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2018

Journal Article

Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation

Cully, Tanya R., Choi, Rocky H., Bjorksten, Andrew R., Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2018). Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. Proceedings of the National Academy of Sciences of the United States of America, 115 (32), 201800490-8220. doi: 10.1073/pnas.1800490115

Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation

2018

Journal Article

Store-operated Ca2+ entry is activated by every action potential in skeletal muscle

Koenig, Xaver, Choi, Rocky H. and Launikonis, Bradley S. (2018). Store-operated Ca2+ entry is activated by every action potential in skeletal muscle. Communications Biology, 1 (1) 31, 31. doi: 10.1038/s42003-018-0033-7

Store-operated Ca2+ entry is activated by every action potential in skeletal muscle

2018

Journal Article

NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat

Launikonis, Bradley S., Cully, Tanya R., Csernoch, Laszlo and Stephenson, D. George (2018). NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat. The Journal of General Physiology, 150 (1), 95-110. doi: 10.1085/jgp.201711891

NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat

2017

Journal Article

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

2017

Journal Article

Dantrolene requires Mg2+ to arrest malignant hyperthermia

Choi, Rocky H., Koenig, Xaver and Launikonis, Bradley S. (2017). Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proceedings of the National Academy of Sciences of the United States of America, 114 (18), 4811-4815. doi: 10.1073/pnas.1619835114

Dantrolene requires Mg2+ to arrest malignant hyperthermia

2017

Journal Article

Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle

Bakker, Anthony J., Cully, Tanya R., Wingate, Catherine D., Barclay, Christopher J. and Launikonis, Bradley S. (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. Journal of General Physiology, 149 (3), 323-334. doi: 10.1085/jgp.201611727

Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle

2017

Journal Article

Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

Cully, Tanya R., Murphy, Robyn M., Roberts, Llion, Raastad, Truls, Fassett, Robert G., Coombes, Jeff S., Jayasinghe, Isuru D. and Launikonis, Bradley S. (2017). Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise. Nature Communications, 8 (1) 14266, 14266.1-14266.10. doi: 10.1038/ncomms14266

Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

2016

Journal Article

A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres

Cully, Tanya R., Edwards, Joshua N., Murphy, Robyn M. and Launikonis, Bradley S. (2016). A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres. Journal of Physiology, 594 (11), 2795-2810. doi: 10.1113/JP271658

A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres

2016

Journal Article

Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle

Cully, Tanya R. and Launikonis, Bradley S. (2016). Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle. American Journal of Physiology: Cell Physiology, 310 (8), C673-C680. doi: 10.1152/ajpcell.00366.2015

Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle

2016

Journal Article

Additional in-series compliance reduces muscle force summation and alters the time course of force relaxation during fixed-end contractions

Mayfield, Dean L., Launikonis, Bradley S., Cresswell, Andrew G. and Lichtwark, Glen A. (2016). Additional in-series compliance reduces muscle force summation and alters the time course of force relaxation during fixed-end contractions. Journal of Experimental Biology, 219 (22), 3587-3596. doi: 10.1242/jeb.143123

Additional in-series compliance reduces muscle force summation and alters the time course of force relaxation during fixed-end contractions

2014

Journal Article

Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle

Cully, Tanya R., Edwards, Joshua N. and Launikonis, Bradley S. (2014). Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle. Journal of Physiology, 592 (17), 3727-3746. doi: 10.1113/jphysiol.2014.274274

Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle

2014

Journal Article

Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging

Jayasinghe, Isuru D., Munro, Michelle, Baddeley, David, Launikonis, Bradley S. and Soeller, Christian (2014). Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging. Journal of the Royal Society Interface, 11 (99) 0570, 20140570. doi: 10.1098/rsif.2014.0570

Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging

2014

Journal Article

Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke

Cheng, Yi-Lin, Park, Jong-Sung, Manzanero, Silvia, Choi, Yuri, Baik, Sang-Ha, Okun, Eitan, Gelderblom, Mathias, Fann, David Yang-Wei, Magnus, Tim, Launikonis, Bradley S., Mattson, Mark P., Sobey, Christopher G., Jo, Dong-Gyu and Arumugam, Thiruma V. (2014). Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiology of Disease, 62, 286-295. doi: 10.1016/j.nbd.2013.10.009

Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke

2013

Journal Article

Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle

Jayasinghe, Isuru D. and Launikonis, Bradley S. (2013). Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle. Journal of Cell Science, 126 (17), 4048-4058. doi: 10.1242/jcs.131565

Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle

2013

Journal Article

Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers

Jayasinghe, Isuru D., Lo, Harriet P., Morgan, Garry P., Baddeley, David, Parton, Robert G., Soeller, Christian and Launikonis, Bradley S. (2013). Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers. Biophysical Journal, 104 (11), L19-L21. doi: 10.1016/j.bpj.2013.04.029

Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers

2013

Journal Article

Store-operated Ca2+ entry is not required for store refilling in skeletal muscle

Cully, Tanya R. and Launikonis, Bradley S. (2013). Store-operated Ca2+ entry is not required for store refilling in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 40 (5), 338-344. doi: 10.1111/1440-1681.12078

Store-operated Ca2+ entry is not required for store refilling in skeletal muscle

2013

Journal Article

Evidence that the EphA2 receptor exacerbates ischemic brain injury

Thundyil, John, Manzanero, Silvia, Pavlovski, Dale, Cully, Tanya R., Lok, Ker-Zhing, Widiapradja, Alexander, Chunduri, Prasad, Jo, Dong-Gyu, Naruse, Chie, Asano, Masahide, Launikonis, Bradley S., Sobey, Christopher G., Coulthard, Mark G. and Arumugam, Thiruma V. (2013). Evidence that the EphA2 receptor exacerbates ischemic brain injury. PLoS One, 8 (1) e53528, e53528.1-e53528.8. doi: 10.1371/journal.pone.0053528

Evidence that the EphA2 receptor exacerbates ischemic brain injury

2012

Journal Article

Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart

Ma, Yi, Zhang, Lin, Launikonis, Bradley S. and Chen, Chen (2012). Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart. Endocrinology, 153 (11), 5480-5490. doi: 10.1210/en.2012-1404

Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart

2012

Journal Article

Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle.

Cully, Tanya R., Edwards, Joshua N., Friedrich, Oliver, Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2012). Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle.. American Journal of Physiology - Cell Physiology, 303 (5), C567-C576. doi: 10.1152/ajpcell.00144.2012

Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle.

2012

Journal Article

Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium

Ma, Yi, Zhang, Lin, Edwards, Joshua N., Launikonis, Breadley S. and Chen, Chen (2012). Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. PLoS One, 7 (4) e35265, e35265.1-e35265.9. doi: 10.1371/journal.pone.0035265

Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium