Designer Nanoparticles Enable mRNA Protein Factories (2023-2026)
Abstract
Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.
