

Gete, Dereje G., Doust, Jenny, Mortlock, Sally, Montgomery, Grant and Mishra, Gita D. (2024). Risk of iron deficiency in women with endometriosis: a population-based prospective cohort study. Women's Health Issues, 34 (3), 317-324. doi: 10.1016/j.whi.2024.03.004

Risk of iron deficiency in women with endometriosis: a population-based prospective cohort study

2024

Journal Article

Genetic control of DNA methylation is largely shared across European and East Asian populations

Hatton, Alesha A., Cheng, Fei-Fei, Lin, Tian, Shen, Ren-Juan, Chen, Jie, Zheng, Zhili, Qu, Jia, Lyu, Fan, Harris, Sarah E., Cox, Simon R., Jin, Zi-Bing, Martin, Nicholas G., Fan, Dongsheng, Montgomery, Grant W., Yang, Jian, Wray, Naomi R., Marioni, Riccardo E., Visscher, Peter M. and McRae, Allan F. (2024). Genetic control of DNA methylation is largely shared across European and East Asian populations. Nature Communications, 15 (1) 2713, 1-12. doi: 10.1038/s41467-024-47005-0

Genetic control of DNA methylation is largely shared across European and East Asian populations

2024

Journal Article

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

Scholz, Markus, Horn, Katrin, Pott, Janne, Wuttke, Matthias, Kühnapfel, Andreas, Nasr, M. Kamal, Kirsten, Holger, Li, Yong, Hoppmann, Anselm, Gorski, Mathias, Ghasemi, Sahar, Li, Man, Tin, Adrienne, Chai, Jin-Fang, Cocca, Massimiliano, Wang, Judy, Nutile, Teresa, Akiyama, Masato, Åsvold, Bjørn Olav, Bansal, Nisha, Biggs, Mary L., Boutin, Thibaud, Brenner, Hermann, Brumpton, Ben, Burkhardt, Ralph, Cai, Jianwen, Campbell, Archie, Campbell, Harry, Chalmers, John ... Pattaro, Cristian (2024). X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nature Communications, 15 (1) 586, 1-17. doi: 10.1038/s41467-024-44709-1

X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

2024

Journal Article

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

Mbarek, Hamdi, Gordon, Scott D., Duffy, David L., Hubers, Nikki, Mortlock, Sally, Beck, Jeffrey J., Hottenga, Jouke-Jan, Pool, René, Dolan, Conor V., Actkins, Ky’Era V., Gerring, Zachary F., Van Dongen, Jenny, Ehli, Erik A., Iacono, William G., Mcgue, Matt, Chasman, Daniel I., Gallagher, C. Scott, Schilit, Samantha L. P., Morton, Cynthia C., Paré, Guillaume, Willemsen, Gonneke, Whiteman, David C., Olsen, Catherine M., Derom, Catherine, Vlietinck, Robert, Gudbjartsson, Daniel, Cannon-Albright, Lisa, Krapohl, Eva, Plomin, Robert ... Martin, Nicholas G. (2024). Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity. Human Reproduction, 39 (1), 240-257. doi: 10.1093/humrep/dead247

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

Funding

Current funding

  • 2020 - 2024
    Improved clinical outcomes from understanding risk factors for reproductive diseases
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2022 - 2023
    Environmental Risk Factors for Endometriosis
    Endometriosis Australia Ltd
    Open grant
  • 2019 - 2023
    Endometriosis Susceptibility Genes in Endometrial Stem/Progenitor Cells
    United States Congressionally Directed Medical Research Programs - Peer Reviewed Medical Research Program
    Open grant
  • 2019 - 2023
    Causes of Endometriosis
    Research Donation Generic
    Open grant
  • 2018 - 2020
    A detailed analysis of existing databases from the Australian Longitudinal Study on Women's Health (MRFF Accelerated Research Program administered by Jean Hailes Foundation)
    MRFF Accelerated Research Program administered by Jean Hailes Foundation
    Open grant
  • 2018 - 2021
    Differential regulation of endometrial gene expression in endometriosis and disease subtypes
    NHMRC Project Grant
    Open grant
  • 2017 - 2024
    ACRF Cancer Ultrastructure and Function Facility
    Australian Cancer Research Foundation
    Open grant
  • 2017 - 2021
    M-PreM study: Reproductive factors, from menarche to pre-menopause, and the risk of cardiometabolic and respiratory conditions before menopause
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Genome-wide analysis of gene coding variants increasing risk of endometriosis
    NHMRC Project Grant
    Open grant
  • 2016 - 2019
    Identification and function of genes that increase risk for endometriosis (NHMRC Project Grant administered by The University of Melbourne).
    University of Melbourne
    Open grant
  • 2016 - 2019
    Translating gene discovery for key diseases into clinical outcomes
    NHMRC Research Fellowship
    Open grant
  • 2009 - 2011
    The immunogenetics of ankylosing spondylitis: a genetic and functional investigation of IL23R and related genes
    NHMRC Project Grant
    Open grant

Supervision

Availability

Professor Grant Montgomery is:
Available for supervision

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Supervision history

Current supervision

  • Master Philosophy

    Spatial resolved analysis of endometrial tissue

    Associate Advisor

    Other advisors: Dr Brett McKinnon

  • Doctor Philosophy

    Regulation of the endocannabinoid system in the endometrium across menstrual cycle and implications in endometriosis

    Associate Advisor

    Other advisors: Dr Brett McKinnon, Dr Akwasi Amoako

  • Doctor Philosophy

    Investigating the relationship between Endometriosis and Cancer risk.

    Associate Advisor

    Other advisors: Dr Sally Mortlock

  • Doctor Philosophy

    Exploring the role of clinical, lifestyle, environmental and molecular factors in endometriosis risk

    Associate Advisor

    Other advisors: Dr Allan McRae, Dr Sally Mortlock

Completed supervision

Media

Enquiries

Contact Professor Grant Montgomery directly for media enquiries about:

  • Endometriosis
  • Genetics

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For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au