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2000 Journal Article Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production In Vitro by a new C5a receptor antagonistHaynes, DR, Harkin, DG, Bignold, LP, Hutchens, MJ, Taylor, SM and Fairlie, DP (2000). Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production In Vitro by a new C5a receptor antagonist. Biochemical Pharmacology, 60 (5), 729-733. doi: 10.1016/S0006-2952(00)00361-0 |
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2000 Journal Article The first solution structure of a single a-helical turn. A pentapeptide a -Helix stabilized by a metal clipKelso, M. J., Hoang, H. N., Appleton, T. G. and Fairlie, D. (2000). The first solution structure of a single a-helical turn. A pentapeptide a -Helix stabilized by a metal clip. Journal of Americal Chemical Society, 122 (42), 10488-10489. doi: 10.1021/ja002416i |
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2000 Journal Article Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium bindingCusack, R. M., Grondahl, L., Abbenante, G., Fairlie, D. P., Gahan, L. R., Hanson, G. R. and Hambley, T. W. (2000). Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium binding. Journal of The Chemical Society-perkin Transactions 2 (2), 323-331. doi: 10.1039/a906090a |
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2000 Journal Article Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processingFairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., March, D. R., Bergman, D. A., Chai, C. L. L. and Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43 (7), 1271-1281. doi: 10.1021/jm990315t |
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2000 Journal Article Is oxidative damage by b- amyloid and prion peptides mediated by hydrogen atom transfer from glycine a-carbon to methionine sulfur within b- sheets?Rauk, A., Armstrong, D. A. and Fairlie, D. P. (2000). Is oxidative damage by b- amyloid and prion peptides mediated by hydrogen atom transfer from glycine a-carbon to methionine sulfur within b- sheets?. Journal of American Chemical Society, 122 (40), 9761-9767. doi: 10.1021/ja994436u |
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2000 Journal Article Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 proteaseTyndall, J. D. A., Reid, R. C., Tyssen, D. P., Jardine, D. K., Todd, B., Passmore, M., March, D. R., Pattenden, L., Bergman, D. A., Alewood, D., Hu, S., Alewood, P.F., Birch, C. J., Martin, J. L. and Fairlie, D. (2000). Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. Journal of Medicinal Chemistry, 43 (19), 3495-3504. doi: 10.1021/jm000013n |
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2000 Journal Article Characterization of copper interactions with alzheimer amyloid bpeptides: Identification of an attomolar-affinity copper binding site on Amyloid 1-42Atwood, C. S., Scarpa, R. C., Huang, X., Moir, R. D., Jones, W. D., Fairlie, D. P., Tanzi, R. E. and Bush, A. I. (2000). Characterization of copper interactions with alzheimer amyloid bpeptides: Identification of an attomolar-affinity copper binding site on Amyloid 1-42. Journal of Neurochemistry, 75 (3), 1219-1233. doi: 10.1046/j.1471-4159.2000.0751219.x |
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2000 Journal Article Regulators of the anaphylatoxin C5aTaylor, SM and Fairlie, DP (2000). Regulators of the anaphylatoxin C5a. Expert Opinion in Therapeutic Patents, 10 (4), 449-458. doi: 10.1517/13543776.10.4.449 |
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1999 Journal Article Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reductionHuang, XD, Cuajungco, MP, Atwood, CS, Hartshorn, MA, Tyndall, JDA, Hanson, GR, Stokes, KC, Leopold, M, Multhaup, G, Goldstein, LE, Scarpa, RC, Saunders, AJ, Lim, J, Moir, RD, Glabe, C, Bowden, EF, Masters, CL, Fairlie, DP, Tanzi, RE and Bush, AI (1999). Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction. Journal of Biological Chemistry, 274 (52), 37111-37116. doi: 10.1074/jbc.274.52.37111 |
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1999 Journal Article Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.Brinkworth, R. I., Fairlie, D., Leung, D. and Young, P. R. (1999). Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.. Journal of General Virology, 80 (5), 1167-1177. doi: 10.1099/0022-1317-80-5-1167 |
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1999 Journal Article Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the ratShort, Anna, Wong, Allan K., Finch, Angela M., Haaima, Gerald, Shiels, Ian A., Fairlie, David P. and Taylor, Stephen M. (1999). Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. British Journal of Pharmacology, 126 (2), 551-554. doi: 10.1038/sj.bjp.0702338 |
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1999 Journal Article Pharmacological characterization of antagonists of the C5a receptorPaczkowski, NJ, Finch, AM, Whitmore, JB, Short, AJ, Wong, AK, Monk, PN, Cain, SA, Fairlie, DP and Taylor, SM (1999). Pharmacological characterization of antagonists of the C5a receptor. British Journal of Pharmacology, 128 (10), 1461-1466. doi: 10.1038/sj.bjp.0702938 |
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1999 Journal Article Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.Qiu, L., Kelso, M., Hansen, C., West, M. L., Fairlie, D. and Parsons, P. (1999). Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.. British Journal of Cancer, 80 (8), 1252-1258. doi: 10.1038/sj.bjc.6690493 |
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1999 Journal Article The possible origin of free radicals from amyloid peptides in Alzheimer's diseaseBush, A. I., Huang, X. and Fairlie, D. (1999). The possible origin of free radicals from amyloid peptides in Alzheimer's disease. Neurobiology of Aging, 20 (3), 335-337. doi: 10.1016/S0197-4580(99)00058-5 |
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1999 Journal Article Con formational homogeneity in molecular recognition by proteolytic enzymesTyndall, J. and Fairlie, D. (1999). Con formational homogeneity in molecular recognition by proteolytic enzymes. Journal of Molecular Recognition, 12 (6), 363-370. doi: 10.1002/(SICI)1099-1352(199911/12)12:63.3.CO;2-D |
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1999 Journal Article Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5aFinch, A., Wong, A. K., Paczkowski, N. J., Wadi, S. K., Craik, D. J., Fairlie, D. and Taylor, S. M. (1999). Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. Journal of Medicinal Chemistry, 42 (6), 1965-1974. doi: 10.1021/jm9806594 |
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1999 Journal Article Cu (II ) Potentiation of Alzheimer Ab NeurotoxicityHuang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D., Hanson, G. R., Stokes, K. C., Leopold, M., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Saunders, A. J., Lim, J., Moir, R. D., Glabe, C., Bowden, E. F., Masters, C. L., Fairlie, D., Tanzi, R. E. and Bush, A. I. (1999). Cu (II ) Potentiation of Alzheimer Ab Neurotoxicity. Jornal of Biological Chemistry, 274 (52), 37111-37116. |
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1999 Journal Article X-ray absorption spectroscopy of cadmium phytochelatin and model systemsPickering, I. J., Prince, R. C., George, G. N., Rauser, W. E., Wickramasinghe, W. A., Watson, A. A., Dameron, C., Dance, I. G., Fairlie, D. and Salt, D. E. (1999). X-ray absorption spectroscopy of cadmium phytochelatin and model systems. Biochimica Et Biophysica Acta, 1429 (2), 351-364. doi: 10.1016/S0167-4838(98)00242-8 |
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1999 Journal Article Development of C5a receptor antagonistsWong, A., Taylor, S. M. and Fairlie, D. (1999). Development of C5a receptor antagonists. Investigational Drugs, 2 (7), 686-693. |
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1999 Journal Article Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 proteaseMartin, J. L., Begun, J., Schindeler, A., Wickramasinghe, W. A., Alewood, D., Alewood, P. F., Bergman, D. A., Brinkworth, R. I., Abbenante, G., March, D. R., Reid, R. C., Fairlie, D. P. and Armstrong, Richard A. (1999). Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease. Biochemistry, 38 (25), 7978-7988. doi: 10.1021/bi990174x |
