
Overview
Background
Dr Antiopi Varelias leads the Transplantation Immunology laboratory at the QIMR Berghofer Medical Research Institute, Brisbane, Australia and is the Coordinator of the Immunology and Infectious diseases seminar series at the Institute. She was awarded her PhD from The University of Adelaide (Faculty of Medicine) in 2002 and held post-doctoral positions within the University of Adelaide’s Department of Surgery (TQEH) and Haematology/Oncology Unit, TQEH before moving to Brisbane to join the Bone Marrow Transplantation laboratory at QIMR Berghofer in 2008, at the time led by Professor Geoff Hill. Under Professor Hill’s mentorship, she has published many original research articles in peer-reviewed high-ranking journals on graft-versus-host disease and has presented her research findings at many international and national scientific meetings. As a chief investigator, she has been the recipient of funding from the NH&MRC and CCQ and is a member of several professional societies (ASTCT, TTS, TSANZ, AAI, ASI, SMI, ICIS).
Dr Varelias’s research interests focus on improving our fundamental understanding of the pathophysiology of graft-versus-host disease using innovative technologies and pre-clinical models, with the view of translating these findings into clinical practice and thereby provide better transplant outcomes for patients. Current research aims to define the immunological basis that underpins graft-versus-host disease, with an emphasis on cellular, cytokine and microbiome interactions that regulate mucosal immunity during stem cell transplantation.
Availability
- Dr Antiopi Varelias is:
- Available for supervision
Works
Search Professor Antiopi Varelias’s works on UQ eSpace
2013
Journal Article
Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo
Zhang, Ping, Tey, Siok-Keen, Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Raju, Jyothy, Leveque, Lucie, Markey, Kate A., Varelias, Antiopi, Clouston, Andrew D., Lane, Steven W., Macdonald, Kelli P. A. and Hill, Geoffrey R. (2013). Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo. Journal of Immunology, 191 (10), 5291-5303. doi: 10.4049/jimmunol.1301181
2013
Journal Article
Promoting regulation via the inhibition of DNAM-1 after transplantation
Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Leveque, Lucie, Chan, Christopher J., Robb, Renee J., Markey, Kate A., Alexander, Kylie A., Varelias, Antiopi, Clouston, Andrew D., Smyth, Mark J., MacDonald, Kelli P.A. and Hill, Geoffrey R. (2013). Promoting regulation via the inhibition of DNAM-1 after transplantation. Blood, 121 (17), 3511-3520. doi: 10.1182/blood-2012-07-444026
2012
Journal Article
Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets
Markey, Kate A., Koyama, Motoko, Kuns, Rachel D., Lineburg, Katie E., Wilson, Yana A., Olver, Stuart D., Raffelt, Neil C., Don, Alistair L. J., Varelias, Antiopi, Robb, Renee J., Cheong, Melody, Engwerda, Christian R., Steptoe, Raymond J., Ramshaw, Hayley S., Lopez, Angel F., Vega-Ramos, Javier, Lew, Andrew M., Villadangos, Jose A., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2012). Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets. Blood, 119 (24), 5918-5930. doi: 10.1182/blood-2011-12-398164
2012
Journal Article
Identification and expansion of highly suppressive CD8 +FoxP3 + regulatory T cells after experimental allogeneic bone marrow transplantation
Robb, R.J., Lineburg, K.E., Kuns, R.D., Wilson, Y.A., Raffelt, N.C., Olver, S.D., Varelias, A., Alexander, K.A., Teal, B.E., Sparwasser, T., Hammerling, G.J., Markey, K.A., Koyama, M., Clouston, A.D., Engwerda, C.R., Hill, G.R. and MacDonald, K.P.A. (2012). Identification and expansion of highly suppressive CD8 +FoxP3 + regulatory T cells after experimental allogeneic bone marrow transplantation. Blood, 119 (24), 5898-5908. doi: 10.1182/blood-2011-12-396119
2012
Journal Article
Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease
Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Raffelt, Neil C., Wilson, Yana A., Don, Alistair L. J., Lineburg, Katie E., Cheong, Melody, Robb, Renee J., Markey, Kate A., Varelias, Antiopi, Malissen, Bernard, Hammerling, Gunter J., Clouston, Andrew D., Engwerda, Christian R., Bhat, Purnima, MacDonald, Kelli P. A. and Hill, Geoffrey R. (2012). Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease. Nature Medicine, 18 (1), 135-142. doi: 10.1038/nm.2597
2011
Journal Article
Type I-IFNs control GVHD and GVL responses after transplantation
Robb, Renee J., Kreijveld, Ellen, Kuns, Rachel D., Wilson, Yana A., Olver, Stuart D., Don, Alistair L. J., Raffelt, Neil C., De Weerd, Nicole A., Lineburg, Katie E., Varelias, Antiopi, Markey, Kate A., Koyama, Motoko, Clouston, Andrew D., Hertzog, Paul J., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2011). Type I-IFNs control GVHD and GVL responses after transplantation. Blood, 118 (12), 3399-3409. doi: 10.1182/blood-2010-12-325746
2010
Journal Article
Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma
Hill, Geoffrey R., Olver, Stuart D., Kuns, Rachel D., Varelias, Antiopi, Raffelt, Neil C., Don, Alistair L., Markey, Kate A., Wilson, Yana A., Smyth, Mark J., Iwakura, Yoichiro, Tocker, Joel, Clouston, Andrew D. and MacDonald, Kelli P. A. (2010). Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood, 116 (5), 819-828. doi: 10.1182/blood-2009-11-256495
Supervision
Availability
- Dr Antiopi Varelias is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Defining the critical determinants of viral-mediated pneumonitis after bone marrow transplantation.
Principal Advisor
Other advisors: Dr Quan Nguyen, Dr Seweryn Bialasiewicz
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Doctor Philosophy
Pathogenic and Protective Cytokine Interactions in Graft-versus-Host Disease
Associate Advisor
Completed supervision
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2021
Doctor Philosophy
Classification and functional characterisation of the murine gut bacterial family Muribaculaceae
Associate Advisor
Other advisors: Professor Phil Hugenholtz
Media
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