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2002 Journal Article Synthesis and structural properties of patellamide a derivatives and their copper(II) compoundsBernhardt, P. V., Comba, P., Fairlie, D. P., Gahan, L. R., Hanson, G. R. and Lotzbeyer, L. (2002). Synthesis and structural properties of patellamide a derivatives and their copper(II) compounds. Chemistry-a European Journal, 8 (7), 1527-1536. doi: 10.1002/1521-3765(20020402)8:73.3.CO;2-6 |
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2002 Journal Article Mimetics of the Peptide beta-StrandGlenn, Matthew P. and Fairlie, David P. (2002). Mimetics of the Peptide beta-Strand. Mini-Reviews in Medicinal Chemistry, 2 (5), 433-445. doi: 10.2174/1389557023405747 |
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2002 Journal Article Cyclic octapeptides containing thiazole. Effect of stereochemistry and degree of flexibility on calcium binding propertiesCusack, R. M., Grondahl, L., Fairlie, D. P., Gahan, L. R. and Hanson, G. R. (2002). Cyclic octapeptides containing thiazole. Effect of stereochemistry and degree of flexibility on calcium binding properties. Journal of The Chemical Society-perkin Transactions 2 (3), 556-563. doi: 10.1039/b109168a |
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2001 Journal Article Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitorsLeung, D., Schroder, K., White, H., Fang, N. X., Stoermer, M. J., Abbenante, G., Martin, J. L., Young, P. R. and Fairlie, D. P. (2001). Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. Journal of Biological Chemistry, 276 (49), 45762-45771. doi: 10.1074/jbc.M107360200 |
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2001 Journal Article Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonistStrachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and R. A. North (2001). Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. British Journal of Pharmacology, 134 (12), 1778-1786. doi: 10.1038/sj.bjp.0704417 |
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2001 Journal Article Protease inhibitorsFairlie, DP (2001). Protease inhibitors. Current Medicinal Chemistry, 8 (8), U2-U2. |
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2001 Journal Article Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytesWoodruff, Trent M., Strachan, Anna J., Sanderson, Sam D., Monk, Peter N., Wong, Allan K., Fairlie, David P. and Taylor, Stephen M. (2001). Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes. Inflammation, 25 (3), 171-177. doi: 10.1023/A:1011036414353 |
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2001 Journal Article Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptorCain, S. A., Woodruff, T. M., Taylor, S. M., Fairlie, D. P., Sanderson, S. D. and Monk, P. N. (2001). Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor. Biochemical Pharmacology, 61 (12), 1571-1579. doi: 10.1016/S0006-2952(01)00608-6 |
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2001 Journal Article Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteasesTyndall, JDA and Fairlie, DP (2001). Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases. Current Medicinal Chemistry, 8 (8), 893-907. doi: 10.2174/0929867013372715 |
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2001 Journal Article Novel Cylindrical, Conical, and Macrocyclic Peptides from the Cyclooligomerization of Functionalized Thiazole Amino AcidsSingh, Y., Sokolenko, N., Kelso, M. J., Gahan, L. R., Abbenante, G. and Fairlie, D. P. (2001). Novel Cylindrical, Conical, and Macrocyclic Peptides from the Cyclooligomerization of Functionalized Thiazole Amino Acids. Journal of the American Chemical Society, 123 (2), 333-334. doi: 10.1021/ja002666z |
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2001 Journal Article Proteolysis of human hemoglobin by schistosome cathepsin DBrindley, P. J., Kalinna, B. H., Wong, J. Y. M., Bogitsh, B. J., King, L. T., Smyth, D. J., Verity, C. K., Abbenante, G., Brinkworth, R. I., Fairlie, D. P., Smythe, M. L., Milburn, P. J., Bielefeldt-Ohmann, H., Zheng, Y. and McManus, D. P. (2001). Proteolysis of human hemoglobin by schistosome cathepsin D. Molecular And Biochemical Parasitology, 112 (1), 103-112. doi: 10.1016/S0166-6851(00)00351-0 |
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2001 Journal Article PrefaceFairlie, D. P. (2001). Preface. Current Medicinal Chemistry, 8 (8) doi: 10.2174/0929867013372724 |
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2000 Journal Article An efficient Fmoc strategy for the rapid synthesis of peptide para-nitroanilidesAbbenante, J., Leung, D., Bond, T. J. and Fairlie, D. P. (2000). An efficient Fmoc strategy for the rapid synthesis of peptide para-nitroanilides. Letters in Peptide Science, 7 (6), 347-351. doi: 10.1023/A:1013016323676 |
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2000 Journal Article A new small molecule C5a receptor antagonist inhibits the reverse- passive Arthus reaction and endotoxic shock in ratsStrachan, Anna J., Woodruff, Trent M., Haaima, Gerald, Fairlie, David P. and Taylor, Stephen M. (2000). A new small molecule C5a receptor antagonist inhibits the reverse- passive Arthus reaction and endotoxic shock in rats. Journal of Immunology, 164 (12), 6560-6565. doi: 10.4049/jimmunol.164.12.6560 |
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2000 Journal Article Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cellsQiu, Ling, Burgess, Andrew, Fairlie, David P., Leonard, Helen, Parsons, Peter G. and Gabrielli, Brian G. (2000). Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells. Molecular Biology of the Cell, 11 (6), 2069-2083. doi: 10.1091/mbc.11.6.2069 |
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2000 Journal Article Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F)Poulsen, Sally-Ann, Watson, Andrew A., Fairlie, David P. and Craik, David J. (2000). Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F). Journal of Structural Biology, 130 (2-3), 142-152. doi: 10.1006/jsbi.2000.4267 |
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2000 Journal Article Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents Anna Walduck, Mike J. Kelso, David P. Fairlie, Allan Saul, Peter G. ParsonsAndrews, Kathy T., Walduck, Anna, Kelso, Mike J., Fairlie, David P., Saul, Allan and Parsons, Peter G. (2000). Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents Anna Walduck, Mike J. Kelso, David P. Fairlie, Allan Saul, Peter G. Parsons. International Journal for Parasitology, 30 (6), 761-768. doi: 10.1016/S0020-7519(00)00043-6 |
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2000 Journal Article Protease inhibitors: Current status and future prospectsLeung, D., Abbenante, G. and Fairlie, D. P. (2000). Protease inhibitors: Current status and future prospects. Journal of Medicinal Chemistry, 43 (3), 305-341. doi: 10.1021/jm990412m |
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2000 Journal Article Inhibitors of beta-amyloid formation based on the beta-secretase cleavage siteAbbenante, G., Kovacs, D. M., Leung, D. L., Craik, D. J., Tanzi, R. E. and Fairlie, D. P. (2000). Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. Biochemical And Biophysical Research Communications, 268 (1), 133-135. doi: 10.1006/bbrc.2000.2098 |
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2000 Journal Article Cell phenotype as a target of drug therapy in chronic inflammatory diseasesShiels, I. A., Taylor, S. M. and Fairlie, D. P. (2000). Cell phenotype as a target of drug therapy in chronic inflammatory diseases. Medical Hypotheses, 54 (2), 193-197. doi: 10.1054/mehy.1999.0017 |
