Overview
Availability
- Dr Hao Song is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Hao Song’s works on UQ eSpace
2020
Journal Article
Lyophilization enabled disentanglement of polyethylenimine on rambutan-like silica nanoparticles for enhanced plasmid DNA delivery
Geng, Jing, Song, Hao, Gao, Fang, Kong, Yueqi, Fu, Jianye, Luo, Jiangqi, Yang, Yannan and Yu, Chengzhong (2020). Lyophilization enabled disentanglement of polyethylenimine on rambutan-like silica nanoparticles for enhanced plasmid DNA delivery. Journal of Materials Chemistry B, 8 (21), 4593-4600. doi: 10.1039/d0tb00720j
2020
Journal Article
Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells
Wang, Yue, Tang, Jie, Yang, Yannan, Song, Hao, Fu, Jianye, Gu, Zhengying and Yu, Chengzhong (2020). Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells. Angewandte Chemie International Edition, 132 (7) ange.201914264, 2717-2721. doi: 10.1002/anie.201914264
2020
Journal Article
Arginine biosynthesis by a bacterial symbiont enables nitric oxide production and facilitates larval settlement in the marine-sponge host
Song, Hao, Hewitt, Olivia H. and Degnan, Sandie M. (2020). Arginine biosynthesis by a bacterial symbiont enables nitric oxide production and facilitates larval settlement in the marine-sponge host. Current Biology, 31 (2), 433-437.e3. doi: 10.1016/j.cub.2020.10.051
2020
Journal Article
Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment
Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei and Yu, Chengzhong (2020). Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment. Chemical Science, 11 (38), 10421-10430. doi: 10.1039/d0sc02803g
2019
Journal Article
Fractal-in-a-sphere: confined self-assembly of fractal silica nanoparticles
Fu, Jianye, Jiao, Jinqing, Song, Hao, Gu, Zhengying, Liu, Yang, Geng, Jing, Jack, Kevin S., Du, Ai, Tang, Jie and Yu, Chengzhong (2019). Fractal-in-a-sphere: confined self-assembly of fractal silica nanoparticles. Chemistry of Materials, 32 (1) acs.chemmater.9b03864, 341-347. doi: 10.1021/acs.chemmater.9b03864
2019
Journal Article
Ultralarge interlayer distance and C,N-codoping enable superior sodium storage capabilities of MoS2 nanoonions
Wu, Chenghao, Song, Hao, Tang, Cheng, Du, Aijun, Yu, Chengzhong, Huang, Zhendong, Wu, Minghong and Zhang, Haijiao (2019). Ultralarge interlayer distance and C,N-codoping enable superior sodium storage capabilities of MoS2 nanoonions. Chemical Engineering Journal, 378 122249, 122249. doi: 10.1016/j.cej.2019.122249
2019
Journal Article
Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives
Wang, Yue, Yang, Yannan, Shi, Yiru, Song, Hao and Yu, Chengzhong (2019). Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives. Advanced Materials, 32 (18) 1904106, 1904106. doi: 10.1002/adma.201904106
2019
Journal Article
DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles
Song, Hao, Yang, Yannan, Tang, Jie, Gu, Zhengying, Wang, Yue, Zhang, Min and Yu, Chengzhong (2019). DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles. Advanced Therapeutics, 3 (1) 1900154, 1900154. doi: 10.1002/adtp.201900154
2019
Journal Article
Modulating ion diffusivity and electrode conductivity of carbon nanotube@mesoporous carbon fibers for high performance aluminum-selenium batteries
Kong, Yueqi, Nanjundan, Ashok Kumar, Liu, Yang, Song, Hao, Huang, Xiaodan and Yu, Chengzhong (2019). Modulating ion diffusivity and electrode conductivity of carbon nanotube@mesoporous carbon fibers for high performance aluminum-selenium batteries. Small, 15 (51) 1904310, e1904310. doi: 10.1002/smll.201904310
2019
Journal Article
Responsively aggregatable sub-6 nm nanochelators induce simultaneous antiangiogenesis and vascular obstruction for enhanced tumor vasculature targeted therapy
Yang, Yannan, Tang, Jie, Zhang, Min, Gu, Zhengying, Song, Hao, Yang, Yang and Yu, Chengzhong (2019). Responsively aggregatable sub-6 nm nanochelators induce simultaneous antiangiogenesis and vascular obstruction for enhanced tumor vasculature targeted therapy. Nano Letters, 19 (11), 7750-7759. doi: 10.1021/acs.nanolett.9b02691
2019
Journal Article
Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2
Li, Huimin, Guo, Huilin, Lei, Chang, Liu, Li, Xu, Liqin, Feng, Yaping, Ke, Jin, Fang, Wei, Song, Hao, Xu, Chun, Yu, Chengzhong and Long, Xing (2019). Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Advanced Materials, 31 (46) 1904535, 1904535. doi: 10.1002/adma.201904535
2019
Journal Article
Electron tomography: a unique tool solving intricate hollow nanostructures
Song, Hao, Yang, Yannan, Geng, Jing, Gu, Zhengying, Zou, Jin and Yu, Chengzhong (2019). Electron tomography: a unique tool solving intricate hollow nanostructures. Advanced Materials, 31 (38) 1801564, 1801564. doi: 10.1002/adma.201801564
2019
Journal Article
Heterogeneous contraction-mediated asymmetric carbon colloids
Liu, Zhenhui, Song, Hao, Zhao, Yunlong, He, Ruhan, Meng, Jiashen, Yu, Qiang, Owusu, Kwadwo Asare, Yu, Chengzhong, Zhao, Dongyuan, Zhou, Liang and Mai, Liqiang (2019). Heterogeneous contraction-mediated asymmetric carbon colloids. ACS Materials Letters, 1 (3), 290-296. doi: 10.1021/acsmaterialslett.9b00179
2019
Journal Article
Mechanism of iron oxide-induced macrophage activation: the impact of composition and the underlying signaling pathway
Gu, Zhengying, Liu, Tianqing, Tang, Jie, Yang, Yannan, Song, Hao, Tuong, Zewen K., Fu, Jianye and Yu, Chengzhong (2019). Mechanism of iron oxide-induced macrophage activation: the impact of composition and the underlying signaling pathway. Journal of the American Chemical Society, 141 (15) jacs.8b10904, 6122-6126. doi: 10.1021/jacs.8b10904
2019
Journal Article
Core–shell Prussian blue analogs with compositional heterogeneity and open cages for oxygen evolution reaction
Zhang, Wuxiang, Song, Hao, Cheng, Yan, Liu, Chao, Wang, Chaohai, Khan, Muhammad Abdul Nasir, Zhang, Hao, Liu, Jizi, Yu, Chengzhong, Wang, Lianjun and Li, Jiansheng (2019). Core–shell Prussian blue analogs with compositional heterogeneity and open cages for oxygen evolution reaction. Advanced Science, 6 (7) 1801901, 1801901. doi: 10.1002/advs.201801901
2019
Journal Article
Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations
Fu, Jianye, Gu, Zhengying, Liu, Yang, Zhang, Jun, Song, Hao, Yang, Yannan, Yang, Yang, Noonan, Owen, Tang, Jie and Yu, Chengzhong (2019). Bottom-up self-assembly of heterotrimeric nanoparticles and their secondary Janus generations. Chemical Science, 10 (44), 10388-10394. doi: 10.1039/c9sc02961c
2018
Journal Article
Superhydrophobic dendritic mesoporous organosilica nano-particles with ultrahigh-content of gradient organic moieties
Kalantari, Mohammad, Liu, Yang, Strounina, Ekaterina, Yang, Yannan, Song, Hao and Yu, Chengzhong (2018). Superhydrophobic dendritic mesoporous organosilica nano-particles with ultrahigh-content of gradient organic moieties. Journal of Materials Chemistry A, 6 (36), 17579-17586. doi: 10.1039/c8ta06268d
2018
Journal Article
Hybrid nanoreactors: enabling an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy
Yang, Yannan, Tang, Jie, Abbaraju, Prasanna Lakshmi, Jambhrunkar, Manasi, Song, Hao, Zhang, Min, Lei, Chang, Fu, Jianye, Gu, Zhengying, Liu, Yang and Yu, Chengzhong (2018). Hybrid nanoreactors: enabling an off-the-shelf strategy for concurrently enhanced chemo-immunotherapy. Angewandte Chemie, 130 (36), 11938-11943. doi: 10.1002/ange.201807595
2018
Journal Article
Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling
Wang, Yue, Song, Hao, Yang, Yannan, Liu, Yang, Tang, Jie and Yu, Chengzhong (2018). Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling. Chemistry of Materials, 30 (16) acs.chemmater.8b02712, 5770-5776. doi: 10.1021/acs.chemmater.8b02712
2018
Journal Article
Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy
Lu, Yao, Yang, Yannan, Gu, Zhengying, Zhang, Jun, Song, Hao, Xiang, Guangya and Yu, Chengzhong (2018). Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy. Biomaterials, 175, 82-92. doi: 10.1016/j.biomaterials.2018.05.025
Funding
Current funding
Past funding
Supervision
Availability
- Dr Hao Song is:
- Available for supervision
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Available projects
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A nanotechnology for long-lasting oral drug delivery.
Medication adherence is required for the effectiveness of all pharmacotherapies, especially for long-term treatment of chronic illness and infectious diseases such as malaria, diabetes, and HIV. However, intensive dosage regimens with a high pill burden are associated with a low adherence rate, leading to compromised or even failure of therapies. My project aims to realize the ideal of ‘pillbox in a capsule’, i.e. taking a single tablet that will provide sustained drug release over several days, by developing a long-lasting oral drug delivery platform with prolonged gastrointestinal transit time. Inspired by bio-adhesive natural systems, where spiky surfaces enable strong adhesion, this project will engineer silica particles with a spiky morphology as well as their assembled medical devices as oral drug delivery vehicles, and their interactions at the bio-interfaces in the gastrointestinal environment will be investigated in detail. On completion, this project will produce guidelines for the rational design of novel oral drug delivery systems, and new potential clinical strategies for simplified oral medications to improve medication adherence and patient outcomes.
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Virus-mimicking nanoparticles for DNA vaccine
DNA vaccine, as the third generation vaccine technology, representing the latest biotechnological breakthrough in vaccine development. Compared to conventional recombinant vaccines usually only stimulating the antibody responses, DNA vaccine show advantages in evoking both cellular and humoral immunity to fulfill the demand in combating chronic infectious diseases. Moreover, the cost-effectiveness and fast speed of production make DNA vaccine an ideal strategy to deal with outbreaks such as SARS-COV-2 and H5N1 for the sake of both public and animal healthcare. To enable a successful DNA vaccine technology, it is critical to develop efficient gene vectors to transport and regulate the DNA molecules to be highly expressed in target cells. Mimicking the morphology of the virus, this project aims to fabricate a series of virus-like silica nanoparticles with tailored physicochemical features for plasmid DNA delivery and investigate their gene translation and vaccine performance. The completion of this project will provide fundamental understandings of the impact of designer particle nanostructure/chemistry on DNA transfection and vaccine immunogenicity.
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Nature-inspired spiky nanomaterials probed at the bio-nano interfaces
The intriguing nature systems have inspired remarkable advances in the development of functional nanomaterials for biomedical applications. Nature creations such as pollen grains and virus with spiky topological features at various length scales enable multivalent interactions at bio-interfaces, and typically exhibit intriguing surface adhesive property. This project aims to apply this nature-derived principle to engineer nanoparticles for enhanced intracellular delivery of biomolecules. Nanomaterials with functional compositions and tailored spiky nanostructures will be fabricated. Their cellular internalization process and biomolecules delivery efficiency will be evaluated. On completion of this project, a versatile and functional drug delivery platform will be established and an in-depth understanding of the spiky nanoparticle-cell interaction will be revealed.
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Antibiotic-free antibacterial nanotechnology
The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. This project aims to develop antibiotic-free antibacterial formulations enabled by advanced nanomaterials. Functional nanomaterials with intrinsic or light-mediated bactericidal properties will be fabricated to enable efficient pathogen killing. Meanwhile, porous nanoparticles will also be engineered to serve as vehicles for the delivery of natural antibacterial compounds, formulating Pickering emulsion for stable and sparable antibacterial nano-agents. On the completion of this project, nano-formulations showing potent antibacterial property and good safety will be provided, and their antibacterial mechanisms, as well as the structure-performance relationship, will be revealed.
Supervision history
Current supervision
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Doctor Philosophy
Biomimetic Nanoparticles for Efficient Vaccine Delivery
Principal Advisor
-
Doctor Philosophy
clinically-oriented synergized immunotherapy strategies for breast cancer
Principal Advisor
-
Doctor Philosophy
Engineering Spiky Nanoparticles Probed at the Nano-Bio Interfaces
Principal Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Multifunctional hybrid mesoporous silica nanoparticles for stimuli-responsive delivery of antimicrobial agents
Associate Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Engineering encapsulation technology for enzyme immobilization
Associate Advisor
-
Doctor Philosophy
Development of a market relevant DNA nano-vaccine platform
Associate Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Synthesis and applications of non-viral gene vectors
Associate Advisor
Other advisors: Professor Michael Yu
Completed supervision
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2023
Doctor Philosophy
Engineering core-shell-type of silica nanoparticles with controllable surface nanotopography as gene delivery vectors
Associate Advisor
Other advisors: Professor Michael Yu
-
2023
Doctor Philosophy
Agriculture Nanotechnology & Materials Engineering: Agricultural Applications of Silica-Based Nanomaterials
Associate Advisor
Other advisors: Professor Michael Yu
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2022
Doctor Philosophy
Nanoparticle-Assisted Signal-Enhancement Technique for Lateral Flow Immunoassays
Associate Advisor
Other advisors: Professor Michael Yu
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2021
Doctor Philosophy
Engineered Aluminosilicate-Based Nanoparticles for Safe and Efficient Vaccine Delivery
Associate Advisor
Other advisors: Professor Linda Lua, Professor Michael Yu
Media
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