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2024 Journal Article Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excessWang, Bing H., Robert, Remy, Marques, Francine Z., Rajapakse, Niwanthi, Kiriazis, Helen, Mackay, Charles R. and Kaye, David M. (2024). Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess. Scientific Reports, 14 (1) 26985, 1-13. doi: 10.1038/s41598-024-75789-0 |
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2023 Journal Article SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike proteinAlbornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0 |
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2022 Journal Article Stimulation of angiotensin converting enzyme 2: A novel treatment strategy for diabetic nephropathyNomura, Haru, Kuruppu, Sanjaya and Rajapakse, Niwanthi W. (2022). Stimulation of angiotensin converting enzyme 2: A novel treatment strategy for diabetic nephropathy. Frontiers in Physiology, 12 813012, 813012. doi: 10.3389/fphys.2021.813012 |
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2022 Journal Article Chronic renin-angiotensin system activation induced neuroinflammation: common mechanisms underlying hypertension and dementia?Tran, Shirley, Kuruppu, Sanjaya and Rajapakse, Niwanthi W. (2022). Chronic renin-angiotensin system activation induced neuroinflammation: common mechanisms underlying hypertension and dementia?. Journal of Alzheimer's Disease, 85 (3), 943-955. doi: 10.3233/JAD-215231 |
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2020 Journal Article Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failureGiam, Beverly, Nomura, Haru, Kuruppu, Sanjaya, Chu, Po-Yin, Essid, Sumia, Kiriazis, Helen, Du, Xiao-Jun, Kaye, David M. and Rajapakse, Niwanthi W. (2020). Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure. Clinical Science, 134 (20), 2755-2769. doi: 10.1042/CS20200087 |
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2019 Journal Article Impaired L-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertensionRajapakse, Niwanthi W., Giam, Beverly, Kuruppu, Sanjaya, Head, Geoffrey A. and Kaye, David M. (2019). Impaired L-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension. Clinical Science, 133 (20), 2061-2067. doi: 10.1042/CS20190851 |
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2019 Journal Article Augmented Endothelial Specific Cationic Amino Acid Transporter‐1 Expression Prevents Renal Fibrosis and Inflammation and Loss of Renal Function in Heart FailureRajapakse, Niwanthi, Giam, Beverly, Chu, Po‐Yin, Essid, Sumia, Kuruppu, Sanjaya, Kiriazis, Helen, Du, Xiao‐Jun and Kaye, David (2019). Augmented Endothelial Specific Cationic Amino Acid Transporter‐1 Expression Prevents Renal Fibrosis and Inflammation and Loss of Renal Function in Heart Failure. The FASEB Journal, 33 (S1), 749.8-749.8. doi: 10.1096/fasebj.2019.33.1_supplement.749.8 |
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2018 Journal Article Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathyGiam, Beverly, Chu, Po-Yin, Kuruppu, Sanjaya, Smith, A. Ian, Horlock, Duncan, Murali, Aishwarya, Kiriazis, Helen, Du, Xiao-Jun, Kaye, David M. and Rajapakse, Niwanthi W. (2018). Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy. Experimental Physiology, 103 (12), 1593-1602. doi: 10.1113/EP087189 |
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2018 Journal Article Serelaxin and augmented L‐arginine transport attenuates renal fibrosis and inflammation in experimental dilated cardiomyopathyRajapakse, Niwanthi, Giam, Beverly, Kuruppu, Sanjaya, Chu, Po‐Yin, Kiriazis, Helen, Du, Xiao‐Jun and Kaye, David (2018). Serelaxin and augmented L‐arginine transport attenuates renal fibrosis and inflammation in experimental dilated cardiomyopathy. The FASEB Journal, 32 (S1), 903.8-903.8. doi: 10.1096/fasebj.2018.32.1_supplement.903.8 |
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2017 Journal Article N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated CardiomyopathyGiam, Beverly, Kuruppu, Sanjaya, Chu, Po-Yin, Smith, A. Ian, Marques, Francine Z., Fiedler, April, Horlock, Duncan, Kiriazis, Helen, Du, Xiao-Jun, Kaye, David M. and Rajapakse, Niwanthi W. (2017). N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy. Scientific Reports, 7 (1) 17718, 1-12. doi: 10.1038/s41598-017-17927-5 |
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2017 Journal Article High fibre diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive miceMarques, Francine Z., Nelson, Erin, Chu, Po-Yin, Horlock, Duncan, Fiedler, April, Ziemann, Mark, Tan, Jian K., Kuruppu, Sanjaya, Rajapakse, Niwanthi W., El-Osta, Assam, Mackay, Charles R. and Kaye, David M. (2017). High fibre diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice. Circulation, 135 (10), 964-977. doi: 10.1161/CIRCULATIONAHA.116.024545 |
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2017 Journal Article The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish speciesHan, Han, Baumann, Kate, Casewell, Nicholas R., Ali, Syed A., Dobson, James, Koludarov, Ivan, Debono, Jordan, Cutmore, Scott C., Rajapakse, Niwanthi W., Jackson, Timothy N. W., Jones, Rob, Hodgson, Wayne C., Fry, Bryan G. and Kuruppu, Sanjaya (2017). The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species. Toxins, 9 (2) 67, 67. doi: 10.3390/toxins9020067 |
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2017 Journal Article The characteristics of astrocyte on Aβ clearance altered in Alzheimer’s disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeateKuruppu, Sanjaya, Rajapakse, Niwanthi W., Parkington, Helena C. and Smith, A. Ian (2017). The characteristics of astrocyte on Aβ clearance altered in Alzheimer’s disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate. American Journal of Translational Research, 9 (7), 3514-3516. |
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2016 Journal Article Stimulating the activity of amyloid-beta degrading enzymes: a novel approach for the therapeutic manipulation of amyloid-beta levelsKuruppu, Sanjaya, Rajapakse, Niwanthi W., Spicer, Alexander J., Parkington, Helena C. and Smith, A. Ian (2016). Stimulating the activity of amyloid-beta degrading enzymes: a novel approach for the therapeutic manipulation of amyloid-beta levels. Journal of Alzheimers Disease, 54 (3), 891-895. doi: 10.3233/JAD-160492 |
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2016 Journal Article Role of renal oxidative stress in the pathogenesis of the cardiorenal syndromeGiam, Beverly, Kaye, David M. and Rajapakse, Niwanthi W. (2016). Role of renal oxidative stress in the pathogenesis of the cardiorenal syndrome. Heart, Lung and Circulation, 25 (8), 874-880. doi: 10.1016/j.hlc.2016.02.022 |
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2016 Journal Article Letter by Rajapakse et al regarding article, "Combined angiotensin receptor antagonism and neprilysin inhibition"Rajapakse, Niwanthi W., Kuruppu, Sanjaya and Smith, A. Ian (2016). Letter by Rajapakse et al regarding article, "Combined angiotensin receptor antagonism and neprilysin inhibition". Circulation, 134 (3), E9-E10. doi: 10.1161/CIRCULATIONAHA.116.023086 |
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2016 Journal Article Canopy venom: proteomic comparison among new world arboreal pit-viper venomsDebono, Jordan, Cochran, Chip, Kuruppu, Sanjaya, Nouwens, Amanda, Rajapakse, Niwanthi W., Kawasaki, Minami, Wood, Kelly, Dobson, James, Baumann, Kate, Jouiaei, Mahdokht, Jackson, Timothy N. W., Koludarov, Ivan, Low, Dolyce, Ali, Syed A., Smith, A. Ian, Barnes, Andrew and Fry, Bryan G. (2016). Canopy venom: proteomic comparison among new world arboreal pit-viper venoms. Toxins, 8 (7) 210, 210.1-210.19. doi: 10.3390/toxins8070210 |
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2016 Journal Article Effects of dietary L-arginine on nitric oxide bioavailability in obese normotensive and obese hypertensive subjectsGiam, Beverly, Kuruppu, Sanjaya, Head, Geoffrey A., Kaye, David M. and Rajapakse, Niwanthi W. (2016). Effects of dietary L-arginine on nitric oxide bioavailability in obese normotensive and obese hypertensive subjects. Nutrients, 8 (6) 364, 364. doi: 10.3390/nu8060364 |
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2016 Journal Article Say NO to obesity-related hypertension: role of the l-arginine-nitric oxide pathwayRajapakse, Niwanthi W., Head, Geoffrey A. and Kaye, David M. (2016). Say NO to obesity-related hypertension: role of the l-arginine-nitric oxide pathway. Hypertension, 67 (5), 813-819. doi: 10.1161/HYPERTENSIONAHA.116.06778 |
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2016 Journal Article N-acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failureGiam, Beverly, Chu, Po-Yin, Kuruppu, Sanjaya, Smith, A. Ian, Horlock, Duncan, Kiriazis, Helen, Du, Xiao-Jun, Kaye, David M. and Rajapakse, Niwanthi W. (2016). N-acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure. Physiological Reports, 4 (7), 1-13. doi: 10.14814/phy2.12757 |
