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2006 Journal Article Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loopsSingh, Y, Hoang, HN, Flanagan, B and Fairlie, DP (2006). Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loops. Organic Letters, 8 (6), 1053-1056. doi: 10.1021/ol052842e |
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2006 Journal Article Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic AcidKahnberg, P. C., Lucke, A., Glenn, M. P., Boyle, G. M., Tyndall, J. D., Parsons, P. G. and Fairlie, D. P. (2006). Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic Acid. Journal of Medicinal Chemistry, 49 (26), 7611-7622. doi: 10.1021/jm050214x |
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2005 Journal Article Nonpeptide ligands that target peptide-activated GPCRs in inflammationBlakeney, JS and Fairlie, DP (2005). Nonpeptide ligands that target peptide-activated GPCRs in inflammation. Current Medicinal Chemistry, 12 (25), 3027-3042. doi: 10.2174/092986705774462888 |
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2005 Journal Article Therapeutic targets in inflammatory diseaseHume, David A. and Fairlie, David P. (2005). Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 (25), 2925-2929. doi: 10.2174/092986705774462923 |
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2005 Journal Article Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding siteHigginbottom, Adrian, Cain, Stuart A., Woodruff, Trent M., Proctor, Lavinia M., Madala, Praveen K., Tyndall, Joel D. A., Taylor, Stephen M., Fairlie, David P. and Monk, Peter N. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280 (18), 17831-17840. doi: 10.1074/jbc.M410797200 |
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2005 Journal Article A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitisWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005). A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 (5), 883-892. doi: 10.1016/j.intimp.2005.01.003 |
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2005 Journal Article Single turn peptide alpha helices with exceptional stability in waterShepherd, N. E., Hoang, H. N., Abbenante, G. and Fairlie, D. P. (2005). Single turn peptide alpha helices with exceptional stability in water. Journal of The American Chemical Society, 127 (9), 2974-2983. doi: 10.1021/ja0456003 |
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2005 Journal Article Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactionsChappell, Keith J., Nall, Tessa A., Stoermer, Martin J., Fang, Ning-Xia, Tyndall, Joel D. A., Fairlie, David P. and Young, Paul R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280 (4), 2896-2903. doi: 10.1074/jbc.M409931200 |
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2005 Journal Article Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazolesSingh, Y, Stoermer, MJ, Lucke, AJ, Guthrie, T and Fairlie, DP (2005). Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles. Journal of The American Chemical Society, 127 (18), 6563-6572. doi: 10.1021/ja0455300 |
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2005 Journal Article Proteases universally recognize beta strands in their active sitesTyndall, JDA, Nall, T and Fairlie, DP (2005). Proteases universally recognize beta strands in their active sites. Chemical Reviews, 105 (3), 973-999. doi: 10.1021/cr040669e |
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2005 Journal Article Protease inhibitors in the clinicAbbenante, Giovanni and Fairlie , David P. (2005). Protease inhibitors in the clinic. Medicinal Chemistry, 1 (1), 71-104. doi: 10.2174/1573406053402569 |
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2005 Journal Article Tumour necrosis factor alpha converting enzymeFairlie, D (2005). Tumour necrosis factor alpha converting enzyme. Current Medicinal Chemistry, 12 (25), 2923-2924. doi: 10.2174/092986705774462897 |
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2005 Journal Article Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structureTyndall, J. D. A., Pfeiffer, B., Abbenante, G. and Fairlie, D. P. (2005). Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 105 (3), 793-826. doi: 10.1021/cr040689g |
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2005 Journal Article Over 100 peptide-activated GPCRS recognize turn motifs in ligandsFairlie, D. P., Tyndall, J. D. A., Abbenante, G. and Pfeiffer, B. (2005). Over 100 peptide-activated GPCRS recognize turn motifs in ligands. Abstracts of Papers of The American Chemical Society, 229, U106-U106. |
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2004 Journal Article Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solventvan den Brenk, Anna L., Tyndall, Joel D. A., Cusack, Rodney M., Jones, Alun, Fairlie, David P., Gahan, Lawrence R. and Hanson, Graeme R. (2004). Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent. Journal of Inorganic Biochemistry, 98 (11), 1857-1866. doi: 10.1016/j.jinorgbio.2004.08.005 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/j.jhep.2004.02.017 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/S0168-8278(04)00066-2 |
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2004 Journal Article Alpha-turn mimetics: short peptide alpha-Helices composed of cyclic metallopentapeptide modulesKelso, Michael J., Beyer, Renée L., Hoang, Huy N., Lakdawala, Ami S., Snyder, James P., Oliver, Warren V., Robertson, Tom A., Appleton, Trevor G. and Fairlie, David P. (2004). Alpha-turn mimetics: short peptide alpha-Helices composed of cyclic metallopentapeptide modules. Journal of The American Chemical Society, 126 (15), 4828-4842. doi: 10.1021/ja037980i |
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2004 Journal Article Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injuryProctor, Lavinia M., Arumugam, Thiruma V., Shiels, Ian, Reid, Robert C., Fairlie, David P. and Taylor, Stephen M . (2004). Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology, 142 (4), 756-764. doi: 10.1038/sj.bjp.0705819 |
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2004 Journal Article Consecutive cyclic pentapeptide modules form short alpha-helices that are very stable to water and denaturantsShepherd, N. E., Abbenante, G. and Fairlie, D. P. (2004). Consecutive cyclic pentapeptide modules form short alpha-helices that are very stable to water and denaturants. Angewandte Chemie-international Edition, 43 (20), 2687-2690. doi: 10.1002/anie.200352659 |
