Overview
Background
Dr. Wang completed her MPhil study in the University of Queensland (UQ) in 2016 and PhD study in UQ in October 2020. As an early career researcher, Dr.Wang has demonstrated a high impact track record relative to opportunity with award of Dean's award for Excellence in Higher Degree Research (2016), the high proportion (41%) of first-authored publications, 28% of which in the top 10% most cited publications worldwide (Scopus 24/03/2021). She has been actively engaged in a number of professional activities in the research fields, including RHD student supervision, assessment for the master research projects (BIOX7021), talks at national and international conferences (The Australian Colloid and Interface Symposium Brisbane hub, 2021; The Australasian Society for Stem Cell Research ECR Symposium, 2021; BioNano Innovation, 2020) and conference organization (The Australian Colloid and Interface Symposium Brisbane hub, 2021).
Availability
- Dr Yue Wang is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Nanochemistry upregulated mRNA translation
Dr. Wang has pioneered the conceptual design of functional nanomaterials with glutathione-depletion chemistry for upregulated mRNA translation and delivery. She has revealed the contribution of tetrasulfide bond composition of nanoparticles to GSH depletion and activation of mammalian target of rapamycin complex1 pathway for stimulated mRNA translation and enhanced delivery efficiency in hard-to-transfect APCs. This work demonstrates that, for the first time, nanoparticles not only act as a carrier for mRNA, but also a regulator to modulate mRNA translation machineries and pathways. This presents a new research direction that has not been reported. Considering the intrinsic GSH regeneration catalysed by intracellular glutathione reductase (GR), She further developed a confined growth technology to prepare zeolitic imidazolate framework-8 (ZIF-8) and MONs complex (MONs-ZIF-8), with zinc cations inhibited GR activity and tetrasulfide bond triggered GSH oxidation to synergistically enable long-term GSH depletion and enhanced mRNA delivery .
Works
Search Professor Yue Wang’s works on UQ eSpace
2020
Other Outputs
Designed synthesis of silica based nanocarriers for mRNA delivery
Wang, Yue (2020). Designed synthesis of silica based nanocarriers for mRNA delivery. PhD Thesis, Australian Institute for Bioengineering & Nanotechnology, The University of Queensland. doi: 10.14264/b28d1e7
2020
Journal Article
Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme
Wang, Yue and Yu, Chengzhong (2020). Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme. Angewandte Chemie, 132 (52) ange.202003545, 23578-23590. doi: 10.1002/ange.202003545
2020
Journal Article
Eliciting immunogenic cell death via a unitized nanoinducer
Dai, Zan, Tang, Jie, Gu, Zhengying, Wang, Yue, Yang, Yang, Yang, Yannan and Yu, Chengzhong (2020). Eliciting immunogenic cell death via a unitized nanoinducer. Nano Letters, 20 (9), 6246-6254. doi: 10.1021/acs.nanolett.0c00713
2020
Journal Article
Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity
Jambhrunkar, M., Yang, Y., Yu, M., Zhang, M., Abbaraju, P. L., Ghosh, T., Kalantari, M., Wang, Y., McMillan, N. A. J. and Yu, C. (2020). Pristine large pore benzene-bridged mesoporous organosilica nanoparticles as an adjuvant and co-delivery platform for eliciting potent antitumor immunity. Materials Today Advances, 6 100069, 100069. doi: 10.1016/j.mtadv.2020.100069
2020
Journal Article
Shaping nanoparticles for interface catalysis: concave hollow spheres via deflation–inflation asymmetric growth
Yu, Rongtai, Huang, Xiaodan, Liu, Yang, Kong, Yueqi, Gu, Zhengying, Yang, Yang, Wang, Yue, Ban, Wenhuang, Song, Hao and Yu, Chengzhong (2020). Shaping nanoparticles for interface catalysis: concave hollow spheres via deflation–inflation asymmetric growth. Advanced Science, 7 (13) 2000393, 2000393. doi: 10.1002/advs.202000393
2020
Journal Article
Antibiotic‐free strategies: antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives (Adv. Mater. 18/2020)
Wang, Yue, Yang, Yannan, Shi, Yiru, Song, Hao and Yu, Chengzhong (2020). Antibiotic‐free strategies: antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives (Adv. Mater. 18/2020). Advanced Materials, 32 (18) 2070138, 2070138. doi: 10.1002/adma.202070138
2020
Journal Article
Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells
Wang, Yue, Tang, Jie, Yang, Yannan, Song, Hao, Fu, Jianye, Gu, Zhengying and Yu, Chengzhong (2020). Functional nanoparticles with a reducible tetrasulfide motif to upregulate mRNA translation and enhance transfection in hard-to-transfect cells. Angewandte Chemie International Edition, 132 (7) ange.201914264, 2717-2721. doi: 10.1002/anie.201914264
2020
Journal Article
Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment
Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei and Yu, Chengzhong (2020). Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment. Chemical Science, 11 (38), 10421-10430. doi: 10.1039/d0sc02803g
2019
Journal Article
Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives
Wang, Yue, Yang, Yannan, Shi, Yiru, Song, Hao and Yu, Chengzhong (2019). Antibiotic‐free antibacterial strategies enabled by nanomaterials: progress and perspectives. Advanced Materials, 32 (18) 1904106, 1904106. doi: 10.1002/adma.201904106
2019
Journal Article
DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles
Song, Hao, Yang, Yannan, Tang, Jie, Gu, Zhengying, Wang, Yue, Zhang, Min and Yu, Chengzhong (2019). DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles. Advanced Therapeutics, 3 (1) 1900154, 1900154. doi: 10.1002/adtp.201900154
2018
Journal Article
Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling
Wang, Yue, Song, Hao, Yang, Yannan, Liu, Yang, Tang, Jie and Yu, Chengzhong (2018). Kinetically controlled dendritic mesoporous silica nanoparticles: from dahlia- to pomegranate-like structures by micelle filling. Chemistry of Materials, 30 (16) acs.chemmater.8b02712, 5770-5776. doi: 10.1021/acs.chemmater.8b02712
2018
Journal Article
Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance
Wang, Yue, Song, Hao, Yu, Meihua, Xu, Chun, Liu, Yang, Tang, Jie, Yang, Yannan and Yu, Chengzhong (2018). Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance. Journal of Materials Chemistry B, 6 (24), 4089-4095. doi: 10.1039/c8tb00544c
2016
Journal Article
Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure-release relationship for prolonged antibacterial performance
Nor, Yusilawati Ahmad, Zhang, Hongwei, Purwajanti, Swasmi, Song, Hao, Meka, Anand Kumar, Wang, Yue, Mitter, Neena, Mahony, Donna and Yu, Chengzhong (2016). Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure-release relationship for prolonged antibacterial performance. Journal of Materials Chemistry B, 4 (43), 7014-7021. doi: 10.1039/c6tb01778a
2016
Journal Article
Rational design of multifunctional dendritic mesoporous silica nanoparticles to load curcumin and enhance efficacy for breast cancer therapy
Wang, Jiao, Wang, Yue, Liu, Qiang, Yang, Linnan, Zhu, Rongrong, Yu, Chengzhong and Wang, Shilong (2016). Rational design of multifunctional dendritic mesoporous silica nanoparticles to load curcumin and enhance efficacy for breast cancer therapy. ACS Applied Materials and Interfaces, 8 (40), 26511-26523. doi: 10.1021/acsami.6b08400
2016
Other Outputs
Designed synthesis of large pore mesoporous silica nanoparticles as nano-carriers for bio-applications
Wang, Yue (2016). Designed synthesis of large pore mesoporous silica nanoparticles as nano-carriers for bio-applications. MPhil Thesis, Aust Institute for Bioengineering & Nanotechnology, The University of Queensland. doi: 10.14264/uql.2016.816
2016
Journal Article
Small-sized and large-pore dendritic mesoporous silica nanoparticles enhance antimicrobial enzyme delivery
Wang, Yue, Nor, Yusilawati Ahmad, Song, Hao, Yang, Yannan, Xu, Chun, Yu, Meihua and Yu, Chengzhong (2016). Small-sized and large-pore dendritic mesoporous silica nanoparticles enhance antimicrobial enzyme delivery. Journal of Materials Chemistry B, 4 (15), 2646-2653. doi: 10.1039/c6tb00053c
2015
Journal Article
Preparation of fluorescent mesoporous hollow silica-fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy
Yang, Yannan, Yu, Meihua, Song, Hao, Wang, Yue and Yu, Chengzhong (2015). Preparation of fluorescent mesoporous hollow silica-fullerene nanoparticles via selective etching for combined chemotherapy and photodynamic therapy. Nanoscale, 7 (28), 11894-11898. doi: 10.1039/c5nr02769a
Funding
Current funding
Supervision
Availability
- Dr Yue Wang is:
- Available for supervision
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Available projects
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Developing nanostructured antimicrobial coating for biomedical devices
Biomedical devices such as catheters are routinely used in a diverse range of clinical settings, the inevitable bacterial infection remains a major threat to human health. Among them, catheter-associated-urinary tract infections are a global challenge and difficult to treat due to the formation of biofilms. Traditional treatment using antibiotics leads to ever increasing antibiotics resistance. This project will use state-of-the-art nanotechnology to solve the above problems. Novel silica nanoparticles with a pollen-like morphology will be prepared to disrupt bacterial membrane. Their compositions can be tuned to cause chemical damage towards bacteria. The impacts of various structural parameters on catheter coating, antiadhesive, antibacterial and antibiofilm performances as well as urinary drainage flow will be evaluated. If successful, this technology can be used to develop next-generation antibacterial coating for biomedical devices, providing invaluable benefits to human healthcare.
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Developing efficient nano-transfection agents for mRNA vaccine delivery
The mRNA technology has received tremendous success in the development of COVID vaccines, however the performance of current mRNA cancer vaccines is low. Roche and BioNTech collaborated mRNA based personalized cancer vaccines (RO7198457 cancer vaccine) only gave a 4% response rate. Based on our ground-breaking findings of nanochemistry upregulated mRNA translation, this project aims to develop a new-generation of mRNA cancer vaccine formulations with improved efficacy. New delivery platforms will be prepared to improve the mRNA cancer vaccine performance and simplify the dosages. The impact of structural parameters of nano-carriers on mRNA transfection, antigen presenting and cellular immunity will be systematically investigated. Successful completion of this project has the potential to provide a revolutionised mRNA cancer vaccine technology.
Media
Enquiries
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