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2016 Journal Article Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic miceJames, Cini R., Buckle, Irina, Muscate, Franziska, Otsuka, Masayuki, Nakao, Mari, Oon, Jack S. H., Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2016). Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunology and Cell Biology, 94 (5), 509-519. doi: 10.1038/icb.2016.7 |
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2016 Conference Publication Type 1 diabetes susceptibility genes impair gut physiology and lead to perturbations in the microbiotaMullaney, J., Stephens, J. and Hamilton-Williams, E. (2016). Type 1 diabetes susceptibility genes impair gut physiology and lead to perturbations in the microbiota. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200 |
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2016 Conference Publication Development of a model for antigen-specific tolerising immunotherapy and response in NOD miceBuckle, I, Steptoe, R. J., Thomas, R. and Hamilton-Williams, E. E. (2016). Development of a model for antigen-specific tolerising immunotherapy and response in NOD mice. International Congress of Immunology (ICI 2016), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. |
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2015 Journal Article Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetesPang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015). Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 (8) e41, e41.1-e41.9. doi: 10.1038/cti.2015.17 |
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2013 Journal Article Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexityHamilton-Williams, Emma E., Rainbow, Daniel B., Cheung, Jocelyn, Christensen, Mikkel, Lyons, Paul A., Peterson, Laurence B., Steward, Charles A., Sherman, Linda A. and Wicker, Linda S. (2013). Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mammalian Genome, 24 (9-10), 358-375. doi: 10.1007/s00335-013-9466-y |
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2013 Journal Article Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetesLin, Xiaotian, Hamilton-Williams, Emma E., Rainbow, Daniel B., Hunter, Kara M., Dai, Yang D., Cheung, Jocelyn, Peterson, Laurence B., Wicker, Linda S. and Sherman, Linda A. (2013). Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes. Journal of Immunology, 190 (7), 3109-3120. doi: 10.4049/jimmunol.1203422 |
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2012 Journal Article PTPN22 alters the development of regulatory T cells in the thymusMaine, Christian J., Hamilton-Williams, Emma E., Cheung, Jocelyn, Stanford, Stephanie M., Bottini, Nunzio, Wicker, Linda S. and Sherman, Linda A. (2012). PTPN22 alters the development of regulatory T cells in the thymus. Journal of Immunology, 188 (11), 5267-5275. doi: 10.4049/jimmunol.1200150 |
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2012 Journal Article Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5Hamilton-Williams, Emma E., Cheung, Jocelyn, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2012). Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes, 61 (1), 166-174. doi: 10.2337/db11-0790 |
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2011 Journal Article Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic miceSheng, Huiming, Hassanali, Saleena, Nugent, Courtney, Wen, Li, Hamilton-Williams, Emma, Dias, Peter and Dai, Yang D. (2011). Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. Journal of Immunology, 187 (4), 1591-1600. doi: 10.4049/jimmunol.1100231 |
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2011 Conference Publication Exosome-like microparticles can stimulate both innate and adaptive autoimmunity in non-obese diabetes miceDai, Yang, Sheng, Huiming, Hassanali, Saleema, Nugent, Courtney, Wen, Li, Hamilton-Williams, Emma and Dias, Peter (2011). Exosome-like microparticles can stimulate both innate and adaptive autoimmunity in non-obese diabetes mice. AMER ASSOC IMMUNOLOGISTS. |
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2010 Journal Article Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-CellsHamilton-Williams, Emma E., Wong, S.B. Justin, Martinez, Xavier, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2010). Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells. Diabetes, 59 (6), 1478-1486. doi: 10.2337/db09-1801 |
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2009 Journal Article Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic miceHamilton-Williams, Emma E., Martinez, Xavier, Clark, Jan, Howlett, Sarah, Hunter, Kara M., Rainbow, Daniel B., Wen, Li, Shlomchik, Mark J., Katz, Jonathan D., Beilhack, Georg F., Wicker, Linda S. and Sherman, Linda A. (2009). Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. Journal of Immunology, 183 (3), 1533-1541. doi: 10.4049/jimmunol.0900428 |
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2009 Journal Article Correction to: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injuryHeymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Correction to: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (7), 2114-2114. doi: 10.1172/JCI38399C1 |
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2009 Journal Article Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injuryHeymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (5), 1286-1297. doi: 10.1172/JCI38399 |
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2009 Conference Publication Antigen-specific suppression of non-lymphoid tissue auto-antibody production by CD25(+) FoxP3(+) regulatory T cellsKurts, Christian, Ludwig-Portugall, Isis, Hamilton-Williams, Emma E., Gottschalk, Catherine and Gotot, Janine (2009). Antigen-specific suppression of non-lymphoid tissue auto-antibody production by CD25(+) FoxP3(+) regulatory T cells. BETHESDA: AMER ASSOC IMMUNOLOGISTS. |
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2009 Journal Article CD25(+) T-reg specifically suppress auto-Ab generation against pancreatic tissue autoantigensLudwig-Portugall, Isis, Hamilton-Williams, Emma E., Gotot, Janine and Kurts, Christian (2009). CD25(+) T-reg specifically suppress auto-Ab generation against pancreatic tissue autoantigens. European Journal of Immunology, 39 (1), 225-233. doi: 10.1002/eji.200838699 |
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2009 Conference Publication Expression of the Diabetes Associated Alleles of ldd3 and ldd5 in DCs Drives Loss of Tolerance in NOD MiceHamilton-Williams, Emma E., Martinez, Xavier, Hunter, Kara M., Rainbow, Dan, Wicker, Linda S. and Sherman, Linda A. (2009). Expression of the Diabetes Associated Alleles of ldd3 and ldd5 in DCs Drives Loss of Tolerance in NOD Mice. 9th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, San Francisco Ca, Jun 11-14, 2009. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. doi: 10.1016/j.clim.2009.03.270 |
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2008 Journal Article Cutting edge: CD25(+) regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigensLudwig-Portugall, Isis, Hamilton-Williams, Emma E., Gottschalk, Catherine and Kurts, Christian (2008). Cutting edge: CD25(+) regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. Journal of Immunology, 181 (7), 4447-4451. doi: 10.4049/jimmunol.181.7.4447 |
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2008 Conference Publication CD8 T cells specific for a glomerular antigen induce renal inflammation in a CD4 help dependent fashion and may cause progressing GlomerulonephritisHeymann, F., Hamilton-Williams, E. E., Ludwig-Portugall, I., Quaggin, S., Floege, J., Groene, H. and Kurts, C. (2008). CD8 T cells specific for a glomerular antigen induce renal inflammation in a CD4 help dependent fashion and may cause progressing Glomerulonephritis. SPRINGER WIEN. |
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2008 Conference Publication Restoration of CD8 self-tolerance in NOD mice by protective Idd9 genesHamilton-Williams, Emma, Martinez, Javier, Wong, Justin, Wicker, Linda and Sherman, Linda (2008). Restoration of CD8 self-tolerance in NOD mice by protective Idd9 genes. FEDERATION AMER SOC EXP BIOL. |
