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2012 Journal Article Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLARamasamy, Adaikalavan, Kuokkanen, Mikko, Vedantam, Sailaja, Gajdos, Zofia K., Alves, Alexessander Couto, Lyon, Helen N., Ferreira, Manuel A. R., Strachan, David P., Zhao, Jing Hua, Abramson, Michael J., Brown, Matthew A., Coin, Lachlan, Dharmage, Shyamali C., Duffy, David L., Haahtela, Tari, Heath, Andrew C., Janson, Christer, Kahonen, Mika, Khaw, Kay-Tee, Laitinen, Jaana, Le Souef, Peter, Lehtimaki, Terho, Madden, Pamela A. F., Marks, Guy B., Martin, Nicholas G., Matheson, Melanie C., Palmer, Cameron D., Palotie, Aarno, Pouta, Anneli ... Hirschhorn, Joel N. (2012). Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA. PLoS One, 7 (9 Article No. e44008) e44008, e44008-1-e44008-10. doi: 10.1371/journal.pone.0044008 |
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2012 Journal Article Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortiumVerhoeven, Virginie J. M., Hysi, Pirro G., Saw, Seang-Mei, Vitart, Veronique, Mirshahi, Alireza, Guggenheim, Jeremy A., Cotch, Mary Frances, Yamashiro, Kenji, Baird, Paul N., Mackey, David A., Wojciechowski, Robert, Ikram, M. Kamran, Hewitt, Alex W., Duggal, Priya, Janmahasatian, Sarayut, Khor, Chiea-Chuen, Fan, Qiao, Zhou, Xin, Young, Terri L., Tai, E-Shyong, Goh, Liang-Kee, Li, Yi-Ju, Aung, Tin, Vithana, Eranga, Teo, Yik-Ying, Tay, Wanting, Sim, Xueling, Rudan, Igor, Hayward, Caroline ... Klaver, Caroline C. W. (2012). Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Human Genetics, 131 (9), 1467-1480. doi: 10.1007/s00439-012-1176-0 |
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2012 Journal Article Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokersHartz, Sarah M., Short, Susan E., Saccone, Nancy L., Culverhouse, Robert, Chen, LiShiun, Schwantes-An, Tae-Hwi, Coon, Hilary, Han, Younghun, Stephens, Sarah H., Sun, Juzhong, Chen, Xiangning, Ducci, Francesca, Dueker, Nicole, Franceschini, Nora, Frank, Josef, Geller, Frank, Guobjartsson, Daniel, Hansel, Nadia N., Jiang, Chenhui, Keskitalo-Vuokko, Kaisu, Liu, Zhen, Lyytikainen, Leo-Pekka, Michel, Martha, Rawal, Rajesh, Hum, Sc, Rosenberger, Albert, Scheet, Paul, Shaffer, John R., Teumer, Alexander ... Bierut, Laura J. (2012). Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Archives of General Psychiatry, 69 (8), 854-861. doi: 10.1001/archgenpsychiatry.2012.124 |
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2012 Journal Article Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for AtherosclerosisInouye, Michael, Ripatti, Samuli, Kettunen, Johannes, Lyytikainen, Leo-Pekka, Oksala, Niku, Laurila, Pirkka-Pekka, Kangas, Antti J., Soininen, Pasi, Savolainen, Markku J., Viikari, Jorma, Kahonen, Mika, Perola, Markus, Salomaa, Veikko, Raitakari, Olli, Lehtimaki, Terho, Taskinen, Marja-Riitta, Jaervelin, Marjo-Riitta, Ala-Korpela, Mika, Palotie, Aarno and de Bakker, Paul I. W. (2012). Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis. Plos Genetics, 8 (8) e1002907. doi: 10.1371/journal.pgen.1002907 |
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2012 Journal Article Childhood Physical, Environmental, and Genetic Predictors of Adult Hypertension The Cardiovascular Risk in Young Finns StudyJuhola, Jonna, Oikonen, Mervi, Magnussen, Costan G., Mikkila, Vera, Siitonen, Niina, Jokinen, Eero, Laitinen, Tomi, Wurtz, Peter, Gidding, Samuel S., Taittonen, Leena, Seppala, Ilkka, Jula, Antti, Kahonen, Mika, Hutri-Kahonen, Nina, Lehtimaki, Terho, Viikari, Jorma S. A., Juonala, Markus and Raitakari, Olli T. (2012). Childhood Physical, Environmental, and Genetic Predictors of Adult Hypertension The Cardiovascular Risk in Young Finns Study. Circulation, 126 (4), 402-409. doi: 10.1161/CIRCULATIONAHA.111.085977 |
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2012 Journal Article WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture riskZheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimaki, Terho, Bergstrom, Ulrica, Kahonen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lyytikainen, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, Prince, Richard L., Sievanen, Harri, Leslie, William D., Mellstrom, Dan, Eisman, John A., Moverare-Skrtic, Sofia, Goltzman, David, Hanley, David A., Jones, Graeme, Pourcain, Beate St. ... Lorentzon, Mattias (2012). WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. Plos Genetics, 8 (7) e1002745, e1002745.1-e1002745.13. doi: 10.1371/journal.pgen.1002745 |
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2012 Journal Article Evidence of inbreeding depression on human heightMcQuillan, Ruth, Eklund, Niina, Pirastu, Nicola, Kuningas, Maris, McEvoy, Brian P., Esko, Tonu, Corre, Tanguy, Davies, Gail, Kaakinen, Marika, Lyytikainen, Leo-Pekka, Kristiansson, Kati, Havulinna, Aki S., Gogele, Martin, Vitart, Veronique, Tenesa, Albert, Aulchenko, Yurii, Hayward, Caroline, Johansson, Asa, Boban, Mladen, Ulivi, Sheila, Robino, Antonietta, Boraska, Vesna, Igl, Wilmar, Wild, Sarah H., Zgaga, Lina, Amin, Najaf, Theodoratou, Evropi, Polasek, Ozren, Girotto, Giorgia ... Wilson, James F. (2012). Evidence of inbreeding depression on human height. Plos Genetics, 8 (7) e1002655, e1002655. doi: 10.1371/journal.pgen.1002655 |
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2012 Journal Article A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone RegulationCoviello, Andrea D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimaki, Terho, Keildson, Sarah, Lunetta, Kathryn L., He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Mei, Yong, Koster, Annemarie, Lohman, Kurt, Lyytikainen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R., Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania ... Perry, John R. B. (2012). A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation. Plos Genetics, 8 (7) e1002805. doi: 10.1371/journal.pgen.1002805 |
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2012 Journal Article Selection and microevolution of coat pattern are cryptic in a wild population of sheepGratten, J., Pilkington, J. G., Brown, E. A., Clutton-Brock, T. H., Pemberton, J. M. and Slate, J. (2012). Selection and microevolution of coat pattern are cryptic in a wild population of sheep. Molecular Ecology, 21 (12), 2977-2990. doi: 10.1111/j.1365-294X.2012.05536.x |
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2012 Journal Article The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variantsMowry, B. J. and Gratten, J. (2012). The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants. Molecular Psychiatry, 18 (1), 38-52. doi: 10.1038/mp.2012.34 |
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2012 Journal Article Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fractureEstrada, Karol, Styrkarsdottir, Unnur, Evangelou, Evangelos, Hsu, Yi-Hsiang, Duncan, Emma L., Ntzani, Evangelia E., Oei, Ling, Albagha, Omar M. E., Amin, Najaf, Kemp, John P., Koller, Daniel L., Li, Guo, Liu, Ching-Ti, Minster, Ryan L., Moayyeri, Alireza, Vandenput, Liesbeth, Willner, Dana, Xiao, Su-Mei, Yerges-Armstrong, Laura M., Zheng, Hou-Feng, Alonso, Nerea, Eriksson, Joel, Kammerer, Candace M., Kaptoge, Stephen K., Leo, Paul J., Thorleifsson, Gudmar, Wilson, Scott G., Wilson, James F., Aalto, Ville ... Rivadeneira, Fernando (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44 (5), 491-501. doi: 10.1038/ng.2249 |
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2012 Journal Article Parental Smoking in Childhood and Brachial Artery Flow-Mediated Dilatation in Young Adults The Cardiovascular Risk in Young Finns Study and the Childhood Determinants of Adult Health StudyJuonala, Markus, Magnussen, Costan G., Venn, Alison, Gall, Seana, Kahonen, Mika, Laitinen, Tomi, Taittonen, Leena, Lehtimaki, Terho, Jokinen, Eero, Sun, Cong, Viikari, Jorma S. A., Dwyer, Terence and Raitakari, Olli T. (2012). Parental Smoking in Childhood and Brachial Artery Flow-Mediated Dilatation in Young Adults The Cardiovascular Risk in Young Finns Study and the Childhood Determinants of Adult Health Study. Arteriosclerosis Thrombosis and Vascular Biology, 32 (4), 1024-1031. doi: 10.1161/ATVBAHA.111.243261 |
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2012 Journal Article Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome TraitsKristiansson, Kati, Perola, Markus, Tikkanen, Emmi, Kettunen, Johannes, Surakka, Ida, Havulinna, Aki S., Stancakova, Alena, Barnes, Chris, Widen, Elisabeth, Kajantie, Eero, Eriksson, Johan G., Viikari, Jorma, Kahonen, Mika, Lehtimaki, Terho, Raitakari, Olli T., Hartikainen, Anna-Liisa, Ruokonen, Aimo, Pouta, Anneli, Jula, Antti, Kangas, Antti J., Soininen, Pasi, Ala-Korpela, Mika, Mannisto, Satu, Jousilahti, Pekka, Bonnycastle, Lori L., Jarvelin, Marjo-Riitta, Kuusisto, Johanna, Collins, Francis S., Laakso, Markku ... Salomaa, Veikko (2012). Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits. Circulation-Cardiovascular Genetics, 5 (2), 242-249. doi: 10.1161/CIRCGENETICS.111.961482 |
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2012 Journal Article Genome-wide association study identifies multiple loci influencing human serum metabolite levelsKettunen, Johannes, Tukiainen, Taru, Sarin, Antti-Pekka, Ortega-Alonso, Alfredo, Tikkanen, Emmi, Lyytikainen, Leo-Pekka, Kangas, Antti J., Soininen, Pasi, Wuertz, Peter, Silander, Kaisa, Dick, Danielle M., Rose, Richard J., Savolainen, Markku J., Viikari, Jorma, Kahonen, Mika, Lehtimaki, Terho, Pietilainen, Kirsi H., Inouye, Michael, McCarthy, Mark I., Jula, Antti, Eriksson, Johan, Raitakari, Olli T., Salomaa, Veikko, Kaprio, Jaakko, Jarvelin, Marjo-Riitta, Peltonen, Leena, Perola, Markus, Freimer, Nelson B., Ala-Korpela, Mika ... Ripatti, Samuli (2012). Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nature Genetics, 44 (3), 269-U65. doi: 10.1038/ng.1073 |
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2012 Journal Article Supine and upright haemodynamic effects of sublingual nitroglycerin and inhaled salbutamol: a double-blind, placebo-controlled, randomized studyTahvanainen, Anna M., Tikkakoski, Antti J., Leskinen, Miia H., Nordhausen, Klaus, Kahonen, Mika, Koobi, Tiit, Mustonen, Jukka T. and Porsti, Ilkka H. (2012). Supine and upright haemodynamic effects of sublingual nitroglycerin and inhaled salbutamol: a double-blind, placebo-controlled, randomized study. Journal of Hypertension, 30 (2), 297-306. doi: 10.1097/HJH.0b013e32834e4b26 |
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2012 Journal Article Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey - A Meta-Analysis of Three Independent StudiesHernesniemi, Jussi A., Seppala, Ilkka, Lyytikainen, Leo-Pekka, Mononen, Nina, Oksala, Niku, Hutri-Kahonen, Nina, Juonala, Markus, Taittonen, Leena, Smith, Erin N., Schork, Nicholas J., Chen, Wei, Srinivasan, Sathanur R., Berenson, Gerald S., Murray, Sarah S., Laitinen, Tomi, Jula, Antti, Kettunen, Johannes, Ripatti, Samuli, Laaksonen, Reijo, Viikari, Jorma, Kahonen, Mika, Raitakari, Olli T. and Lehtimaki, Terho (2012). Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey - A Meta-Analysis of Three Independent Studies. Plos One, 7 (1) e28931. doi: 10.1371/journal.pone.0028931 |
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2011 Journal Article Fetal Growth and Preterm Birth Influence Cardiovascular Risk Factors and Arterial Health in Young Adults The Cardiovascular Risk in Young Finns StudySkilton, Michael R., Viikari, Jorma S. A., Juonala, Markus, Laitinen, Tomi, Lehtimaki, Terho, Taittonen, Leena, Kahonen, Mika, Celermajer, David S. and Raitakari, Olli T. (2011). Fetal Growth and Preterm Birth Influence Cardiovascular Risk Factors and Arterial Health in Young Adults The Cardiovascular Risk in Young Finns Study. Arteriosclerosis Thrombosis and Vascular Biology, 31 (12), 2975-2981. doi: 10.1161/ATVBAHA.111.234757 |
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2011 Journal Article Genetic Variants and Blood Pressure in a Population-Based Cohort The Cardiovascular Risk in Young Finns StudyOikonen, Mervi, Tikkanen, Emmi, Juhola, Jonna, Tuovinen, Tarja, Seppala, Ilkka, Juonala, Markus, Taittonen, Leena, Mikkila, Vera, Kahonen, Mika, Ripatti, Samuli, Viikari, Jorma, Lehtimaki, Terho, Havulinna, Aki S., Kee, Frank, Newton-Cheh, Christopher, Peltonen, Leena, Schork, Nicholas J., Murray, Sarah S., Berenson, Gerald S., Chen, Wei, Srinivasan, Sathanur R., Salomaa, Veikko and Raitakari, Olli T. (2011). Genetic Variants and Blood Pressure in a Population-Based Cohort The Cardiovascular Risk in Young Finns Study. Hypertension, 58 (6), 1079-U228. doi: 10.1161/HYPERTENSIONAHA.111.179291 |
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2011 Journal Article A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterolSurakka, Ida, Isaacs, Aaron, Karssen, Lennart C., Laurila, Pirkka-Pekka P., Middelberg, Rita P. S., Tikkanen, Emmi, Ried, Janina S., Lamina, Claudia, Mangino, Massimo, Igl, Wilmar, Hottenga, Jouke-Jan, Lagou, Vasiliki, van der Harst, Pim, Leach, Irene Mateo, Esko, Tonu, Kutalik, Zoltan, Wainwright, Nicholas W., Struchalin, Maksim V., Sarin, Antti-Pekka, Kangas, Antti J., Viikari, Jorma S., Perola, Markus, Rantanen, Taina, Petersen, Ann-Kristin, Soininen, Pasi, Johansson, Asa, Soranzo, Nicole, Heath, Andrew C., Papamarkou, Theodore ... Ripatti, Samuli (2011). A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. PLoS Genetics, 7 (10) e1002333, e1002333. doi: 10.1371/journal.pgen.1002333 |
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2011 Journal Article Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaqueBis, Joshua C., Kavousi, Maryam, Franceschini, Nora, Isaacs, Aaron, Abecasis, Goncalo R., Schminke, Ulf, Post, Wendy S., Smith, Albert V., Cupples, L. Adrienne, Markus, Hugh S., Schmidt, Reinhold, Huffman, Jennifer E., Lehtimaki, Terho, Baumert, Jens, Muenzel, Thomas, Heckbert, Susan R., Dehghan, Abbas, North, Kari, Oostra, Ben, Bevan, Steve, Stoegerer, Eva-Maria, Hayward, Caroline, Raitakari, Olli, Meisinger, Christa, Schillert, Arne, Sanna, Serena, Voelzke, Henry, Cheng, Yu-Ching, Thorsson, Bolli ... O'Donnell, Christopher J. (2011). Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nature Genetics, 43 (10), 940-U40. doi: 10.1038/ng.920 |
