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Dr Christopher Howard
Dr

Christopher Howard

Email: 
Phone: 
+61 7 334 64209

Overview

Availability

Dr Christopher Howard is:
Available for supervision

Qualifications

  • Doctor of Philosophy, Queensland University of Technology

Research interests

  • Protein engineering, Programmable Bionanomaterials, Molecular Discovery, Bio Nano Technologies

Works

Search Professor Christopher Howard’s works on UQ eSpace

78 works between 2005 and 2025

1 - 20 of 78 works

Featured

2023

Journal Article

A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments

Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1

A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments

Featured

2023

Journal Article

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

Moles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

Featured

2023

Journal Article

A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern

Vedelago, Courtney, Li, Junrong, Lowry, Kym, Howard, Christopher, Wuethrich, Alain and Trau, Matt (2023). A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern. ACS Sensors, 8 (4), 1648-1657. doi: 10.1021/acssensors.2c02782

A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern

2025

Journal Article

Multiplexing label-free polymeric nanocarriers via antipolymer antibodies

Humphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2025). Multiplexing label-free polymeric nanocarriers via antipolymer antibodies. ACS Sensors. doi: 10.1021/acssensors.4c03184

Multiplexing label-free polymeric nanocarriers via antipolymer antibodies

2025

Journal Article

Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer

Liu, Feifei, Howard, Christopher B., Huda, Pie, Fletcher, Nicholas L., Bell, Craig A., Blakey, Idriss, Agrez, Michael and Thurecht, Kristofer J. (2025). Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer. Biomaterials, 317 123089, 123089. doi: 10.1016/j.biomaterials.2025.123089

Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer

2025

Journal Article

Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus – A novel animal test case

Johnston, Ryan A., Habarugira, Gervais, Harrison, Jessica J., Isberg, Sally R., Moran, Jasmin, Morgan, Mahali S., Davis, Steven S., Melville, Lorna, Howard, Christopher B., Henry, Charles S., Macdonald, Joanne, Bielefeldt-Ohmann, Helle, Hall, Roy A. and Hobson-Peters, Jody (2025). Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus – A novel animal test case. Sensors and Actuators B: Chemical, 422 136611, 1-11. doi: 10.1016/j.snb.2024.136611

Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus – A novel animal test case

2024

Journal Article

A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies

Agrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2024). A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies. Scientific Reports, 14 (1) 26737, 1-17. doi: 10.1038/s41598-024-78150-7

A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies

2024

Journal Article

mRNA Display Pipeline for Protein Biosensor Construction

Cui, Zhenling, Ayva, Cagla Ergun, Liew, Yi Jin, Guo, Zhong, Mutschler, Roxane, Dreier, Birgit, Fiorito, Maria M, Walden, Patricia, Howard, Christopher B, Ely, Fernanda, Plückthun, Andreas, Pretorius, Carel, Ungerer, Jacobus PJ, Buckle, Ashley M and Alexandrov, Kirill (2024). mRNA Display Pipeline for Protein Biosensor Construction. ACS Sensors, 9 (6), 2846-2857. doi: 10.1021/acssensors.3c02471

mRNA Display Pipeline for Protein Biosensor Construction

2024

Journal Article

LowTempGAL: a highly responsive low temperature-inducible GAL system in Saccharomyces cerevisiae

Lu, Zeyu, Shen, Qianyi, Bandari, Naga Chandra, Evans, Samuel, Mcdonnell, Liam, Liu, Lian, Jin, Wanli, Luna-Flores, Carlos Horacio, Collier, Thomas, Talbo, Gert, Mccubbin, Tim, Esquirol, Lygie, Myers, Chris, Trau, Matt, Dumsday, Geoff, Speight, Robert, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2024). LowTempGAL: a highly responsive low temperature-inducible GAL system in Saccharomyces cerevisiae. Nucleic Acids Research, 52 (12) gkae460, 7367-7383. doi: 10.1093/nar/gkae460

LowTempGAL: a highly responsive low temperature-inducible GAL system in Saccharomyces cerevisiae

2024

Journal Article

EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer

Moles, Ernest, Chang, David, Mansfeld, Friederike, Duly, Alastair, Kimpton, Kathleen, Logan, Amy, Howard, Christopher, Thurecht, Kristofer and Kavallaris, Maria (2024). EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer. International Journal of Nanomedicine, 2024 (19), 3623-3639. doi: 10.2147/ijn.s450534

EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer

2024

Journal Article

Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma

Logan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007

Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma

2023

Journal Article

Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered Saccharomyces cerevisiae

Peng, Bingyin, Weintraub, Sarah J., Lu, Zeyu, Evans, Samuel, Shen, Qianyi, McDonnell, Liam, Plan, Manuel, Collier, Thomas, Cheah, Li Chen, Ji, Lei, Howard, Christopher B., Anderson, Will, Trau, Matt, Dumsday, Geoff, Bredeweg, Erin L., Young, Eric M., Speight, Robert and Vickers, Claudia E. (2023). Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered Saccharomyces cerevisiae. ACS Synthetic Biology, 13 (1), 141-156. doi: 10.1021/acssynbio.3c00363

Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered Saccharomyces cerevisiae

2023

Journal Article

An immunomodulating peptide with potential to suppress tumour growth and autoimmunity

Agrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide with potential to suppress tumour growth and autoimmunity. Scientific Reports, 13 (1) 19741, 19741. doi: 10.1038/s41598-023-47229-y

An immunomodulating peptide with potential to suppress tumour growth and autoimmunity

2023

Journal Article

Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation

Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036

Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation

2023

Journal Article

Profiling proteomics responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae

Lu, Zeyu, Shen, Qianyi, Liu, Lian, Talbo, Gert, Speight, Robert, Trau, Matt, Dumsday, Geoff, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2023). Profiling proteomics responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae. Engineering Microbiology, 3 (3) 100079, 100079. doi: 10.1016/j.engmic.2023.100079

Profiling proteomics responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae

2023

Journal Article

An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage

Agrez, Michael, Rybchyn, Mark Stephen, De Silva, Warusavithana Gunawardena Manori, Mason, Rebecca Sara, Chandler, Christopher, Piva, Terrence J., Thurecht, Kristofer, Fletcher, Nicholas, Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew, Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage. Scientific Reports, 13 (1) 11702, 1-19. doi: 10.1038/s41598-023-38890-4

An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage

2023

Conference Publication

Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis

Frankenbach, Tina, Landgraf, Marietta, Fletcher, Nicholas, Howard, Christopher, Ravichandran, Akhilandeshwari, Akhter, Dewan, Shafiee, Abbas, Holzapfel, Boris M., Thurecht, Kristofer, McGovern, Jacqui and Hutmacher, Dietmar W. (2023). Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis. Tissue Engineering and Regenerative Medicine International Society (TERMIS), Krakow, Poland, 28 June - 1 July 2022. New Rochelle, NY United States: Mary Ann Liebert.

Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis

2023

Journal Article

Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma

Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760

Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma

2022

Journal Article

Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes

Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012

Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes

2022

Journal Article

PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth

Movahedi, Fatemeh, Liu, Jie, Sun, Bing, Cao, Pei, Sun, Luyao, Howard, Christopher, Gu, Wenyi and Xu, Zhi Ping (2022). PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth. Pharmaceutics, 14 (7) 1488, 1488. doi: 10.3390/pharmaceutics14071488

PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth

Funding

Current funding

  • 2025 - 2027
    "COVID & Beyond": Innovative rapid response nanoprobes to detect the next pandemic threat.
    NHMRC IDEAS Grants
    Open grant
  • 2023 - 2025
    Research and Development of Membrane Technology
    Aegros Biopharma Pty Ltd
    Open grant

Past funding

  • 2022 - 2025
    An integrated nano-bioengineered chip for enhanced molecular evolution
    ARC Discovery Projects
    Open grant
  • 2021 - 2024
    Innovative delivery methods for the biologic soluble RAGE to prevent Type 1 Diabetes
    JDRF Pilot and Innovation Awards
    Open grant
  • 2020 - 2023
    Novel Virus Trap Nanotechnology for COVID-19 Detection
    Advance Queensland Industry Research Fellowships
    Open grant
  • 2019 - 2022
    Smart affinity membranes for manufacture of high value therapeutic proteins
    ARC Linkage Projects
    Open grant
  • 2019 - 2020
    Evaluation of recombinant biologics for immune modulation
    Servatus Biopharmaceuticals
    Open grant
  • 2019
    Production and analysis of recombinant therapeutics for immune modulation
    Servatus Biopharmaceuticals
    Open grant
  • 2019
    Expression of recombinant proteins in mammalian cells
    Servatus Biopharmaceuticals
    Open grant
  • 2018
    Continuous chromatography system for advanced bioprocessing
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    Provision of research services to Minomic International Ltd
    Minomic International Ltd
    Open grant
  • 2017 - 2023
    ARC Training Centre for Biopharmaceutical Innovation
    ARC Industrial Transformation Training Centres
    Open grant
  • 2016 - 2017
    EGFR targeted nanoparticle feasibility study
    Samyang Biopharmaceuticals Corporation
    Open grant
  • 2016 - 2019
    Next generation hybrid nanomaterials: bispecific antibody-targeted polymers
    ARC Linkage Projects
    Open grant
  • 2016 - 2018
    Immuno-polymeric drugs for prostate cancer therapy
    NHMRC Project Grant
    Open grant

Supervision

Availability

Dr Christopher Howard is:
Available for supervision

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Available projects

Supervision history

Current supervision

  • Doctor Philosophy

    Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae

    Principal Advisor

    Other advisors: Professor Gary Schenk

  • Doctor Philosophy

    Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae

    Principal Advisor

    Other advisors: Professor Gary Schenk

  • Doctor Philosophy

    Development of next-generation molecular tools for diagnostics

    Principal Advisor

    Other advisors: Professor Matt Trau

  • Doctor Philosophy

    Surface engineering of nanoyeast

    Principal Advisor

    Other advisors: Professor Matt Trau

  • Doctor Philosophy

    Development of next-generation molecular tools for diagnostics

    Principal Advisor

    Other advisors: Professor Matt Trau

  • Doctor Philosophy

    mRNA cancer therapies

    Associate Advisor

    Other advisors: Professor Timothy Mercer, Associate Professor Seth Cheetham

  • Doctor Philosophy

    Investigating therapeutic potentials of brain-derived exosomes

    Associate Advisor

    Other advisors: Professor Matt Trau, Dr Richard Lobb

  • Doctor Philosophy

    Towards n-plex quantification of molecular interactions for evolution-free biopanning

    Associate Advisor

    Other advisors: Professor Matt Trau

  • Doctor Philosophy

    An integrated nano-bioengineered chip for enhanced molecular evolution

    Associate Advisor

    Other advisors: Professor Matt Trau

  • Doctor Philosophy

    Integration of innovative platform technologies for the diagnosis of flaviviral infections

    Associate Advisor

    Other advisors: Associate Professor Jody Peters

  • Doctor Philosophy

    Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification

    Associate Advisor

    Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones

  • Doctor Philosophy

    Towards n-plex quantification of molecular interactions for evolution-free biopanning

    Associate Advisor

    Other advisors: Professor Matt Trau

Completed supervision

Media

Enquiries

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