Overview
Background
Professor Grant Montgomery FAHMS FSRB Hon FRSNZ
Professor Montgomery was born in New Zealand, completed PhD studies in Animal Science at Massey University and post-doctoral research in France. In 1987, he co-founded the New Zealand Sheep Genomics Program in the Biochemistry Department at the University of Otago and pioneered the introduction of genome mapping methods in farm animals. He moved to Australia in 1999 and joined the Queensland Institute of Medical Research where he ran a successful genome mapping program for human complex disease. In 2016, he moved to the University of Queensland and holds joint appointments at the Institute for Molecular Bioscience (IMB) and the Queensland Brain Institute (QBI). He is a National Health and Medical Research Council Leadership Fellow and Director of the UQ Genome Innovation Hub. He was elected a Fellow the Society for Reproductive Biology in 2012, Fellow of the Australian Academy of Health and Medical Sciences in 2015, and Honorary Fellow of the Royal Society of New Zealand in 2016. His research focusses on discovery of critical genes and pathways increasing risk for common diseases especially reproductive diseases including endometriosis.
Availability
- Professor Grant Montgomery is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Massey University
Research impacts
Professor Montgomery has made substantial contributions to the worldwide effort to map genomic regions contributing to risk for complex traits and diseases, including endometriosis, age at menarche and menopause, cancers of the reproductive tract, melanoma and inflammatory bowel disease. He is conducting systems genetics and functional studies to identify the genes and pathways affected by these genetic risk factors. His work has identified possible target genes and functional consequences of genetic risk factors in genomic regions associated with endometriosis providing novel insights into the causes of this important disease. He lead a consortium of leading endometriosis clinicians and researchers in Australia awarded a MRFF Frontiers in Health and Medical Science to develop earlier diagnosis and personalised treatments for endometriosis. He is co-leader of International Endometriois Genetics Consortium, Patron of the Endometriosis Association (QLD) Inc (QENDO) and has worked closely with QENDO, other patient groups, clinicians and politicians to help develop the National Action Plan for Endometriosis. He is on the Executive Committee of the National Endometriosis Clinical and Scientific Trials (NECST) Network. He is also Director of the UQ Genome Innovation Hub developing novel methods and pipelines for genomics in health and agriculature that can be widely applied in programs across The University of Queensland.
Works
Search Professor Grant Montgomery’s works on UQ eSpace
Featured
2015
Journal Article
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk
Painter J.N., O'Mara T.A., Batra J., Cheng T., Lose F.A., Dennis J., Michailidou K., Tyrer J.P., Ahmed S., Ferguson K., Healey C.S., Kaufmann S., Hillman K.M., Walpole C., Moya L., Pollock P., Jones A., Howarth K., Martin L., Gorman M., Hodgson S., De Polanco M.M.E., Sans M., Carracedo A., Castellvi-Bel S., Rojas-Martinez A., Santos E., Teixeira M.R., Carvajal-Carmona L. ... Spurdle A.B. (2015). Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk. Human Molecular Genetics, 24 (5), 1478-1492. doi: 10.1093/hmg/ddu552
Featured
2014
Journal Article
Genetic and environmental exposures constrain epigenetic drift over the human life course
Shah, Sonia, McRae, Allan F., Marioni, Riccardo E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Redmond, Paul, Cox, Simon R., Pattie, Alison, Corley, Janie, Murphy, Lee, Martin, Nicholas G., Montgomery, Grant W., Starr, John M., Wray, Naomi R., Deary, Ian J. and Visscher, Peter M. (2014). Genetic and environmental exposures constrain epigenetic drift over the human life course. Genome Research, 24 (11), 1725-1733. doi: 10.1101/gr.176933.114
Featured
2014
Journal Article
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Perry, John R. B., Day, Felix, Elks, Cathy E., Sulem, Patrick, Thompson, Deborah J., Ferreira, Teresa, He, Chunyan, Chasman, Daniel I., Esko, Toenu, Thorleifsson, Gudmar, Albrecht, Eva, Ang, Wei Q., Corre, Tanguy, Cousminer, Diana L., Feenstra, Bjarke, Franceschini, Nora, Ganna, Andrea, Johnson, Andrew D., Kjellqvist, Sanela, Lunetta, Kathryn L., McMahon, George, Nolte, Ilja M., Paternoster, Lavinia, Porcu, Eleonora, Smith, Albert V., Stolk, Lisette, Teumer, Alexander, Tsernikova, Natalia, Tikkanen, Emmi ... Middeldorp, Christel (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92-97. doi: 10.1038/nature13545
Featured
2014
Journal Article
Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets
Rahmioglu, Nilufer, Nyholt, Dale R., Morris, Andrew P., Missmer, Stacey A., Montgomery, Grant W. and Zondervan, Krina T. (2014). Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets. Human Reproduction Update, 20 (5) dmu015, 702-716. doi: 10.1093/humupd/dmu015
Featured
2014
Journal Article
Contribution of genetic variation to transgenerational inheritance of DNA methylation
McRae, Allan F., Powell, Joseph E., Henders, Anjali K., Bowdler, Lisa, Hemani, Gibran, Shah, Sonia, Painter, Jodie N., Martin, Nicholas G., Visscher, Peter M. and Montgomery, Grant W. (2014). Contribution of genetic variation to transgenerational inheritance of DNA methylation. Genome Biology, 15 (5) ARTN R73, 1-10. doi: 10.1186/gb-2014-15-5-r73
Featured
2013
Journal Article
Systematic identification of trans eQTLs as putative drivers of known disease associations
Westra, Harm-Jan, Peters, Marjolein J., Esko, Tonu, Yaghootkar, Hanieh, Schurmann, Claudia, Kettunen, Johannes, Christiansen, Mark W., Fairfax, Benjamin P., Schramm, Katharina, Powell, Joseph E., Zhernakova, Alexandra, Zhernakova, Daria V., Veldink, Jan H., Van den Berg, Leonard H., Karjalainen, Juha, Withoff, Sebo, Uitterlinden, Andre G., Hofman, Albert, Rivadeneira, Fernando, Hoen, Peter A. C't, Reinmaa, Eva, Fischer, Krista, Nelis, Mari, Milani, Lili, Melzer, David, Ferrucci, Luigi, Singleton, Andrew B., Hernandez, Dena G., Nalls, Michael A. ... Franke, Lude (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45 (10), 1238-U195. doi: 10.1038/ng.2756
Featured
2012
Journal Article
Genome-wide association meta-analysis identifies new endometriosis risk loci
Nyholt, Dale R., Low, Siew-Kee, Anderson, Carl A., Painter, Jodie N., Uno, Satoko, Morris, Andrew P., MacGregor, Stuart, Gordon, Scott D., Henders, Anjali K., Martin, Nicholas G., Attia, John, Holliday, Elizabeth G., McEvoy, Mark, Scott, Rodney J., Kennedy, Stephen H., Treloar, Susan A., Missmer, Stacey A., Adachi, Sosuke, Tanaka, Kenichi, Nakamura, Yusuke, Zondervan, Krina T., Zembutsu, Hitoshi and Montgomery, Grant W. (2012). Genome-wide association meta-analysis identifies new endometriosis risk loci. Nature Genetics, 44 (12), 1355-1359. doi: 10.1038/ng.2445
Featured
2012
Journal Article
Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent
Powell, Joseph E., Henders, Anjali K., McRae, Allan F., Wright, Margaret J., Martin, Nicholas G., Dermitzakis, Emmanouil T., Montgomery, Grant W. and Visscher, Peter M. (2012). Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. Genome Research, 22 (3), 456-466. doi: 10.1101/gr.126540.111
Featured
2012
Journal Article
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
Stolk L., Perry J.R.B., Chasman D.I., He C., Mangino M., Sulem P., Barbalic M., Broer L., Byrne E.M., Ernst F., Esko T., Franceschini N., Gudbjartsson D.F., Hottenga J.-J., Kraft P., McArdle P.F., Porcu E., Shin S.-Y., Smith A.V., Van Wingerden S., Zhai G., Zhuang W.V., Albrecht E., Alizadeh B.Z., Aspelund T., Bandinelli S., Lauc L.B., Beckmann J.S., Boban M. ... Lunetta K.L. (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44 (3), 260-268. doi: 10.1038/ng.1051
Featured
2011
Journal Article
Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis
Painter, JN, Anderson, CA, Nyholt, DR, Macgregor, S, Lin, JH, Lee, SH, Lambert, A, Zhao, ZZ, Roseman, F, Guo, Q, Gordon, SD, Wallace, L, Henders, AK, Visscher, PM, Kraft, P, Martin, NG, Morris, AP, Treloar, SA, Kennedy, SH, Missmer, SA, Montgomery, GW and Zondervan, KT (2011). Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nature Genetics, 43 (1), 51-54. doi: 10.1038/ng.731
2024
Journal Article
Endometrial cell-type specific regulation of the endocannabinoids system and the impact of menstrual cycle and endometriosis
Tanaka, Keisuke, Subramaniam, Sugarniya, Atluri, Sharat, Amoako, Akwasi A., Mortlock, Sally, Montgomery, Grant W. and McKinnon, Brett (2024). Endometrial cell-type specific regulation of the endocannabinoids system and the impact of menstrual cycle and endometriosis. Cannabis and Cannabinoid Research. doi: 10.1089/can.2024.0081
2024
Journal Article
Genetic regulation of ovulation rate and multiple births
Montgomery, G. W. (2024). Genetic regulation of ovulation rate and multiple births. Reproduction, Fertility and Development, 36 (14) RD24083. doi: 10.1071/rd24083
2024
Journal Article
Exploring the germline genetics of in situ and invasive cutaneous melanoma: a genome-wide association study meta-analysis
Ingold, Nathan, Seviiri, Mathias, Ong, Jue Sheng, Neale, Rachel E., Pandeya, Nirmala, Whiteman, David C., Olsen, Catherine M., Martin, Nicholas G., Duffy, David L., Khosrotehrani, Kiarash, Hayward, Nicholas, Montgomery, Grant W., MacGregor, Stuart and Law, Matthew H. (2024). Exploring the germline genetics of in situ and invasive cutaneous melanoma: a genome-wide association study meta-analysis. JAMA Dermatology, 160 (9), 964. doi: 10.1001/jamadermatol.2024.2601
2024
Journal Article
Predicting disease recurrence in patients with endometriosis: an observational study
Holdsworth-Carson, Sarah J., Chung, Jessica, Machalek, Dorothy A., Li, Rebecca, Jun, Byung Kyu, Griffiths, Meaghan J., Churchill, Molly, McCaughey, Tristan, Nisbet, Debbie, Dior, Uri, Donoghue, Jacqueline F., Montgomery, Grant W., Reddington, Charlotte, Girling, Jane E., Healey, Martin and Rogers, Peter A. W. (2024). Predicting disease recurrence in patients with endometriosis: an observational study. BMC Medicine, 22 (1) 320, 1-35. doi: 10.1186/s12916-024-03508-7
2024
Journal Article
Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Kentistou, Katherine A., Kaisinger, Lena R., Stankovic, Stasa, Vaudel, Marc, Mendes de Oliveira, Edson, Messina, Andrea, Walters, Robin G., Liu, Xiaoxi, Busch, Alexander S., Helgason, Hannes, Thompson, Deborah J., Santoni, Federico, Petricek, Konstantin M., Zouaghi, Yassine, Huang-Doran, Isabel, Gudbjartsson, Daniel F., Bratland, Eirik, Lin, Kuang, Gardner, Eugene J., Zhao, Yajie, Jia, Raina Y., Terao, Chikashi, Riggan, Marjorie J., Bolla, Manjeet K., Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Bradfield, Jonathan P., Broer, Linda, Campbell, Archie ... The China Kadoorie Biobank Collaborative Group (2024). Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nature Genetics, 56 (8), 1-2. doi: 10.1038/s41588-024-01857-w
2024
Journal Article
Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Kentistou, Katherine A., Kaisinger, Lena R., Stankovic, Stasa, Vaudel, Marc, Mendes de Oliveira, Edson, Messina, Andrea, Walters, Robin G., Liu, Xiaoxi, Busch, Alexander S., Helgason, Hannes, Thompson, Deborah J., Santoni, Federico, Petricek, Konstantin M., Zouaghi, Yassine, Huang-Doran, Isabel, Gudbjartsson, Daniel F., Bratland, Eirik, Lin, Kuang, Gardner, Eugene J., Zhao, Yajie, Jia, Raina Y., Terao, Chikashi, Riggan, Marjorie J., Bolla, Manjeet K., Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Bradfield, Jonathan P., Broer, Linda, Campbell, Archie ... The China Kadoorie Biobank Collaborative Group (2024). Understanding the genetic complexity of puberty timing across the allele frequency spectrum. Nature Genetics, 56 (7), 1-15. doi: 10.1038/s41588-024-01798-4
2024
Journal Article
Risk of iron deficiency in women with endometriosis: a population-based prospective cohort study
Gete, Dereje G., Doust, Jenny, Mortlock, Sally, Montgomery, Grant and Mishra, Gita D. (2024). Risk of iron deficiency in women with endometriosis: a population-based prospective cohort study. Women's Health Issues, 34 (3), 317-324. doi: 10.1016/j.whi.2024.03.004
2024
Journal Article
Genetic control of DNA methylation is largely shared across European and East Asian populations
Hatton, Alesha A., Cheng, Fei-Fei, Lin, Tian, Shen, Ren-Juan, Chen, Jie, Zheng, Zhili, Qu, Jia, Lyu, Fan, Harris, Sarah E., Cox, Simon R., Jin, Zi-Bing, Martin, Nicholas G., Fan, Dongsheng, Montgomery, Grant W., Yang, Jian, Wray, Naomi R., Marioni, Riccardo E., Visscher, Peter M. and McRae, Allan F. (2024). Genetic control of DNA methylation is largely shared across European and East Asian populations. Nature Communications, 15 (1) 2713, 1-12. doi: 10.1038/s41467-024-47005-0
2024
Journal Article
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
Scholz, Markus, Horn, Katrin, Pott, Janne, Wuttke, Matthias, Kühnapfel, Andreas, Nasr, M. Kamal, Kirsten, Holger, Li, Yong, Hoppmann, Anselm, Gorski, Mathias, Ghasemi, Sahar, Li, Man, Tin, Adrienne, Chai, Jin-Fang, Cocca, Massimiliano, Wang, Judy, Nutile, Teresa, Akiyama, Masato, Åsvold, Bjørn Olav, Bansal, Nisha, Biggs, Mary L., Boutin, Thibaud, Brenner, Hermann, Brumpton, Ben, Burkhardt, Ralph, Cai, Jianwen, Campbell, Archie, Campbell, Harry, Chalmers, John ... Pattaro, Cristian (2024). X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements. Nature Communications, 15 (1) 586, 1-17. doi: 10.1038/s41467-024-44709-1
2024
Journal Article
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
Mbarek, Hamdi, Gordon, Scott D., Duffy, David L., Hubers, Nikki, Mortlock, Sally, Beck, Jeffrey J., Hottenga, Jouke-Jan, Pool, René, Dolan, Conor V., Actkins, Ky’Era V., Gerring, Zachary F., Van Dongen, Jenny, Ehli, Erik A., Iacono, William G., Mcgue, Matt, Chasman, Daniel I., Gallagher, C. Scott, Schilit, Samantha L. P., Morton, Cynthia C., Paré, Guillaume, Willemsen, Gonneke, Whiteman, David C., Olsen, Catherine M., Derom, Catherine, Vlietinck, Robert, Gudbjartsson, Daniel, Cannon-Albright, Lisa, Krapohl, Eva, Plomin, Robert ... Martin, Nicholas G. (2024). Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity. Human Reproduction, 39 (1), 240-257. doi: 10.1093/humrep/dead247
Funding
Current funding
Supervision
Availability
- Professor Grant Montgomery is:
- Available for supervision
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Supervision history
Current supervision
-
Master Philosophy
Spatial resolved analysis of endometrial tissue
Associate Advisor
Other advisors: Dr Brett McKinnon
-
Doctor Philosophy
Regulation of the endocannabinoid system in the endometrium across menstrual cycle and implications in endometriosis
Associate Advisor
Other advisors: Dr Brett McKinnon, Dr Akwasi Amoako
-
Doctor Philosophy
Investigating the relationship between Endometriosis and Cancer risk.
Associate Advisor
Other advisors: Dr Sally Mortlock
-
Doctor Philosophy
Exploring the role of clinical, lifestyle, environmental and molecular factors in endometriosis risk
Associate Advisor
Other advisors: Dr Allan McRae, Dr Sally Mortlock
Completed supervision
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2023
Doctor Philosophy
Regulation of transcription in human endometrium and endometriosis
Principal Advisor
Other advisors: Dr Sally Mortlock
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2023
Doctor Philosophy
Investigation of both epidemiological and genetic risk factors for endometriosis: novel insights and important clinical implications
Principal Advisor
Other advisors: Dr Sally Mortlock
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2016
Doctor Philosophy
Complex trait genetics: mapping, correlation and causation
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
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2012
Doctor Philosophy
Various approaches to identify breast cancer susceptibility genes.
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna
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2008
Doctor Philosophy
The Aetiology of Obsesity in Australian Families
Associate Advisor
Other advisors: Professor Nick Martin
Media
Enquiries
Contact Professor Grant Montgomery directly for media enquiries about:
- Endometriosis
- Genetics
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