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2020 Journal Article Engineering fluorescent gold nanoclusters using xanthate-functionalized hydrophilic polymers: toward enhanced monodispersity and stabilityDeepagan, Veerasikku Gopal, Leiske, Meike N., Fletcher, Nicholas L., Rudd, David, Tieu, Terence, Kirkwood, Nicholas, Thurecht, Kristofer J., Kempe, Kristian, Voelcker, Nicolas H. and Cifuentes-Rius, Anna (2020). Engineering fluorescent gold nanoclusters using xanthate-functionalized hydrophilic polymers: toward enhanced monodispersity and stability. Nano Letters, 21 (1) acs.nanolett.0c03930, 476-484. doi: 10.1021/acs.nanolett.0c03930 |
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2020 Journal Article The impact of polymer size and cleavability on the intravenous pharmacokinetics of PEG-based hyperbranched polymers in ratsMarasini, Nirmal, Fu, Changkui, Fletcher, Nicholas L., Subasic, Christopher, Er, Gerald, Mardon, Karine, Thurecht, Kristofer J., Whittaker, Andrew K. and Kaminskas, Lisa M. (2020). The impact of polymer size and cleavability on the intravenous pharmacokinetics of PEG-based hyperbranched polymers in rats. Nanomaterials, 10 (12) 2452, 1-16. doi: 10.3390/nano10122452 |
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2020 Journal Article Effect of chain‐end chemistries on the efficiency of coupling antibodies to polymers using unnatural amino acidsSivaram, Amal J., Wardiana, Andri, Preethi, S. S. Hema, Fuchs, Adrian V., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2020). Effect of chain‐end chemistries on the efficiency of coupling antibodies to polymers using unnatural amino acids. Macromolecular Rapid Communications, 41 (21) 2000294, e2000294. doi: 10.1002/marc.202000294 |
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2020 Journal Article Controlling the biological fate of micellar nanoparticles: balancing stealth and targetingSivaram, Amal J., Wardiana, Andri, Alcantara, Sheilajen, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Howard, Christopher B., Mahler, Stephen M., Alexander, Cameron, Kent, Stephen J., Bell, Craig A. and Thurecht, Kristofer J. (2020). Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting. ACS Nano, 14 (10) acsnano.0c06033, 13739-13753. doi: 10.1021/acsnano.0c06033 |
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2020 Journal Article Next‐generation polymeric nanomedicines for oncology: perspectives and future directionsFletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2020). Next‐generation polymeric nanomedicines for oncology: perspectives and future directions. Macromolecular Rapid Communications, 41 (18) 2000319, 2000319. doi: 10.1002/marc.202000319 |
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2020 Journal Article Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistributionHumphries, James, Pizzi, David, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2020). Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistribution. Biomacromolecules, 21 (8) acs.biomac.0c00765, 3318-3331. doi: 10.1021/acs.biomac.0c00765 |
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2020 Journal Article Synthesis of biscarboxylic acid functionalised EDTA mimicking polymers and their ability to form Zr(iv) chelation mediated nanostructuresLeiske, Meike N., Walker, Julia A., Zia, Aadarash, Fletcher, Nicholas L., Thurecht, Kristofer J., Davis, Thomas P. and Kempe, Kristian (2020). Synthesis of biscarboxylic acid functionalised EDTA mimicking polymers and their ability to form Zr(iv) chelation mediated nanostructures. Polymer Chemistry, 11 (16), 2799-2810. doi: 10.1039/d0py00304b |
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2020 Journal Article Understanding the uptake of nanomedicines at different stages of brain cancer using a modular nanocarrier platform and precision bispecific antibodiesHouston, Zachary H., Bunt, Jens, Chen, Kok-Siong, Puttick, Simon, Howard, Christopher B., Fletcher, Nicholas L., Fuchs, Adrian V., Cui, Jiwei, Ju, Yi, Cowin, Gary, Song, Xin, Boyd, Andrew W., Mahler, Stephen M., Richards, Linda J., Caruso, Frank and Thurecht, Kristofer J. (2020). Understanding the uptake of nanomedicines at different stages of brain cancer using a modular nanocarrier platform and precision bispecific antibodies. ACS Central Science, 6 (5) acscentsci.9b01299, 727-738. doi: 10.1021/acscentsci.9b01299 |
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2020 Journal Article Direct comparison of poly(ethylene glycol) and phosphorylcholine drug-loaded nanoparticles in vitro and in vivoNoy, Janina-Miriam, Chen, Fan, Akhter, Dewan T., Houston, Zachary H., Fletcher, Nicholas L., Thurecht, Kristofer J. and Stenzel, Martina H. (2020). Direct comparison of poly(ethylene glycol) and phosphorylcholine drug-loaded nanoparticles in vitro and in vivo. Biomacromolecules, 21 (6) acs.biomac.0c00257, 2320-2333. doi: 10.1021/acs.biomac.0c00257 |
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2020 Journal Article Investigation of the therapeutic potential of a synergistic delivery system through dual controlled release of camptothecin-doxorubicinZhao, Yongmei, Fletcher, Nicholas L., Gemmell, Anna, Houston, Zachary H., Howard, Christopher B., Blakey, Idriss, Liu, Tianqing and Thurecht, Kristofer J. (2020). Investigation of the therapeutic potential of a synergistic delivery system through dual controlled release of camptothecin-doxorubicin. Advanced Therapeutics, 3 (6) 1900202, 1900202. doi: 10.1002/adtp.201900202 |
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2020 Journal Article Oral delivery of multicompartment nanomedicines for colorectal cancer therapeutics: combining loco-regional delivery with cell-target specificityAkhter, Dewan T., Simpson, Joshua D., Fletcher, Nicholas L., Houston, Zachary H., Fuchs, Adrian V., Bell, Craig A. and Thurecht, Kristofer J. (2020). Oral delivery of multicompartment nanomedicines for colorectal cancer therapeutics: combining loco-regional delivery with cell-target specificity. Advanced Therapeutics, 3 (2) 1900171, 1-13. doi: 10.1002/adtp.201900171 |
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2020 Journal Article Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic deliveryEdiriweera, Gayathri R., Simpson, Joshua D., Fuchs, Adrian V., Venkatachalam, Taracad K., Van De Walle, Matthias, Howard, Christopher B., Mahler, Stephen M., Blinco, James P., Fletcher, Nicholas L., Houston, Zachary H., Bell, Craig A. and Thurecht, Kristofer J. (2020). Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery. Chemical Science, 11 (12), 3268-3280. doi: 10.1039/d0sc00078g |
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2020 Journal Article Targeted beta therapy of prostate cancer with 177Lu-labelled Miltuximab® antibody against glypican-1 (GPC-1)Yeh, Mei-Chun, Tse, Brian W. C., Fletcher, Nicholas L., Houston, Zachary H., Lund, Maria, Volpert, Marianna, Stewart, Chelsea, Sokolowski, Kamil A., Jeet, Varinder, Thurecht, Kristofer J., Campbell, Douglas H., Walsh, Bradley J., Nelson, Colleen C. and Russell, Pamela J. (2020). Targeted beta therapy of prostate cancer with 177Lu-labelled Miltuximab® antibody against glypican-1 (GPC-1). EJNMMI Research, 10 (1) 46, 46. doi: 10.1186/s13550-020-00637-x |
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2019 Journal Article Poly(2-oxazoline) macromonomers as building blocks for functional and biocompatible polymer architecturesPizzi, David, Humphries, James, Morrow, Joshua P., Fletcher, Nicholas L., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2019). Poly(2-oxazoline) macromonomers as building blocks for functional and biocompatible polymer architectures. European Polymer Journal, 121 109258, 109258. doi: 10.1016/j.eurpolymj.2019.109258 |
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2019 Journal Article Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cellsSimpson, Joshua D., Ediriweera, Gayathri R., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2019). Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells. Biomaterials Science, 7 (11), 4661-4674. doi: 10.1039/c9bm00957d |
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2019 Journal Article Modulating targeting of poly(ethylene glycol) particles to tumor cells using bispecific antibodiesCui, Jiwei, Ju, Yi, Houston, Zachary H., Glass, Joshua J., Fletcher, Nicholas L., Alcantara, Sheilajen, Dai, Qiong, Howard, Christopher B., Mahler, Stephen M., Wheatley, Adam K., De Rose, Robert, Brannon, Paul T., Paterson, Brett M., Donnelly, Paul S., Thurecht, Kristofer J., Caruso, Frank and Kent, Stephen J. (2019). Modulating targeting of poly(ethylene glycol) particles to tumor cells using bispecific antibodies. Advanced Healthcare Materials, 8 (9) 1801607, e1801607. doi: 10.1002/adhm.201801607 |
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2019 Journal Article Ultrasound-responsive nanobubbles for enhanced intravitreal drug migration: An ex vivo evaluationThakur, Sachin S., Chen, Ying-Shan, Houston, Zachary H., Fletcher, Nicholas, Barnett, Nigel L., Thurecht, Kristofer J., Rupenthal, Ilva D. and Parekh, Harendra S. (2019). Ultrasound-responsive nanobubbles for enhanced intravitreal drug migration: An ex vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 136, 102-107. doi: 10.1016/j.ejpb.2019.01.014 |
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2019 Journal Article Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell CarcinomaCrawford, Theo, Fletcher, Nicholas, Veitch, Margaret, Gonzalez Cruz, Jazmina L., Pett, Nicola, Brereton, Ian, Wells, James W., Mobli, Mehdi and Tesiram, Yasvir (2019). Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma. Frontiers in Medicine, 6 (FEB) 22, 22. doi: 10.3389/fmed.2019.00022 |
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2019 Journal Article Importance of polymer length in fructose-based polymeric micelles for an enhanced biological activityLu, Mingxia, Chen, Fan, Cao, Cheng, Garvey, Christopher J., Fletcher, Nicholas L., Houston, Zachary H., Lu, Hongxu, Lord, Megan S., Thurecht, Kristofer J. and Stenzel, Martina H. (2019). Importance of polymer length in fructose-based polymeric micelles for an enhanced biological activity. Macromolecules, 52 (2) acs.macromol.8b02381, 477-486. doi: 10.1021/acs.macromol.8b02381 |
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2018 Journal Article RNA interference to enhance radiation therapy: targeting the DNA damage responseRatnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018). RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439, 14-23. doi: 10.1016/j.canlet.2018.09.011 |
