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2017 Journal Article Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptorsChen, Xiumin, Keramidas, Angelo and Lynch, Joseph W. (2017). Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptors. Neuropharmacology, 125, 243-253. doi: 10.1016/j.neuropharm.2017.07.027 |
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2017 Journal Article Gamma 1-containing GABA-A receptors cluster at synapses where they mediate slower synaptic currents than gamma 2-containing GABA-A receptorsDixon, Christine L., Sah, Pankaj, Keramidas, Angelo, Lynch, Joseph W. and Durisic, Nela (2017). Gamma 1-containing GABA-A receptors cluster at synapses where they mediate slower synaptic currents than gamma 2-containing GABA-A receptors. Frontiers in Molecular Neuroscience, 10 178, 178. doi: 10.3389/fnmol.2017.00178 |
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2017 Journal Article Structure-function analysis of the GlyR alpha 2 subunit autism mutation p.R323L reveals a gain-of-functionZhang, Yan, Ho, Thi Nhu Thao, Harvey, Robert J., Lynch, Joseph W. and Keramidas, Angelo (2017). Structure-function analysis of the GlyR alpha 2 subunit autism mutation p.R323L reveals a gain-of-function. Frontiers in Molecular Neuroscience, 10 158, 158. doi: 10.3389/fnmol.2017.00158 |
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2017 Journal Article Probing the structural mechanism of partial agonism in glycine receptors using the fluorescent artificial amino acid, ANAPSoh, Ming S., Estrada-Mondragon, Argel, Durisic, Nela, Keramidas, Angelo and Lynch, Joseph W. (2017). Probing the structural mechanism of partial agonism in glycine receptors using the fluorescent artificial amino acid, ANAP. ACS Chemical Biology, 12 (3), 805-813. doi: 10.1021/acschembio.6b00926 |
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2017 Journal Article Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1aChassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114 |
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2017 Journal Article Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1Inserra, Marco C., Isreal, Mathilde, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmerman, Katharina, Lewis, Richard J., Brierley, Stuart M. and Vetter, Irina (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7 (1) 42810, 42810. doi: 10.1038/srep42810 |
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2016 Journal Article Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitationIslam, Robiul, Keramidas, Angelo, Xu, Li, Durisic, Nela, Sah, Pankaj and Lynch, Joseph W. (2016). Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation. ACS Chemical Neuroscience, 7 (12), 1647-1657. doi: 10.1021/acschemneuro.6b00168 |
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2016 Journal Article The free zinc concentration in the synaptic cleft of artificial glycinergic synapses rises to at least 1 µmZhang, Yan, Keramidas, Angelo and Lynch, Joseph W. (2016). The free zinc concentration in the synaptic cleft of artificial glycinergic synapses rises to at least 1 µm. Frontiers in Molecular Neuroscience, 9 (SEP2016) 88, 88. doi: 10.3389/fnmol.2016.00088 |
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2016 Journal Article Investigating the mechanism by which gain-of-function mutations to the a1 glycine receptor cause hyperekplexiaZhang, Yan, Bode, Anna, Nguyen, Bindi, Angelo Keramidas and Lynch, Joseph W. (2016). Investigating the mechanism by which gain-of-function mutations to the a1 glycine receptor cause hyperekplexia. Journal of Biological Chemistry, 291 (29), 15332-15341. doi: 10.1074/jbc.M116.728592 |
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2015 Journal Article Correlating structural and energetic changes in glycine receptor activationScott, Suzanne, Lynch, Joseph W and Keramidas, Angelo (2015). Correlating structural and energetic changes in glycine receptor activation. Journal of Biological Chemistry, 290 (9), 5621-5634. doi: 10.1074/jbc.M114.616573 |
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2015 Journal Article Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinationsZhang, Yan, Dixon, Christine L., Keramidas, Angelo and Lynch, Joseph W. (2015). Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations. Neuropharmacology, 89, 391-397. doi: 10.1016/j.neuropharm.2014.10.026 |
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2015 Journal Article Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activityDixon, Christine L., Harrison, Neil L., Lynch, Joseph W. and Keramidas, Angelo (2015). Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. British Journal of Pharmacology, 172 (14), 3522-3536. doi: 10.1111/bph.13142 |
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2014 Journal Article GABAa receptor α and γ subunits shape synaptic currents via different mechanismsDixon, Christine, Sah, Pankaj, Lynch, Joseph W. and Keramidas, Angelo (2014). GABAa receptor α and γ subunits shape synaptic currents via different mechanisms. Journal of Biological Chemistry, 289 (9), 5399-5411. doi: 10.1074/jbc.M113.514695 |
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2013 Journal Article New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanismsBode, Anna, Wood, Sian-Elin, Mullins, Jonathan G. L., Keramidas, Angelo, Cushion, Thomas D., Thomas, Rhys H., Pickrell, William O., Drew, Cheney J. G., Masri, Amira, Jones, Elizabeth A., Vassallo, Grace, Born, Alfred P., Alehan, Fusun, Aharoni, Sharon, Bannasch, Gerald, Bartsch, Marius, Kara, Bulent, Krause, Amanda, Karam, Elie G., Matta, Stephanie, Jain, Vivek, Mandel, Hanna, Freilinger, Michael, Graham, Gail E., Hobson, Emma, Chatfield, Sue, Vincent-Delorme, Catherine, Rahme, Jubran E., Afawi, Zaid ... Lynch, Joseph W. (2013). New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms. Journal of Biological Chemistry, 288 (47), 33745-33759. doi: 10.1074/jbc.M113.509240 |
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2013 Journal Article Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle diseaseJames, Victoria M., Bode, Anna, Chung, Seo-Kyung, Gill, Jennifer L., Nielsen, Maartje, Cowan, Frances M., Vujic, Mihailo, Thomas, Rhys H., Rees, Mark I., Harvey, Kirsten, Keramidas, Angelo, Topf, Maya, Ginjaar, Ieke, Lynch, Joseph W. and Harvey, Robert J. (2013). Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiology of Disease, 52, 137-149. doi: 10.1016/j.nbd.2012.12.001 |
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2012 Journal Article An outline of desensitization in pentameric ligand-gated ion channel receptorsKeramidas, Angelo and Lynch, Joseph W. (2012). An outline of desensitization in pentameric ligand-gated ion channel receptors. Cellular and Molecular Life Sciences, 70 (7), 1241-1253. doi: 10.1007/s00018-012-1133-z |
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2010 Journal Article The activation mechanism of alpha(1)beta(2)gamma(2S) and alpha(3)beta(3)gamma(2S) GABA(A) receptorsKeramidas, Angelo and Harrison, Neil L. (2010). The activation mechanism of alpha(1)beta(2)gamma(2S) and alpha(3)beta(3)gamma(2S) GABA(A) receptors. Journal of General Physiology, 135 (1), 59-75. doi: 10.1085/jgp.200910317 |
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2008 Conference Publication Agonist-dependent single channel current and Gating in alpha(4)beta(2)delta and alpha(1)beta(2)gamma(2S) GABA(A) receptorsKeramidas, Angelo and Harrison, Neil L. (2008). Agonist-dependent single channel current and Gating in alpha(4)beta(2)delta and alpha(1)beta(2)gamma(2S) GABA(A) receptors. New York, United States: Rockefeller University Press. doi: 10.1085/jgp.200709871 |
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2008 Journal Article Taurine is a potent activator of extrasynaptic GABAA receptors in the thalamusJia, Fan, Yue, Minerva, Chandra, Dev, Keramidas, Angelo, Goldstein, Peter A., Homanics, Gregg E. and Harrison, Neil L. (2008). Taurine is a potent activator of extrasynaptic GABAA receptors in the thalamus. Journal of Neuroscience, 28 (1), 106-115. doi: 10.1523/JNEUROSCI.3996-07.2008 |
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2006 Journal Article The pre-M1 segment of the alpha 1 subunit is a transduction element in the activation of the GABA(A) receptorKeramidas, Angelo, Kash, Thomas L. and Harrison, Neil L. (2006). The pre-M1 segment of the alpha 1 subunit is a transduction element in the activation of the GABA(A) receptor. The Journal of Physiology, 575 (1), 11-22. doi: 10.1113/jphysiol.2005.102756 |
