Overview
Background
Dr. Wang completed her MPhil study in the University of Queensland (UQ) in 2016 and PhD study in UQ in October 2020. As an early career researcher, Dr.Wang has demonstrated a high impact track record relative to opportunity with award of Dean's award for Excellence in Higher Degree Research (2016), the high proportion (41%) of first-authored publications, 28% of which in the top 10% most cited publications worldwide (Scopus 24/03/2021). She has been actively engaged in a number of professional activities in the research fields, including RHD student supervision, assessment for the master research projects (BIOX7021), talks at national and international conferences (The Australian Colloid and Interface Symposium Brisbane hub, 2021; The Australasian Society for Stem Cell Research ECR Symposium, 2021; BioNano Innovation, 2020) and conference organization (The Australian Colloid and Interface Symposium Brisbane hub, 2021).
Availability
- Dr Yue Wang is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Nanochemistry upregulated mRNA translation
Dr. Wang has pioneered the conceptual design of functional nanomaterials with glutathione-depletion chemistry for upregulated mRNA translation and delivery. She has revealed the contribution of tetrasulfide bond composition of nanoparticles to GSH depletion and activation of mammalian target of rapamycin complex1 pathway for stimulated mRNA translation and enhanced delivery efficiency in hard-to-transfect APCs. This work demonstrates that, for the first time, nanoparticles not only act as a carrier for mRNA, but also a regulator to modulate mRNA translation machineries and pathways. This presents a new research direction that has not been reported. Considering the intrinsic GSH regeneration catalysed by intracellular glutathione reductase (GR), She further developed a confined growth technology to prepare zeolitic imidazolate framework-8 (ZIF-8) and MONs complex (MONs-ZIF-8), with zinc cations inhibited GR activity and tetrasulfide bond triggered GSH oxidation to synergistically enable long-term GSH depletion and enhanced mRNA delivery .
Works
Search Professor Yue Wang’s works on UQ eSpace
2024
Journal Article
Engineered silica nanoparticles for nucleic acid delivery
Zhang, Yue, Yu, Yingjie, Yang, Yannan, Wang, Yue and Yu, Chengzhong (2024). Engineered silica nanoparticles for nucleic acid delivery. Small Methods, 8 (3) 2300812. doi: 10.1002/smtd.202300812
2024
Journal Article
A core–shell‐structured zeolitic imidazolate framework@cationic antimicrobial agent templated silica nanocomposite for tackling antibiotic resistant bacteria infection
Kan, Qihui, Song, Yaping, Yao, Yining, Zhang, Jun, Xian, He, Cheng, Dan, Wang, Yue, Mao, Liang, Wang, Meiyan and Yu, Chengzhong (2024). A core–shell‐structured zeolitic imidazolate framework@cationic antimicrobial agent templated silica nanocomposite for tackling antibiotic resistant bacteria infection. Aggregate, 5 (3). doi: 10.1002/agt2.523
2024
Journal Article
Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications
Yao, Yining, Ye, Zilin, Zhang, Yue, Wang, Yue and Yu, Chengzhong (2024). Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications. Advanced Materials Interfaces, 11 (17). doi: 10.1002/admi.202300946
2023
Journal Article
Engineering crystallinity gradients for tailored CaO2 nanostructures: enabling alkalinity-reinforced anticancer activity with minimized Ca2+/H2O2 production
Shi, Yiru, Dai, Zan, Wang, Yue, Luo, Jiangqi, Cai, Larry, Tang, Jie, Yu, Chengzhong and Yang, Yannan (2023). Engineering crystallinity gradients for tailored CaO2 nanostructures: enabling alkalinity-reinforced anticancer activity with minimized Ca2+/H2O2 production. Nano Letters, 23 (23), 10657-10666. doi: 10.1021/acs.nanolett.3c01963
2023
Journal Article
Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery
Zhang, Yue, Xian, He, Strounina, Ekaterina, Gunther, Kimberley S., Sweet, Matthew J., Chen, Chen, Yu, Chengzhong and Wang, Yue (2023). Mesoporous Organosilica Nanoparticles with Tetrasulphide Bond to Enhance Plasmid DNA Delivery. Pharmaceutics, 15 (3) 1013, 1-11. doi: 10.3390/pharmaceutics15031013
2023
Journal Article
Nanobiotechnology-enabled mRNA stabilization
Xian, He, Zhang, Yue, Yu, Chengzhong and Wang, Yue (2023). Nanobiotechnology-enabled mRNA stabilization. Pharmaceutics, 15 (2) 620, 620. doi: 10.3390/pharmaceutics15020620
2022
Journal Article
Synthesis of mesoporous organosilica nanoparticles with a high tetrasulphide content and large pores
Zhang, Yue, Wang, Yue, Song, Yaping, Luo, Jiangqi, Yu, Yingjie and Yu, Chengzhong (2022). Synthesis of mesoporous organosilica nanoparticles with a high tetrasulphide content and large pores. Microporous and Mesoporous Materials, 346 112316, 112316. doi: 10.1016/j.micromeso.2022.112316
2022
Journal Article
Cationic and anionic antimicrobial agents co-templated mesostructured silica nanocomposites with a spiky nanotopology and enhanced biofilm inhibition performance
Song, Yaping, Sun, Qiang, Luo, Jiangqi, Kong, Yueqi, Pan, Bolin, Zhao, Jing, Wang, Yue and Yu, Chengzhong (2022). Cationic and anionic antimicrobial agents co-templated mesostructured silica nanocomposites with a spiky nanotopology and enhanced biofilm inhibition performance. Nano-Micro Letters, 14 (1) 83, 83. doi: 10.1007/s40820-022-00826-4
2022
Journal Article
Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity
Tang, Jie, Yang, Yang, Qu, Jingjing, Ban, Wenhuang, Song, Hao, Gu, Zhengying, Yang, Yannan, Cai, Larry, Theivendran, Shevanuja, Wang, Yue, Zhang, Min and Yu, Chengzhong (2022). Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity. Chemical Science, 13 (29), 8507-8517. doi: 10.1039/d1sc05319a
2022
Journal Article
Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie International Edition, 61 (12) e202112752, 1-22. doi: 10.1002/anie.202112752
2022
Journal Article
Dendritic mesoporous nanoparticles: structure, synthesis and properties
Xu, Chun, Lei, Chang, Wang, Yue and Yu, Chengzhong (2022). Dendritic mesoporous nanoparticles: structure, synthesis and properties. Angewandte Chemie, 134 (12) e202112752, 1-22. doi: 10.1002/ange.202112752
2021
Journal Article
Submicron-sized vermiculite assisted oregano oil for controlled release and long-term bacterial inhibition
Kothalawala, Sukitha Geethma, Zhang, Jun, Wang, Yue and Yu, Chengzhong (2021). Submicron-sized vermiculite assisted oregano oil for controlled release and long-term bacterial inhibition. Antibiotics, 10 (11) 1324, 1324. doi: 10.3390/antibiotics10111324
2021
Journal Article
Calcium-doped silica nanoparticles mixed with phosphate-doped silica nanoparticles for rapid and stable occlusion of dentin tubules
Cao, Yuxue, Xu, Chun, Wright, Patricia P., Liu, Jingyu, Kong, Yueqi, Wang, Yue, Huang, Xiaodan, Song, Hao, Fu, Jianye, Gao, Fang, Liu, Yang, Walsh, Laurence J. and Lei, Chang (2021). Calcium-doped silica nanoparticles mixed with phosphate-doped silica nanoparticles for rapid and stable occlusion of dentin tubules. ACS Applied Nano Materials, 4 (9) acsanm.1c01365, 8761-8769. doi: 10.1021/acsanm.1c01365
2021
Journal Article
Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities
Gu, Zhengying, Liu, Tianqing, Liu, Chao, Yang, Yannan, Tang, Jie, Song, Hao, Wang, Yue, Yang, Yang and Yu, Chengzhong (2021). Ferroptosis-strengthened metabolic and inflammatory regulation of tumor-associated macrophages provokes potent tumoricidal activities. Nano Letters, 21 (15) acs.nanolett.1c01401, 6471-6479. doi: 10.1021/acs.nanolett.1c01401
2021
Journal Article
Benzene-bridged organosilica modified mesoporous silica nanoparticles via an acid-catalysis approach
Zhang, Ye, Gu, Zhengying, Liu, Yang, Hu, Wenli, Liu, Chao, Shu, Weikang, Wang, Yue and Yu, Chengzhong (2021). Benzene-bridged organosilica modified mesoporous silica nanoparticles via an acid-catalysis approach. Langmuir, 37 (8), 2780-2786. doi: 10.1021/acs.langmuir.0c03541
2020
Journal Article
Emerging concepts of nanobiotechnology in mRNA delivery
Wang, Yue and Yu, Chengzhong (2020). Emerging concepts of nanobiotechnology in mRNA delivery. Angewandte Chemie International Edition, 59 (52) anie.202003545, 23374-23385. doi: 10.1002/anie.202003545
2020
Journal Article
Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation
Tang, Jie, Meka, Anand Kumar, Theivendran, Shevanuja, Wang, Yue, Yang, Yannan, Song, Hao, Fu, Jianye, Ban, Wenhuang, Gu, Zhengying, Lei, Chang, Li, Shumin and Yu, Chengzhong (2020). Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation. Angewandte Chemie International Edition, 59 (49) anie.202001469, 22054-22062. doi: 10.1002/anie.202001469
2020
Journal Article
Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bio-regulators for enhanced mRNA delivery in vivo
Wang, Yue, Song, Hao, Liu, Chao, Zhang, Ye, Kong, Yueqi, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2020). Confined growth of ZIF-8 in dendritic mesoporous organosilica nanoparticles as bio-regulators for enhanced mRNA delivery in vivo. National Science Review, 8 (8) nwaa268, 1-10. doi: 10.1093/nsr/nwaa268
2020
Other Outputs
Designed synthesis of silica based nanocarriers for mRNA delivery
Wang, Yue (2020). Designed synthesis of silica based nanocarriers for mRNA delivery. PhD Thesis, Australian Institute for Bioengineering & Nanotechnology, The University of Queensland. doi: 10.14264/b28d1e7
2020
Journal Article
Eliciting immunogenic cell death via a unitized nanoinducer
Dai, Zan, Tang, Jie, Gu, Zhengying, Wang, Yue, Yang, Yang, Yang, Yannan and Yu, Chengzhong (2020). Eliciting immunogenic cell death via a unitized nanoinducer. Nano Letters, 20 (9), 6246-6254. doi: 10.1021/acs.nanolett.0c00713
Funding
Current funding
Supervision
Availability
- Dr Yue Wang is:
- Available for supervision
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Available projects
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Developing nanostructured antimicrobial coating for biomedical devices
Biomedical devices such as catheters are routinely used in a diverse range of clinical settings, the inevitable bacterial infection remains a major threat to human health. Among them, catheter-associated-urinary tract infections are a global challenge and difficult to treat due to the formation of biofilms. Traditional treatment using antibiotics leads to ever increasing antibiotics resistance. This project will use state-of-the-art nanotechnology to solve the above problems. Novel silica nanoparticles with a pollen-like morphology will be prepared to disrupt bacterial membrane. Their compositions can be tuned to cause chemical damage towards bacteria. The impacts of various structural parameters on catheter coating, antiadhesive, antibacterial and antibiofilm performances as well as urinary drainage flow will be evaluated. If successful, this technology can be used to develop next-generation antibacterial coating for biomedical devices, providing invaluable benefits to human healthcare.
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Developing efficient nano-transfection agents for mRNA vaccine delivery
The mRNA technology has received tremendous success in the development of COVID vaccines, however the performance of current mRNA cancer vaccines is low. Roche and BioNTech collaborated mRNA based personalized cancer vaccines (RO7198457 cancer vaccine) only gave a 4% response rate. Based on our ground-breaking findings of nanochemistry upregulated mRNA translation, this project aims to develop a new-generation of mRNA cancer vaccine formulations with improved efficacy. New delivery platforms will be prepared to improve the mRNA cancer vaccine performance and simplify the dosages. The impact of structural parameters of nano-carriers on mRNA transfection, antigen presenting and cellular immunity will be systematically investigated. Successful completion of this project has the potential to provide a revolutionised mRNA cancer vaccine technology.
Media
Enquiries
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