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2025 Journal Article From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in MammalsLaunikonis, Bradley S. and Murphy, Robyn M. (2025). From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in Mammals. Annual Review of Physiology, 87 (1), 131-150. doi: 10.1146/annurev-physiol-022724-105205 |
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2025 Book Chapter Ryanodine Receptor 1 Calcium Leak in Non-Shivering ThermogenesisMeizoso-Huesca, Aldo and Launikonis, Bradley S. (2025). Ryanodine Receptor 1 Calcium Leak in Non-Shivering Thermogenesis. Biochemistry of Non-Shivering Thermogenesis in Vertebrates. (pp. 116-129) Boca Raton: CRC Press. doi: 10.1201/9781003391470-10 |
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2025 Journal Article BPS2025 - Ryanodine receptor Ca2+ leak signaling remains functionally intact and regulates energy expenditure in sedentary, aged mouse muscleHuesca, Aldo Meizoso, Choi, Rocky, Lamboley, Cedric, Beard, Nicole A., Blackmore, Daniel and Launikonis, Bradley S. (2025). BPS2025 - Ryanodine receptor Ca2+ leak signaling remains functionally intact and regulates energy expenditure in sedentary, aged mouse muscle. Biophysical Journal, 124 (3), 271a. doi: 10.1016/j.bpj.2024.11.1540 |
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2024 Journal Article Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain‐of‐function mouseGaglianone, Rhayanna B. and Launikonis, Bradley S. (2024). Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain‐of‐function mouse. Acta Physiologica, 240 (3) e14098, e14098. doi: 10.1111/apha.14098 |
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2023 Journal Article Ryanodine receptor activity and store‐operated Ca <sup>2+</sup> entry: critical regulators of Ca <sup>2+</sup> content and function in skeletal musclePearce, Luke, Meizoso‐Huesca, Aldo, Seng, Crystal, Lamboley, Cedric R., Singh, Daniel P. and Launikonis, Bradley S. (2023). Ryanodine receptor activity and store‐operated Ca 2+ entry: critical regulators of Ca 2+ content and function in skeletal muscle. The Journal of Physiology, 601 (19), 4183-4202. doi: 10.1113/jp279512 |
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2023 Journal Article A bivalent remipede toxin promotes calcium release via ryanodine receptor activationMaxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w |
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2023 Journal Article Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammalsSingh, Daniel P., Pearce, Luke, Choi, Rocky H., Meizoso-Huesca, Aldo, Wette, Stefan G., Scott, John W., Lamboley, Cedric R., Murphy, Robyn M. and Launikonis, Bradley S. (2023). Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proceedings of the National Academy of Sciences, 120 (4) e2117503120, 1-12. doi: 10.1073/pnas.2117503120 |
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2022 Journal Article Tiny changes in cytoplasmic [Ca<sup>2+</sup>] cause large changes in mitochondrial Ca<sup>2+</sup>: what are the triggers and functional implications?Seng, Crystal, Pearce, Luke, Meizoso-Huesca, Aldo, Singh, Daniel P., Murphy, Robyn M., Lamboley, Cedric and Launikonis, Bradley S. (2022). Tiny changes in cytoplasmic [Ca2+] cause large changes in mitochondrial Ca2+: what are the triggers and functional implications?. American Journal of Physiology-Cell Physiology, 323 (4), C1285-C1289. doi: 10.1152/ajpcell.00092.2022 |
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2022 Journal Article Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c)Barclay, Christopher J. and Launikonis, Bradley S. (2022). Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c). The Journal of general physiology, 154 (9) e20211299404062022c. doi: 10.1085/jgp.20211299404062022c |
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2022 Journal Article A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibersBarclay, Christopher J. and Launikonis, Bradley S. (2022). A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers. Journal of General Physiology, 154 (9) e202112994. doi: 10.1085/jgp.202112994 |
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2022 Journal Article Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscleMeizoso-Huesca, Aldo, Pearce, Luke, Barclay, Christopher J. and Launikonis, Bradley S. (2022). Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle. Proceedings of the National Academy of Sciences, 119 (4) e2119203119, 1-8. doi: 10.1073/pnas.2119203119 |
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2022 Journal Article Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screeningZhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip and Cornea, Razvan L. (2022). Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. Journal of Biological Chemistry, 298 (1) 101412, 101412. doi: 10.1016/j.jbc.2021.101412 |
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2021 Journal Article Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscleLamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166 |
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2021 Journal Article The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscleMeizoso-Huesca, Aldo and Launikonis, Bradley S. (2021). The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle. Journal of General Physiology, 153 (1) e202012747, 1-12. doi: 10.1085/jgp.202012747 |
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2020 Journal Article Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised miceLilliu, Elena, Hilber, Karlheinz, Launikonis, Bradley S. and Koenig, Xaver (2020). Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised mice. Frontiers in Physiology, 11 597647, 1-11. doi: 10.3389/fphys.2020.597647 |
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2020 Journal Article A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contractionFerreira, Juan J., Pequera, Germán, Launikonis, Bradley S., Ríos, Eduardo and Brum, Gustavo (2020). A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction. The Journal of Physiology, 599 (1) JP279917, 157-170. doi: 10.1113/jp279917 |
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2020 Journal Article Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction couplingHuerlimann, Roger, Maes, Gregory E., Maxwell, Michael J., Mobli, Mehdi, Launikonis, Bradley S., Jerry, Dean R. and Wade, Nicholas M. (2020). Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene, 752 144765, 144765. doi: 10.1016/j.gene.2020.144765 |
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2020 Conference Publication Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptationsSingh, Daniel P., Watt, Matthew J. and Launikonis, Bradley S. (2020). Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptations. 64th Annual Meeting of the Biophysical-Society, San Diego, CA, United States, 15-19 February 2020. St. Louis, MO, United States: Cell Press. |
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2020 Journal Article RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assaysRebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S. and Cornea, Razvan L. (2020). RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Scientific Reports, 10 (1) 1791, 1791. doi: 10.1038/s41598-020-58461-1 |
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2020 Journal Article A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functionsAzimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081 |
