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2018 Journal Article Effect of Binding on Enantioselectivity of Epoxide HydrolaseZaugg, Julian, Gumulya, Yosephine, Bodén, Mikael, Mark, Alan E and Malde, Alpeshkumar K (2018). Effect of Binding on Enantioselectivity of Epoxide Hydrolase. Journal of Chemical Information and Modeling, 58 (3), 630-640. doi: 10.1021/acs.jcim.7b00353 |
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2018 Journal Article Determinants of thermostability in the cytochrome P450 foldHarris, Kurt L., Thomson, Raine E. S., Strohmaier, Silja J., Gumulya, Yosephine and Gillam, Elizabeth M. J. (2018). Determinants of thermostability in the cytochrome P450 fold. Biochimica et Biophysica Acta - Proteins and Proteomics, 1866 (1), 97-115. doi: 10.1016/j.bbapap.2017.08.003 |
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2017 Journal Article Learning epistatic interactions from sequence-activity data to predict enantioselectivityZaugg, Julian, Gumulya, Yosephine, Malde, Alpeshkumar K and Bodén, Mikael (2017). Learning epistatic interactions from sequence-activity data to predict enantioselectivity. Journal of computer-aided molecular design, 31 (12), 1085-1096. doi: 10.1007/s10822-017-0090-x |
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2017 Journal Article Genetically programmed chiral organoborane synthesisJennifer Kan, S. B., Huang, Xiongyi, Gumulya, Yosephine, Chen, Kai and Arnold, Frances H. (2017). Genetically programmed chiral organoborane synthesis. Nature, 552 (7683), 132-136. doi: 10.1038/nature24996 |
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2016 Journal Article Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro' approach to protein engineeringGumulya, Yosephine and Gillam, Elizabeth M. J. (2016). Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro' approach to protein engineering. Biochemical Journal, 474 (1), 1-19. doi: 10.1042/BCJ20160507 |
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2014 Book Chapter Computational tools for directed evolution: a comparison of prospective and retrospective strategiesZaugg, Julian, Gumulya, Yosephine, Gillam, Elizabeth M. J. and Bodén, Mikael (2014). Computational tools for directed evolution: a comparison of prospective and retrospective strategies. Directed evolution library creation: methods and protocols. (pp. 315-333) edited by Elizabeth M. J. Gillam, Janine N. Copp and David F. Ackerley. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-1053-3_21 |
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2012 Journal Article Many pathways in laboratory evolution can lead to improved enzymes: How to escape from local minimaGumulya, Yosephine, Sanchis, Joaquin and Reetz, Manfred T. (2012). Many pathways in laboratory evolution can lead to improved enzymes: How to escape from local minima. ChemBioChem, 13 (7), 1060-1066. doi: 10.1002/cbic.201100784 |
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2011 Journal Article Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary PathwaysGumulya, Yosephine and Reetz, Manfred T. (2011). Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary Pathways. ChemBioChem, 12 (16), 2502-2510. doi: 10.1002/cbic.201100412 |
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2010 Journal Article Increasing the stability of an enzyme toward hostile organic solvents by directed evolution based on iterative saturation mutagenesis using the B-FIT methodReetz, Manfred T., Soni, Pankaj, Fernandez, Layla, Gumulya, Yosephine and Carballeira, Jose D. (2010). Increasing the stability of an enzyme toward hostile organic solvents by directed evolution based on iterative saturation mutagenesis using the B-FIT method. Chemical Communications, 46 (45), 8657-8658. doi: 10.1039/c0cc02657c |
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2010 Journal Article Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methodsReetz, Manfred T., Prasad, Shreenath, Carballeira, Jose D., Gumulya, Yosephine and Bocola, Marco (2010). Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methods. Journal of the American Chemical Society, 132 (26), 9144-9152. doi: 10.1021/ja1030479 |
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2010 Journal Article An efficient method for mutant library creation in Pichia pastoris useful in directed evolutionFernandez, Layla, Jiao, Ning, Soni, Pankaj, Gumulya, Yosephine, De Oliveira, Luciana Gonzaga and Reetz, Manfred T. (2010). An efficient method for mutant library creation in Pichia pastoris useful in directed evolution. Biocatalysis and Biotransformation, 28 (2), 122-129. doi: 10.3109/10242420903505834 |
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2008 Journal Article Evaluation of the laccase from Myceliophthora thermophila as industrial biocatalyst for polymerization reactionsHollmann, Frank, Gumulya, Yosephine, Toelle, Christoph, Liese, Andreas and Thum, Oliver (2008). Evaluation of the laccase from Myceliophthora thermophila as industrial biocatalyst for polymerization reactions. Macromolecules, 41 (22), 8520-8524. doi: 10.1021/ma801763t |
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2008 Journal Article Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templatesSanchis, Joaquin, Fernandez, Layla, Carballeira, J. Daniel, Drone, Jullien, Gumulya, Yosephine, Hoebenreich, Horst, Kahakeaw, Daniel, Kille, Sabrina, Lohmer, Renate, Peyralans, Jerome J. -P., Podtetenieff, John, Prasad, Shreenath, Soni, Pankaj, Taglieber, Andreas, Wu, Sheng, Zilly, Felipe E. and Reetz, Manfred T. (2008). Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates. Applied Microbiology and Biotechnology, 81 (2), 387-397. doi: 10.1007/s00253-008-1678-9 |
