Professor David Owen
Professor

David Owen

Email: 

Background

David is a passionate and driven scientist with a successful track record in translational commercially focused technical and academic leadership. David has worked in academia and industry at the interface of chemistry, biochemistry and biology. He has successfully designed and developed several oncology nanomedicines and driven them forward into clinical trials.

As Director of the Protein Expression Facility (PEF) within The University of Queensland, David and his team strive to build collaborations and provide excellent service provision with a wide variety of researchers across academia and industry. Through this work we ensure PEF achieves its vision to be a world leader in protein research services and innovative solutions for protein production driving scientific success.

Availability

Professor David Owen is:
Available for supervision

Research interests

  • Protein Science

  • Nanotechnology

  • Radiotheranostics

  • Cancer Biology

  • Bioconjugation

Search Professor David Owen’s works on UQ eSpace

46 works between 1991 and 2023
All (46) Journal Article (41) Conference Publication (3) Other Outputs (2)

21 - 40 of 46 works

2011

Journal Article

Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers

Kaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Boyd, Ben J., Owen, David J. and Porter, Christopher J. H. (2011). Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers. Molecular Pharmaceutics, 8 (2), 338-349. doi: 10.1021/mp1001872

Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers

2010

Journal Article

Dendrimers enhance delivery of small molecule and biological drugs: Control solubility, half-life, toxicity and targeting

Owen, David and Barrett, Paul (2010). Dendrimers enhance delivery of small molecule and biological drugs: Control solubility, half-life, toxicity and targeting. ONdrugDelivery (4), 21-24.

Dendrimers enhance delivery of small molecule and biological drugs: Control solubility, half-life, toxicity and targeting

2010

Journal Article

Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate

Koohang, Ali, Bailey, Jessica L., Coates, Robert M., Erickson, Hans K., Owen, David and Poulter, C. Dale (2010). Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. Journal of Organic Chemistry, 75 (14), 4769-4777. doi: 10.1021/jo100718z

Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate

2009

Journal Article

Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol

Adams, Tim E., Sous, Mariana El, Hawkins, Bill C., Hirner, Sebastian, Holloway, Georgina, Khoo, Mui Ling, Owen, David J., Paul Savage, G., Seammells, Peter J. and Rizzacasa, Mark A. (2009). Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol. Journal of the American Chemical Society, 131 (4), 1607-1616. doi: 10.1021/ja808402e

Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol

2007

Journal Article

Total synthesis of (-)-episilvestrol and (-)-silvestrol

El Sous, Mariana, Khoo, Mui Ling, Holloway, Georgina, Owen, David, Scammells, Peter J. and Rizzacasa, Mark A. (2007). Total synthesis of (-)-episilvestrol and (-)-silvestrol. Angewandte Chemie - International Edition, 46 (41), 7835-7838. doi: 10.1002/anie.200702700

Total synthesis of (-)-episilvestrol and (-)-silvestrol

2007

Journal Article

Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria

Davis, Chris B., Hartnell, Regan D., Madge, Paul D., Owen, David J., Thomson, Robin J., Chong, Andrew K.J., Coppel, Ross L. and Von Itzstein, Mark (2007). Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria. Carbohydrate Research, 342 (12-13), 1773-1780. doi: 10.1016/j.carres.2007.04.027

Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria

2007

Journal Article

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents

Owen, David J., Davis, Chris B., Hartnell, Regan D., Madge, Paul D., Thomson, Robin J., Chong, Andrew K.J., Coppel, Ross L. and Von Itzstein, Mark (2007). Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents. Bioorganic and Medicinal Chemistry Letters, 17 (8), 2274-2277. doi: 10.1016/j.bmcl.2007.01.068

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents

2003

Journal Article

Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetes

Pei, Yazhong, Lilly, Michael J., Owen, David J., D'Souza, Lawrence J., Tang, Xiao-Qing, Yu, Jinghua, Nazarbaghi, Ramina, Hunter, Andrew, Anderson, Christen M., Glasco, Susan, Ede, Nicholas J., James, Ian W., Maitra, Uday, Chandrasekaran, S., Moos, Walter H. and Ghosh, Soumitra S. (2003). Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetes. Journal of Organic Chemistry, 68 (1), 92-103. doi: 10.1021/jo020446t

Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetes

2002

Journal Article

A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides)

Owen, David J., Thomson, Robin J. and Von Itzstein, Mark (2002). A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides). Carbohydrate Research, 337 (21-23), 2017-2022. doi: 10.1016/S0008-6215(02)00133-7

A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides)

2001

Journal Article

Synthesis of Functional <i>Ras</i> Lipoproteins and Fluorescent Derivatives

Kuhn, Karsten, Owen, David J., Bader, Benjamin, Wittinghofer, Alfred, Kuhlmann, Jürgen and Waldmann, Herbert (2001). Synthesis of Functional Ras Lipoproteins and Fluorescent Derivatives. Journal of the American Chemical Society, 123 (6), 1023-1035. doi: 10.1021/ja002723o

Synthesis of Functional <i>Ras</i> Lipoproteins and Fluorescent Derivatives

2000

Journal Article

Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125

Blake, Patrick S, Taylor, David R, Crisp, Carol M, Mander, Lewis N and Owen, David J (2000). Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125. Phytochemistry, 55 (8), 887-890. doi: 10.1016/S0031-9422(00)00237-5

Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125

2000

Journal Article

Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II

Thoma N.H., Iakovenko A., Owen D., Scheidig A.S., Waldmann H., Goody R.S. and Alexandrov K. (2000). Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II. Biochemistry, 39 (39), 12043-12052. doi: 10.1021/bi000835m

Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II

2000

Journal Article

A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides

Owen, David J. and Von Itzstein, Mark (2000). A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides. Carbohydrate Research, 328 (3), 287-292. doi: 10.1016/S0008-6215(00)00110-5

A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides

2000

Journal Article

Bioorganic synthesis of lipid-modified proteins for the study of signal transduction

Bader, Benjamin, Kuhn, Karsten, Owen, David J., Waldmann, Herbert, Wittinghofer, Alfred and Kuhlmann, Jürgen (2000). Bioorganic synthesis of lipid-modified proteins for the study of signal transduction. Nature, 403 (6766), 223-226. doi: 10.1038/35003249

Bioorganic synthesis of lipid-modified proteins for the study of signal transduction

1999

Journal Article

Peptide conjugates as tools for the study of biological signal transduction

Eisele, Frank, Owen, David J. and Waldmann, Herbert (1999). Peptide conjugates as tools for the study of biological signal transduction. Bioorganic and Medicinal Chemistry, 7 (2), 193-224. doi: 10.1016/S0968-0896(98)00204-1

Peptide conjugates as tools for the study of biological signal transduction

1999

Journal Article

Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitors

Koohang, Ali, Coates, Robert M., Owen, David and Poulter, C. Dale (1999). Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitors. Journal of Organic Chemistry, 64 (1), 6-7. doi: 10.1021/jo981833z

Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitors

1999

Journal Article

Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells

Owen, DJ, Alexandrov, K, Rostkova, E, Scheidig, AJ, Goody, RS and Waldmann, H (1999). Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells. Angewandte Chemie-International Edition, 38 (4), 509-512. doi: 10.1002/(SICI)1521-3773(19990215)38:43.3.CO;2-V

Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells

1998

Journal Article

Identification of GA113, GA114, GA115 and GA116 and further novel gibberellins in Raphanus sativus

Nakayama, Massyoshi, Nishijima, Takaaki, Koshioka, Masaji, Yamane, Hisakazu, Owen, David J. and Mander, Lewis N. (1998). Identification of GA113, GA114, GA115 and GA116 and further novel gibberellins in Raphanus sativus. Phytochemistry, 48 (4), 587-593. doi: 10.1016/s0031-9422(98)00035-1

Identification of GA113, GA114, GA115 and GA116 and further novel gibberellins in Raphanus sativus

1998

Journal Article

Synthesis and confirmation of structure for a new gibberellin, 2β- hydroxy-GA12 (GA110), from spinach and oil palm

Owen, David J., Mander, Lewis N., Storey, John M.D., Huntley, Rachael P., Gaskin, Paul, Lenton, John R., Gage, Douglas A. and Zeevaart, Jan A.D. (1998). Synthesis and confirmation of structure for a new gibberellin, 2β- hydroxy-GA12 (GA110), from spinach and oil palm. Phytochemistry, 47 (3), 331-337. doi: 10.1016/S0031-9422(97)00577-3

Synthesis and confirmation of structure for a new gibberellin, 2β- hydroxy-GA12 (GA110), from spinach and oil palm

1997

Journal Article

Synthesis of 12-hydroxy C20-gibberellins

Mander, Lewis N. and Owen, David J. (1997). Synthesis of 12-hydroxy C20-gibberellins. Tetrahedron, 53 (6), 2137-2162. doi: 10.1016/s0040-4020(96)01109-x

Synthesis of 12-hydroxy C20-gibberellins

Current funding

  • 2025 - 2027
    Hybrid quantum sensors for rapid detection of chemical and biochemical agents as a tool to mitigate the risks of terrorist attacks
    Queensland Government Department of Environment, Science and Innovation
    Open grant
  • 2023 - 2028
    ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals
    ARC Industrial Transformation Research Hubs
    Open grant

Past funding

  • 2024
    Conjugation of targeting protein moieties to non-viral vectors such as lipid nanoparticles (LNPs) (University College London administered UKRI BBSRC grant)
    University College London
    Open grant

Availability

Professor David Owen is:
Available for supervision

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Supervision history

Current supervision

Enquiries

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