Dr Randal Moldrich
Dr

Randal Moldrich

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Dr Randal Moldrich is:
Available for supervision
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Fields of research

Basic pharmacology Biological Sciences Biomedical and Clinical Sciences Developmental genetics (incl. sex determination) Epigenetics (incl. genome methylation and epigenomics) Genetics Neurogenetics Neurosciences Paediatrics Pharmacology and pharmaceutical sciences

Research interests

  • Neurodevelopmental disorders

    From bench to bedside

Search Professor Randal Moldrich’s works on UQ eSpace

46 works between 1999 and 2017
All (46) Journal Article (38) Conference Publication (8)

21 - 40 of 46 works

2008

Journal Article

Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain

Moldrich, R. X., Laine, J., Visel, A., Beart, P. M., Laffaire, J., Rossier, J. and Potier, M. C. (2008). Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain. Neuroscience, 154 (4), 1255-1266. doi: 10.1016/j.neuroscience.2008.01.089

Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain

2008

Journal Article

Nuclear Factor I Gene Expression in the Developing Forebrain

Plachez, Celine, Lindwall, Charlotta, Sunn, Nana, Piper, Michael, Moldrich, Randal X., Campbell, Christine E., Osinski, Jason M., Gronostajski, Richard M. and Richards, Linda J. (2008). Nuclear Factor I Gene Expression in the Developing Forebrain. Journal of Comparative Neurology, 508 (3), 385-401. doi: 10.1002/cne.21645

Nuclear Factor I Gene Expression in the Developing Forebrain

2007

Journal Article

A yeast model of Down syndrome

Moldrich, R. X. (2007). A yeast model of Down syndrome. International journal of developmental neuroscience, 25 (8), 539-543. doi: 10.1016/j.ijdevneu.2007.10.001

A yeast model of Down syndrome

2007

Journal Article

Down syndrome gene dosage imbalance on cerebellum development

Moldrich, Randal X., Dauphinot, Luce, Laffaire, Julien, Rossier, Jean and Potier, Marie-Claude (2007). Down syndrome gene dosage imbalance on cerebellum development. Progress in Neurobiology, 82 (2), 87-94. doi: 10.1016/j.pneurobio.2007.02.006

Down syndrome gene dosage imbalance on cerebellum development

2006

Journal Article

Transcriptional disruptions in Down syndrome: A case study in the Ts1Cje mouse cerebellum during post-natal development

Potier, M.-C., Rivals, I., Mercier, G., Ettwiller, L., Moldrich, R. X., Laffaire, J., Personnaz, L., Rossier, J. and Dauphinot, L. (2006). Transcriptional disruptions in Down syndrome: A case study in the Ts1Cje mouse cerebellum during post-natal development. Journal of Neurochemistry, 97 (s1), 104-109. doi: 10.1111/j.1471-4159.2005.03624.x

Transcriptional disruptions in Down syndrome: A case study in the Ts1Cje mouse cerebellum during post-natal development

2005

Journal Article

The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome

Dauphinot, L., Lyle, R., Rivals, I., Dang, M.T., Moldrich, R. X., Golfier, G., Ettwiller, L., Toyama, K., Rossier, J., Personnaz, L., Antonarakis, S. E., Epstein, C. J., Sinet, P. M. and Potier, M. C. (2005). The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome. Human Molecular Genetics, 14 (3), 373-384. doi: 10.1093/hmg/ddi033

The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome

2005

Journal Article

Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury

Reddrop, C, Moldrich, RX, Beart, PM, Farso, M, Liberatore, GT, Howells, DW, Petersen, KU, Schleuning, WD and Medcalf, RL (2005). Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury. Stroke, 36 (6), 1241-1246. doi: 10.1161/01.STR.0000166050.84056.48

Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury

2004

Conference Publication

Transcriptome modifications in postnatal cerebellum devleopment of Ts1Cje mice, a model for Trisomy 21

Potier, MC, Dauphinot, L, Dang, MT, Golfier, G, Moldrich, R, Rossier, J, Toyama, K, Sinet, PM, Rivals, I, Personnaz, L, Lyle, R, Antonarakis, S and Epstein, C (2004). Transcriptome modifications in postnatal cerebellum devleopment of Ts1Cje mice, a model for Trisomy 21. 35th Annual Meeting of the Transactions-of-the-American-Society-for-Neurochemistry, New York Ny, Aug 14-18, 2004. OXFORD: BLACKWELL PUBLISHING LTD.

Transcriptome modifications in postnatal cerebellum devleopment of Ts1Cje mice, a model for Trisomy 21

2003

Journal Article

Glutamate metabotropic receptors as targets for drug therapy in epilepsy

Moldrich, RX, Chapman, AG, De Sarro, G and Meldrumb, BS (2003). Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology, 476 (1-2), 3-16. doi: 10.1016/S0014-2999(03)02149-6

Glutamate metabotropic receptors as targets for drug therapy in epilepsy

2003

Journal Article

Emerging Signalling and Protein Interactions Mediated Via Metabotropic Glutamate Receptors

Moldrich, R. X. and Beart, P. M. (2003). Emerging Signalling and Protein Interactions Mediated Via Metabotropic Glutamate Receptors. Current Drug Targets, 2 (2), 109-122. doi: 10.2174/1568007033482922

Emerging Signalling and Protein Interactions Mediated Via Metabotropic Glutamate Receptors

2003

Journal Article

Modulation of intracellular Ca2+ levels by Scorpaenidae venoms

Church, JE, Moldrich, RX, Beart, PM and Hodgson, WC (2003). Modulation of intracellular Ca2+ levels by Scorpaenidae venoms. Toxicon, 41 (6), 679-689. doi: 10.1016/S0041-0101(03)00038-2

Modulation of intracellular Ca2+ levels by Scorpaenidae venoms

2002

Conference Publication

The mGlu2/3 agonist 2R,4R-APDC induces adenosine release via phospholipase C and calmodulin kinase in cultured murine astrocytes.

Moldrich, RX, Aprico, K, O'Shea, RD and Beart, PM (2002). The mGlu2/3 agonist 2R,4R-APDC induces adenosine release via phospholipase C and calmodulin kinase in cultured murine astrocytes.. 4th International Meeting on Metabotropic Glutamate Receptors, Taorimina Italy, Sep 15-20, 2002. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD.

The mGlu2/3 agonist 2R,4R-APDC induces adenosine release via phospholipase C and calmodulin kinase in cultured murine astrocytes.

2002

Conference Publication

Astrocyte mGlu(2/3)-mediated camp potentiation is calcium sensitive: Studies in murine neuronal and astrocyte cultures

Beart, PM, Aprico, K, O'Shea, RD and Moldrich, RX (2002). Astrocyte mGlu(2/3)-mediated camp potentiation is calcium sensitive: Studies in murine neuronal and astrocyte cultures. 4th International Meeting on Metabotropic Glutamate Receptors, Taorimina Italy, Sep 15-20, 2002. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD.

Astrocyte mGlu(2/3)-mediated camp potentiation is calcium sensitive: Studies in murine neuronal and astrocyte cultures

2002

Journal Article

Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures

Moldrich, RX, Aprico, K, Diwakarla, S, O'Shea, RD and Beart, PM (2002). Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures. Neuropharmacology, 43 (2), 189-203. doi: 10.1016/S0028-3908(02)00111-9

Astrocyte mGlu(2/3)-mediated cAMP potentiation is calcium sensitive: studies in murine neuronal and astrocyte cultures

2001

Conference Publication

The mGlu2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) and injury in murine pure neuronal cultures

Moldrich, RX and Beart, PM (2001). The mGlu2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) and injury in murine pure neuronal cultures. OXFORD: BLACKWELL SCIENCE LTD.

The mGlu2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) and injury in murine pure neuronal cultures

2001

Journal Article

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

Moldrich, RX, Beart, PM, Jane, DE, Chapman, AG and Meldrum, BS (2001). Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology, 40 (5), 732-735. doi: 10.1016/S0028-3908(01)00002-8

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

2001

Journal Article

Anti-epileptic activity of group II metabotropic glutamate receptor agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (-)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)

Moldrich, RX, Jeffrey, M, Talebi, A, Beart, PM, Chapman, AG and Meldrum, BS (2001). Anti-epileptic activity of group II metabotropic glutamate receptor agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (-)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Neuropharmacology, 41 (1), 8-18. doi: 10.1016/S0028-3908(01)00044-2

Anti-epileptic activity of group II metabotropic glutamate receptor agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (-)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)

2001

Conference Publication

Kainate receptors, cellular signaling and excitotoxic neuronal death: New pharmacological evidence for the functional involvement of low-affinity and metabotropic kainate receptors

Giardina, SF, Carroll, FY, Moldrich, RX, Finkelstein, DI, Horne, MK, Lawrence, AJ, Cheung, NS and Beart, PM (2001). Kainate receptors, cellular signaling and excitotoxic neuronal death: New pharmacological evidence for the functional involvement of low-affinity and metabotropic kainate receptors. Meeting on Excitatory Amino Acids - 10 Years Later, Manaus Brazil, Nov 18-22, 1998. AMSTERDAM: I O S PRESS.

Kainate receptors, cellular signaling and excitotoxic neuronal death: New pharmacological evidence for the functional involvement of low-affinity and metabotropic kainate receptors

2001

Journal Article

The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice

Moldrich, RX, Talebi, A, Beart, PM, Chapman, AG and Meldrum, BS (2001). The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice. Neuroscience Letters, 299 (1-2), 125-129. doi: 10.1016/S0304-3940(00)01732-8

The mGlu(2/3) agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice

2001

Journal Article

Group II mGlu receptor agonists fail to protect against various neurotoxic insults induced in murine cortical, striatal and cerebellar granular pure neuronal cultures

Moldrich, RX, Giardina, SF and Beart, PM (2001). Group II mGlu receptor agonists fail to protect against various neurotoxic insults induced in murine cortical, striatal and cerebellar granular pure neuronal cultures. Neuropharmacology, 41 (1), 19-31. doi: 10.1016/S0028-3908(01)00045-4

Group II mGlu receptor agonists fail to protect against various neurotoxic insults induced in murine cortical, striatal and cerebellar granular pure neuronal cultures

Past funding

  • 2015 - 2022
    Neurodevelopment of the preterm infant
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    Mapping cerebral circuits in Down syndrome
    Fondation Jerome Lejeune
    Open grant
  • 2012
    The role of epigenetics in epilepsy
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2009
    The role of the Son gene in the developing brain and Down syndrome
    UQ Early Career Researcher
    Open grant
  • 2008 - 2009
    Down Syndrome candidate gene, Son, in the developing brain
    Fondation Jerome Lejeune
    Open grant
  • 2008
    UQ Travel Awards Category 2 - Randal Moldrich
    UQ Travel Grants Scheme
    Open grant
  • 2007 - 2008
    Down syndrome gene regulation of the proliferation rate of neural precursor cells
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2007 - 2009
    NHMRC CJ Martin Fellowship: Understanding the neuropathy of Down Syndrome and identification of molecular targets for therapeutic intervention
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Availability

Dr Randal Moldrich is:
Available for supervision

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Enquiries

Contact Dr Randal Moldrich directly for media enquiries about:

  • Angelman Syndrome

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