Skip to menu Skip to content Skip to footer
Dr Pie Huda
Dr

Pie Huda

Email: 

Overview

Background

Dr Pie Huda is a protein engineer and research fellow at the Australian Institute for Bioengineering and Nanotechnology (AIBN), at the University of Queensland (UQ). Her research focus on development of antibodies, antibody fragments and antibody mimetics as targeting tools for nanomaterials, drugs and probes in applications such as radiopharmaceuticals. Pie is uniquely positioned at UQ, working under Professor David Owen who is the director of the Protein Expression Facility (PEF), enabling access to state-of-the-art instrumentation and specialised capabilities. She has collaborated with several Australian biotech industry partners and academic groups in the development of targeting biologics.

Availability

Dr Pie Huda is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of Copenhagen

Works

Search Professor Pie Huda’s works on UQ eSpace

22 works between 2012 and 2024

1 - 20 of 22 works

2024

Journal Article

Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma

Logan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007

Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma

2023

Journal Article

Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation

Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036

Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation

2023

Journal Article

RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo

Ardana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J. and Williams, Charlotte C. (2023). RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo. Molecular Pharmaceutics, 20 (6), 3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085

RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo

2023

Journal Article

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

Moles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

2023

Journal Article

Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic

Chu, Weijing, Houston, Zachary H., Fletcher, Nicholas L., Huda, Pie, Ahamed, Muneer, Lim, Ting Xiang, Day, Bryan W., Pinkham, Mark and Thurecht, Kristofer J. (2023). Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic. Biomacromolecules, 24 (6), 2674-2690. doi: 10.1021/acs.biomac.3c00138

Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic

2023

Journal Article

Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma

Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760

Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma

2022

Journal Article

Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery

Gao, Zhiliang, Li, Xiaoyu, Zhao, Kaijie, Geng, Huimin, Zhang, Peiyu, Ju, Yi, Huda, Pie, Howard, Christopher B, Thurecht, Kristofer J, Ashokkumar, Muthupandian, Hao, Jingcheng and Cui, Jiwei (2022). Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery. Chemical Communications, 58 (56), 7777-7780. doi: 10.1039/d2cc01874h

Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery

2022

Journal Article

Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

Fletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h

Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

2022

Journal Article

Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics

Ahmed, Salma E., Fletcher, Nicholas L., Prior, Amber R., Huda, Pie, Bell, Craig A. and Thurecht, Kristofer J. (2022). Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics. Polymer Chemistry, 13 (27), 4004-4017. doi: 10.1039/d2py00257d

Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics

2022

Conference Publication

Immuno-PET agents for targeting glioblastoma

Ghosh, S., Huda, P., Fletcher, N., Howard, C., Lu, Y., Campbell, D., Walsh, B. and Thurecht, K. (2022). Immuno-PET agents for targeting glioblastoma. Australian and New Zealand Society of Nuclear Medicine (ANZSNM) 52nd ASM, Brisbane, QLD, Australia, 13–15 May 2022. Richmond, VIC, Australia: John Wiley & Sons.

Immuno-PET agents for targeting glioblastoma

2022

Journal Article

Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery

Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Howard, Christopher B., Walsh, Bradley, Campbell, Douglas, Pinkham, Mark B. and Thurecht, Kristofer J. (2022). Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery. Molecular Pharmaceutics, 19 (5), 1233-1247. doi: 10.1021/acs.molpharmaceut.1c00996

Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery

2022

Journal Article

Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption

Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416

Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption

2022

Journal Article

Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation

Johansen, Nicolai Tidemand, Bonaccorsi, Marta, Bengtsen, Tone, Larsen, Andreas Haahr, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, Pie, Berndtsson, Jens, Darwish, Tamim, Yepuri, Nageshewar Rao, Martel, Anne, Pomorski, Thomas Günther, Bertarello, Andrea, Sansom, Mark, Rapp, Mikaela, Crehuet, Ramon, Schubeis, Tobias, Lindorff-Larsen, Kresten, Pintacuda, Guido and Arleth, Lise (2022). Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation. eLife, 11 e71887. doi: 10.7554/elife.71887

Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation

2022

Journal Article

Clinical development of an anti-GPC-1 antibody for the treatment of cancer

Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas, Campbell, Douglas, Thurecht, Kristofer J. and Walsh, Bradley (2022). Clinical development of an anti-GPC-1 antibody for the treatment of cancer. Expert Opinion on Biological Therapy, 22 (5), 603-613. doi: 10.1080/14712598.2022.2033204

Clinical development of an anti-GPC-1 antibody for the treatment of cancer

2021

Journal Article

Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering

Jensen, Grethe V., Rosenmejer, Katrine R., Huda, Pie and Arleth, Lise (2021). Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering. Molecular Pharmaceutics, 18 (9), 3272-3280. doi: 10.1021/acs.molpharmaceut.1c00164

Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering

2020

Journal Article

Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin

Tieu, Terence, Wojnilowicz, Marcin, Huda, Pie, Thurecht, Kristofer J., Thissen, Helmut, Voelcker, Nicolas H. and Cifuentes-Rius, Anna (2020). Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin. Biomaterials Science, 9 (1), 133-147. doi: 10.1039/d0bm01335h

Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin

2020

Journal Article

Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets

Niamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088

Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets

2018

Journal Article

Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering

Midtgaard, Søren Roi, Darwish, Tamim A., Pedersen, Martin Cramer, Huda, Pie, Larsen, Andreas Haahr, Jensen, Grethe Vestergaard, Kynde, Søren Andreas Røssell, Skar-Gislinge, Nicholas, Nielsen, Agnieszka Janina Zygadlo, Olesen, Claus, Blaise, Mickael, Dorosz, Jerzy Józef, Thorsen, Thor Seneca, Venskutonytė, Raminta, Krintel, Christian, Møller, Jesper V., Frielinghaus, Henrich, Gilbert, Elliot Paul, Martel, Anne, Kastrup, Jette Sandholm, Jensen, Poul Erik, Nissen, Poul and Arleth, Lise (2018). Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering. FEBS Journal, 285 (2), 357-371. doi: 10.1111/febs.14345

Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering

2017

Conference Publication

Combined SAXS and Microfludics for time-resolved structural studies of bimolecules

Arleth, Lise, Jensen, Grethe Vestergaard, Huda, Pie, Skou, Soren, Shang, Weifeng and Chakravarthy, Srinivas (2017). Combined SAXS and Microfludics for time-resolved structural studies of bimolecules. XXIV IUCr Congress, Hyderabad, India, 21-28 August 2018. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/S2053273317089641

Combined SAXS and Microfludics for time-resolved structural studies of bimolecules

2015

Journal Article

PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice

Huda, Pie, Binderup, Tina, Pedersen, Martin Cramer, Midtgaard, Soren Roi, Elema, Dennis Ringkjobing, Kjaer, Andreas, Jensen, Mikael and Arleth, Lise (2015). PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice. PLoS One, 10 (7) e0129310. doi: 10.1371/journal.pone.0129310

PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice

Funding

Past funding

  • 2024
    Conjugation of targeting protein moieties to non-viral vectors such as lipid nanoparticles (LNPs) (University College London administered UKRI BBSRC grant)
    University College London
    Open grant

Supervision

Availability

Dr Pie Huda is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

For media enquiries about Dr Pie Huda's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au