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Dr Antiopi Varelias
Dr

Antiopi Varelias

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Overview

Background

Dr Antiopi Varelias leads the Transplantation Immunology laboratory at the QIMR Berghofer Medical Research Institute, Brisbane, Australia and is the Coordinator of the Immunology and Infectious diseases seminar series at the Institute. She was awarded her PhD from The University of Adelaide (Faculty of Medicine) in 2002 and held post-doctoral positions within the University of Adelaide’s Department of Surgery (TQEH) and Haematology/Oncology Unit, TQEH before moving to Brisbane to join the Bone Marrow Transplantation laboratory at QIMR Berghofer in 2008, at the time led by Professor Geoff Hill. Under Professor Hill’s mentorship, she has published many original research articles in peer-reviewed high-ranking journals on graft-versus-host disease and has presented her research findings at many international and national scientific meetings. As a chief investigator, she has been the recipient of funding from the NH&MRC and CCQ and is a member of several professional societies (ASTCT, TTS, TSANZ, AAI, ASI, SMI, ICIS).

Dr Varelias’s research interests focus on improving our fundamental understanding of the pathophysiology of graft-versus-host disease using innovative technologies and pre-clinical models, with the view of translating these findings into clinical practice and thereby provide better transplant outcomes for patients. Current research aims to define the immunological basis that underpins graft-versus-host disease, with an emphasis on cellular, cytokine and microbiome interactions that regulate mucosal immunity during stem cell transplantation.

Availability

Dr Antiopi Varelias is:
Available for supervision

Works

Search Professor Antiopi Varelias’s works on UQ eSpace

45 works between 2010 and 2024

1 - 20 of 45 works

Featured

2019

Journal Article

Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization

Varelias, Antiopi, Gartlan, Kate H., Wilkinson, Andrew N., Olver, Stuart D., Samson, Luke D., Tey, Siok-Keen, MacDonald, Kelli P. A. and Hill, Geoffrey R. (2019). Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization. Blood Advances, 3 (5), 718-723. doi: 10.1182/bloodadvances.2018025601

Expansion of IL-17A-secreting CD8 + mucosa-associated invariant T cells in peripheral blood following stem cell mobilization

Featured

2018

Journal Article

Recipient mucosal-associated invariant T cells control GVHD within the colon

Varelias, Antiopi, Bunting, Mark D., Ormerod, Kate L., Koyama, Motoko, Olver, Stuart D., Straube, Jasmin, Kuns, Rachel D., Robb, Renee J., Henden, Andrea S., Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H., Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Y. W., Fairlie, David P., Clouston, Andrew D., McCluskey, James, Rossjohn, Jamie, Lane, Steven W., Hugenholtz, Philip and Hill, Geoffrey R. (2018). Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation, 128 (5), 1919-1936. doi: 10.1172/JCI91646

Recipient mucosal-associated invariant T cells control GVHD within the colon

Featured

2017

Journal Article

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A ., Hugenholtz, Philip and Hill, Geoffrey R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood, 129 (15), 2172-2185. doi: 10.1182/blood-2016-08-732628

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Featured

2015

Journal Article

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

Varelias, Antiopi, Gartlan, Kate H., Kreijveld, Ellen, Olver, Stuart D., Lor, Mary, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Raffelt, Neil C., Cheong, Melody, Alexander, Kylie A., Koyama, Motoko, Markey, Kate A., Sturgeon, Elise, Leach, Justine, Reddy, Pavan, Kennedy, Glen A., Yanik, Gregory A., Blazar, Bruce R., Tey, Siok-Keen, Clouston, Andrew D., MacDonald, Kelli P. A., Cooke, Kenneth R. and Hill, Geoffrey R. (2015). Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation. Blood, 125 (15), 2435-2444. doi: 10.1182/blood-2014-07-590232

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

Featured

2014

Journal Article

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

Kennedy, Glen A., Varelias, Antiopi, Vuckovic, Slavica, Le Texier, Laetitia, Gartlan, Kate H., Zhang, Ping, Thomas, Gethin, Anderson, Lisa, Boyle, Glen, Cloonan, Nicole, Leach, Justine, Sturgeon, Elise, Avery, Judy, Olver, Stuart D., Lor, Mary, Misra, Ashish K., Hutchins, Cheryl, Morton, A. James, Durrant, Simon T. S., Subramoniapillai, Elango, Butler, Jason P., Curley, Cameron I., MacDonald, Kelli P. A., Tey, Siok-Keen and Hill, Geoffrey R. (2014). Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. The Lancet Oncology, 15 (13), 1451-1459. doi: 10.1016/S1470-2045(14)71017-4

Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial

2024

Journal Article

Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD

Wang, Yewei, Ullah, Md Ashik, Waltner, Olivia G., Bhise, Shruti S., Ensbey, Kathleen S., Schmidt, Christine R., Legg, Samuel R.W., Sekiguchi, Tomoko, Nelson, Ethan L., Kuns, Rachel D., Nemychenkov, Nicole S., Atilla, Erden, Yeh, Albert C., Takahashi, Shuichiro, Boiko, Julie R., Varelias, Antiopi, Blazar, Bruce R., Koyama, Motoko, Minnie, Simone A., Clouston, Andrew D., Furlan, Scott N., Zhang, Ping and Hill, Geoffrey R. (2024). Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD. Journal of Clinical Investigation, 134 (11) e170125, 19-19. doi: 10.1172/jci170125

Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD

2024

Journal Article

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation

Zhang, Ping, Fleming, Peter, Andoniou, Christopher E., Waltner, Olivia G., Bhise, Shruti S., Martins, Jose Paulo, McEnroe, Benjamin A., Voigt, Valentina, Daly, Sheridan, Kuns, Rachel D., Ekwe, Adaeze P., Henden, Andrea S., Saldan, Alda, Olver, Stuart, Varelias, Antiopi, Smith, Corey, Schmidt, Christine R., Ensbey, Kathleen S., Legg, Samuel R.W., Sekiguchi, Tomoko, Minnie, Simone A., Gradwell, Mark, Wagenaar, Irma, Clouston, Andrew D., Koyama, Motoko, Furlan, Scott N., Kennedy, Glen A., Ward, E Sally, Degli-Esposti, Mariapia A. ... Tey, Siok-Keen (2024). IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation. Journal of Clinical Investigation, 134 (7) e174184. doi: 10.1172/jci174184

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation

2024

Journal Article

Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation

Takahashi, Shuichiro, Minnie, Simone A., Ensbey, Kathleen S., Schmidt, Christine R., Sekiguchi, Tomoko, Legg, Samuel R. W., Zhang, Ping, Koyama, Motoko, Olver, Stuart D., Collinge, Alika D., Keshmiri, Sara, Comstock, Melissa L., Varelias, Antiopi, Green, Damian J. and Hill, Geoffrey R. (2024). Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Blood, 143 (16), 1656-1669. doi: 10.1182/blood.2023022000

Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation

2023

Journal Article

Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity

Koyama, Motoko, Hippe, Daniel S., Srinivasan, Sujatha, Proll, Sean C., Miltiadous, Oriana, Li, Naisi, Zhang, Ping, Ensbey, Kathleen S., Hoffman, Noah G., Schmidt, Christine R., Yeh, Albert C., Minnie, Simone A., Strenk, Susan M., Fiedler, Tina L., Hattangady, Namita, Kowalsky, Jacob, Grady, Willian M., Degli-Esposti, Mariapia A., Varelias, Antiopi, Clouston, Andrew D., van den Brink, Marcel R.M., Dey, Neelendu, Randolph, Timothy W., Markey, Kate A., Fredricks, David N. and Hill, Geoffrey R. (2023). Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity. Immunity, 56 (8), 1876-1893.e8. doi: 10.1016/j.immuni.2023.06.024

Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity

2022

Journal Article

TIGIT inhibition and lenalidomide synergistically promote anti-myeloma immune responses after stem cell transplantation in mice

Minnie, Simone A., Waltner, Olivia G., Ensbey, Kathleen S., Olver, Stuart D., Collinge, Alika D., Sester, David P., Schmidt, Christine R., Legg, Samuel R.W., Takahashi, Shuichiro, Nemychenkov, Nicole S., Sekiguchi, Tomoko, Driessens, Gregory, Zhang, Ping, Koyama, Motoko, Spencer, Andrew, Holmberg, Leona A., Furlan, Scott N., Varelias, Antiopi and Hill, Geoffrey R. (2022). TIGIT inhibition and lenalidomide synergistically promote anti-myeloma immune responses after stem cell transplantation in mice. Journal of Clinical Investigation, 133 (4) e157907, 1-11. doi: 10.1172/jci157907

TIGIT inhibition and lenalidomide synergistically promote anti-myeloma immune responses after stem cell transplantation in mice

2022

Journal Article

Editorial: Mouse Models of Hematopoietic Stem Cell Transplantation

Varelias, Antiopi, Zhang, Ping and Hashimoto, Daigo (2022). Editorial: Mouse Models of Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 13 882592, 1-2. doi: 10.3389/fimmu.2022.882592

Editorial: Mouse Models of Hematopoietic Stem Cell Transplantation

2022

Journal Article

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children

Oyong, Damian. A., Loughland, Jessica. R., Soon, Megan. S.F., Chan, Jo-Anne, Andrew, Dean, Wines, Bruce D., Hogarth, P. Mark, Olver, Stuart D., Collinge, Alika D., Varelias, Antiopi, Beeson, James G., Kenangalem, Enny, Price, Ric N., Anstey, Nicholas M., Minigo, Gabriela and Boyle, Michelle J. (2022). Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children. eBioMedicine, 75 103784, 1-22. doi: 10.1016/j.ebiom.2021.103784

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children

2021

Journal Article

CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant

Yeh, Albert C., Varelias, Antiopi, Reddy, Anupama, Barone, Sierra M., Olver, Stuart D., Chilson, Kate, Onstad, Lynn E., Ensbey, Kathleen S., Henden, Andrea S, Samson, Luke, Jaeger, Carla A, Bi, Timothy, Dahlman, Kimberly B., Kim, Tae Kon, Zhang, Ping, Degli-Esposti, Mariapia A., Newell, Evan W., Jagasia, Madan H., Irish, Jonathan M., Lee, Stephanie J. and Hill, Geoffrey R. (2021). CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant. Blood, 138 (26), 2874-2885. doi: 10.1182/blood.2020009492

CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant

2021

Journal Article

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

2021

Journal Article

A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis

Kennedy, Glen, Tey, Siok-Keen, Buizen, Luke, Varelias, Antiopi, Gartlan, Kate H., Curley, Cameron, Olver, Stuart, Chang, Karshing, Butler, Jason, Misra, Ashish, Subramoniapillai, Elango, Morton, Anthony, Durrant, Simon, Henden, Andrea S, Moore, John, Ritchie, David S, Gottlieb, David, Cooney, Julian P, Paul, Sanjoy K and Hill, Geoffrey R. (2021). A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis. Blood, 137 (14), 1970-1979. doi: 10.1182/blood.2020009050

A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis

2020

Journal Article

Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease

Engel, Jessica A., Lee, Hyun Jae, Williams, Cameron G., Kuns, Rachel, Olver, Stuart, Lansink, Lianne Im, Soon, Megan Sf, Andersen, Stacey B., Powell, Joseph E., Svensson, Valentine, Teichmann, Sarah A., Hill, Geoffrey R., Varelias, Antiopi, Koyama, Motoko and Haque, Ashraful (2020). Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease. JCI Insight, 5 (13) 137990. doi: 10.1172/jci.insight.137990

Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease

2020

Journal Article

ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome

Cheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko and Hill, Geoffrey R. (2020). ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome. Cancer Immunology Research, 8 (8), 1085-1098. doi: 10.1158/2326-6066.cir-19-0653

ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome

2020

Journal Article

PAG1 limits allergen-induced type 2 inflammation in the murine lung

Ullah, Md Ashik, Vicente, Cristina T., Collinson, Natasha, Curren, Bodie, Sikder, Md Al Amin, Sebina, Ismail, Simpson, Jennifer, Varelias, Antiopi, Lindquist, Jonathan A., Ferreira, Manuel A. R. and Phipps, Simon (2020). PAG1 limits allergen-induced type 2 inflammation in the murine lung. Allergy, 75 (2) all.13991, 336-345. doi: 10.1111/all.13991

PAG1 limits allergen-induced type 2 inflammation in the murine lung

2020

Journal Article

Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice

Bowerman, Kate L., Varelias, Antiopi, Lachner, Nancy, Kuns, Rachel D., Hill, Geoffrey R. and Hugenholtz, Philip (2020). Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice. Gut Microbes, 11 (4), 1-17. doi: 10.1080/19490976.2019.1705729

Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice

2020

Journal Article

MAIT cells promote tumor initiation, growth and metastases via tumor MR1

Yan, Juming, Allen, Stacey, McDonald, Elizabeth, Das, Indrajit, Mak, Jeffrey Y. W., Liu, Ligong, Fairlie, David P., Meehan, Bronwyn S., Chen, Zhenjun, Corbett, Alexandra J., Varelias, Antiopi, Smyth, Mark J. and Teng, Michele W. L. (2020). MAIT cells promote tumor initiation, growth and metastases via tumor MR1. Cancer Discovery, 10 (1), 124-141. doi: 10.1158/2159-8290.cd-19-0569

MAIT cells promote tumor initiation, growth and metastases via tumor MR1

Supervision

Availability

Dr Antiopi Varelias is:
Available for supervision

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Available projects

  • Understanding the immunological basis of increased mortality driven by a respiratory syncytial viral infection after stem cell transplantation.

    Background

    Viral infection and reactivation following stem cell transplantation (SCT) is a common complication following this procedure, which is performed for the treatment of blood cancers. One such pathogen is respiratory syncytial virus (RSV), a common community-acquired infection that leads to significant morbidity in immunocompromised SCT patients. Current treatment strategies for patients infected with RSV is the use of anti-viral agents however these are ineffective. Thus, this complication remains a significant clinical problem where new treatments are desperately needed. To address this, a better understanding of the immunological mechanisms that underlie this disease are essential.

    Aims

    The specific aim of this project is to establish a robust model of RSV infection in the stem cell transplant setting using Pneumonia Virus of Mice (PVM), the murine relative of RSV. This will enable the contribution of host innate and acquired mucosal immune responses to the viral infection to be dissected.

    Approaches / Techniques to be utilised

    This project is not limited to, but will involve, extensive animal work, flow cytometry, immunological assays, molecular and viral techniques.

    This project is suitable for Honours, Masters and PhD students. Please contact Dr Varelias (antiopi.varelias@qimrberghofer.edu.au) for further details.

  • Dissecting the immunoregulatory interactions between cytokines, innate cells and intestinal microbiota during homeostasis and in acute graft-versus-host disease.

    Background

    To date, stem cell transplantation (SCT) remains the preferred treatment option for the majority of blood cancers. Chemotherapy/radiation during conditioning damages intestinal epithelium resulting in systemic exposure to microbial products normally sequestered in the intestinal lumen, in addition to a marked cytokine release. We have demonstrated that these microbial products and cytokines modulate graft-versus-host disease (GVHD) and thereby transplant outcome. Numerous approaches in the clinic targeting intestinal microbiota to harness GVHD such as gut decontaminating antibiotics, introduction of beneficial bacteria or targeting anaerobic bacteria have been attempted but these have shown varied effects. A greater understanding of the cellular and molecular mechanisms underlying these approaches will inform of new strategies that could be adopted to protect against unrestrained immune activation and GVHD. Recently, we demonstrated that mucosal associated invariant T (MAIT) cells, activated in response to engagement with microbial-derived riboflavin derivatives loaded onto MR1 ligands, protected against intestinal acute GVHD.

    Aims

    The overall aim of this project is to further investigate the host innate immune response and its interaction with intestinal microbiota during homeostasis and in acute GVHD.

    Approaches / Techniques to be utilised

    This project is not limited to, but will involve, extensive animal work, flow cytometry, immunological assays, molecular and microbiological techniques.

    This project is suitable for Honours, Masters and PhD students. Please contact Dr Varelias (antiopi.varelias@qimrberghofer.edu.au) for further details.

Supervision history

Current supervision

  • Doctor Philosophy

    Defining the critical determinants of viral-mediated pneumonitis after bone marrow transplantation.

    Principal Advisor

    Other advisors: Dr Quan Nguyen, Dr Seweryn Bialasiewicz

  • Doctor Philosophy

    Modulating Donor T Cell Polarisation After Bone Marrow Transplantation to Prevent Graft-Versus-Host Disease

    Associate Advisor

    Other advisors: Associate Professor Kate Gartlan

Completed supervision

  • 2021

    Doctor Philosophy

    Classification and functional characterisation of the murine gut bacterial family Muribaculaceae

    Associate Advisor

    Other advisors: Professor Phil Hugenholtz

Media

Enquiries

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