
Overview
Availability
- Dr Christopher Howard is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Protein engineering, Programmable Bionanomaterials, Molecular Discovery, Bio Nano Technologies
Works
Search Professor Christopher Howard’s works on UQ eSpace
Featured
2023
Journal Article
A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments
Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1
Featured
2023
Journal Article
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia
Moles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262
Featured
2023
Journal Article
A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern
Vedelago, Courtney, Li, Junrong, Lowry, Kym, Howard, Christopher, Wuethrich, Alain and Trau, Matt (2023). A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern. ACS Sensors, 8 (4), 1648-1657. doi: 10.1021/acssensors.2c02782
2025
Journal Article
Multiplexing label-free polymeric nanocarriers via antipolymer antibodies
Humphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2025). Multiplexing label-free polymeric nanocarriers via antipolymer antibodies. ACS Sensors. doi: 10.1021/acssensors.4c03184
2025
Journal Article
Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer
Liu, Feifei, Howard, Christopher B., Huda, Pie, Fletcher, Nicholas L., Bell, Craig A., Blakey, Idriss, Agrez, Michael and Thurecht, Kristofer J. (2025). Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer. Biomaterials, 317 123089, 123089. doi: 10.1016/j.biomaterials.2025.123089
2025
Journal Article
Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus – A novel animal test case
Johnston, Ryan A., Habarugira, Gervais, Harrison, Jessica J., Isberg, Sally R., Moran, Jasmin, Morgan, Mahali S., Davis, Steven S., Melville, Lorna, Howard, Christopher B., Henry, Charles S., Macdonald, Joanne, Bielefeldt-Ohmann, Helle, Hall, Roy A. and Hobson-Peters, Jody (2025). Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus – A novel animal test case. Sensors and Actuators B: Chemical, 422 136611, 1-11. doi: 10.1016/j.snb.2024.136611
2024
Journal Article
A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies
Agrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2024). A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies. Scientific Reports, 14 (1) 26737, 1-17. doi: 10.1038/s41598-024-78150-7
2024
Journal Article
mRNA Display Pipeline for Protein Biosensor Construction
Cui, Zhenling, Ayva, Cagla Ergun, Liew, Yi Jin, Guo, Zhong, Mutschler, Roxane, Dreier, Birgit, Fiorito, Maria M, Walden, Patricia, Howard, Christopher B, Ely, Fernanda, Plückthun, Andreas, Pretorius, Carel, Ungerer, Jacobus PJ, Buckle, Ashley M and Alexandrov, Kirill (2024). mRNA Display Pipeline for Protein Biosensor Construction. ACS Sensors, 9 (6), 2846-2857. doi: 10.1021/acssensors.3c02471
2024
Journal Article
LowTempGAL: a highly responsive low temperature-inducible GAL system in Saccharomyces cerevisiae
Lu, Zeyu, Shen, Qianyi, Bandari, Naga Chandra, Evans, Samuel, Mcdonnell, Liam, Liu, Lian, Jin, Wanli, Luna-Flores, Carlos Horacio, Collier, Thomas, Talbo, Gert, Mccubbin, Tim, Esquirol, Lygie, Myers, Chris, Trau, Matt, Dumsday, Geoff, Speight, Robert, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2024). LowTempGAL: a highly responsive low temperature-inducible GAL system in Saccharomyces cerevisiae. Nucleic Acids Research, 52 (12) gkae460, 7367-7383. doi: 10.1093/nar/gkae460
2024
Journal Article
EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer
Moles, Ernest, Chang, David, Mansfeld, Friederike, Duly, Alastair, Kimpton, Kathleen, Logan, Amy, Howard, Christopher, Thurecht, Kristofer and Kavallaris, Maria (2024). EGFR targeting of liposomal doxorubicin improves recognition and suppression of non-small cell lung cancer. International Journal of Nanomedicine, 2024 (19), 3623-3639. doi: 10.2147/ijn.s450534
2024
Journal Article
Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma
Logan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007
2023
Journal Article
Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered Saccharomyces cerevisiae
Peng, Bingyin, Weintraub, Sarah J., Lu, Zeyu, Evans, Samuel, Shen, Qianyi, McDonnell, Liam, Plan, Manuel, Collier, Thomas, Cheah, Li Chen, Ji, Lei, Howard, Christopher B., Anderson, Will, Trau, Matt, Dumsday, Geoff, Bredeweg, Erin L., Young, Eric M., Speight, Robert and Vickers, Claudia E. (2023). Integration of yeast episomal/integrative plasmid causes genotypic and phenotypic diversity and improved sesquiterpene production in metabolically engineered Saccharomyces cerevisiae. ACS Synthetic Biology, 13 (1), 141-156. doi: 10.1021/acssynbio.3c00363
2023
Journal Article
An immunomodulating peptide with potential to suppress tumour growth and autoimmunity
Agrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide with potential to suppress tumour growth and autoimmunity. Scientific Reports, 13 (1) 19741, 19741. doi: 10.1038/s41598-023-47229-y
2023
Journal Article
Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation
Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036
2023
Journal Article
Profiling proteomics responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae
Lu, Zeyu, Shen, Qianyi, Liu, Lian, Talbo, Gert, Speight, Robert, Trau, Matt, Dumsday, Geoff, Howard, Christopher B., Vickers, Claudia E. and Peng, Bingyin (2023). Profiling proteomics responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae. Engineering Microbiology, 3 (3) 100079, 100079. doi: 10.1016/j.engmic.2023.100079
2023
Journal Article
An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage
Agrez, Michael, Rybchyn, Mark Stephen, De Silva, Warusavithana Gunawardena Manori, Mason, Rebecca Sara, Chandler, Christopher, Piva, Terrence J., Thurecht, Kristofer, Fletcher, Nicholas, Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Blyth, Benjamin, Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew, Gooding, Hayley and Gallagher, Laura (2023). An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage. Scientific Reports, 13 (1) 11702, 1-19. doi: 10.1038/s41598-023-38890-4
2023
Conference Publication
Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis
Frankenbach, Tina, Landgraf, Marietta, Fletcher, Nicholas, Howard, Christopher, Ravichandran, Akhilandeshwari, Akhter, Dewan, Shafiee, Abbas, Holzapfel, Boris M., Thurecht, Kristofer, McGovern, Jacqui and Hutmacher, Dietmar W. (2023). Dox- loaded mpeg nanoparticles as a promising treatment in a humanized mouse model for breast cancer bone metastasis. Tissue Engineering and Regenerative Medicine International Society (TERMIS), Krakow, Poland, 28 June - 1 July 2022. New Rochelle, NY United States: Mary Ann Liebert.
2023
Journal Article
Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma
Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760
2022
Journal Article
Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes
Farokhinejad, Fahimeh, Li, Junrong, Hugo, Leon E., Howard, Christopher B., Wuethrich, Alain and Trau, Matt (2022). Detection of Dengue Virus 2 with single infected mosquito resolution using yeast affinity bionanofragments and plasmonic SERS nanoboxes. Analytical Chemistry, 94 (41), 14177-14184. doi: 10.1021/acs.analchem.2c02012
2022
Journal Article
PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth
Movahedi, Fatemeh, Liu, Jie, Sun, Bing, Cao, Pei, Sun, Luyao, Howard, Christopher, Gu, Wenyi and Xu, Zhi Ping (2022). PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth. Pharmaceutics, 14 (7) 1488, 1488. doi: 10.3390/pharmaceutics14071488
Funding
Current funding
Supervision
Availability
- Dr Christopher Howard is:
- Available for supervision
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Available projects
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Molecular Discovery and bioengineering of innovative biologics to detect pandemic threat pathogens, new virus variants and emerging viruses
Explore the molecular discovery and bioengineering of innovative biologics for the detection of pandemic threat pathogens, such as Sars Cov2, SCV2 variants and influenza.
Supervision history
Current supervision
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Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
-
Doctor Philosophy
Development of next-generation molecular tools for diagnostics
Principal Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
Surface engineering of nanoyeast
Principal Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
Development of next-generation molecular tools for diagnostics
Principal Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
mRNA cancer therapies
Associate Advisor
Other advisors: Professor Timothy Mercer, Associate Professor Seth Cheetham
-
Doctor Philosophy
Investigating therapeutic potentials of brain-derived exosomes
Associate Advisor
Other advisors: Professor Matt Trau, Dr Richard Lobb
-
Doctor Philosophy
Towards n-plex quantification of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
An integrated nano-bioengineered chip for enhanced molecular evolution
Associate Advisor
Other advisors: Professor Matt Trau
-
Doctor Philosophy
Integration of innovative platform technologies for the diagnosis of flaviviral infections
Associate Advisor
Other advisors: Associate Professor Jody Peters
-
Doctor Philosophy
Engineering Novel Theranostics for High Grade Glioma Through Site-Specific EphA2 Antibody Modification
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
Doctor Philosophy
Towards n-plex quantification of molecular interactions for evolution-free biopanning
Associate Advisor
Other advisors: Professor Matt Trau
Completed supervision
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2024
Doctor Philosophy
Engineering synthetic regulatory circuits for precise metabolic control in Saccharomyces cerevisiae
Principal Advisor
Other advisors: Professor Gary Schenk
-
2023
Doctor Philosophy
Discovery and Development of a Novel Human Glypican-1 Monoclonal Antibody for Targeting Solid Cancers
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
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2021
Doctor Philosophy
Evaluation of the impact of the upstream bioprocess parameters on the proteomic profile of recombinant factor IX
Principal Advisor
Other advisors: Professor Benjamin Schulz
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2020
Doctor Philosophy
Development of novel bioconjugation strategies for creating cancer-targeting nanomaterials
Principal Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
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2024
Doctor Philosophy
Development of Antibody Delivery Systems Against Intracellular Targets
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
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2023
Doctor Philosophy
Novel antibody theranostics for oncology
Associate Advisor
Other advisors: Dr Pie Huda, Professor Kristofer Thurecht
-
2023
Doctor Philosophy
Bioengineering yeast nanofragment affinity probes for dengue diagnostics
Associate Advisor
Other advisors: Dr Alain Wuethrich, Professor Matt Trau
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2022
Doctor Philosophy
Engineering and production of recombinant proteins with appropriate glycostructures for early in vivo studies
Associate Advisor
Other advisors: Dr Lucia Zacchi, Professor Benjamin Schulz
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2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Nick Fletcher, Professor Kristofer Thurecht
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2019
Doctor Philosophy
Isolation and characterisation of antibodies against human and canine EphA2_ targets for comparative studies in brain cancer
Associate Advisor
Other advisors: Dr Martina Jones, Professor Andrew Whittaker, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Isolation and development of antibodies for active targeting of nanocells for cancer therapy
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
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2018
Doctor Philosophy
Engineering lipid-coated calcium phosphate nanoparticles with multiple ligands to amplify in vivo tumor target delivery
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
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2017
Master Philosophy
Development of anti-PEG bispecific antibodies for targeting PEGylated nanoparticles to tumour cells
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler
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2017
Doctor Philosophy
Development and Application of Novel Biosensor Technologies
Associate Advisor
Other advisors: Dr Martina Jones, Emeritus Professor Stephen Mahler
Media
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