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Dr Soumyalekshmi Nair
Dr

Soumyalekshmi Nair

Email: 

Overview

Background

Soumyalekshmi Nair has a degree in Veterinary and Animal Sciences (2009) and a Master of Veterinary Science in Animal Biotechnology (2011) from India. She completed her PhD in 2021 from the Faculty of Medicine, the University of Queensland. In her PhD she investigated the role of extracellular vesicles in gestational diabetes mellitus which involves developing extracellular vesicle -based biomarker for the early screening of pregnant women as well as therapeutic targets for the treatment of women with gestational diabetes. She was awarded the Research Training Scholarship from the University of Queensland and received prestigious awards from the Society of Reproductive Investigation and Australian and New Zealand Society for Extracellular Vesicles. Currently she is a Postdoctoral Research Fellow at the Exosome Biology Lab, UQ Centre for Clinical Research (UQCCR). Her research interest is understanding the molecular mechanism by which extracellular vesicles can regulate the key signalling pathways in diseases such as obesity, diabetes, and ovarian cancer, with a focus on translating this knowledge into clinical utility. She has several key publications in the field including research articles and reviews and presented at major national and international conferences. She is passionate about supporting women in science and enhancing community engagement in Science, Technology, Engineering and Mathematics (STEM).

Availability

Dr Soumyalekshmi Nair is:
Available for supervision

Qualifications

  • Bachelor of Veterinary Science, unknown
  • Masters (Research) of Veterinary Sciences, unknown
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Extracellular Vesicles

    In our research we investigate the role of extracellular vesicles in the pathophysiology of diseases with a focus on harnessing their biomarker and therapeutic potential

Research impacts

The research work on gestational diabetes elucidated the role of extracellular vesicle signalling in the regulation of glucose homeostasis in metabolic conditions. The major impact of my publications has been (1) Identifying the role of extracellular vesicle and their cargo in metabolic conditions and development of non-invasive biomarkers for the diagnosis and prognosis of diseases. (2) The study provided new insights into the molecular mechanism by which extracellular vesicles can regulate the functions of recipient cells. This can aid in the development of therapeutic targets for the treatment of diseases.

Works

Search Professor Soumyalekshmi Nair’s works on UQ eSpace

32 works between 2017 and 2024

1 - 20 of 32 works

2024

Journal Article

Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering

Alharbi, Mona, Lai, Andrew, Godbole, Nihar, Guanzon, Dominic, Nair, Soumyalekshmi, Zuñiga, Felipe, Quinn, Alexander, Yang, Mengliu, Wu, Sherry Y. and Salomon, Carlos (2024). Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering. International Journal of Cancer, 155 (8), 1510-1523. doi: 10.1002/ijc.35055

Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering

2024

Journal Article

Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy

Nair, Soumyalekshmi, Razo-Azamar, Melissa, Jayabalan, Nanthini, Dalgaard, Louise T., Palacios-González, Berenice, Sørensen, Anne, Kampmann, Ulla, Handberg, Aase, Carrion, Flavio and Salomon, Carlos (2024). Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy. Cytokine and Growth Factor Reviews, 76, 86-98. doi: 10.1016/j.cytogfr.2023.12.004

Advances in extracellular vesicles as mediators of cell-to-cell communication in pregnancy

2024

Journal Article

Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease

Garcia, Nahuel Aquiles, Gonzalez-King, Hernan, Mellergaard, Maiken, Nair, Soumyalekshmi, Salomon, Carlos and Handberg, Aase (2024). Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease. Frontiers in Physiology, 15 1328362, 1-16. doi: 10.3389/fphys.2024.1328362

Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for chronic kidney disease

2024

Journal Article

Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A

Palma, Carlos, Lai, Andrew, Scholz‐Romero, Katherin, Chittoory, Haarika, Van Haeringen, Benjamin, Carrion, Flavio, Handberg, Aase, Lappas, Martha, Lakhani, Sunil R., McCart Reed, Amy E, McIntyre, H. David, Nair, Soumyalekshmi and Salomon, Carlos (2024). Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A. Journal of Extracellular Biology, 3 (1) e135, e135. doi: 10.1002/jex2.135

Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A

2023

Journal Article

Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification

Iannotta, Dalila, Amruta A., Lai, Andrew, Nair, Soumyalekshmi, Koifman, Na'ama, Lappas, Martha, Salomon, Carlos and Wolfram, Joy (2023). Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification. Small, 20 (18) 2307240, 1-14. doi: 10.1002/smll.202307240

Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification

2023

Journal Article

Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19

Nair, Soumyalekshmi, Nova-Lamperti, Estefania, Labarca, Gonzalo, Kulasinghe, Arutha, Short, Kirsty R., Carrión, Flavio and Salomon, Carlos (2023). Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19. Journal of Translational Medicine, 21 (1) 709, 1-19. doi: 10.1186/s12967-023-04552-2

Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19

2023

Journal Article

Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus

Rani, Shikha, Lai, Andrew, Nair, Soumya, Sharma, Shayna, Handberg, Aase, Carrion, Flavio, Möller, Andreas and Salomon, Carlos (2023). Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus. Cytokine and Growth Factor Reviews, 73, 52-68. doi: 10.1016/j.cytogfr.2023.06.004

Extracellular vesicles as mediators of cell-cell communication in ovarian cancer and beyond – A lipids focus

2023

Journal Article

Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

Nair, Soumyalekshmi, Ormazabal, Valeska, Carrion, Flavio, Handberg, Aase, McIntyre, H. David and Salomon, Carlos (2023). Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes. Clinical Science, 137 (16), 1311-1332. doi: 10.1042/cs20220150

Extracellular vesicle-mediated targeting strategies for long-term health benefits in gestational diabetes

2023

Conference Publication

Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia

D'Crus, Angel Nilesh, Jellins, Jessica, Lai, Andrew, Guanzon, Dominic, Carrion, Flavio, Nair, Soumyalekshmi, Hyett, Jon and Salomon, Carlos (2023). Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.

Effect of aspirin on the circulating extracellular vesicle proteomic profile in women at risk for preeclampsia

2023

Conference Publication

Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes

Nair, Soumyalekshmi S., Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Carrion, Flavio, Lappas, Martha and Salomon, Carlos (2023). Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes. 70th Annual Meeting of the Society for Reproductive Investigation (SRI), Brisbane, QLD, Australia, 21-25 March 2023. Heidelberg, Germany: Springer.

Unique tissue specific miRNA motifs in placenta and adipose tissue regulate changes in insulin sensitivity in healthy pregnancy and gestational diabetes

2022

Journal Article

A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

James-Allan, Laura B, Rosario, Frederick J, Madi, Lana, Barner, Kelsey, Nair, Soumyalekshmi, Lai, Andrew, Carrion, Flavio, Powell, Theresa L, Salomon, Carlos and Jansson, Thomas (2022). A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice. Clinical Science, 136 (21), 1535-1549. doi: 10.1042/cs20220484

A novel technique using chronic infusion of small extracellular vesicles from gestational diabetes mellitus causes glucose intolerance in pregnant mice

2022

Journal Article

The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles

Ormazabal, Valeska, Nair, Soumyalekshmi, Carrión, Flavio, Mcintyre, H David and Salomon, Carlos (2022). The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles. Cardiovascular diabetology, 21 (1) 174, 174. doi: 10.1186/s12933-022-01597-3

The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles

2021

Other Outputs

Identification of therapeutic targets to regulate insulin sensitivity: potential role of placental exosomes

Nair, Soumyalekshmi Sukumaran (2021). Identification of therapeutic targets to regulate insulin sensitivity: potential role of placental exosomes. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/667b450

Identification of therapeutic targets to regulate insulin sensitivity: potential role of placental exosomes

2021

Journal Article

Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

Nair, Soumyalekshmi, Guanzon, Dominic, Jayabalan, Nanthini, Lai, Andrew, Scholz-Romero, Katherin, Kalita de Croft, Priyakshi, Ormazabal, Valeska, Palma, Carlos, Diaz, Emilio, McCarthy, Elizabeth A., Shub, Alexis, Miranda, Jezid, Gratacós, Eduard, Crispi, Fátima, Duncombe, Gregory, Lappas, Martha, McIntyre, H. David, Rice, Gregory and Salomon, Carlos (2021). Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus. Journal of Translational Medicine, 19 (1) 360, 1-17. doi: 10.1186/s12967-021-02999-9

Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus

2021

Journal Article

Extracellular vesicles and their potential role inducing changes in maternal insulin sensitivity during gestational diabetes mellitus

Nair, Soumyalekshmi, Ormazabal, Valeska, Lappas, Martha, McIntyre, H. David and Salomon, Carlos (2021). Extracellular vesicles and their potential role inducing changes in maternal insulin sensitivity during gestational diabetes mellitus. American Journal of Reproductive Immunology, 85 (2) e13361, e13361. doi: 10.1111/aji.13361

Extracellular vesicles and their potential role inducing changes in maternal insulin sensitivity during gestational diabetes mellitus

2020

Journal Article

Circulating placental extracellular vesicles and their potential roles during pregnancy

Nakahara, Angela, Nair, Soumyalekshmi, Ormazabal, Valeska, Elfeky, Omar, Garvey, Cathryn E., Longo, Sherri and Salomon, Carlos (2020). Circulating placental extracellular vesicles and their potential roles during pregnancy. Ochsner Journal, 20 (4), 439-445. doi: 10.31486/toj.20.0049

Circulating placental extracellular vesicles and their potential roles during pregnancy

2020

Journal Article

Extracellular vesicles as critical mediators of maternal-fetal communication during pregnancy and their potential role in maternal metabolism

Nair, Soumyalekshmi and Salomon, Carlos (2020). Extracellular vesicles as critical mediators of maternal-fetal communication during pregnancy and their potential role in maternal metabolism. Placenta, 98, 60-68. doi: 10.1016/j.placenta.2020.06.011

Extracellular vesicles as critical mediators of maternal-fetal communication during pregnancy and their potential role in maternal metabolism

2020

Book Chapter

Potential role of exosomes in reproductive medicine and pregnancy

Nair, Soumyalekshmi and Salomon, Carlos (2020). Potential role of exosomes in reproductive medicine and pregnancy. Exosomes: A Clinical Compendium. (pp. 357-381) edited by Lawrence Edelstein, John Smythies, Peter Quesenberry and Denis Noble. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-816053-4.00016-X

Potential role of exosomes in reproductive medicine and pregnancy

2019

Conference Publication

Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy

Nair, Soumyalekshmi, Ormazabal, Valeska, Ramirez, Macarena, Lai, Andrew, Scholz Romero, Katherin, McIntyre, David, Diaz, Emilio, Zuniga, Felipe, Lappas, Martha and Salomon, Carlos (2019). Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy. Meeting of the International Federation of Placenta Associations (IFPA), Tokyo, Japan, 21-24 September, 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.307

Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy

2019

Conference Publication

Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy

Nair, Soumyalekshmi S., Lai, Andrew, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079

Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy

Funding

Past funding

  • 2023 - 2024
    Identification of Early Biomarkers of Gestational Diabetes Mellitus for Long Term Health Outcomes in Mothers and Children
    WHRTN EMCR Grant
    Open grant

Supervision

Availability

Dr Soumyalekshmi Nair is:
Available for supervision

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Media

Enquiries

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