Overview
Background
Dr Pie Huda is a protein engineer and research fellow at the Australian Institute for Bioengineering and Nanotechnology (AIBN), at the University of Queensland (UQ). Her research focus on development of antibodies, antibody fragments and antibody mimetics as targeting tools for nanomaterials, drugs and probes in applications such as radiopharmaceuticals. Pie is uniquely positioned at UQ, working under Professor David Owen who is the director of the Protein Expression Facility (PEF), enabling access to state-of-the-art instrumentation and specialised capabilities. She has collaborated with several Australian biotech industry partners and academic groups in the development of targeting biologics.
Availability
- Dr Pie Huda is:
- Available for supervision
Qualifications
- Doctor of Philosophy, University of Copenhagen
Works
Search Professor Pie Huda’s works on UQ eSpace
2024
Journal Article
Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma
Logan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007
2023
Journal Article
Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation
Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036
2023
Journal Article
RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo
Ardana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J. and Williams, Charlotte C. (2023). RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo. Molecular Pharmaceutics, 20 (6), 3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085
2023
Journal Article
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia
Moles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262
2023
Journal Article
Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic
Chu, Weijing, Houston, Zachary H., Fletcher, Nicholas L., Huda, Pie, Ahamed, Muneer, Lim, Ting Xiang, Day, Bryan W., Pinkham, Mark and Thurecht, Kristofer J. (2023). Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic. Biomacromolecules, 24 (6), 2674-2690. doi: 10.1021/acs.biomac.3c00138
2023
Journal Article
Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma
Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760
2022
Journal Article
Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery
Gao, Zhiliang, Li, Xiaoyu, Zhao, Kaijie, Geng, Huimin, Zhang, Peiyu, Ju, Yi, Huda, Pie, Howard, Christopher B, Thurecht, Kristofer J, Ashokkumar, Muthupandian, Hao, Jingcheng and Cui, Jiwei (2022). Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery. Chemical Communications, 58 (56), 7777-7780. doi: 10.1039/d2cc01874h
2022
Journal Article
Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance
Fletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h
2022
Journal Article
Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics
Ahmed, Salma E., Fletcher, Nicholas L., Prior, Amber R., Huda, Pie, Bell, Craig A. and Thurecht, Kristofer J. (2022). Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics. Polymer Chemistry, 13 (27), 4004-4017. doi: 10.1039/d2py00257d
2022
Conference Publication
Immuno-PET agents for targeting glioblastoma
Ghosh, S., Huda, P., Fletcher, N., Howard, C., Lu, Y., Campbell, D., Walsh, B. and Thurecht, K. (2022). Immuno-PET agents for targeting glioblastoma. Australian and New Zealand Society of Nuclear Medicine (ANZSNM) 52nd ASM, Brisbane, QLD, Australia, 13–15 May 2022. Richmond, VIC, Australia: John Wiley & Sons.
2022
Journal Article
Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery
Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Howard, Christopher B., Walsh, Bradley, Campbell, Douglas, Pinkham, Mark B. and Thurecht, Kristofer J. (2022). Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery. Molecular Pharmaceutics, 19 (5), 1233-1247. doi: 10.1021/acs.molpharmaceut.1c00996
2022
Journal Article
Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption
Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416
2022
Journal Article
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
Johansen, Nicolai Tidemand, Bonaccorsi, Marta, Bengtsen, Tone, Larsen, Andreas Haahr, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, Pie, Berndtsson, Jens, Darwish, Tamim, Yepuri, Nageshewar Rao, Martel, Anne, Pomorski, Thomas Günther, Bertarello, Andrea, Sansom, Mark, Rapp, Mikaela, Crehuet, Ramon, Schubeis, Tobias, Lindorff-Larsen, Kresten, Pintacuda, Guido and Arleth, Lise (2022). Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation. eLife, 11 e71887. doi: 10.7554/elife.71887
2022
Journal Article
Clinical development of an anti-GPC-1 antibody for the treatment of cancer
Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas, Campbell, Douglas, Thurecht, Kristofer J. and Walsh, Bradley (2022). Clinical development of an anti-GPC-1 antibody for the treatment of cancer. Expert Opinion on Biological Therapy, 22 (5), 603-613. doi: 10.1080/14712598.2022.2033204
2021
Journal Article
Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering
Jensen, Grethe V., Rosenmejer, Katrine R., Huda, Pie and Arleth, Lise (2021). Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering. Molecular Pharmaceutics, 18 (9), 3272-3280. doi: 10.1021/acs.molpharmaceut.1c00164
2020
Journal Article
Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin
Tieu, Terence, Wojnilowicz, Marcin, Huda, Pie, Thurecht, Kristofer J., Thissen, Helmut, Voelcker, Nicolas H. and Cifuentes-Rius, Anna (2020). Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin. Biomaterials Science, 9 (1), 133-147. doi: 10.1039/d0bm01335h
2020
Journal Article
Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets
Niamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088
2018
Journal Article
Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering
Midtgaard, Søren Roi, Darwish, Tamim A., Pedersen, Martin Cramer, Huda, Pie, Larsen, Andreas Haahr, Jensen, Grethe Vestergaard, Kynde, Søren Andreas Røssell, Skar-Gislinge, Nicholas, Nielsen, Agnieszka Janina Zygadlo, Olesen, Claus, Blaise, Mickael, Dorosz, Jerzy Józef, Thorsen, Thor Seneca, Venskutonytė, Raminta, Krintel, Christian, Møller, Jesper V., Frielinghaus, Henrich, Gilbert, Elliot Paul, Martel, Anne, Kastrup, Jette Sandholm, Jensen, Poul Erik, Nissen, Poul and Arleth, Lise (2018). Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering. FEBS Journal, 285 (2), 357-371. doi: 10.1111/febs.14345
2017
Conference Publication
Combined SAXS and Microfludics for time-resolved structural studies of bimolecules
Arleth, Lise, Jensen, Grethe Vestergaard, Huda, Pie, Skou, Soren, Shang, Weifeng and Chakravarthy, Srinivas (2017). Combined SAXS and Microfludics for time-resolved structural studies of bimolecules. XXIV IUCr Congress, Hyderabad, India, 21-28 August 2018. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/S2053273317089641
2015
Journal Article
PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice
Huda, Pie, Binderup, Tina, Pedersen, Martin Cramer, Midtgaard, Soren Roi, Elema, Dennis Ringkjobing, Kjaer, Andreas, Jensen, Mikael and Arleth, Lise (2015). PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice. PLoS One, 10 (7) e0129310. doi: 10.1371/journal.pone.0129310
Funding
Past funding
Supervision
Availability
- Dr Pie Huda is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of a versatile targeted alpha therapy platform
Principal Advisor
Other advisors: Professor David Owen, Dr Nick Fletcher
-
Doctor Philosophy
The effect of avidity on nanobody-based formats for theranostic applications
Associate Advisor
Other advisors: Dr Jodi Saunus, Dr Nick Fletcher, Professor Kristofer Thurecht
-
Doctor Philosophy
The Molecular Characterisation of Myeloperoxidase (MPO) and its role in autoimmunity
Associate Advisor
Other advisors: Professor Ranjeny Thomas, Associate Professor Fiona Simpson, Professor David Owen
Completed supervision
-
2024
Doctor Philosophy
Biologics as Peptide Delivery Vehicles for Immunotherapy
Associate Advisor
Other advisors: Associate Professor Idriss Blakey, Professor Kristofer Thurecht
-
2023
Doctor Philosophy
Understanding Immunogenicity in Nanomedicine
Associate Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Professor Kristofer Thurecht
-
2023
Doctor Philosophy
Novel antibody theranostics for oncology
Associate Advisor
Other advisors: Dr Christopher Howard, Professor Kristofer Thurecht
Media
Enquiries
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