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2024 Journal Article A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradientsThapa, Ashvriya, Beh, Jia Hao, Robinson, Samuel D., Deuis, Jennifer R., Tran, Hue, Vetter, Irina and Keramidas, Angelo (2024). A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients. Journal of Biological Chemistry, 300 (10) 107757, 107757. doi: 10.1016/j.jbc.2024.107757 |
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2024 Journal Article Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severityLin, Susan X. N., Ahring, Philip K., Keramidas, Angelo, Liao, Vivian W. Y., Møller, Rikke S., Chebib, Mary and Absalom, Nathan L. (2024). Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity. Brain, 147 (1), 224-239. doi: 10.1093/brain/awad285 |
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2024 Journal Article Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7)Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152 |
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2023 Journal Article GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanismsRagnarsson, Lotten, Zhang, Zihan, Das, Sooraj S., Tran, Poanna, Andersson, Åsa, Portes, Vincent Des, Demestre, Cecilia Altuzzara, Remerand, Ganaelle, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Lesca, Gaetan, Anggono, Victor, Vetter, Irina and Keramidas, Angelo (2023). GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. Epilepsia, 64 (12), 3377-3388. doi: 10.1111/epi.17776 |
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2023 Journal Article Ant venoms contain vertebrate-selective pain-causing sodium channel toxinsRobinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F. and Vetter, Irina (2023). Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nature Communications, 14 (1) 2977, 1-11. doi: 10.1038/s41467-023-38839-1 |
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2022 Journal Article Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABAA receptorKuanyshbek, Alibek, Wang, Meng, Andersson, Åsa, Tuifua, Marie, Palmer, Elizabeth E., Sachdev, Rani K., Mu, Ting-Wei, Vetter, Irina and Keramidas, Angelo (2022). Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABAA receptor. Neuropharmacology, 221 109295, 109295. doi: 10.1016/j.neuropharm.2022.109295 |
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2022 Journal Article Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptorsWang, Meng, Cotter, Edmund, Wang, Ya-Juan, Fu, Xu, Whittsette, Angela L., Lynch, Joseph W., Wiseman, R. Luke, Kelly, Jeffery W., Keramidas, Angelo and Mu, Ting-Wei (2022). Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors. Cell and Bioscience, 12 (1) 48, 1-20. doi: 10.1186/s13578-022-00783-w |
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2022 Journal Article Shisa7-dependent regulation of GABAA receptor single-channel gating kineticsCastellano, David, Wu, Kunwei, Keramidas, Angelo and Lu, Wei (2022). Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics. Journal of Neuroscience, 42 (47), 8758-8766. doi: 10.1523/JNEUROSCI.0510-22.2022 |
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2021 Journal Article A pain-causing and paralytic ant venom glycopeptideRobinson, Samuel D., Kambanis, Lucas, Clayton, Daniel, Hinneburg, Hannes, Corcilius, Leo, Mueller, Alexander, Walker, Andrew A., Keramidas, Angelo, Kulkarni, Sameer S., Jones, Alun, Vetter, Irina, Thaysen-Andersen, Morten, Payne, Richard J., King, Glenn F. and Undheim, Eivind A.B. (2021). A pain-causing and paralytic ant venom glycopeptide. iScience, 24 (10) 103175, 1-21. doi: 10.1016/j.isci.2021.103175 |
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2021 Journal Article Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunitYong, Xuan Ling Hilary, Zhang, Lingrui, Yang, Liming, Chen, Xiumin, Tan, Jing Zhi Anson, Yu, Xiaojun, Chandra, Mintu, Livingstone, Emma, Widagdo, Jocelyn, Vieira, Marta M., Roche, Katherine W., Lynch, Joseph W., Keramidas, Angelo, Collins, Brett M. and Anggono, Victor (2021). Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit. Cell Reports, 36 (1) 109338, 1-21. doi: 10.1016/j.celrep.2021.109338 |
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2020 Journal Article Proteostasis regulators restore function of epilepsy-associated GABAA receptorsDi, Xiao-Jing, Wang, Ya-Juan, Cotter, Edmund, Wang, Meng, Whittsette, Angela L., Han, Dong-Yun, Sangwung, Panjamaporn, Brown, Renae, Lynch, Joseph W., Keramidas, Angelo and Mu, Ting-Wei (2020). Proteostasis regulators restore function of epilepsy-associated GABAA receptors. Cell Chemical Biology, 27 (1), 1-e7. doi: 10.1016/j.chembiol.2020.08.012 |
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2020 Journal Article Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptorsChen, Xiumin, Keramidas, Angelo, Harvey, Robert J. and Lynch, Joseph W. (2020). Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors. Neurobiology of Disease, 140 104850, 104850. doi: 10.1016/j.nbd.2020.104850 |
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2020 Journal Article A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibitionLanglhofer, Georg, Schaefer, Natascha, Maric, Hans M., Keramidas, Angelo, Zhang, Yan, Baumann, Peter, Blum, Robert, Breitinger, Ulrike, Strømgaard, Kristian, Schlosser, Andreas, Kessels, Michael M., Koch, Dennis, Qualmann, Britta, Breitinger, Hans-Georg, Lynch, Joseph W. and Villmann, Carmen (2020). A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition. Journal of Neuroscience, 40 (25), JN-RM. doi: 10.1523/jneurosci.2490-19.2020 |
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2019 Journal Article The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiaeAtif, Mohammed, Lynch, Joseph W. and Keramidas, Angelo (2019). The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae. British Journal of Pharmacology, 177 (1) bph.14855, 175-187. doi: 10.1111/bph.14855 |
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2019 Journal Article GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistanceAtif, Mohammed, Smith, Jennifer J., Estrada-Mondragon, Argel, Xiao, Xue, Salim, Angela A., Capon, Robert J., Lynch, Joseph W. and Keramidas, Angelo (2019). GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance. PLOS Pathogens, 15 (1) e1007570, e1007570. doi: 10.1371/journal.ppat.1007570 |
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2018 Journal Article SAHA (Vorinostat) corrects inhibitory synaptic deficits caused by missense epilepsy mutations to the GABA(A) receptor gamma 2 subunitDurisic, Nela, Keramidas, Angelo, Dixon, Christine L. and Lynch, Joseph W. (2018). SAHA (Vorinostat) corrects inhibitory synaptic deficits caused by missense epilepsy mutations to the GABA(A) receptor gamma 2 subunit. Frontiers in Molecular Neuroscience, 11 89, 89. doi: 10.3389/fnmol.2018.00089 |
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2018 Journal Article Structure/Function Studies of the alpha 4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape ResponsesLeacock, Sophie, Syed, Parnayan, James, Victoria M., Bode, Anna, Kawakami, Koichi, Keramidas, Angelo, Suster, Maximiliano, Lynch, Joseph W. and Harvey, Robert J. (2018). Structure/Function Studies of the alpha 4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses. Frontiers in Molecular Neuroscience, 11 23, 23. doi: 10.3389/fnmol.2018.00023 |
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2017 Journal Article Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsyChen, Xiumin, Durisic, Nela, Lynch, Joseph W. and Keramidas, Angelo (2017). Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy. Neurobiology of Disease, 108, 213-224. doi: 10.1016/j.nbd.2017.08.020 |
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2017 Journal Article Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortusAtif, Mohammed, Estrada-Mondragon, Argel, Nguyen, Bindi, Lynch, Joseph W. and Keramidas, Angelo (2017). Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus. PLoS Pathogens, 13 (10) e1006663, e1006663. doi: 10.1371/journal.ppat.1006663 |
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2017 Journal Article Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptorsChen, Xiumin, Keramidas, Angelo and Lynch, Joseph W. (2017). Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptors. Neuropharmacology, 125, 243-253. doi: 10.1016/j.neuropharm.2017.07.027 |
