Overview
Availability
- Dr Hao Song is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Hao Song’s works on UQ eSpace
2024
Journal Article
Rapid room-temperature synthesis of biocompatible metal–organic framework for enzyme immobilization with improved stability and on-demand release
Weng, Yilun, Yan, Penghui, Sun, Baode, Wan, Andria, You, Jiakang, Xu, Xin, Lu, Zeyu, Stewart, Glen A., Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2024). Rapid room-temperature synthesis of biocompatible metal–organic framework for enzyme immobilization with improved stability and on-demand release. Chemical Engineering Journal, 497 154471, 1-10. doi: 10.1016/j.cej.2024.154471
2024
Journal Article
Mechanistic study on phytase stabilization using alginate encapsulation
Weng, Yilun, Sun, Baode, Jin, Wanli, Yan, Penghui, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2024). Mechanistic study on phytase stabilization using alginate encapsulation. Food Hydrocolloids, 151 109837, 1-11. doi: 10.1016/j.foodhyd.2024.109837
2024
Journal Article
ZIF-90-decorated silica nanoparticles with a spiky surface: a novel approach to drug delivery
Sharma, Manoj Kumar, Cheng, Dan, Qu, Jingjing, Song, Hao, Yu, Chengzhong, Ganguli, Ashok K. and Tang, Jie (2024). ZIF-90-decorated silica nanoparticles with a spiky surface: a novel approach to drug delivery. New Journal of Chemistry, 48 (13), 5760-5768. doi: 10.1039/d3nj05187k
2024
Journal Article
A pioglitazone nanoformulation designed for cancer-associated fibroblast reprogramming and cancer treatment
Theivendran, Shevanuja, Xian, He, Qu, Jingjing, Song, Yaping, Sun, Bing, Song, Hao and Yu, Chengzhong (2024). A pioglitazone nanoformulation designed for cancer-associated fibroblast reprogramming and cancer treatment. Nano Letters, 24 (15), 4354-4361. doi: 10.1021/acs.nanolett.3c04706
2024
Journal Article
Pore engineering of micro/mesoporous nanomaterials for encapsulation, controlled release and variegated applications of essential oils
Su, Xiaoyu, Li, Biao, Chen, Shuiyan, Wang, Xinmin, Song, Hao, Shen, Baode, Zheng, Qin, Yang, Ming and Yue, Pengfei (2024). Pore engineering of micro/mesoporous nanomaterials for encapsulation, controlled release and variegated applications of essential oils. Journal of Controlled Release, 367, 107-134. doi: 10.1016/j.jconrel.2024.01.005
2023
Journal Article
Powering mesoporous silica nanoparticles into bioactive nanoplatforms for antibacterial therapies: strategies and challenges
Li, Biao, Liao, Yan, Su, Xiaoyu, Chen, Shuiyan, Wang, Xinmin, Shen, Baode, Song, Hao and Yue, Pengfei (2023). Powering mesoporous silica nanoparticles into bioactive nanoplatforms for antibacterial therapies: strategies and challenges. Journal of Nanobiotechnology, 21 (1) 325, 325. doi: 10.1186/s12951-023-02093-w
2023
Journal Article
A hierarchical spatial assembly approach of silica-polymer composites leads to versatile silica/carbon nanoparticles
Cheng, Dan, Zhang, Jun, Fu, Jianye, Song, Hao and Yu, Chengzhong (2023). A hierarchical spatial assembly approach of silica-polymer composites leads to versatile silica/carbon nanoparticles. Science Advances, 9 (40) eadi7502, eadi7502. doi: 10.1126/sciadv.adi7502
2023
Journal Article
Lipase-powered asymmetric silica nanomotors with a tailored head-tail structure for enhanced mucus penetration
Ban, Wenhuang, Qu, Jingjing, Cai, Larry, Fu, Jianye, Wu, Weixi, Song, Hao, Yu, Chengzhong and Tang, Jie (2023). Lipase-powered asymmetric silica nanomotors with a tailored head-tail structure for enhanced mucus penetration. Applied Materials Today, 34 101916, 101916. doi: 10.1016/j.apmt.2023.101916
2023
Journal Article
Engineering nanoparticle toolkits for mRNA delivery
Sun, Bing, Wu, Weixi, Narasipura, Eshan A., Ma, Yutian, Yu, Chengzhong, Fenton, Owen S. and Song, Hao (2023). Engineering nanoparticle toolkits for mRNA delivery. Advanced Drug Delivery Reviews, 200 115042. doi: 10.1016/j.addr.2023.115042
2023
Journal Article
A general strategy for direct growth of yolk-shell MOF-on-MOF hybrids
Li, Jiaxin, Bao, Tong, Zhang, Chaoqi, Song, Hao, Zou, Yingying, Yuan, Ling, Xi, Yamin, Yu, Chengzhong and Liu, Chao (2023). A general strategy for direct growth of yolk-shell MOF-on-MOF hybrids. Chemical Engineering Journal, 472 144926, 1-9. doi: 10.1016/j.cej.2023.144926
2023
Journal Article
Alginate-based materials for enzyme encapsulation
Weng, Yilun, Yang, Guangze, Li, Yang, Xu, Letao, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Alginate-based materials for enzyme encapsulation. Advances in Colloid and Interface Science, 318 102957, 102957. doi: 10.1016/j.cis.2023.102957
2023
Journal Article
Effect of glucose pretreatment on Cu-ZnO-Al<sub>2</sub>O<sub>3</sub> catalyzed CO<sub>2</sub> hydrogenation to methanol
Jiang, Xiuyun, Yang, Wenbing, Song, Hao, Ke, Jucang, Li, Peng, Li, Rui, Ma, Qingxiang, Sun, Jian, Zhao, Tian-Sheng and Tsubaki, Noritatsu (2023). Effect of glucose pretreatment on Cu-ZnO-Al2O3 catalyzed CO2 hydrogenation to methanol. Rsc Advances, 13 (32), 22493-22502. doi: 10.1039/d3ra03607c
2023
Journal Article
Scalable manufacturing of enzyme loaded alginate particles with excellent thermal and storage stability for industrial applications
Weng, Yilun, Wan, Andria, Li, Yang, Liu, Yun, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Scalable manufacturing of enzyme loaded alginate particles with excellent thermal and storage stability for industrial applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 667 131412, 1-10. doi: 10.1016/j.colsurfa.2023.131412
2023
Journal Article
Spatial specific Janus s‐scheme photocatalyst with enhanced H2 O2 production performance
Xia, Chunhong, Yuan, Ling, Song, Hao, Zhang, Chaoqi, Li, Zimeng, Zou, Yingying, Li, Jiaxin, Bao, Tong, Yu, Chengzhong and Liu, Chao (2023). Spatial specific Janus s‐scheme photocatalyst with enhanced H2 O2 production performance. Small, 19 (29) e2300292, e2300292. doi: 10.1002/smll.202300292
2023
Journal Article
Improved enzyme thermal stability, loading and bioavailability using alginate encapsulation
Weng, Yilun, Ranaweera, Supun, Zou, Da, Cameron, Anna, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Improved enzyme thermal stability, loading and bioavailability using alginate encapsulation. Food Hydrocolloids, 137 108385, 1-13. doi: 10.1016/j.foodhyd.2022.108385
2023
Journal Article
Encapsulation of enzymes in food industry using spray drying: recent advances and process scale-ups
Weng, Yilun, Li, Yang, Chen, Xiaojing, Song, Hao and Zhao, Chun-Xia (2023). Encapsulation of enzymes in food industry using spray drying: recent advances and process scale-ups. Critical Reviews in Food Science and Nutrition, 64 (22), 1-18. doi: 10.1080/10408398.2023.2193982
2023
Journal Article
Bioengineered materials with selective antimicrobial toxicity in biomedicine
Makvandi, Pooyan, Song, Hao, Yiu, Cynthia K. Y., Sartorius, Rossella, Zare, Ehsan Nazarzadeh, Rabiee, Navid, Wu, Wei-Xi, Paiva-Santos, Ana Cláudia, Wang, Xiang-Dong, Yu, Cheng-Zhong and Tay, Franklin R. (2023). Bioengineered materials with selective antimicrobial toxicity in biomedicine. Military Medical Research, 10 (1) 8, 1-20. doi: 10.1186/s40779-023-00443-1
2022
Journal Article
Surface chemistry of spiky silica nanoparticles tailors polyethyleneimine binding and intracellular DNA delivery
Cheng, Dan, Theivendran, Shevanuja, Tang, Jie, Cai, Larry, Zhang, Jun, Song, Hao and Yu, Chengzhong (2022). Surface chemistry of spiky silica nanoparticles tailors polyethyleneimine binding and intracellular DNA delivery. Journal of Colloid and Interface Science, 628 (Part B), 297-305. doi: 10.1016/j.jcis.2022.08.038
2022
Journal Article
Luminescent nanoparticle-arrays synthesized via polymer pen lithography
Wang, Ping, Bao, Shuyi, Qiao, Shuqian, Li, Ce, Jiang, Zhang, Song, Hao, Wang, Yilin, Zhan, Qiuqiang and Huang, Ling (2022). Luminescent nanoparticle-arrays synthesized via polymer pen lithography. Nano Research, 16 (2), 3125-3129. doi: 10.1007/s12274-022-4968-0
2022
Journal Article
Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity
Tang, Jie, Yang, Yang, Qu, Jingjing, Ban, Wenhuang, Song, Hao, Gu, Zhengying, Yang, Yannan, Cai, Larry, Theivendran, Shevanuja, Wang, Yue, Zhang, Min and Yu, Chengzhong (2022). Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity. Chemical Science, 13 (29), 8507-8517. doi: 10.1039/d1sc05319a
Funding
Current funding
Past funding
Supervision
Availability
- Dr Hao Song is:
- Available for supervision
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Available projects
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A nanotechnology for long-lasting oral drug delivery.
Medication adherence is required for the effectiveness of all pharmacotherapies, especially for long-term treatment of chronic illness and infectious diseases such as malaria, diabetes, and HIV. However, intensive dosage regimens with a high pill burden are associated with a low adherence rate, leading to compromised or even failure of therapies. My project aims to realize the ideal of ‘pillbox in a capsule’, i.e. taking a single tablet that will provide sustained drug release over several days, by developing a long-lasting oral drug delivery platform with prolonged gastrointestinal transit time. Inspired by bio-adhesive natural systems, where spiky surfaces enable strong adhesion, this project will engineer silica particles with a spiky morphology as well as their assembled medical devices as oral drug delivery vehicles, and their interactions at the bio-interfaces in the gastrointestinal environment will be investigated in detail. On completion, this project will produce guidelines for the rational design of novel oral drug delivery systems, and new potential clinical strategies for simplified oral medications to improve medication adherence and patient outcomes.
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Virus-mimicking nanoparticles for DNA vaccine
DNA vaccine, as the third generation vaccine technology, representing the latest biotechnological breakthrough in vaccine development. Compared to conventional recombinant vaccines usually only stimulating the antibody responses, DNA vaccine show advantages in evoking both cellular and humoral immunity to fulfill the demand in combating chronic infectious diseases. Moreover, the cost-effectiveness and fast speed of production make DNA vaccine an ideal strategy to deal with outbreaks such as SARS-COV-2 and H5N1 for the sake of both public and animal healthcare. To enable a successful DNA vaccine technology, it is critical to develop efficient gene vectors to transport and regulate the DNA molecules to be highly expressed in target cells. Mimicking the morphology of the virus, this project aims to fabricate a series of virus-like silica nanoparticles with tailored physicochemical features for plasmid DNA delivery and investigate their gene translation and vaccine performance. The completion of this project will provide fundamental understandings of the impact of designer particle nanostructure/chemistry on DNA transfection and vaccine immunogenicity.
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Nature-inspired spiky nanomaterials probed at the bio-nano interfaces
The intriguing nature systems have inspired remarkable advances in the development of functional nanomaterials for biomedical applications. Nature creations such as pollen grains and virus with spiky topological features at various length scales enable multivalent interactions at bio-interfaces, and typically exhibit intriguing surface adhesive property. This project aims to apply this nature-derived principle to engineer nanoparticles for enhanced intracellular delivery of biomolecules. Nanomaterials with functional compositions and tailored spiky nanostructures will be fabricated. Their cellular internalization process and biomolecules delivery efficiency will be evaluated. On completion of this project, a versatile and functional drug delivery platform will be established and an in-depth understanding of the spiky nanoparticle-cell interaction will be revealed.
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Antibiotic-free antibacterial nanotechnology
The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. This project aims to develop antibiotic-free antibacterial formulations enabled by advanced nanomaterials. Functional nanomaterials with intrinsic or light-mediated bactericidal properties will be fabricated to enable efficient pathogen killing. Meanwhile, porous nanoparticles will also be engineered to serve as vehicles for the delivery of natural antibacterial compounds, formulating Pickering emulsion for stable and sparable antibacterial nano-agents. On the completion of this project, nano-formulations showing potent antibacterial property and good safety will be provided, and their antibacterial mechanisms, as well as the structure-performance relationship, will be revealed.
Supervision history
Current supervision
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Doctor Philosophy
Engineering Spiky Nanoparticles Probed at the Nano-Bio Interfaces
Principal Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Biomimetic Nanoparticles for Efficient Vaccine Delivery
Principal Advisor
-
Doctor Philosophy
clinically-oriented synergized immunotherapy strategies for breast cancer
Principal Advisor
-
Doctor Philosophy
Synthesis and applications of non-viral gene vectors
Associate Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Multifunctional hybrid mesoporous silica nanoparticles for stimuli-responsive delivery of antimicrobial agents
Associate Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Engineering encapsulation technology for enzyme immobilization
Associate Advisor
-
Doctor Philosophy
Development of a market relevant DNA nano-vaccine platform
Associate Advisor
Other advisors: Professor Michael Yu
Completed supervision
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2023
Doctor Philosophy
Engineering core-shell-type of silica nanoparticles with controllable surface nanotopography as gene delivery vectors
Associate Advisor
Other advisors: Professor Michael Yu
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2023
Doctor Philosophy
Agriculture Nanotechnology & Materials Engineering: Agricultural Applications of Silica-Based Nanomaterials
Associate Advisor
Other advisors: Professor Michael Yu
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2022
Doctor Philosophy
Nanoparticle-Assisted Signal-Enhancement Technique for Lateral Flow Immunoassays
Associate Advisor
Other advisors: Professor Michael Yu
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2021
Doctor Philosophy
Engineered Aluminosilicate-Based Nanoparticles for Safe and Efficient Vaccine Delivery
Associate Advisor
Other advisors: Professor Linda Lua, Professor Michael Yu
Media
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