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2010 Journal Article Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in miceHarrison, Rosemary S., Ruiz-Gomez, Gloria, Hill, Timothy A., Chow, Shiao Y., Shepherd, Nicholas E., Lohman, Rink-Jan, Abbenante, Giovanni, Hoang, Huy N. and Fairlie, David P. (2010). Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice. Journal of Medicinal Chemistry, 53 (23), 8400-8408. doi: 10.1021/jm101139f |
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2010 Journal Article Inhibitors selective for HDAC6 in enzymes and cellsGupta, Praveer K., Reid, Robert C., Liu, Ligong, Lucke, Andrew J., Broomfield, Steve A., Andrews, Melanie R., Sweet, Matthew J. and Fairlie, David P. (2010). Inhibitors selective for HDAC6 in enzymes and cells. Bioorganic & Medicinal Chemistry Letters, 20 (23), 7067-7070. doi: 10.1016/j.bmcl.2010.09.100 |
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2010 Journal Article Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938)Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2010). Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938). Journal of Medicinal Chemistry, 53 (22), 8208-8208. doi: 10.1021/jm1013314 |
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2010 Journal Article Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cellsSuen, JY, Gardiner, B, Grimmond, S and Fairlie, DP (2010). Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells. PLoS One, 5 (11) e13809, e13809-1-e13809-14. doi: 10.1371/journal.pone.0013809 |
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2010 Journal Article Novel agonists and antagonists for human protease activated receptor 2Barry, Grant D., Suen, Jacky Y., Le, Giang T., Cotterell, Adam, Reid, Robert C. and Fairlie, David P. (2010). Novel agonists and antagonists for human protease activated receptor 2. Journal of Medicinal Chemistry, 53 (20), 7428-7440. doi: 10.1021/jm100984y |
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2010 Journal Article Selective hexapeptide agonists and antagonists for human complement C3a receptorScully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2010). Selective hexapeptide agonists and antagonists for human complement C3a receptor. Journal of Medicinal Chemistry, 53 (13), 4938-4948. doi: 10.1021/jm1003705 |
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2010 Journal Article Update 1 of: Proteases universally recognize beta strands in their active sitesMadala, Praveen K., Tyndall, Joel D. A., Nall, Tessa and Fairlie, David P. (2010). Update 1 of: Proteases universally recognize beta strands in their active sites. Chemical Reviews, 110 (4), 1-33. doi: 10.1021/cr900368a |
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2010 Journal Article Update 1 of: Beta-strand mimeticsLoughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: Beta-strand mimetics. Chemical Reviews, 110 (6), 1-38. doi: 10.1021/cr900395y |
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2010 Journal Article Update 1 of: beta-strand mimeticsLoughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: beta-strand mimetics. Chemical Reviews, 110 (6), PR32-PR69. doi: 10.1021/cr040648k |
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2010 Journal Article Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potencyHarrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Goméz, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni and Fairlie, David P. (2010). Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency. Proceedings of the National Academy of Sciences of the United States of America, 107 (26), 11686-11691. doi: 10.1073/pnas.1002498107 |
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2010 Journal Article Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPSHalili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363 |
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2010 Journal Article Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structureRuiz-Gomez, Gloria, Tyndall, Joel D. A., Pfeiffer, Bernhard, Abbenante, Giovanni and Fairlie, David (2010). Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 110 (6), 1-41. doi: 10.1021/cr900344w |
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2010 Journal Article Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive ratsIyer, Abishek, Fenning, Andrew, Lim, Junxian, Le, Giang T, Reid, Robert C, Halili, Maria A, Fairlie, David P and Brown, Lindsay (2010). Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. British Journal of Pharmacology, 159 (7), 1408-1417. doi: 10.1111/j.1476-5381.2010.00637.x |
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2010 Journal Article Update 1 of: Over One Hundred Petide-Activated G Protein-Coupled Receptors Recognized Ligands with Turn StructureRuiz-Gomez, Gloria, Tyndall, Joel D. A., Pfeiffer, Bernhard, Abbenante, Giovanni and Fairlie, David P. (2010). Update 1 of: Over One Hundred Petide-Activated G Protein-Coupled Receptors Recognized Ligands with Turn Structure. Chemical Reviews, 110 (4), PR1-PR41. |
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2010 Journal Article Noncovalent tripeptidyl benzyl- And cyclohexyl-amine inhibitors of the cysteine protease caspase-1Loser, Reik, Abbenante, Giovanni, Madala, Praveen K., Halili, Maria, Le, Giang T. and Fairlie, David P. (2010). Noncovalent tripeptidyl benzyl- And cyclohexyl-amine inhibitors of the cysteine protease caspase-1. Journal of Medicinal Chemistry, 53 (6), 2651-2655. doi: 10.1021/jm901790w |
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2010 Journal Article Inflammatory lipid mediators in adipocyte function and obesityIyer, Abishek, Fairlie, David P., Prins, Johannes B., Hammock, Bruce D. and Brown, Lindsay (2010). Inflammatory lipid mediators in adipocyte function and obesity. Nature Reviews Endocrinology, 6 (2), 71-82. doi: 10.1038/nrendo.2009.264 |
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2009 Journal Article In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flavivirusesKampmann, T., Yennamalli, R., Campbell, P., Stoermer, M. J., Fairlie, D. P., Kobe, B. and Young, P. R. (2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Research, 84 (3), 234-241. doi: 10.1016/j.antiviral.2009.09.007 |
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2009 Journal Article Left- and right-handed alpha-helical turns in homo- and hetero-chiral helical scaffoldsShepherd, N. E., Hoang, H. N., Abbenante, G and Fairlie, D. P. (2009). Left- and right-handed alpha-helical turns in homo- and hetero-chiral helical scaffolds. Journal of the American Chemical Society, 131 (43), 15877-15886. doi: 10.1021/ja9065283 |
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2009 Journal Article Structure-activity relationships for substrate-based inhibitors of human complement factor BRuiz-Gomez, G, Lim, J, Halili, M. A., Le, G. T., Madala, P. K., Abbenante, G and Fairlie, D. P. (2009). Structure-activity relationships for substrate-based inhibitors of human complement factor B. JOURNAL OF MEDICINAL CHEMISTRY, 52 (19), 6042-6052. doi: 10.1021/jm900781m |
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2009 Journal Article Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteasesStoermer, Martin J., Leung, Donmienne, Young, Paul R. and Fairlie, David P. (2009). Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases. Australian Journal of Chemistry, 62 (9), 988-992. doi: 10.1071/CH09150 |
