Overview
Background
Soumyalekshmi Nair has a degree in Veterinary and Animal Sciences (2009) and a Master of Veterinary Science in Animal Biotechnology (2011) from India. She completed her PhD in 2021 from the Faculty of Medicine, the University of Queensland. In her PhD she investigated the role of extracellular vesicles in gestational diabetes mellitus which involves developing extracellular vesicle -based biomarker for the early screening of pregnant women as well as therapeutic targets for the treatment of women with gestational diabetes. She was awarded the Research Training Scholarship from the University of Queensland and received prestigious awards from the Society of Reproductive Investigation and Australian and New Zealand Society for Extracellular Vesicles. Currently she is a Postdoctoral Research Fellow at the Exosome Biology Lab, UQ Centre for Clinical Research (UQCCR). Her research interest is understanding the molecular mechanism by which extracellular vesicles can regulate the key signalling pathways in diseases such as obesity, diabetes, and ovarian cancer, with a focus on translating this knowledge into clinical utility. She has several key publications in the field including research articles and reviews and presented at major national and international conferences. She is passionate about supporting women in science and enhancing community engagement in Science, Technology, Engineering and Mathematics (STEM).
Availability
- Dr Soumyalekshmi Nair is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Veterinary Science, Kerala Veterinary and Animal Sciences University
- Masters (Research) of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences
- Doctor of Philosophy, The University of Queensland
Research interests
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Extracellular Vesicles
In our research we investigate the role of extracellular vesicles in the pathophysiology of diseases with a focus on harnessing their biomarker and therapeutic potential
Research impacts
The research work on gestational diabetes elucidated the role of extracellular vesicle signalling in the regulation of glucose homeostasis in metabolic conditions. The major impact of my publications has been (1) Identifying the role of extracellular vesicle and their cargo in metabolic conditions and development of non-invasive biomarkers for the diagnosis and prognosis of diseases. (2) The study provided new insights into the molecular mechanism by which extracellular vesicles can regulate the functions of recipient cells. This can aid in the development of therapeutic targets for the treatment of diseases.
Works
Search Professor Soumyalekshmi Nair’s works on UQ eSpace
2019
Conference Publication
Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy
Nair, Soumyalekshmi, Ormazabal, Valeska, Ramirez, Macarena, Lai, Andrew, Scholz Romero, Katherin, McIntyre, David, Diaz, Emilio, Zuniga, Felipe, Lappas, Martha and Salomon, Carlos (2019). Protein analysis in skeletal muscle from gestational diabetes mellitus and their association with insulin signalling during pregnancy. Meeting of the International Federation of Placenta Associations (IFPA), Tokyo, Japan, 21-24 September, 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.307
2019
Conference Publication
Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy
Nair, Soumyalekshmi S., Lai, Andrew, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Quantitative proteomics using SWATH in skeletal muscle and placenta from gestational diabetes mellitus reveals novel alterations associated with glucose metabolism and insulin sensitivity during pregnancy. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079
2019
Conference Publication
Levels of extracellular vesicles and their associated miRNAs in maternal and fetal circulation during normal and diabetic pregnancies
Ormazabal, Valeska, Adam, Stefanie, Nair, Soumyalekshmi, Scholz-Romero, Katherin, Diaz, Emilio, Zuniga, Felipe, McIntyre, David, Lappas, Martha and Salomon, Carlos (2019). Levels of extracellular vesicles and their associated miRNAs in maternal and fetal circulation during normal and diabetic pregnancies. Meeting of the International Federation of Placenta Associations (IFPA), Tokyo, Japan, 21-24 September, 2018. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2019.06.306
2018
Journal Article
Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity
Nair, Soumyalekshmi, Jayabalan, Nanthini, Guanzon, Dominic, Palma, Carlos, Scholz-Romero, Katherin, Elfeky, Omar, Zuñiga, Felipe, Ormazabal, Valeska, Diaz, Emilio, Rice, Gregory E., Duncombe, Gregory, Jansson, Thomas, McIntyre, Harold David, Lappas, Martha and Salomon, Carlos (2018). Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity. Clinical Science, 132 (22), 2451-2467. doi: 10.1042/cs20180487
2018
Journal Article
Salivary exosomes as potential biomarkers in cancer
Nair, Soumyalekshmi, Tang, Kai Dun, Kenny, Liz and Punyadeera, Chamindie (2018). Salivary exosomes as potential biomarkers in cancer. Oral Oncology, 84, 31-40. doi: 10.1016/j.oraloncology.2018.07.001
2018
Journal Article
Association between insulin resistance and the development of cardiovascular disease
Ormazabal, Valeska, Nair, Soumyalekshmi, Elfeky, Omar, Aguayo, Claudio, Salomon, Carlos and Zuñiga, Felipe A. (2018). Association between insulin resistance and the development of cardiovascular disease. Cardiovascular Diabetology, 17 (1) 122, 122. doi: 10.1186/s12933-018-0762-4
2018
Journal Article
Extracellular vesicles and their immunomodulatory functions in pregnancy
Nair, Soumyalekshmi and Salomon, Carlos (2018). Extracellular vesicles and their immunomodulatory functions in pregnancy. Seminars in Immunopathology, 40 (5), 1-13. doi: 10.1007/s00281-018-0680-2
2018
Journal Article
Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth
Miranda, Jezid, Paules, Cristina, Nair, Soumyalekshmi, Lai, Andrew, Palma, Carlos, Scholz-Romero, Katherin, Rice, Gregory E., Gratacos, Eduard, Crispi, Fatima and Salomon, Carlos (2018). Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth. Placenta, 64, 34-43. doi: 10.1016/j.placenta.2018.02.006
2018
Conference Publication
Interactions between placental exosomes and skeletal muscle implication in cell metabolism in gestational diabetes mellitus
Nair, Soumyalekshmi, Jayabalan, Nanthini, Guanzon, Dominic, Lai, Andrew, Scholz-Romero, Katherin, Elfeky, Omar, Zuniga, Felipe, Diaz, Emilio, McIntyre, David, Rice, Gregory E., Lappas, Martha and Salomon, Carlos (2018). Interactions between placental exosomes and skeletal muscle implication in cell metabolism in gestational diabetes mellitus. 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego, CA, United States, 6-10 March 2018. Thousand Oaks, CA, United States: Sage. doi: 10.1177/1933719118759999
2017
Journal Article
Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes
Jayabalan, Nanthini, Nair, Soumyalekshmi, Nuzhat, Zarin, Rice, Gregory E., Zuniga, Felipe A., Sobrevia, Luis, Leiva, Andrea, Sanhueza, Carlos, Agustin Gutierrez, Jaime, Lappas, Martha, Freeman, Dilys Jane and Salomon, Carlos (2017). Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes. Frontiers in Endocrinology, 8 (SEP) 239, 239. doi: 10.3389/fendo.2017.00239
2017
Conference Publication
Extracellular vesicles (ev) size in shallow trophoblast invasion in old world non-human primates
Schlabritz-Loutsevitch, Natalia, Dick, Edward, Hubbard, Gene, Perez, Cathy, Chuecos, Marcel, Nair, Soumyalekshmi, Palma, Carlos, Kinhal, Vyjayanthi and Salomon, Carlos (2017). Extracellular vesicles (ev) size in shallow trophoblast invasion in old world non-human primates. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester England, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.153
2017
Conference Publication
Exosomes present in circulation of women with gestational diabetes mellitus carry a specific set of microRNAs associated with insulin resistant
Guanzon, Dominic, Jayabalan, Nanthini, Palma, Carlos, Nair, Soumyalekshmi, Scholz-Romero, Katherin, Kinhal, Vyjayanthi, Lai, Andrew, McIntyre, David, Jansson, Thomas, Rice, Gregory, Lappas, Martha and Salomon, Carlos (2017). Exosomes present in circulation of women with gestational diabetes mellitus carry a specific set of microRNAs associated with insulin resistant. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester, United Kingdom, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.134
2017
Conference Publication
Differential effect of maternal hypoxia on syncytiotrophoblast-and endothelial-derived exosomes in an ex vivo human dual-perfusion system
Schlabritz-Loutsevitch, Natalia, Nair, Soumyalekshmi, Bednov, Andrey, Moore, David, Brownbill, Paul, Ventolini, Gary, Palma, Carlos, Kinhal, Vyjayanthi and Salomon, Carlos (2017). Differential effect of maternal hypoxia on syncytiotrophoblast-and endothelial-derived exosomes in an ex vivo human dual-perfusion system. Meeting of the International-Federation-of-Placenta-Associations (IFPA), Manchester England, Aug 30-Sep 2 2017. London, United Kingdom: Elsevier. doi: 10.1016/j.placenta.2017.07.290
Funding
Past funding
Supervision
Availability
- Dr Soumyalekshmi Nair is:
- Available for supervision
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