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2022

Journal Article

Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials

Henry, Cían J., Semova, Gergana, Barnes, Ellen, Cotter, Isabel, Devers, Tara, Rafaee, Aisyah, Slavescu, Andreea, Cathain, Niamh O., McCollum, Danielle, Roche, Edna, Mockler, David, Allen, John, Meehan, Judith, Klingenberg, Claus, Latour, Jos M., van den Hoogen, Agnes, Strunk, Tobias, Giannoni, Eric, Schlapbach, Luregn J., Degtyareva, Marina, Plötz, Frans B., de Boode, Willem P., Naver, Lars, Wynn, James L., Küster, Helmut, Janota, Jan, Keij, Fleur M., Reiss, Irwin K. M., Bliss, Joseph M. ... Molloy, Eleanor J. (2022). Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials. Pediatric Research, 91 (4), 735-742. doi: 10.1038/s41390-021-01883-y

Neonatal sepsis: a systematic review of core outcomes from randomised clinical trials

2022

Journal Article

Pediatric Organ Dysfunction Information Update Mandate (PODIUM) contemporary organ dysfunction criteria: executive summary

Bembea, Melania M., Agus, Michael, Akcan-Arikan, Ayse, Alexander, Peta, Basu, Rajit, Bennett, Tellen D., Bohn, Desmond, Brandão, Leonardo R., Brown, Ann-Marie, Carcillo, Joseph A., Checchia, Paul, Cholette, Jill, Cheifetz, Ira M., Cornell, Timothy, Doctor, Allan, Eckerle, Michelle, Erickson, Simon, Farris, Reid W D, Faustino, E Vincent S, Fitzgerald, Julie C., Fuhrman, Dana Y., Giuliano, John S., Guilliams, Kristin, Gaies, Michael, Gorga, Stephen M., Hall, Mark, Hanson, Sheila J., Hartman, Mary, Hassinger, Amanda B. ... Zimmerman, Jerry J. (2022). Pediatric Organ Dysfunction Information Update Mandate (PODIUM) contemporary organ dysfunction criteria: executive summary. Pediatrics, 149 (1) e2021052888B, S1-S12. doi: 10.1542/peds.2021-052888B

Pediatric Organ Dysfunction Information Update Mandate (PODIUM) contemporary organ dysfunction criteria: executive summary

2022

Journal Article

Scoring systems for organ dysfunction and multiple organ dysfunction: the PODIUM Consensus Conference

Schlapbach, Luregn J., Weiss, Scott L., Bembea, Melania M., Carcillo, Joseph A., Leclerc, Francis, Leteurtre, Stephane, Tissieres, Pierre, Wynn, James L., Zimmerman, Jerry and Lacroix, Jacques (2022). Scoring systems for organ dysfunction and multiple organ dysfunction: the PODIUM Consensus Conference. Pediatrics, 149 (Supplement 1) e2021052888D, S23-S31. doi: 10.1542/peds.2021-052888D

Scoring systems for organ dysfunction and multiple organ dysfunction: the PODIUM Consensus Conference

2022

Journal Article

Refining the pediatric multiple organ dysfunction syndrome

Weiss, Scott L., Carcillo, Joseph A., Leclerc, Francis, Leteurtre, Stephane, Schlapbach, Luregn J., Tissieres, Pierre, Wynn, James L. and Lacroix, Jacques (2022). Refining the pediatric multiple organ dysfunction syndrome. Pediatrics, 149 (1) e2021052888C, S13-S22. doi: 10.1542/peds.2021-052888C

Refining the pediatric multiple organ dysfunction syndrome

2021

Journal Article

Cost impact of procalcitonin-guided decision making on duration of antibiotic therapy for suspected early-onset sepsis in neonates

Geraerds, A. J.L.M., van Herk, Wendy, Stocker, Martin, el Helou, Salhab, Dutta, Sourabh, Fontana, Matteo S., Schuerman, Frank A. B. A., van den Tooren-de Groot, Rita K., Wieringa, Jantien, Janota, Jan, van der Meer-Kappelle, Laura H., Moonen, Rob, Sie, Sintha D., de Vries, Esther, Donker, Albertine E., Zimmerman, Urs, Schlapbach, Luregn J., de Mol, Amerik C., Hoffman-Haringsma, Angelique, Roy, Madan, Tomaske, Maren, Kornelisse, René F., van Gijsel, Juliette, Visser, Eline G., van Rossum, Annemarie M. C. and Polinder, Suzanne (2021). Cost impact of procalcitonin-guided decision making on duration of antibiotic therapy for suspected early-onset sepsis in neonates. Critical Care, 25 (1) 367, 367. doi: 10.1186/s13054-021-03789-x

Cost impact of procalcitonin-guided decision making on duration of antibiotic therapy for suspected early-onset sepsis in neonates

2021

Journal Article

Antibiotics for neonatal sepsis in low-income and middle-income countries—where to go from here?

Schlapbach, Luregn J., van Rossum, Annemarie and Carrol, Enitan D. (2021). Antibiotics for neonatal sepsis in low-income and middle-income countries—where to go from here?. The Lancet Infectious Diseases, 21 (12), 1617-1618. doi: 10.1016/S1473-3099(21)00199-7

Antibiotics for neonatal sepsis in low-income and middle-income countries—where to go from here?

2021

Journal Article

Neonatal sepsis definitions from randomised clinical trials

Hayes, Rían, Hartnett, Jack, Semova, Gergana, Murray, Cian, Murphy, Katherine, Carroll, Leah, Plapp, Helena, Hession, Louise, O’Toole, Jonathan, McCollum, Danielle, Roche, Edna, Jenkins, Elinor, Mockler, David, Hurley, Tim, McGovern, Matthew, Allen, John, Meehan, Judith, Plötz, Frans B., Strunk, Tobias, de Boode, Willem P., Polin, Richard, Wynn, James L., Degtyareva, Marina, Küster, Helmut, Janota, Jan, Giannoni, Eric, Schlapbach, Luregn J., Keij, Fleur M., Reiss, Irwin K. M. ... Molloy, Eleanor J. (2021). Neonatal sepsis definitions from randomised clinical trials. Pediatric Research, 93 (5), 1-8. doi: 10.1038/s41390-021-01749-3

Neonatal sepsis definitions from randomised clinical trials

2021

Journal Article

Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department

Harley, Amanda, Lister, Paula, Gilholm, Patricia, Rice, Michael, Venkatesh, Bala, Johnston, Amy N.B., Massey, Debbie, Irwin, Adam, Gibbons, Kristen and Schlapbach, Luregn J. (2021). Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department. Critical Care Explorations, 3 (11) e0573, 1-14. doi: 10.1097/cce.0000000000000573

Queensland Pediatric Sepsis Breakthrough Collaborative: Multicenter Observational Study to Evaluate the Implementation of a Pediatric Sepsis Pathway Within the Emergency Department

2021

Journal Article

Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis

Boeddha, Navin P., Driessen, Gertjan J., Hagedoorn, Nienke N., Kohlfuerst, Daniela S., Hoggart, Clive J., van Rijswijk, Angelique L., Ekinci, Ebru, Priem, Debby, Schlapbach, Luregn J., Herberg, Jethro A., de Groot, Ronald, Anderson, Suzanne T., Fink, Colin G., Carrol, Enitan D., van der Flier, Michiel, Martinón-Torres, Federico, Levin, Michael, Leebeek, Frank W., Zenz, Werner, de Maat, Moniek P. M., Hazelzet, Jan A., Emonts, Marieke and Dik, Willem A. (2021). Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis. Critical Care Explorations, 3 (11) e0569, e0569. doi: 10.1097/CCE.0000000000000569

Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis

2021

Journal Article

Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: a before and after cohort study

Venkatesh, Balasubramanian, Schlapbach, Luregn, Mason, Donna, Wilks, Kathryn, Seaton, Robert, Lister, Paula, Irwin, Adam, Lane, Paul, Redpath, Lyndell, Gibbons, Kristen, Ergetu, Endrias and Rice, Michael (2021). Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: a before and after cohort study. The Lancet Regional Health - Western Pacific, 18 100305, 100305. doi: 10.1016/j.lanwpc.2021.100305

Impact of 1-hour and 3-hour sepsis time bundles on patient outcomes and antimicrobial use: a before and after cohort study

2021

Journal Article

Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study

Harley, Amanda, Schlapbach, Luregn J., Lister, Paula, Massey, Debbie, Gilholm, Patricia and Johnston, Amy N. B. (2021). Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study. BMC Health Services Research, 21 (1) 1161, 1161. doi: 10.1186/s12913-021-07128-2

Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study

2021

Journal Article

Long-term functional outcomes after sepsis for adult and pediatric critical care patients—protocol for a systematic review

Simpson, Adam, Long, Deborah, Fleischmann-Struzek, Carolin, Minogue, Jessicah, Venkatesh, Balasubramanian, Hammond, Naomi E., Tian, David H. and Schlapbach, Luregn J. (2021). Long-term functional outcomes after sepsis for adult and pediatric critical care patients—protocol for a systematic review. Frontiers in Pediatrics, 9 734205, 734205. doi: 10.3389/fped.2021.734205

Long-term functional outcomes after sepsis for adult and pediatric critical care patients—protocol for a systematic review

2021

Journal Article

Metabolic resuscitation in pediatric sepsis: a narrative review

Schlapbach, Luregn J., de Oliveira, Claudio Flauzinho, Raman, Sainath and de Souza, Daniela (2021). Metabolic resuscitation in pediatric sepsis: a narrative review. Translational Pediatrics, 10 (10), 2678-2688. doi: 10.21037/tp-21-1

Metabolic resuscitation in pediatric sepsis: a narrative review

2021

Journal Article

Parental and healthcare professional concern in the diagnosis of paediatric sepsis: a protocol for a prospective multicentre observational study

Sever, Zoe, Schlapbach, Luregn J, Jessup, Melanie, George, Shane and Harley, Amanda (2021). Parental and healthcare professional concern in the diagnosis of paediatric sepsis: a protocol for a prospective multicentre observational study. BMJ Open, 11 (9) e045910, e045910. doi: 10.1136/bmjopen-2020-045910

Parental and healthcare professional concern in the diagnosis of paediatric sepsis: a protocol for a prospective multicentre observational study

2021

Journal Article

A pediatric perspective on World Sepsis Day in 2021: leveraging lessons from the pandemic to reduce the global pediatric sepsis burden?

Schlapbach, Luregn J., Reinhart, Konrad, Kissoon, Niranjan and On behalf of the Pediatric Sepsis Data CoLaboratory (Sepsis CoLab) and the Global Sepsis Alliance (GSA) (2021). A pediatric perspective on World Sepsis Day in 2021: leveraging lessons from the pandemic to reduce the global pediatric sepsis burden?. American Journal of Physiology-Lung Cellular and Molecular Physiology, 321 (3), L608-L613. doi: 10.1152/ajplung.00331.2021

A pediatric perspective on World Sepsis Day in 2021: leveraging lessons from the pandemic to reduce the global pediatric sepsis burden?

2021

Journal Article

A novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies

Nijman, Ruud G., Oostenbrink, Rianne, Moll, Henriette A., Casals-Pascual, Climent, von Both, Ulrich, Cunnington, Aubrey, De, Tisham, Eleftheriou, Irini, Emonts, Marieke, Fink, Colin, van der Flier, Michiel, de Groot, Ronald, Kaforou, Myrsini, Kohlmaier, Benno, Kuijpers, Taco W., Lim, Emma, Maconochie, Ian K., Paulus, Stephane, Martinon-Torres, Federico, Pokorn, Marko, Romaine, Sam T., Calle, Irene Rivero, Schlapbach, Luregn J., Smit, Frank J., Tsolia, Maria, Usuf, Effua, Wright, Victoria J., Yeung, Shunmay, Zavadska, Dace ... Carrol, Enitan D. (2021). A novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies. Frontiers in Pediatrics, 9 688272, 1-18. doi: 10.3389/fped.2021.688272

A novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies

2021

Journal Article

Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations

Tu, Quyen, Cotta, Menino, Raman, Sainath, Graham, Nicolette, Schlapbach, Luregn and Roberts, Jason A (2021). Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations. Expert Review of Clinical Pharmacology, 14 (11), 1-17. doi: 10.1080/17512433.2021.1961578

Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations

2021

Journal Article

0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial

Raman, Sainath, Schibler, Andreas, Le Marsney, Renate, Trnka, Peter, Kennedy, Melanie, Mattke, Adrian, Gibbons, Kristen and Schlapbach, Luregn J. (2021). 0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial. Trials, 22 (1) 427. doi: 10.1186/s13063-021-05376-5

0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial

2021

Journal Article

Treatment of Multisystem Inflammatory Syndrome in Children

McArdle, Andrew J., Vito, Ortensia, Patel, Harsita, Seaby, Eleanor G., Shah, Priyen, Wilson, Clare, Broderick, Claire, Nijman, Ruud, Tremoulet, Adriana H., Munblit, Daniel, Ulloa-Gutierrez, Rolando, Carter, Michael J., De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A., Kaforou, Myrsini, Cunnington, Aubrey J., Levin, Michael, Vazquez, Jorge Agrimbau, Carmona, Rodrigo, Perez, Laura, Rubinos, Mayra, Veliz, Natalia, Yori, Silvana, Haerynck, Filomeen, Hoste, Levi, Leal, Izabel Alves, Da Silva, Andre Ricardo Araujo ... Kandawasvika, Gwendoline (2021). Treatment of Multisystem Inflammatory Syndrome in Children. New England Journal of Medicine, 385 (1) NEJMoa2102968, 11-22. doi: 10.1056/NEJMoa2102968

Treatment of Multisystem Inflammatory Syndrome in Children

2021

Journal Article

Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)

Irwin, Adam D., Coin, Lachlan J. M., Harris, Patrick N. A., Cotta, Menino Osbert, Bauer, Michelle J., Buckley, Cameron, Balch, Ross, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Beatson, Scott A., Forde, Brian M., Paterson, David, Clark, Julia, Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Schlapbach, Luregn J. and Roberts, Jason A. (2021). Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT). Frontiers in Cellular and Infection Microbiology, 11 667680, 1-8. doi: 10.3389/fcimb.2021.667680

Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)