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2016 Journal Article N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and NeprilysinSmith, A. Ian, Rajapakse, Niwanthi W., Kleifeld, Oded, Lomonte, Bruno, Sikanyika, Nkumbu L., Spicer, Alexander J., Hodgson, Wayne C., Conroy, Paul J., Small, David H., Kaye, David M., Parkington, Helena C., Whisstock, James C. and Kuruppu, Sanjaya (2016). N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin. Scientific Reports, 6 (1) 22413, 22413.1-22413.11. doi: 10.1038/srep22413 |
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2015 Journal Article Cardio-protective effects of combined l-arginine and insulin: mechanism and therapeutic actions in myocardial ischemia-reperfusion injuryVenardos, Kylie M., Rajapakse, Niwanthi W., Williams, David, Hoe, Louise S., Peart, Jason N. and Kaye, David M. (2015). Cardio-protective effects of combined l-arginine and insulin: mechanism and therapeutic actions in myocardial ischemia-reperfusion injury. European Journal of Pharmacology, 769, 64-70. doi: 10.1016/j.ejphar.2015.09.046 |
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2015 Journal Article Pathogenesis and treatment of the cardiorenal syndrome: implications of L-arginine-nitric oxide pathway impairmentRajapakse, Niwanthi W., Nanayakkara, Shane and Kaye, David M. (2015). Pathogenesis and treatment of the cardiorenal syndrome: implications of L-arginine-nitric oxide pathway impairment. Pharmacology & Therapeutics, 154, 1-12. doi: 10.1016/j.pharmthera.2015.05.011 |
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2015 Journal Article Augmented endothelial-specific L-arginine transport blunts the contribution of the sympathetic nervous system to obesity induced hypertension in miceRajapakse, Niwanthi W., Karim, Florian, Evans, Roger G., Kaye, David M. and Head, Geoffrey A. (2015). Augmented endothelial-specific L-arginine transport blunts the contribution of the sympathetic nervous system to obesity induced hypertension in mice. Plos One, 10 (7) e0131424, e0131424. doi: 10.1371/journal.pone.0131424 |
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2015 Journal Article Augmented endothelial l-arginine transport ameliorates pressure-overload-induced cardiac hypertrophyRajapakse, Niwanthi W., Johnston, Tamara, Kiriazis, Helen, Chin-Dusting, Jaye P., Du, Xiao-Jun and Kaye, David M. (2015). Augmented endothelial l-arginine transport ameliorates pressure-overload-induced cardiac hypertrophy. Experimental Physiology, 100 (7), 796-804. doi: 10.1113/EP085250 |
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2014 Journal Article Endothelial cationic amino acid transporter-1 overexpression blunts the effects of oxidative stress on pressor responses to behavioural stress in miceRajapakse, Niwanthi W., Konstantinidis, George, Evans, Roger G., Nguyen-Huu, Thu-Phuc, Kaye, David M. and Head, Geoffrey A. (2014). Endothelial cationic amino acid transporter-1 overexpression blunts the effects of oxidative stress on pressor responses to behavioural stress in mice. Clinical and Experimental Pharmacology and Physiology, 41 (12), 1031-1037. doi: 10.1111/1440-1681.12279 |
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2014 Journal Article Nitric oxide inhibits the production of soluble endothelin converting enzyme-1Kuruppu, Sanjaya, Rajapakse, Niwanthi W., Dunstan, Rhys A. and Smith, A. Ian (2014). Nitric oxide inhibits the production of soluble endothelin converting enzyme-1. Molecular and Cellular Biochemistry, 396 (1-2), 49-54. doi: 10.1007/s11010-014-2141-0 |
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2014 Journal Article Augmented endothelial-specific L-arginine transport prevents obesity-induced hypertensionRajapakse, N. W., Karim, F., Straznicky, N. E., Fernandez, S., Evans, R. G., Head, G. A. and Kaye, D. M. (2014). Augmented endothelial-specific L-arginine transport prevents obesity-induced hypertension. Acta Physiologica, 212 (1), 39-48. doi: 10.1111/apha.12344 |
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2014 Journal Article Renal oxygenation in acute renal ischemia-reperfusion injuryAbdelkader, Amany, Ho, Julie, Ow, Connie P. C., Eppel, Gabriela A., Rajapakse, Niwanthi W., Schlaich, Markus P. and Evans, Roger G. (2014). Renal oxygenation in acute renal ischemia-reperfusion injury. American Journal of Physiology-Renal Physiology, 306 (9), F1026-F1038. doi: 10.1152/ajprenal.00281.2013 |
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2014 Journal Article Production of soluble Neprilysin by endothelial cellsKuruppu, Sanjaya, Rajapakse, Niwanthi W., Minond, Dmitriy and Smith, A. Ian (2014). Production of soluble Neprilysin by endothelial cells. Biochemical and Biophysical Research Communications, 446 (2), 423-427. doi: 10.1016/j.bbrc.2014.01.158 |
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2014 Journal Article Endothelial cationic amino acid transporter-1 overexpression can prevent oxidative stress and increases in arterial pressure in response to superoxide dismutase inhibition in miceKonstantinidis, G., Head, G. A., Evans, R. G., Nguyen-Huu, T. -P., Venardos, K., Croft, K. D., Mori, T. A., Kaye, D. M. and Rajapakse, N. W. (2014). Endothelial cationic amino acid transporter-1 overexpression can prevent oxidative stress and increases in arterial pressure in response to superoxide dismutase inhibition in mice. Acta Physiologica, 210 (4), 845-853. doi: 10.1111/apha.12215 |
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2013 Journal Article Endothelin-converting enzyme-1 inhibition and renoprotection in end-stage renal diseaseKuruppu, Sanjaya, Rajapakse, Niwanthi W. and Smith, A. Ian (2013). Endothelin-converting enzyme-1 inhibition and renoprotection in end-stage renal disease. Pflugers Archiv - European Journal of Physiology, 465 (7), 929-934. doi: 10.1007/s00424-013-1216-1 |
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2013 Journal Article Insulin-mediated activation of the L-arginine nitric oxide pathway in man, and its impairment in diabetesRajapakse, Niwanthi W., Chong, Abigail L., Zhang, Wei-Zheng and Kaye, David M. (2013). Insulin-mediated activation of the L-arginine nitric oxide pathway in man, and its impairment in diabetes. Plos One, 8 (5) e61840, e61840. doi: 10.1371/journal.pone.0061840 |
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2013 Journal Article Role of cellular L-arginine uptake and nitric oxide production on renal blood flow and arterial pressure regulationRajapakse, Niwanthi W. and Mattson, David L. (2013). Role of cellular L-arginine uptake and nitric oxide production on renal blood flow and arterial pressure regulation. Current Opinion in Nephrology and Hypertension, 22 (1), 45-50. doi: 10.1097/MNH.0b013e32835a6ff7 |
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2012 Journal Article Evidence that renal arginine transport is impaired in spontaneously hypertensive ratsRajapakse, N. W., Kuruppu, S., Hanchapola, I., Venardos, K., Mattson, D. L., Smith, A. I., Kaye, D. M. and Evans, R. G. (2012). Evidence that renal arginine transport is impaired in spontaneously hypertensive rats. American Journal of Physiology-Renal Physiology, 302 (12), F1554-F1562. doi: 10.1152/ajprenal.00084.2011 |
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2011 Journal Article Role of l-arginine uptake mechanisms in renal blood flow responses to angiotensin II in ratsRajapakse, N. W. and Mattson, D. L. (2011). Role of l-arginine uptake mechanisms in renal blood flow responses to angiotensin II in rats. Acta Physiologica, 203 (3), 391-400. doi: 10.1111/j.1748-1716.2011.02330.x |
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2010 Journal Article Angiotensin II and neurohumoral control of the renal medullary circulationEvans, Roger G., Head, Geoffrey A., Eppel, Gabriela A., Burke, Sandra L. and Rajapakse, Niwanthi W. (2010). Angiotensin II and neurohumoral control of the renal medullary circulation. Clinical and Experimental Pharmacology and Physiology, 37 (2), E58-E69. doi: 10.1111/j.1440-1681.2009.05233.x |
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2009 Journal Article Role of l-arginine in nitric oxide production in health and hypertensionRajapakse, Niwanthi W. and Mattson, David L. (2009). Role of l-arginine in nitric oxide production in health and hypertension. Clinical and Experimental Pharmacology and Physiology, 36 (3), 249-255. doi: 10.1111/j.1440-1681.2008.05123.x |
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2008 Journal Article Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in ratsRajapakse, Niwanthi W., De Miguel, Carmen, Das, Satarupa and Mattson, David L. (2008). Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in rats. Hypertension, 52 (6), 1084-1090. doi: 10.1161/HYPERTENSIONAHA.108.114298 |
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2006 Journal Article ANG II type 2 receptors and neural control of intrarenal blood flowRajapakse, Niwanthi W., Eppel, Gabriela A., Widdop, Robert E. and Evans, Roger G. (2006). ANG II type 2 receptors and neural control of intrarenal blood flow. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 291 (6), R1669-R1676. doi: 10.1152/ajpregu.00183.2006 |
