![Dr Soumyalekshmi Nair](/sites/default/files/profiles/35468.jpeg)
Overview
Background
Soumyalekshmi Nair has a degree in Veterinary and Animal Sciences (2009) and a Master of Veterinary Science in Animal Biotechnology (2011) from India. She completed her PhD in 2021 from the Faculty of Medicine, the University of Queensland. In her PhD she investigated the role of extracellular vesicles in gestational diabetes mellitus which involves developing extracellular vesicle -based biomarker for the early screening of pregnant women as well as therapeutic targets for the treatment of women with gestational diabetes. She was awarded the Research Training Scholarship from the University of Queensland and received prestigious awards from the Society of Reproductive Investigation and Australian and New Zealand Society for Extracellular Vesicles. Currently she is a Postdoctoral Research Fellow at the Exosome Biology Lab, UQ Centre for Clinical Research (UQCCR). Her research interest is understanding the molecular mechanism by which extracellular vesicles can regulate the key signalling pathways in diseases such as obesity, diabetes, and ovarian cancer, with a focus on translating this knowledge into clinical utility. She has several key publications in the field including research articles and reviews and presented at major national and international conferences. She is passionate about supporting women in science and enhancing community engagement in Science, Technology, Engineering and Mathematics (STEM).
Availability
- Dr Soumyalekshmi Nair is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Veterinary Science, unknown
- Masters (Research) of Veterinary Sciences, unknown
- Doctor of Philosophy, The University of Queensland
Research interests
-
Extracellular Vesicles
In our research we investigate the role of extracellular vesicles in the pathophysiology of diseases with a focus on harnessing their biomarker and therapeutic potential
Research impacts
The research work on gestational diabetes elucidated the role of extracellular vesicle signalling in the regulation of glucose homeostasis in metabolic conditions. The major impact of my publications has been (1) Identifying the role of extracellular vesicle and their cargo in metabolic conditions and development of non-invasive biomarkers for the diagnosis and prognosis of diseases. (2) The study provided new insights into the molecular mechanism by which extracellular vesicles can regulate the functions of recipient cells. This can aid in the development of therapeutic targets for the treatment of diseases.
Works
Search Professor Soumyalekshmi Nair’s works on UQ eSpace
2024
Journal Article
Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering
Alharbi, Mona, Lai, Andrew, Godbole, Nihar, Guanzon, Dominic, Nair, Soumyalekshmi, Zuñiga, Felipe, Quinn, Alexander, Yang, Mengliu, Wu, Sherry Y. and Salomon, Carlos (2024). Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering. International Journal of Cancer, 155 (8), 1510-1523. doi: 10.1002/ijc.35055
2024
Journal Article
Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy
Nair, Soumyalekshmi, Razo-Azamar, Melissa, Jayabalan, Nanthini, Dalgaard, Louise T., Palacios-González, Berenice, Sørensen, Anne, Kampmann, Ulla, Handberg, Aase, Carrion, Flavio and Salomon, Carlos (2024). Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy. Cytokine and Growth Factor Reviews, 76, 86-98. doi: 10.1016/j.cytogfr.2023.12.004
2024
Journal Article
Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease
Garcia, Nahuel Aquiles, Gonzalez-King, Hernan, Mellergaard, Maiken, Nair, Soumyalekshmi, Salomon, Carlos and Handberg, Aase (2024). Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease. Frontiers in Physiology, 15 1328362, 1-16. doi: 10.3389/fphys.2024.1328362
2024
Journal Article
Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A
Palma, Carlos, Lai, Andrew, Scholz‐Romero, Katherin, Chittoory, Haarika, Van Haeringen, Benjamin, Carrion, Flavio, Handberg, Aase, Lappas, Martha, Lakhani, Sunil R., McCart Reed, Amy E, McIntyre, H. David, Nair, Soumyalekshmi and Salomon, Carlos (2024). Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A. Journal of Extracellular Biology, 3 (1) e135, e135. doi: 10.1002/jex2.135
2023
Journal Article
Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification
Iannotta, Dalila, Amruta A., Lai, Andrew, Nair, Soumyalekshmi, Koifman, Na'ama, Lappas, Martha, Salomon, Carlos and Wolfram, Joy (2023). Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification. Small, 20 (18) 2307240, 1-14. doi: 10.1002/smll.202307240
2023
Journal Article
Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19
Nair, Soumyalekshmi, Nova-Lamperti, Estefania, Labarca, Gonzalo, Kulasinghe, Arutha, Short, Kirsty R., Carrión, Flavio and Salomon, Carlos (2023). Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19. Journal of Translational Medicine, 21 (1) 709, 1-19. doi: 10.1186/s12967-023-04552-2
2023
Journal Article
Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus
Rani, Shikha, Lai, Andrew, Nair, Soumya, Sharma, Shayna, Handberg, Aase, Carrion, Flavio, Möller, Andreas and Salomon, Carlos (2023). Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus. Cytokine and Growth Factor Reviews, 73, 52-68. doi: 10.1016/j.cytogfr.2023.06.004
2023
Journal Article
Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes
Nair, Soumyalekshmi, Ormazabal, Valeska, Carrion, Flavio, Handberg, Aase, McIntyre, H. David and Salomon, Carlos (2023). Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes. Clinical Science, 137 (16), 1311-1332. doi: 10.1042/cs20220150
2023
Conference Publication
Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia
D'Crus, Angel Nilesh, Jellins, Jessica, Lai, Andrew, Guanzon, Dominic, Carrion, Flavio, Nair, Soumyalekshmi, Hyett, Jon and Salomon, Carlos (2023). Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2023
Conference Publication
Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes
Nair, Soumyalekshmi S., Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Carrion, Flavio, Lappas, Martha and Salomon, Carlos (2023). Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.
2022
Journal Article
A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice
James-Allan, Laura B, Rosario, Frederick J, Madi, Lana, Barner, Kelsey, Nair, Soumyalekshmi, Lai, Andrew, Carrion, Flavio, Powell, Theresa L, Salomon, Carlos and Jansson, Thomas (2022). A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice. Clinical Science, 136 (21), 1535-1549. doi: 10.1042/cs20220484
2022
Journal Article
The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles
Ormazabal, Valeska, Nair, Soumyalekshmi, Carrión, Flavio, Mcintyre, H David and Salomon, Carlos (2022). The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles. Cardiovascular diabetology, 21 (1) 174, 174. doi: 10.1186/s12933-022-01597-3
2021
Other Outputs
Identification of therapeutic targets to regulate insulin sensitivity: potential role of placental exosomes
Nair, Soumyalekshmi Sukumaran (2021). Identification of therapeutic targets to regulate insulin sensitivity: potential role of placental exosomes. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/667b450
2021
Journal Article
Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus
Nair, Soumyalekshmi, Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Kalita de Croft, Priyakshi, Ormazabal, Valeska, Palma, Carlos, Diaz, Emilio, McCarthy, Elizabeth A., Shub, Alexis, Miranda, Jezid, Gratacós, Eduard, Crispi, Fátima, Duncombe, Gregory, Lappas, Martha, McIntyre, H. David, Rice, Gregory and Salomon, Carlos (2021). Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus. Journal of Translational Medicine, 19 (1) 360, 1-17. doi: 10.1186/s12967-021-02999-9
2021
Journal Article
Extracellular vesicles and their potential role inducing changes in maternal insulin sensitivity during gestational diabetes mellitus
Nair, Soumyalekshmi, Ormazabal, Valeska, Lappas, Martha, McIntyre, H. David and Salomon, Carlos (2021). Extracellular vesicles and their potential role inducing changes in maternal insulin sensitivity during gestational diabetes mellitus. American Journal of Reproductive Immunology, 85 (2) e13361, e13361. doi: 10.1111/aji.13361
2020
Journal Article
Circulating placental extracellular vesicles and their potential roles during pregnancy
Nakahara, Angela, Nair, Soumyalekshmi, Ormazabal, Valeska, Elfeky, Omar, Garvey, Cathryn E., Longo, Sherri and Salomon, Carlos (2020). Circulating placental extracellular vesicles and their potential roles during pregnancy. Ochsner Journal, 20 (4), 439-445. doi: 10.31486/toj.20.0049
2020
Journal Article
Extracellular vesicles as critical mediators of maternal-fetal communication during pregnancy and their potential role in maternal metabolism
Nair, Soumyalekshmi and Salomon, Carlos (2020). Extracellular vesicles as critical mediators of maternal-fetal communication during pregnancy and their potential role in maternal metabolism. Placenta, 98, 60-68. doi: 10.1016/j.placenta.2020.06.011
2020
Book Chapter
Potential role of exosomes in reproductive medicine and pregnancy
Nair, Soumyalekshmi and Salomon, Carlos (2020). Potential role of exosomes in reproductive medicine and pregnancy. Exosomes: A Clinical Compendium. (pp. 357-381) edited by Lawrence Edelstein, John Smythies, Peter Quesenberry and Denis Noble. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-816053-4.00016-X
2019
Conference Publication
Levels of extracellular vesicles and their associated miRNAs in maternal and fetal circulation during normal and diabetic pregnancies
Ormazabal, Valeska, Adam, Stefanie, Nair, Soumyalekshmi, Scholz-Romero, Katherin, Diaz, Emilio, Zuniga, Felipe, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Levels of extracellular vesicles and their associated miRNAs in maternal and fetal circulation during normal and diabetic pregnancies. Meeting of the International Federation of Placenta Associations (IFPA), Tokyo, Japan, 21-24 September, 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.306
2019
Journal Article
Quantitative proteomics by SWATH-MS suggest an association between circulating exosomes and maternal metabolic changes in gestational diabetes mellitus
Jayabalan, Nanthini, Lai, Andrew, Nair, Soumyalekshmi, Guanzon, Dominic, Scholz-Romero, Katherin, Palma, Carlos, McIntyre, Harold David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics by SWATH-MS suggest an association between circulating exosomes and maternal metabolic changes in gestational diabetes mellitus. Proteomics, 19 (1-2) 1800164, e1800164. doi: 10.1002/pmic.201800164
Funding
Past funding
Supervision
Availability
- Dr Soumyalekshmi Nair is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Media
Enquiries
For media enquiries about Dr Soumyalekshmi Nair's areas of expertise, story ideas and help finding experts, contact our Media team: