Overview
Availability
- Dr Hao Song is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Hao Song’s works on UQ eSpace
2016
Journal Article
Anion assisted synthesis of large pore hollow dendritic mesoporous organosilica nanoparticles: understanding the composition gradient
Yang, Yannan, Bernardi, Stefano, Song, Hao, Zhang, Jun, Yu, Meihua, Reid, James C., Strounina, Ekaterina, Searles, Debra J. and Yu, Chengzhong (2016). Anion assisted synthesis of large pore hollow dendritic mesoporous organosilica nanoparticles: understanding the composition gradient. Chemistry of Materials, 28 (3), 704-707. doi: 10.1021/acs.chemmater.5b03963
2015
Journal Article
Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery
Xu, Chun, Yu, Meihua, Noonan, Owen, Zhang, Jun, Song, Hao, Zhang, Hongwei, Lei, Chang, Niu, Yuting, Huang, Xiaodan, Yang, Yannan and Yu, Chengzhong (2015). Core-cone structured monodispersed mesoporous silica nanoparticles with ultra-large cavity for protein delivery. Small, 11 (44), 5949-5955. doi: 10.1002/smll.201501449
2015
Journal Article
Self-Organized Mesostructured Hollow Carbon Nanoparticles via a Surfactant-Free Sequential Heterogeneous Nucleation Pathway
Zhang, Hongwei, Yu, Meihua, Song, Hao, Noonan, Owen, Zhang, Jun, Yang, Yannan, Zhou, Liang and Yu, Chengzhong (2015). Self-Organized Mesostructured Hollow Carbon Nanoparticles via a Surfactant-Free Sequential Heterogeneous Nucleation Pathway. Chemistry of Materials, 27 (18), 6297-6304. doi: 10.1021/acs.chemmater.5b01993
2015
Journal Article
Hierarchical SAPO-11 preparation in the presence of glucose
Liu, Zhen, Liu, Lingjing, Song, Hao, Wang, Chuangye, Xing, Wei, Kornarneni, Sridhar and Yan, Zifeng (2015). Hierarchical SAPO-11 preparation in the presence of glucose. Materials Letters, 154, 116-119. doi: 10.1016/j.matlet.2015.04.067
2015
Journal Article
Preparation of fluorescent mesoporous hollow silica-fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy
Yang, Yannan, Yu, Meihua, Song, Hao, Wang, Yue and Yu, Chengzhong (2015). Preparation of fluorescent mesoporous hollow silica-fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy. Nanoscale, 7 (28), 11894-11898. doi: 10.1039/c5nr02769a
2015
Journal Article
New insight into ordered cage-type mesostructures and their pore size determination by electron tomography
Yuan, Pei, Yang, Jie, Zhang, Hongwei, Song, Hao, Huang, Xiaodan, Bao, Xiaojun, Zou, Jin and Yu, Chengzhong (2015). New insight into ordered cage-type mesostructures and their pore size determination by electron tomography. Langmuir, 31 (8), 2545-2553. doi: 10.1021/la504474z
2014
Journal Article
Fabrication of ordered mesoporous carbon hollow fiber membranes via a confined soft templating approach
Li, Jiansheng, Qi, Junwen, Liu, Chao, Zhou, Liang, Song, Hao, Yu, Chengzhong, Shen, Jinyou, Sun, Xiuyun and Wang, Lianjun (2014). Fabrication of ordered mesoporous carbon hollow fiber membranes via a confined soft templating approach. Journal of Materials Chemistry A, 2 (12), 4144-4149. doi: 10.1039/c3ta14884j
2014
Journal Article
The fabrication of porous N-doped carbon from widely available urea formaldehyde resin for carbon dioxide adsorption
Liu, Zhen, Du, Zhenyu, Song, Hao, Wang, Chuangye, Subhan, Fazle, Xing, Wei and Yan, Zifeng (2014). The fabrication of porous N-doped carbon from widely available urea formaldehyde resin for carbon dioxide adsorption. Journal of Colloid and Interface Science, 416, 124-132. doi: 10.1016/j.jcis.2013.10.061
Funding
Current funding
Past funding
Supervision
Availability
- Dr Hao Song is:
- Available for supervision
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Available projects
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A nanotechnology for long-lasting oral drug delivery.
Medication adherence is required for the effectiveness of all pharmacotherapies, especially for long-term treatment of chronic illness and infectious diseases such as malaria, diabetes, and HIV. However, intensive dosage regimens with a high pill burden are associated with a low adherence rate, leading to compromised or even failure of therapies. My project aims to realize the ideal of ‘pillbox in a capsule’, i.e. taking a single tablet that will provide sustained drug release over several days, by developing a long-lasting oral drug delivery platform with prolonged gastrointestinal transit time. Inspired by bio-adhesive natural systems, where spiky surfaces enable strong adhesion, this project will engineer silica particles with a spiky morphology as well as their assembled medical devices as oral drug delivery vehicles, and their interactions at the bio-interfaces in the gastrointestinal environment will be investigated in detail. On completion, this project will produce guidelines for the rational design of novel oral drug delivery systems, and new potential clinical strategies for simplified oral medications to improve medication adherence and patient outcomes.
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Virus-mimicking nanoparticles for DNA vaccine
DNA vaccine, as the third generation vaccine technology, representing the latest biotechnological breakthrough in vaccine development. Compared to conventional recombinant vaccines usually only stimulating the antibody responses, DNA vaccine show advantages in evoking both cellular and humoral immunity to fulfill the demand in combating chronic infectious diseases. Moreover, the cost-effectiveness and fast speed of production make DNA vaccine an ideal strategy to deal with outbreaks such as SARS-COV-2 and H5N1 for the sake of both public and animal healthcare. To enable a successful DNA vaccine technology, it is critical to develop efficient gene vectors to transport and regulate the DNA molecules to be highly expressed in target cells. Mimicking the morphology of the virus, this project aims to fabricate a series of virus-like silica nanoparticles with tailored physicochemical features for plasmid DNA delivery and investigate their gene translation and vaccine performance. The completion of this project will provide fundamental understandings of the impact of designer particle nanostructure/chemistry on DNA transfection and vaccine immunogenicity.
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Nature-inspired spiky nanomaterials probed at the bio-nano interfaces
The intriguing nature systems have inspired remarkable advances in the development of functional nanomaterials for biomedical applications. Nature creations such as pollen grains and virus with spiky topological features at various length scales enable multivalent interactions at bio-interfaces, and typically exhibit intriguing surface adhesive property. This project aims to apply this nature-derived principle to engineer nanoparticles for enhanced intracellular delivery of biomolecules. Nanomaterials with functional compositions and tailored spiky nanostructures will be fabricated. Their cellular internalization process and biomolecules delivery efficiency will be evaluated. On completion of this project, a versatile and functional drug delivery platform will be established and an in-depth understanding of the spiky nanoparticle-cell interaction will be revealed.
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Antibiotic-free antibacterial nanotechnology
The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. This project aims to develop antibiotic-free antibacterial formulations enabled by advanced nanomaterials. Functional nanomaterials with intrinsic or light-mediated bactericidal properties will be fabricated to enable efficient pathogen killing. Meanwhile, porous nanoparticles will also be engineered to serve as vehicles for the delivery of natural antibacterial compounds, formulating Pickering emulsion for stable and sparable antibacterial nano-agents. On the completion of this project, nano-formulations showing potent antibacterial property and good safety will be provided, and their antibacterial mechanisms, as well as the structure-performance relationship, will be revealed.
Supervision history
Current supervision
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Doctor Philosophy
Engineering Spiky Nanoparticles Probed at the Nano-Bio Interfaces
Principal Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Biomimetic Nanoparticles for Efficient Vaccine Delivery
Principal Advisor
-
Doctor Philosophy
clinically-oriented synergized immunotherapy strategies for breast cancer
Principal Advisor
-
Doctor Philosophy
Synthesis and applications of non-viral gene vectors
Associate Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Multifunctional hybrid mesoporous silica nanoparticles for stimuli-responsive delivery of antimicrobial agents
Associate Advisor
Other advisors: Professor Michael Yu
-
Doctor Philosophy
Engineering encapsulation technology for enzyme immobilization
Associate Advisor
-
Doctor Philosophy
Development of a market relevant DNA nano-vaccine platform
Associate Advisor
Other advisors: Professor Michael Yu
Completed supervision
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2023
Doctor Philosophy
Engineering core-shell-type of silica nanoparticles with controllable surface nanotopography as gene delivery vectors
Associate Advisor
Other advisors: Professor Michael Yu
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2023
Doctor Philosophy
Agriculture Nanotechnology & Materials Engineering: Agricultural Applications of Silica-Based Nanomaterials
Associate Advisor
Other advisors: Professor Michael Yu
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2022
Doctor Philosophy
Nanoparticle-Assisted Signal-Enhancement Technique for Lateral Flow Immunoassays
Associate Advisor
Other advisors: Professor Michael Yu
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2021
Doctor Philosophy
Engineered Aluminosilicate-Based Nanoparticles for Safe and Efficient Vaccine Delivery
Associate Advisor
Other advisors: Professor Linda Lua, Professor Michael Yu
Media
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