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2020 Journal Article Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cellsMasterman, Kelly-Anne, Haigh, Oscar L., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Walpole, Carina, Pearson, Frances E., Cebon, Jonathon, Schmidt, Christopher, O'Brien, Liam, Rosendahl, Nikita, Daraj, Ghazal, Caminschi, Irina, Gschweng, Eric H., Hollis, Roger P., Kohn, Donald B., Lahoud, Mireille H. and Radford, Kristen J. (2020). Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells. Journal for ImmunoTherapy of Cancer, 8 (2) e000691, 1-11. doi: 10.1136/jitc-2020-000691 |
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2020 Journal Article Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cellsPearson, Frances E., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Haigh, Oscar L., Masterman, Kelly-Anne, Walpole, Carina, Bridgeman, John S., McLaren, James E., Ladell, Kristin, Miners, Kelly, Llewellyn-Lacey, Sian, Price, David A., Tunger, Antje, Schmitz, Marc, Miles, John J., Lahoud, Mireille H. and Radford, Kristen J. (2020). Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells. Clinical and Translational Immunology, 9 (6) e1141, e1141. doi: 10.1002/cti2.1141 |
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2020 Journal Article Abstract B42: Human CD141+ dendritic cells (cDC1) are impaired in advanced melanoma patients but can be targeted to increase efficacy of anti-PD-1 checkpoint inhibitor therapyO’Brien, Liam, Lee, Yoke Seng, Walpole, Carina, Rojas, Ingrid Leal, Masterman, Kelly-Anne, Atkinson, Victoria, Barbour, Andrew and Radford, Kristen (2020). Abstract B42: Human CD141+ dendritic cells (cDC1) are impaired in advanced melanoma patients but can be targeted to increase efficacy of anti-PD-1 checkpoint inhibitor therapy. Cancer Immunology Research, 8 (3_Supplement). doi: 10.1158/2326-6074.tumimm19-b42 |
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2019 Journal Article MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activitySheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y |
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2019 Journal Article Can Dendritic Cell vaccination prevent leukemia relapse?O’Brien, Liam J., Guillerey, Camille and Radford, Kristen J. (2019). Can Dendritic Cell vaccination prevent leukemia relapse?. Cancers, 11 (6) 875, 875. doi: 10.3390/cancers11060875 |
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2019 Journal Article Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studiesLaw, Soi Cheng, Haigh, Oscar L., Walpole, Carina M., Keane, Colm, Miles, John, Gandhi, Maher K., Radford, Kristen J. and Steptoe, Raymond J. (2019). Simple, rapid and inexpensive typing of common HLA class I alleles for immunological studies. Journal of Immunological Methods, 465, 72-76. doi: 10.1016/j.jim.2018.12.002 |
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2018 Journal Article Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligationPearson, Frances E., Chang, Karshing, Minoda, Yoshihito, Leal Rojas, Ingrid M., Haigh, Oscar L., Daraj, Ghazal, Tullett, Kirsteen M. and Radford, Kristen J. (2018). Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR 3 and TLR 7/8 ligation. Immunology and Cell Biology, 96 (4), 390-400. doi: 10.1111/imcb.12009 |
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2017 Journal Article Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivoMinoda, Yoshihito, Virshup, Isaac, Rojas, Ingrid Leal, Haigh, Oscar, Wong, Yide, Miles, John J., Wells, Christine A. and Radford, Kristen J. (2017). Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo. Frontiers in Immunology, 8 (OCT) 1419, 1419. doi: 10.3389/fimmu.2017.01419 |
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2017 Journal Article Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cellsRojas, Ingrid M. Leal, Mok, Wai-Hong, Pearson, Frances E., Minoda, Yoshihito, Kenna, Tony J., Barnard, Ross T. and Radford, Kristen J. (2017). Human blood cD1c+ dendritic cells promote Th1 and Th17 effector function in memory cD4+ T cells. Frontiers in Immunology, 8 (AUG) 971, 971. doi: 10.3389/fimmu.2017.00971 |
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2016 Journal Article Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognitionTullett, Kirsteen M., Leal Rojas, Ingrid M., Minoda, Yoshihito, Tan, Peck S., Zhang, Jian-Guo, Smith, Corey, Khanna, Rajiv, Shortman, Ken, Caminschi, Irina, Lahoud, Mireille H. and Radford, Kristen J. (2016). Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+ T cell recognition. JCI Insight, 1 (7) e87102, e87102. doi: 10.1172/jci.insight.87102 |
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2015 Journal Article T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complexBeringer, Dennis X., Kleijwegt, Fleur S., Wiede, Florian, Van Der Slik, Arno R., Loh, Khai Lee, Petersen, Jan, Dudek, Nadine L., Duinkerken, Gaby, Laban, Sandra, Joosten, Antoinette, Vivian, Julian P., Chen, Zhenjun, Uldrich, Anthony W., Godfrey, Dale I., McCluskey, James, Price, David A., Radford, Kristen J., Purcell, Anthony W., Nikolic, Tatjana, Reid, Hugh H., Tiganis, Tony, Roep, Bart O. and Rossjohn, Jamie (2015). T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nature Immunology, 16 (11), 1153-1161. doi: 10.1038/ni.3271 |
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2015 Journal Article Human dendritic cell subsets and function in health and diseaseO'Keeffe, Meredith., Mok, Wai Hong. and Radford, Kristen J. (2015). Human dendritic cell subsets and function in health and disease. Cellular and Molecular Life Sciences, 72 (22), 4309-4325. doi: 10.1007/s00018-015-2005-0 |
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2015 Journal Article Differential use of autophagy by primary dendritic cells specialized in cross-presentationMintern, Justine D., Macri, Christophe, Chin, Wei Jin, Panozza, Scott E., Segura, Elodie, Patterson, Natalie L., Zeller, Peter, Bourges, Dorothee, Bedoui, Sammy, McMillan, Paul J., Idris, Adi, Nowell, Cameron J., Brown, Andrew, Radford, Kristen J., Johnston, Angus P. R. and Villadangos, Jose A. (2015). Differential use of autophagy by primary dendritic cells specialized in cross-presentation. Autophagy, 11 (6), 906-917. doi: 10.1080/15548627.2015.1045178 |
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2015 Journal Article A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancerPrue, Rebecca L., Vari, Frank, Radford, Kristen J., Tong, Hui, Hardy, Melinda Y., D'Rozario, Rachael, Waterhouse, Nigel J., Rossetti, Tony, Coleman, Robert, Tracey, Christopher, Goossen, Hans, Gounder, Vinay, Crosbie, Georgina, Hancock, Sonia, Diaz-Guilas, Stephanie, Mainwaring, Paul, Swindle, Peter and Hart, Derek N. J. (2015). A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A*0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer. Journal of Immunotherapy, 38 (2), 71-76. doi: 10.1097/CJI.0000000000000063 |
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2015 Journal Article Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsetsChiang, Meng-Chieh, Tullett, Kirsteen M., Lee, Yoke Seng, Idris, Adi, Ding, Yitian, McDonald, Kylie J., Kassianos, Andrew, Leal Rojas, Ingrid M., Jeet, Varinder, Lahoud, Mireille H. and Radford, Kristen J. (2015). Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets. European Journal of Immunology, 46 (2), 329-339. doi: 10.1002/eji.201546023 |
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2014 Journal Article Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapyTullett, Kirsteen M., Lahoud, Mireille H. and Radford, Kristen J. (2014). Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapy. Frontiers in Immunology, 5 (MAY) Article 239, 1-1. doi: 10.3389/fimmu.2014.00239 |
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2014 Journal Article Dendritic cells and cancer immunotherapyRadford, Kristen J., Tullett, Kirsteen M. and Lahoud, Mireille H. (2014). Dendritic cells and cancer immunotherapy. Current Opinion in Immunology, 27 (1), 26-32. doi: 10.1016/j.coi.2014.01.005 |
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2014 Journal Article FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivoDing, Yitian, Wilkinson, Andrew, Idris, Adi, Fancke, Ben, O’Keeffe, Meredith, Khalil, Dalia, Ju, Xinsheng, Lahoud, Mireille H., Caminschi, Irina, Shortman, Ken, Rodwell, Robyn, Vuckovic, Slavica and Radford, Kristen J. (2014). FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo. Journal of Immunology. doi: 10.4049/jimmunol.1302391 |
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2013 Journal Article New generation of dendritic cell vaccinesRadford, Kristen J. and Caminschi, Irina (2013). New generation of dendritic cell vaccines. Human Vaccines and Immunotherapeutics, 9 (2), 259-264. doi: 10.4161/hv.22487 |
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2012 Journal Article Mincle polarizes human monocyte and neutrophil responses to Candida albicansVijayan, Dipti, Radford, Kristen J., Beckhouse, Anthony G., Ashman, Robert B. and Wells, Christine A. (2012). Mincle polarizes human monocyte and neutrophil responses to Candida albicans. Immunology and Cell Biology, 90 (9), 889-895. doi: 10.1038/icb.2012.24 |
