Overview
Background
I am a microbiologist, molecular cellular biologist, and genetic engineer with expertise in antibody discovery and characterization, yeast and mammalian cell line development, and mass spectrometry proteomics (with a focus on post-translational modifications).
I graduated from Universidad Nacional de Río Cuarto, Argentina. I then obtained a Fulbright Scholarship to pursue my Ph.D. in Microbiology, Immunology, and Cancer Biology at the University of Minnesota, USA. For my dissertation I studied genetic and epigenetic mechanisms of phenotypic variation in the pathogenic yeast Candida albicans. I did post-doctoral work in the laboratories of Dr. Jeffrey Brodsky (University of Pittsburgh, USA), Dr. Julio Caramelo (Fundación Instituto Leloir, Argentina), Dr. Benjamin L. Schulz (SCMB, UQ), and the ARC Training Centre for Biopharmaceutical Innovation (AIBN, UQ). I have received Fellowships from the Dystonia Medical Research Foundation, CONICET-Argentina, Endeavour-Australia, and The University of Queensland.
Research Area and Impact
In my team, we believe we can help prevent, diagnose, treat, and cure diseases; and we work every day to design new antibody-based therapies and to develop novel approaches to discovering antibodies against difficult targets.
Availability
- Dr Lucia Zacchi is:
- Not available for supervision
- Media expert
Qualifications
- Doctor of Philosophy, University of Minnesota
Works
Search Professor Lucia Zacchi’s works on UQ eSpace
Featured
2016
Journal Article
SWATH-MS glycoproteomics reveals consequences of defects in the glycosylation machinery
Zacchi, Lucia F. and Schulz, Benjamin L. (2016). SWATH-MS glycoproteomics reveals consequences of defects in the glycosylation machinery. Molecular and Cellular Proteomics, 15 (7), 2435-2447. doi: 10.1074/mcp.M115.056366
Featured
2015
Journal Article
N-glycoprotein macroheterogeneity: biological implications and proteomic characterization.
Zacchi, Lucia F. and Schulz, Benjamin L. (2015). N-glycoprotein macroheterogeneity: biological implications and proteomic characterization.. Glycoconjugate Journal, 33 (3), 1-18. doi: 10.1007/s10719-015-9641-3
2024
Journal Article
Isolation and Characterization of Antibodies Against Vascular Cell Adhesion Molecule-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction
Perera, Binura, Wu, Yuao, Pickett, Jessica R., Panagides, Nadya, Barretto, Francisca M., Fercher, Christian, Sester, David P., Jones, Martina L., Ta, Hang T. and Zacchi, Lucia F. (2024). Isolation and Characterization of Antibodies Against Vascular Cell Adhesion Molecule-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction. International Journal of Molecular Sciences, 25 (24) 13650, 1-21. doi: 10.3390/ijms252413650
2024
Journal Article
The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy
McCulloch, Timothy R., Rossi, Gustavo R., Miranda‐Hernandez, Socorro, Valencia‐Hernandez, Ana Maria, Alim, Louisa, Belle, Clemence J., Krause, Andrew, Zacchi, Lucia F., Lam, Pui Yeng, Nakamura, Kyohei, Kupz, Andreas, Wells, Timothy J. and Souza‐Fonseca‐Guimaraes, Fernando (2024). The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy. Immunology and Cell Biology, 102 (8), 721-733. doi: 10.1111/imcb.12794
2024
Journal Article
Characterization of novel Rh variant (CETW) associated with haemolytic disease of fetus and newborn using recombinant technology
Zhao, Shen, Radenkovic, Filip, Flower, Robert, Zacchi, Lucia, Jones, Martina, Wilson, Brett, Liew, Yew Wah, Tung, John-Paul and Hyland, Catherine (2024). Characterization of novel Rh variant (CETW) associated with haemolytic disease of fetus and newborn using recombinant technology. Pathology, 56 (Supplement 1), S100-S100. doi: 10.1016/j.pathol.2023.12.336
2023
Journal Article
Targeting endothelial VCAM-1 in atherosclerosis: drug discovery and development of VCAM-1-directed novel therapeutics
Pickett, Jess R., Wu, Yuao, Zacchi, Lucia F. and Ta, Hang T. (2023). Targeting endothelial VCAM-1 in atherosclerosis: drug discovery and development of VCAM-1-directed novel therapeutics. Cardiovascular Research, 119 (13), 2278-2293. doi: 10.1093/cvr/cvad130
2022
Journal Article
Evaluation of phage display biopanning strategies for the selection of anti-cell surface receptor antibodies
Panagides, Nadya, Zacchi, Lucia F., Souza, Mitchell J. De, Morales, Rodrigo A. V., Karnowski, Alexander, Liddament, Mark T., Owczarek, Catherine M., Mahler, Stephen M., Panousis, Con, Jones, Martina L. and Fercher, Christian (2022). Evaluation of phage display biopanning strategies for the selection of anti-cell surface receptor antibodies. International Journal of Molecular Sciences, 23 (15) 8470, 8470. doi: 10.3390/ijms23158470
2021
Journal Article
TorsinA folding and N-linked glycosylation are sensitive to redox homeostasis
Honer, Jonas, Niemeyer, Katie M., Fercher, Christian, Diez Tissera, Ana L., Jaberolansar, Noushin, Jafrani, Yohaann M. A., Zhou, Chun, Caramelo, Julio J., Shewan, Annette M., Schulz, Benjamin L., Brodsky, Jeffrey L. and Zacchi, Lucía F. (2021). TorsinA folding and N-linked glycosylation are sensitive to redox homeostasis. Biochimica et Biophysica Acta. Molecular Cell Research, 1868 (9) 119073, 119073. doi: 10.1016/j.bbamcr.2021.119073
2021
Journal Article
The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence
Jenull, Sabrina, Mair, Theresia, Tscherner, Michael, Penninger, Philipp, Zwolanek, Florian, Silao, Fitz-Gerald S., de San Vicente, Kontxi Martinez, Riedelberger, Michael, Bandari, Naga C., Shivarathri, Raju, Petryshyn, Andriy, Chauhan, Neeraj, Zacchi, Lucia F., -Landmann, Salomé LeibundGut, Ljungdahl, Per O. and Kuchler, Karl (2021). The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence. Cell Reports, 36 (3) 109406, 109406. doi: 10.1016/j.celrep.2021.109406
2021
Journal Article
N-glycosylation on Oryza sativa root germin-like protein 1 is conserved but not required for stability or activity
Rubbab, Tehseen, Pegg, Cassandra L., Phung, Toan K., Nouwens, Amanda S., Yeo, K.Y. Benjamin, Zacchi, Lucia F., Muhammad, Amna, Naqvi, S.M. Saqlan and Schulz, Benjamin L. (2021). N-glycosylation on Oryza sativa root germin-like protein 1 is conserved but not required for stability or activity. Biochemical and Biophysical Research Communications, 553, 72-77. doi: 10.1016/j.bbrc.2021.03.024
2021
Journal Article
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product
Zacchi, Lucia F., Roche-Recinos, Dinora, Pegg, Cassandra L., Phung, Toan K., Napoli, Mark, Aitken, Campbell, Sandford, Vanessa, Mahler, Stephen M., Lee, Yih Yean, Schulz, Benjamin L. and Howard, Christopher B. (2021). Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product. Communications Biology, 4 (1) 390, 390. doi: 10.1038/s42003-021-01903-x
2020
Journal Article
Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis
Fercher, Christian and Zacchi, Lucía F. (2020). Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis. Frontiers in Molecular Biosciences, 7 585643, 585643. doi: 10.3389/fmolb.2020.585643
2020
Journal Article
Identification of novel glycosylation events on human serum-derived factor IX
Pegg, Cassandra L., Zacchi, Lucia F., Recinos, Dinora Roche, Howard, Christopher B. and Schulz, Benjamin L. (2020). Identification of novel glycosylation events on human serum-derived factor IX. Glycoconjugate Journal, 37 (4), 471-483. doi: 10.1007/s10719-020-09922-2
2020
Journal Article
Glycoproteomic measurement of site-specific polysialylation
Pelingon, Ruby, Pegg, Cassandra L., Zacchi, Lucia F., Phung, Toan K., Howard, Christopher B., Xu, Ping, Hardy, Matthew P., Owczarek, Catherine M. and Schulz, Benjamin L. (2020). Glycoproteomic measurement of site-specific polysialylation. Analytical Biochemistry, 596 113625, 113625. doi: 10.1016/j.ab.2020.113625
2020
Journal Article
S-trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants
Zacchi, Lucia F., Roche Recinos, Dinora, Otte, Ellen, Aitken, Campbell, Hunt, Tony, Sandford, Vanessa, Lee, Yih Yean, Schulz, Benjamin L. and Howard, Christopher B. (2020). S-trap eliminates cell culture media polymeric surfactants for effective proteomic analysis of mammalian cell bioreactor supernatants. Journal of Proteome Research, 19 (5), 2149-2158. doi: 10.1021/acs.jproteome.0c00106
2020
Journal Article
DIALib: an automated ion library generator for data independent acquisition mass spectrometry analysis of peptides and glycopeptides
Phung, Toan K., Zacchi, Lucia F. and Schulz, Benjamin L. (2020). DIALib: an automated ion library generator for data independent acquisition mass spectrometry analysis of peptides and glycopeptides. Molecular Omics, 16 (2), 100-112. doi: 10.1039/c9mo00125e
2019
Book Chapter
Data-independent acquisition for yeast glycoproteomics
Zacchi, Lucía F. and Schulz, Benjamin L. (2019). Data-independent acquisition for yeast glycoproteomics. Yeast systems biology. (pp. 191-202) New York, NY USA: Humana Press. doi: 10.1007/978-1-4939-9736-7_11
2018
Journal Article
Pre- and post-puberty expression of genes and proteins in the uterus of Bos indicus heifers: the luteal phase effect post-puberty
Fortes, M. R.S., Zacchi, L. F., Nguyen, L. T., Raidan, F., Weller, M. M.D.C.A., Choo, J. J.Y., Reverter, A., Rego, J. P.A., Boe-Hansen, G. B., Porto-Neto, L. R., Lehnert, S. A., Cánovas, A., Schulz, B. L., Islas-Trejo, A., Medrano, J. F., Thomas, M. G. and Moore, S. S. (2018). Pre- and post-puberty expression of genes and proteins in the uterus of Bos indicus heifers: the luteal phase effect post-puberty. Animal Genetics, 49 (6), 539-549. doi: 10.1111/age.12721
2018
Journal Article
Adipose tissue proteomic analyses to study puberty in Brahman heifers
Nguyen, L. T., Zacchi, L. F., Schulz, B. L., Moore, S. S. and Fortes, M. R. S. (2018). Adipose tissue proteomic analyses to study puberty in Brahman heifers. Journal of Animal Science, 96 (6), 2392-2398. doi: 10.1093/jas/sky128
2017
Journal Article
Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinA Delta E
Zacchi, Lucia F., Dittmar, John C., Mihalevic, Michael J., Shewan, Annette M., Schulz, Benjamin L., Brodsky, Jeffrey L. and Bernstein, Kara A. (2017). Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinA Delta E. Disease Models & Mechanisms, 10 (9), 1129-1140. doi: 10.1242/dmm.029926
Supervision
Availability
- Dr Lucia Zacchi is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
From Target Discovery to Therapeutic Antibodies
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones, Professor Jessica Mar
Completed supervision
-
2025
Doctor Philosophy
Systems biology-guided cell line engineering for production of therapeutic proteins with complex post-translational modifications
Associate Advisor
Other advisors: Professor Esteban Marcellin, Professor Benjamin Schulz
-
2022
Doctor Philosophy
Engineering and production of recombinant proteins with appropriate glycostructures for early in vivo studies
Associate Advisor
Other advisors: Dr Christopher Howard, Professor Benjamin Schulz
-
2019
Doctor Philosophy
Messaging with magnesium: Function of yeast Ost3 proteins in glycosylation and magnesium
Associate Advisor
Other advisors: Professor Benjamin Schulz
Media
Enquiries
Contact Dr Lucia Zacchi directly for media enquiries about:
- Dystonia
- Glycobiology
- Proteomics
- Yeast genetic engineering
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